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1. 发明授权

US09480464B2 Tissue collection system 有权
标题翻译：组织收集系统
公开(公告)号：US09480464B2
公开(公告)日：2016-11-01
申请号：US13561722
申请日：2012-07-30
申请人： Jamie P. Levine , Alexes Hazen , Marc-Alan Levine
发明人： Jamie P. Levine , Alexes Hazen , Marc-Alan Levine
IPC分类号： A61B10/02
CPC分类号： A61B10/0283
摘要： The present invention relates to a tissue collection system. The system includes an outer housing, a first cylindrical fenestrated member within and immovable relative to the outer housing, a second cylindrical fenestrated member defining an inner tissue collection chamber and being positioned within and rotatable relative to the first cylindrical fenestrated member, a plunger axially movable within the second fenestrated member, an elongate rod being connected to the plunger, and one or more stop units attached to the outer housing. The present invention also relates to methods for separating components of a tissue sample using a system according to the present invention.
摘要翻译：本发明涉及组织收集系统。该系统包括外壳体，相对于外壳体内并且不可移动的第一圆柱形开窗构件，限定内组织收集室并定位在第一圆柱形开窗构件内并可相对于第一圆柱形开窗构件旋转的第二圆柱形开窗构件，在第二开窗构件内的细长杆连接到柱塞，以及连接到外壳的一个或多个止挡单元。本发明还涉及使用根据本发明的系统分离组织样品的组分的方法。

2. 发明授权

US08663259B2 Rotational thrombectomy wire 有权
标题翻译：旋转血栓切除术丝
公开(公告)号：US08663259B2
公开(公告)日：2014-03-04
申请号：US13095329
申请日：2011-04-27
申请人： Marc-Alan Levine , Michael Leedle , John D. Leedle
发明人： Marc-Alan Levine , Michael Leedle , John D. Leedle
IPC分类号： A61B17/22
CPC分类号： A61B17/320725 , A61B17/32002 , A61B17/320758 , A61B2017/00331 , A61B2017/320733 , A61B2017/320775
摘要： A rotational thrombectomy wire for breaking up vascular thrombus or other obstructive material having a core having a proximal portion and a distal portion. The distal portion has a smaller diameter than the proximal portion. A cable extends distally of the core. The cable has a first covering material positioned external thereof. A first coil is attached to a distal portion of the cable and has a diameter larger than a diameter of the cable and has a second covering material positioned thereover. The wire is rotatable by a motor.
摘要翻译：一种用于分解血管血栓的旋转性血栓切除线或具有具有近端部分和远端部分的芯的其它阻塞物质。远侧部分具有比近侧部分更小的直径。电缆沿芯线向远侧延伸。电缆具有位于其外部的第一覆盖材料。第一线圈附接到电缆的远端部分并且具有大于电缆直径的直径，并且具有定位在其上的第二覆盖材料。电线可通过电机旋转。

3. 发明授权

US08262691B2 Distal protective device 有权
标题翻译：远端保护装置
公开(公告)号：US08262691B2
公开(公告)日：2012-09-11
申请号：US12005257
申请日：2007-12-26
申请人： James F. McGuckin, Jr. , Marc-Alan Levine , James Erich Bressler
发明人： James F. McGuckin, Jr. , Marc-Alan Levine , James Erich Bressler
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/008
摘要： A distal protection device comprising a catheter having a first strut movable from a collapsed configuration to an expanded configuration having a first dimension and a second strut movable from a collapsed configuration to an expanded configuration having a second dimension larger than the first dimension. Movement of the first strut deploys filter material to a first position having a first deployed dimension and movement of the second strut to a first position deploys filter material to a second deployed dimension larger than the first expanded dimension.
摘要翻译：一种远端保护装置，其包括导管，该导管具有可从折叠构型移动到具有第一尺寸的扩张构型的第一支柱和可从折叠构型移动到具有大于第一尺寸的第二尺寸的扩张构型的第二支柱。第一支柱的运动将过滤材料部署到具有第一展开尺寸的第一位置，并且将第二支柱移动到第一位置将过滤材料展开到大于第一展开尺寸的第二展开尺寸。

4. 发明申请

US20080255654A1 SYSTEM FOR DELIVERING A STENT 审中-公开
标题翻译：提供一个支柱的系统
公开(公告)号：US20080255654A1
公开(公告)日：2008-10-16
申请号：US12053099
申请日：2008-03-21
申请人： Stephen Hebert , Marc-Alan Levine
发明人： Stephen Hebert , Marc-Alan Levine
IPC分类号： A61F2/84 , A61F2/82
CPC分类号： A61F2/95 , A61F2/966 , A61M25/09 , A61M2025/09091 , A61M2025/09175 , A61M2025/09183
摘要： A stent delivery system including an elongate member having a proximal segment and a distal segment, the distal segment having a first coil section, a second coil section, an intermediate coil section located between the first and second coil sections and a plastic material overlying one or more of the coil sections.
摘要翻译：一种支架输送系统，包括具有近端段和远端段的细长构件，所述远端段具有第一线圈段，第二线圈区段，位于第一和第二线圈区段之间的中间线圈段，以及覆盖一个或更多的线圈部分。

5. 发明授权

US07169172B2 Method and apparatus for caged stent delivery 有权
标题翻译：笼式支架输送的方法和装置
公开(公告)号：US07169172B2
公开(公告)日：2007-01-30
申请号：US10286109
申请日：2002-11-01
申请人： Marc-Alan Levine , Stephen Hebert
发明人： Marc-Alan Levine , Stephen Hebert
IPC分类号： A61F2/06
CPC分类号： A61F2/95 , A61F2/97 , A61F2002/9505 , Y10S623/903
摘要： A method and apparatus for caged stent delivery is provided herein. The device can be used to position and deliver any type of stent to a preselected treatment site within an intraluminal cavity. The device comprises a tubular portion, a plurality of arms attached to the distal end of the tubular portion, and a mechanism to open the arms. In operation, the caged device carries a stent in a constricted form to the treatment site for deployment. The arms of the cage are then opened, the stent released and deployed, and the device withdrawn. Several methods are provided to open the arms, including various pullwires, a piston, an electrolytic joint, and an activator. The arms may be constructed of a shape memory alloy and opened when shape memory behavior is effected. The device may be used with conventional catheters or used with a stent-loaded guidewire.
摘要翻译：本文提供了笼式支架输送的方法和装置。该装置可用于将任何类型的支架定位并递送到腔内腔内的预选治疗部位。该装置包括管状部分，连接到管状部分的远端的多个臂以及用于打开臂的机构。在操作中，笼式装置将缩窄形式的支架运送到用于部署的治疗部位。然后打开笼子的臂，将支架释放并展开，并将装置取出。提供几种打开臂的方法，包括各种拉线，活塞，电解接头和活化剂。臂可以由形状记忆合金构成，并且当形状记忆行为被实现时打开。该装置可以与常规导管一起使用或与支架装载的导丝一起使用。

6. 发明申请

US20060116750A1 Guidewire loaded stent for delivery through a catheter 失效
公开(公告)号：US20060116750A1
公开(公告)日：2006-06-01
申请号：US11335205
申请日：2006-01-19
申请人： Stephen Hebert , Marc-Alan Levine
发明人： Stephen Hebert , Marc-Alan Levine
IPC分类号： A61F2/06
CPC分类号： A61F2/966 , A61F2/95 , A61F2/958 , A61F2002/9583 , A61M25/09 , A61M2025/09008 , A61M2025/09183
摘要： A guidewire loaded stent for delivery through a catheter is described herein. The stent delivery assembly can deliver and place a stent within tortuous regions of the body which are accessible to guidewires but inaccessible to stenting catheters. The assembly comprises a guidewire covered in part by a retractable sheath and a radially expandable stent near or at the distal end of the guidewire. The whole assembly is advanced through conventional catheters or it may be used alone. In either case, when the stent is adjacent to a treatment site within the body, the sheath is retracted proximally to expose the stent for radial expansion into contact with the vessel wall. Radio-opaque marker bands are optionally located on either side or both sides of the stent on the guidewire body to aid in visual placement. The assembly can optionally include an expandable balloon on the guidewire for different treatment modalities.

7. 发明授权

US06726700B1 Manipulatable delivery catheter for occlusive devices 失效
标题翻译：用于闭塞装置的可手术输送导管
公开(公告)号：US06726700B1
公开(公告)日：2004-04-27
申请号：US09643085
申请日：2000-08-21
申请人： Marc-Alan Levine
发明人： Marc-Alan Levine
IPC分类号： A61M2900
CPC分类号： A61M25/0147 , A61M25/10 , A61M2025/0177 , A61M2025/1052
摘要： This is in the general field of surgical instruments and is, specifically, a microballoon-tipped delivery catheter with a flexible, proximally-manipulated hinge or joint region. The catheter may have a shaft of varying flexibility which contains several lumen. The inner, or delivery, lumen generally may be used with a guide wire to access target sites within the body via the flexible, small diameter vessels of the body. The delivery lumen may be also used for placement of occlusive materials, e.g., in an aneurysm. Inflation of the micro-balloon, located near the distal tip of the catheter, is effected using the inflation lumen. The push/pull wire lumen contains a wire, which when manipulated, flexes the catheter's distal tip.
摘要翻译：这是在外科器械的一般领域中，具体地说，是具有柔性的，近端操作的铰链或关节区域的微气囊输送导管。该导管可具有包含若干内腔的具有不同柔性的轴。内部或输送腔通常可以与导丝一起使用，以经由身体的柔性的小直径容器进入体内的目标部位。输送腔也可以用于放置封闭材料，例如在动脉瘤中。位于导管远端顶端的微气囊的充气利用充气腔进行。推/拉线腔包含线，当被操纵时，其弯曲导管的远端。

8. 发明授权

US6074407A Delivery catheter for occlusive implants 失效
标题翻译：用于闭塞植入物的输送导管
公开(公告)号：US6074407A
公开(公告)日：2000-06-13
申请号：US950002
申请日：1997-10-14
申请人： Marc-Alan Levine , Michael P. Wallace
发明人： Marc-Alan Levine , Michael P. Wallace
IPC分类号： A61B17/00 , A61B17/12 , A61B19/00 , A61F2/82 , A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12136 , A61B17/1214 , A61B2017/00557 , A61B90/39 , A61M2025/0079 , A61M2025/1052 , A61M2025/1063
摘要： This is a catheter device for delivering vaso-occlusive materials or devices to a desired site with the body. The catheter is a single lumen valved balloon catheter that enhances the accurate placement of the vaso-occlusive material or device. The balloon may be positioned such that it blocks the opening to a vascular malformation such as an aneurysm. In one embodiment, the balloon is automatically inflated as the vaso-occlusive material or device engages a constrictive feature near the distal end as the device is discharged. The catheter device may also have a lengthened distal section that may be placed within the malformation or aneurysm to improving the filling capability of the device. The catheter device may be constructed to have a number of advantageous radioopaque markers to aid in accurately discharging the vaso-occlusive material or device.
摘要翻译：这是用于将血管闭塞材料或装置输送到身体所需位置的导管装置。该导管是单腔管气囊导管，其可增强血管闭塞性材料或装置的精确放置。气球可以被定位成使得其将开口阻塞到诸如动脉瘤的血管畸形。在一个实施例中，当装置被排放时，气囊被自动膨胀，因为血管闭塞性材料或装置接近远端附近的收缩特征。导管装置还可以具有延长的远端部分，其可以放置在畸形或动脉瘤内以改善装置的填充能力。该导管装置可以被构造成具有许多有利的放射性标记，以帮助精确地排出血管闭塞性材料或装置。

9. 发明授权

US10507024B2 Long nose manipulatable catheter 有权
公开(公告)号：US10507024B2
公开(公告)日：2019-12-17
申请号：US13626518
申请日：2012-09-25
申请人： Marc-Alan Levine , Stephen Hebert
发明人： Marc-Alan Levine , Stephen Hebert
IPC分类号： A61B17/12 , A61M25/01 , A61M25/00 , A61M25/10
摘要： A long nose manipulatable catheter is described herein. The catheter generally comprises a flexible joint region defining a main lumen and an adjacent wire lumen. The wire lumen has an opening near or at a distal end of the flexible joint region and a push/pull wire can be pushed or pulled through the wire lumen. The catheter assembly may also comprise at least one radio-opaque marker band for securing the push/pull wire. The joint region has a predetermined length sized to affect a flexure of the joint and is generally located at the distal end of the catheter. The joint region itself may be varied to extend distally from where the braid terminates, or it may extend to encompass a portion of the braid. By varying a length of the joint region, the amount of curvature and flexure of the joint region can be controlled.

10. 发明授权

US09700215B2 Systems and methods for assessing vasculature health and blood clots 有权
公开(公告)号：US09700215B2
公开(公告)日：2017-07-11
申请号：US14052721
申请日：2013-10-12
申请人： Marc-Alan Levine
发明人： Marc-Alan Levine
IPC分类号： A61B5/02 , A61B5/145 , A61B8/08 , A61B8/12 , A61B8/00 , A61B5/00
CPC分类号： A61B5/02007 , A61B5/14503 , A61B5/14539 , A61B5/14542 , A61B5/14551 , A61B5/6851 , A61B5/6852 , A61B8/0833 , A61B8/085 , A61B8/0891 , A61B8/12 , A61B8/445 , A61B8/4494 , A61B8/461 , A61B8/467 , A61B8/485 , A61B8/5223
摘要： A system and method for determining a pH level of blood in a vessel of a patient including a flexible elongated member configured and dimensioned for insertion in the vessel of the patient, a sensor positioned at the distal portion of the elongated member, and a connector connecting the elongated member to an indicator. The sensor measures the pH level of blood downstream of the blood clot. A system and method are also provided for determining a density of a blood clot in a vessel of a patient for subsequent selection of a treatment method. The system includes a sensor positioned at the distal portion of the elongated member, and a connector connecting the elongated member to an indicator, wherein the sensor determines the density of the blood clot and the indicator provides an indication of the density of the clot.

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