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1. 发明申请

US20070104596A1 Actuator system comprising lever mechanism 失效
标题翻译：执行器系统包括杠杆机构
公开(公告)号：US20070104596A1
公开(公告)日：2007-05-10
申请号：US11541348
申请日：2006-09-29
申请人： Jan Preuthun , Ole Nielsen , Steffen Hansen , Bjorn Larsen , Henrik Bengtsson , Leif Johannsen , Finn Jensen
发明人： Jan Preuthun , Ole Nielsen , Steffen Hansen , Bjorn Larsen , Henrik Bengtsson , Leif Johannsen , Finn Jensen
IPC分类号： F04B17/00
CPC分类号： A61M5/16809 , A61M5/14224 , A61M5/14248 , A61M5/16831
摘要： The invention provides a pump assembly comprising an actuator lever, a supporting structure, a pump comprising a pump member moveable by actuation of the actuator lever, and an actuator for moving the actuator lever. A first stationary pivoting joint is formed between the actuator lever and the supporting structure, and a second floating pivoting joint is formed between the actuator lever and the pump member allowing the pump member to float relative to the actuator lever, the floating pivoting point providing a constant-length actuator arm defined between the first pivoting joint and the second pivoting joint.
摘要翻译：本发明提供一种泵组件，其包括致动器杆，支撑结构，包括通过致动器杆的致动而可移动的泵构件的泵和用于使致动器杆移动的致动器。第一固定枢转接头形成在致动器杠杆和支撑结构之间，并且第二浮动枢转接头形成在致动器杆和泵构件之间，允许泵构件相对于致动器杆浮动，浮动枢转点提供恒定长度的致动器臂限定在第一枢转接头和第二枢转接头之间。

2. 发明申请

US20070112301A1 Actuator system comprising detector means 审中-公开
标题翻译：执行器系统包括检测器装置
公开(公告)号：US20070112301A1
公开(公告)日：2007-05-17
申请号：US11540842
申请日：2006-09-29
申请人： Jan Preuthun , Ole Nielsen , Steffen Hansen , Bjorn Larsen , Henrik Bengtsson
发明人： Jan Preuthun , Ole Nielsen , Steffen Hansen , Bjorn Larsen , Henrik Bengtsson
IPC分类号： A61M1/00
CPC分类号： A61M5/14248 , A61M5/14216 , A61M5/14224 , A61M2005/14252 , A61M2005/16863 , F04B43/02 , F04B43/04 , F04B43/06 , F04B51/00 , F04B2201/0201 , F04B2207/043 , F04B2207/70
摘要： The invention provides an actuator system comprising an actuator member having first and second positions. The system further comprises actuating means for moving the actuator member between the first and second positions and detection means for detecting the first respectively the second position and supplying time signals indicative thereof. A controller determines on the basis of supplied time signals the time lapsed when the actuator member is moved between the first and second positions in a given direction, the controller comprising information representing at least one defined time range, each time range being associated with movement of the actuator member in a given direction between the first and second positions and a given actuation force, the controller being adapted to compare the determined time lapsed with the defined time range(s) and perform an action corresponding to the time range associated with the determined time lapsed.
摘要翻译：本发明提供了一种致动器系统，其包括具有第一和第二位置的致动器构件。该系统还包括用于在第一和第二位置之间移动致动器构件的致动装置和用于检测第一分别第二位置和提供指示其的时间信号的检测装置。控制器基于所提供的时间信号确定当致动器构件在给定方向上在第一和第二位置之间移动时所经过的时间，所述控制器包括表示至少一个限定时间范围的信息，每个时间范围与所述致动器构件在给定方向上在所述第一和第二位置之间以及给定的致动力之间，所述控制器适于将确定的经过的时间与所述限定的时间范围进行比较，并执行与所确定的时间范围相关联的时间范围时间过去了

3. 发明申请

US20070021733A1 Internal fluid connector 审中-公开
标题翻译：内部流体连接器
公开(公告)号：US20070021733A1
公开(公告)日：2007-01-25
申请号：US11407647
申请日：2006-04-20
申请人： Steffen Hansen , Bjorn Larsen , Claus Moller , Ole Nielsen , Jim Radmer , Jan Preuthun , Philip Sparholt , Erik Ethelfeld
发明人： Steffen Hansen , Bjorn Larsen , Claus Moller , Ole Nielsen , Jim Radmer , Jan Preuthun , Philip Sparholt , Erik Ethelfeld
IPC分类号： A61K9/22
CPC分类号： A61M5/14248 , A61M5/14216 , A61M5/14224 , A61M5/14526 , A61M5/1486 , A61M2005/14252 , A61M2005/14268 , A61M2005/14506 , A61M2005/14513 , A61M2005/1585
摘要： A medical device is provided comprising a reservoir adapted to contain a fluid drug in an interior thereof, and a pump assembly. The pump assembly comprises a pump inlet, a pump outlet and an internal flow path arranged there between, and a fluid connector having an inlet and an outlet. The fluid connector is arranged to be operated from an initial state in which the fluid connector is arranged within the interior of the pump and an actuated state in which fluid communication is established between the interior of the reservoir and the interior of the pump assembly via the fluid connector and with the outlet of the fluid connector being arranged in the flow path of the pump assembly.
摘要翻译：提供了一种医疗装置，其包括适于在其内部容纳流体药物的储存器和泵组件。泵组件包括泵入口，泵出口和布置在其间的内部流动路径，以及具有入口和出口的流体连接器。流体连接器布置成从初始状态操作，其中流体连接器布置在泵的内部内，以及致动状态，其中在储存器的内部和泵组件的内部之间建立流体连通流体连接器并且流体连接器的出口布置在泵组件的流动路径中。

4. 发明申请

US20060264835A1 Medical skin mountable device 有权
标题翻译：医用皮肤安装装置
公开(公告)号：US20060264835A1
公开(公告)日：2006-11-23
申请号：US11411081
申请日：2006-04-25
申请人： Ole Nielsen , Jim Radmer , Jan Preuthun
发明人： Ole Nielsen , Jim Radmer , Jan Preuthun
IPC分类号： A61M5/32
CPC分类号： A61M5/14248 , A61M5/14216 , A61M5/14224 , A61M5/14526 , A61M5/1486 , A61M2005/14252 , A61M2005/14268 , A61M2005/14506 , A61M2005/14513 , A61M2005/1585
摘要： A medical device is provided comprising a transcutaneous device unit and a reservoir unit. The transcutaneous device unit comprises a transcutaneous device for transporting a fluid through a skin portion of a subject, and a mounting surface adapted for application to the skin of the subject. The reservoir unit comprises a reservoir adapted to contain a fluid drug, the reservoir comprising an outlet means allowing the transcutaneous device to be arranged in fluid communication with an interior of the reservoir, and an expelling assembly for expelling a fluid drug out of the reservoir and through the skin of the subject via the transcutaneous device. The transcutaneous device unit and the reservoir unit further comprise coupling means allowing the reservoir unit to be secured to the transcutaneous device unit in the situation of use. By this arrangement a two-unit system is provided which can be used in a convenient and cost-effective manner.
摘要翻译：提供了包括经皮装置单元和储存器单元的医疗装置。经皮装置单元包括用于输送流体通过受试者的皮肤部分的经皮装置和适于施用于受试者皮肤的安装表面。储存器单元包括适于容纳流体药物的储存器，储存器包括允许经皮装置与储存器的内部流体连通的出口装置和用于将流体药物排出储存器的排出组件，以及通过经皮装置穿过受试者的皮肤。经皮装置单元和储存器单元还包括联接装置，允许储存器单元在使用情况下固定到经皮装置单元。通过这种布置，提供了可以以便利且具有成本效益的方式使用的两单元系统。

5. 发明申请

US20060232351A1 Digital pulse width controlled oscillation modulator 有权
标题翻译：数字脉宽调制振荡器
公开(公告)号：US20060232351A1
公开(公告)日：2006-10-19
申请号：US10548432
申请日：2004-03-23
申请人： Ole Nielsen
发明人： Ole Nielsen
IPC分类号： H03K7/08
CPC分类号： H03M5/08 , H03M3/506 , H03M7/3004 , H03M7/3028 , H03M7/304
摘要： A pulse width modulator (10) for converting a digital signal into a PWM signal, comprising a plurality of integrators (11) with integrator gains (12) arranged in series, a comparator (17) for comparing the output of the last integrator (11′) with a reference, and thereby creating the PWM signal. The modulator further has means (13) for realizing self-oscillation at a desired switching frequency, and a feedback path (14) connected to a point down stream said comparator and leading to a plurality of summing points, each preceding one of said integrators, wherein the PWM signal is quantized in time by the clock frequency of the modulator, and wherein the integrator gains (12) are adapted to reduce any quantization noise.
摘要翻译：一种用于将数字信号转换为PWM信号的脉冲宽度调制器（10），包括具有串联布置的积分器增益（12）的多个积分器（11），比较器（17），用于比较最后一个积分器 '），从而产生PWM信号。调制器还具有用于以期望的开关频率实现自振荡的装置（13）和连接到下游流的所述比较器并且导致多个求和点的反馈路径（14），每个求和点各自在所述积分器之一之前，其中所述PWM信号在调制器的时钟频率上被量化，并且其中所述积分器增益（12）适于减少任何量化噪声。

6. 发明授权

US07112686B2 Process for the preparation of racemic citalopram and/or S-or R-citalopram by separation of a mixture of R-and S-citalopram 有权
标题翻译：通过分离R和S-西酞普兰混合物制备外消旋西酞普兰和/或S-或R-西酞普兰的方法
公开(公告)号：US07112686B2
公开(公告)日：2006-09-26
申请号：US10482000
申请日：2002-06-25
申请人： Rikke E. Humble , Troels V. Christensen , Michael H. Rock , Ole Nielsen , Hans Petersen , Robert Dancer
发明人： Rikke E. Humble , Troels V. Christensen , Michael H. Rock , Ole Nielsen , Hans Petersen , Robert Dancer
IPC分类号： C07D307/78 , C07D307/87 , C07D307/93
CPC分类号： C07D307/87
摘要： The invention relates to a process for the preparation of racemic citalopram free base or an acid addition salt thereof and/or R- or S-citalopram as the free base or an acid addition salt thereof by separation of a mixture of R- and S-citalopram with more than 50% of one of the enantiomers into a fraction consisting of racemic citalopram and/or a fraction of S-citalopram or R-citalopram characterized in that i) citalopram is precipitated from a solvent as the free base or as an acid addition salt thereof; ii) the precipitate formed is separated from the mother liquor; iia) if the precipitate is crystalline it is optionally recrystallised one or more times to form racemic citalopram, and then optionally converted into an acid addition salt thereof; iib) if the precipitate is not crystalline, steps i) and ii) are optionally repeated until a crystalline precipitate is obtained and the crystalline precipitate is recrystallised one or more times to form racemic citalopram, and then optionally converted into an acid addition salt thereof; iii) the mother liquor is optionally subjected to further purification and S-citalopram or R-citalopram is isolated from the mother liquor and optionally converted into an addition salt thereof.
摘要翻译：本发明涉及一种通过分离R和S-的混合物来制备外消旋西酞普兰游离碱或其酸加成盐和/或R-或S-西酞普兰作为游离碱或其酸加成盐的方法，西酞普兰与超过50％的一种对映异构体组成由外消旋西酞普兰和/或S-西酞普兰或R-西酞普兰的部分组成的部分，其特征在于i）西酞普兰作为游离碱或作为酸从溶剂中沉淀出来其加成盐; ii）形成的沉淀物与母液分离; 如果沉淀物是结晶的，则任选地重结晶一次或多次以形成外消旋西酞普兰，然后任选地转化成其酸加成盐; iib）如果沉淀物不结晶，则任选地重复步骤i）和ii），直到获得结晶沉淀物，并将结晶沉淀物重结晶一次或多次以形成外消旋西酞普兰，然后任选地转化为其酸加成盐; iii）任选地将母液进一步纯化，并从母液中分离S-西酞普兰或R-西酞普兰，并任选地转化成其加成盐。

7. 发明申请

US20050122754A1 Half-bridge driver and power conversion system with such driver 有权
标题翻译：半桥驱动器和电源转换系统带有这样的驱动
公开(公告)号：US20050122754A1
公开(公告)日：2005-06-09
申请号：US10499194
申请日：2002-12-05
申请人： Ole Nielsen
发明人： Ole Nielsen
IPC分类号： H02M1/08 , H03K17/06 , H03K17/687 , H02M7/5387
CPC分类号： H03K17/6871 , H03K17/063
摘要： A half-bridge driver includes first and second power switches, connected with their respective current paths in series, a pulse generator for generating a voltage pulse waveform, arranged to drive the first power switch, a first current generator for generating a current pulse for each negative flank of the voltage pulse waveform, a second current generator for generating a current pulse for each positive flank of said voltage pulse waveform, and a differential current receiver circuit. The differential current receiver circuit is connected to the first and second current generators, and is arranged to generate an output signal equal to the difference of the currents flowing through the current generators. The output signal is arranged to drive the second power switch.
摘要翻译：半桥驱动器包括与其各自的电流路径串联连接的第一和第二电源开关，用于产生电压脉冲波形的脉冲发生器，用于驱动第一电源开关，第一电流发生器，用于为每个电流脉冲产生电流脉冲电压脉冲波形的负侧面，用于为所述电压脉冲波形的每个正侧面产生电流脉冲的第二电流发生器和差动电流接收器电路。差分电流接收器电路连接到第一和第二电流发生器，并且被布置为产生等于流过电流发生器的电流的差的输出信号。输出信号被布置成驱动第二电源开关。

8. 发明授权

US08227607B2 Processes for 4-((1R,35)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine or a salt thereof 有权
标题翻译： 4 - （（1R，35）-6-氯-3-苯基茚-1-基）-1,2,2-三甲基哌嗪或其盐的方法
公开(公告)号：US08227607B2
公开(公告)日：2012-07-24
申请号：US12820392
申请日：2010-06-22
申请人： Heidi Lopez de Diego , Ole Nielsen , Lone Munch Ringgard , Henrik Svane , Allan Carsten Dahl , Mark Howells , Benny Bang-Andersen , Lars Ole Lyngsø , Sherry Lynn Collier
发明人： Heidi Lopez de Diego , Ole Nielsen , Lone Munch Ringgard , Henrik Svane , Allan Carsten Dahl , Mark Howells , Benny Bang-Andersen , Lars Ole Lyngsø , Sherry Lynn Collier
IPC分类号： C07D295/073 , C07C35/32
CPC分类号： C07D295/073 , C07B2200/07 , C07C17/16 , C07C25/22 , C07C29/143 , C07C35/32 , C07C2602/08 , C07D241/04 , C12P7/22 , C12P41/004 , C07C35/52
摘要： Methods for the preparation of 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and salts thereof are described.
摘要翻译：描述了制备4 - （（1R，3S）-6-氯-3-苯基茚-1-基）-1,2,2-三甲基哌嗪及其盐的方法。

9. 发明申请

US20110046218A1 CRYSTALLINE BASE OF ESCITALOPRAM AND ORODISPERSIBLE TABLETS COMPRISING ESCITALOPRAM BASE 审中-公开
标题翻译：包括ESCITALOPRAM基板的晶圆和可折叠片
公开(公告)号：US20110046218A1
公开(公告)日：2011-02-24
申请号：US12916750
申请日：2010-11-01
申请人： Robert Dancer , Hans Petersen , Ole Nielsen , Michael Harold Rock , Helle Eliasen , Ken Liljegren
发明人： Robert Dancer , Hans Petersen , Ole Nielsen , Michael Harold Rock , Helle Eliasen , Ken Liljegren
IPC分类号： A61K31/343 , C07D307/87 , A61P25/24
CPC分类号： C07D307/81
摘要： The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile, formulations of said base, a process for the preparation of purified salts of escitalopram, such as the oxalate, using the base, the salts obtained by said process and formulations containing such salts, and a process for the preparation of purified escitalopram free base or salts of escitalopram, such as the oxalate, using the hydrobromide, the salts obtained by said process and formulations containing such salts. Finally the present invention relates to an orodispersible tablet having a hardness of at least 22 N and an oral-disintegration time of less than 120 s and comprising an active pharmaceutical ingredient adsorbed onto a water soluble filler wherein the active pharmaceutical ingredient has a melting point in the range of 40-100° C., as well as a method for making such an orodispersible tablet.
摘要翻译：本发明涉及众所周知的抗抑郁药物依他普仑S-1- [3-（二甲基氨基）丙基] -1-（4-氟苯基）-1,3-二氢-5-异苯并呋喃甲腈的结晶碱，所述制剂为碱，使用碱，草酸盐的纯化盐的制备方法，通过所述方法获得的盐和含有这些盐的制剂的方法，以及制备纯化的依他普仑游离碱或依他普仑的盐的方法，例如草酸盐，使用氢溴酸盐，通过所述方法获得的盐和含有这些盐的制剂。最后，本发明涉及硬度至少为22N，口服崩解时间小于120秒的可分散片剂，其包含吸附在水溶性填料上的活性药物成分，其中活性药物成分的熔点为 40-100℃的范围，以及制造这种可分散片剂的方法。

10. 发明申请

US20070021499A1 CRYSTALLINE BASE OF ESCITALOPRAM AND ORODISPERSIBLE TABLETS COMPRISING ESCITALOPRAM BASE 有权
标题翻译：包括ESCITALOPRAM基板的晶圆和可折叠片
公开(公告)号：US20070021499A1
公开(公告)日：2007-01-25
申请号：US11425522
申请日：2006-06-21
申请人： Robert Dancer , Hans Petersen , Ole Nielsen , Michael Rock , Helle Eliasen , Ken Liljegren
发明人： Robert Dancer , Hans Petersen , Ole Nielsen , Michael Rock , Helle Eliasen , Ken Liljegren
IPC分类号： A61K31/343 , C07D307/02
CPC分类号： C07D307/81
摘要： The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile, formulations of said base, a process for the preparation of purified salts of escitalopram, such as the oxalate, using the base, the salts obtained by said process and formulations containing such salts, and a process for the preparation of purified escitalopram free base or salts of escitalopram, such as the oxalate, using the hydrobromide, the salts obtained by said process and formulations containing such salts. Finally the present invention relates to an orodispersible tablet having a hardness of at least 22 N and an oral-disintegration time of less than 120 s and comprising an active pharmaceutical ingredient adsorbed onto a water soluble filler wherein the active pharmaceutical ingredient has a melting point in the range of 40-100° C., as well as a method for making such an orodispersible tablet.
摘要翻译：本发明涉及众所周知的抗抑郁药物依他普仑S-1- [3-（二甲基氨基）丙基] -1-（4-氟苯基）-1,3-二氢-5-异苯并呋喃甲腈的结晶碱，所述制剂为碱，使用碱，草酸盐的纯化盐的制备方法，通过所述方法获得的盐和含有这些盐的制剂的方法，以及制备纯化的依他普仑游离碱或依他普仑的盐的方法，例如草酸盐，使用氢溴酸盐，通过所述方法获得的盐和含有这些盐的制剂。最后，本发明涉及硬度至少为22N，口服崩解时间小于120秒的可分散片剂，其包含吸附在水溶性填料上的活性药物成分，其中活性药物成分的熔点为 40-100℃的范围，以及制造这种可分散片剂的方法。

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