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1. 发明申请

US20210308422A1 MANIPULATABLE DELIVERY CATHETER FOR OCCLUSIVE DEVICES 有权
公开(公告)号：US20210308422A1
公开(公告)日：2021-10-07
申请号：US16153734
申请日：2018-10-06
申请人： Marc-Alan LEVINE , Stephen HEBERT
发明人： Marc-Alan LEVINE , Stephen HEBERT
IPC分类号： A61M25/01 , A61B17/12 , A61M25/10
摘要： This is in the general field of surgical instruments and is specifically a delivery catheter with a flexible, proximally-manipulated hinge or joint region. The inventive catheter may have a balloon region. The catheter may have a shaft of varying flexibility which contains several lumen. The inner, or delivery, lumen generally may be used with a guidewire to access target sites within the body via the flexible, small diameter vessels of the body. The delivery lumen may be also used for placement of occlusive materials, e.g., in an aneurysm. Inflation of the micro-balloon, located near the distal tip of the catheter, is effected using the inflation lumen. The push/pull wire lumen contains a wire, which when manipulated, flexes the catheter's distal tip. The push/pull wire tubing may have a variable thickness to aid in adjusting the degree of flexibility. Moreover, the delivery catheter may be capable of twisting in a helical or corkscrew-like manner for traversing certain vasculature. This may be accomplished by winding the push/pull wire within the catheter and fixedly attaching it. The catheter may further include an entry in the catheter wall to allow for the insertion of a guidewire; this may facilitate the rapid exchange of catheter devices as desired by the user.

2. 发明授权

US09480464B2 Tissue collection system 有权
标题翻译：组织收集系统
公开(公告)号：US09480464B2
公开(公告)日：2016-11-01
申请号：US13561722
申请日：2012-07-30
申请人： Jamie P. Levine , Alexes Hazen , Marc-Alan Levine
发明人： Jamie P. Levine , Alexes Hazen , Marc-Alan Levine
IPC分类号： A61B10/02
CPC分类号： A61B10/0283
摘要： The present invention relates to a tissue collection system. The system includes an outer housing, a first cylindrical fenestrated member within and immovable relative to the outer housing, a second cylindrical fenestrated member defining an inner tissue collection chamber and being positioned within and rotatable relative to the first cylindrical fenestrated member, a plunger axially movable within the second fenestrated member, an elongate rod being connected to the plunger, and one or more stop units attached to the outer housing. The present invention also relates to methods for separating components of a tissue sample using a system according to the present invention.
摘要翻译：本发明涉及组织收集系统。该系统包括外壳体，相对于外壳体内并且不可移动的第一圆柱形开窗构件，限定内组织收集室并定位在第一圆柱形开窗构件内并可相对于第一圆柱形开窗构件旋转的第二圆柱形开窗构件，在第二开窗构件内的细长杆连接到柱塞，以及连接到外壳的一个或多个止挡单元。本发明还涉及使用根据本发明的系统分离组织样品的组分的方法。

3. 发明授权

US09144508B2 Radially expandable stent 有权
标题翻译：径向扩张支架
公开(公告)号：US09144508B2
公开(公告)日：2015-09-29
申请号：US11948928
申请日：2007-11-30
申请人： Stephen Hebert , Marc-Alan Levine , Aleksandr Leynov
发明人： Stephen Hebert , Marc-Alan Levine , Aleksandr Leynov
IPC分类号： A61F2/06 , A61F2/915 , A61F2/91
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91533 , A61F2002/9155 , A61F2002/91558 , A61F2002/91583 , A61F2230/0054
摘要： A highly compressible stent is described. The stent includes a plurality of circumferentially offset and interconnected undulating rings having intermediate struts disposed between at least some of the undulating ring struts.
摘要翻译：描述了高度可压缩的支架。支架包括多个周向偏移和相互连接的起伏环，其具有设置在至少一些起伏环支柱之间的中间支柱。

4. 发明申请

US20140148831A1 ROTATIONAL THROMBECTOMY WIRE 审中-公开
标题翻译：旋转色差线
公开(公告)号：US20140148831A1
公开(公告)日：2014-05-29
申请号：US14170577
申请日：2014-02-01
申请人： Marc-Alan Levine , Michael Leedle , John D. Leedle
发明人： Marc-Alan Levine , Michael Leedle , John D. Leedle
IPC分类号： A61B17/3207
CPC分类号： A61B17/320725 , A61B17/32002 , A61B17/320758 , A61B2017/00331 , A61B2017/320733 , A61B2017/320775
摘要： A rotational thrombectomy wire for breaking up vascular thrombus or other obstructive material having a core having a proximal portion and a distal portion. The distal portion has a smaller diameter than the proximal portion. A cable extends distally of the core. The cable has a first covering material positioned external thereof. A first coil is attached to a distal portion of the cable and has a diameter larger than a diameter of the cable and has a second covering material positioned thereover. The wire is rotatable by a motor.
摘要翻译：一种用于分解血管血栓的旋转性血栓切除线或具有具有近端部分和远端部分的芯的其它阻塞物质。远侧部分具有比近侧部分更小的直径。电缆沿芯线向远侧延伸。电缆具有位于其外部的第一覆盖材料。第一线圈附接到电缆的远端部分并且具有大于电缆直径的直径，并且具有定位在其上的第二覆盖材料。电线可通过电机旋转。

5. 发明申请

US20140114144A1 SYSTEMS AND METHODS FOR ASSESSING VASCULATURE HEALTH AND BLOOD CLOTS 有权
标题翻译：用于评估血管健康和血液分离的系统和方法
公开(公告)号：US20140114144A1
公开(公告)日：2014-04-24
申请号：US14052721
申请日：2013-10-12
申请人： Marc-Alan Levine
发明人： Marc-Alan Levine
IPC分类号： A61B5/02 , A61B8/08 , A61B5/1455 , A61B5/145
CPC分类号： A61B5/02007 , A61B5/14503 , A61B5/14539 , A61B5/14542 , A61B5/14551 , A61B5/6851 , A61B5/6852 , A61B8/0833 , A61B8/085 , A61B8/0891 , A61B8/12 , A61B8/445 , A61B8/4494 , A61B8/461 , A61B8/467 , A61B8/485 , A61B8/5223
摘要： A system and method for determining a pH level of blood in a vessel of a patient including a flexible elongated member configured and dimensioned for insertion in the vessel of the patient, a sensor positioned at the distal portion of the elongated member, and a connector connecting the elongated member to an indicator. The sensor measures the pH level of blood downstream of the blood clot. A system and method are also provided for determining a density of a blood clot in a vessel of a patient for subsequent selection of a treatment method. The system includes a sensor positioned at the distal portion of the elongated member, and a connector connecting the elongated member to an indicator, wherein the sensor determines the density of the blood clot and the indicator provides an indication of the density of the clot.
摘要翻译：一种用于确定患者血管中的血液pH值的系统和方法，包括构造和尺寸用于插入患者血管的柔性细长构件，位于细长构件的远端部分的传感器和连接器细长构件到指示器。传感器测量血液凝块下游血液的pH值。还提供了一种系统和方法，用于确定患者血管中血凝块的密度，用于随后选择治疗方法。系统包括位于细长构件的远端部分处的传感器和将细长构件连接到指示器的连接器，其中传感器确定血块的密度，并且指示器提供凝块密度的指示。

6. 发明授权

US08696728B2 Guidewire loaded stent for delivery through a catheter 失效
公开(公告)号：US08696728B2
公开(公告)日：2014-04-15
申请号：US11897705
申请日：2007-08-31
申请人： Stephen Hebert , Marc-Alan Levine
发明人： Stephen Hebert , Marc-Alan Levine
IPC分类号： A61F2/06
CPC分类号： A61F2/966 , A61F2/95 , A61F2/958 , A61F2002/9583 , A61M25/09 , A61M2025/09008 , A61M2025/09183
摘要： A guidewire loaded stent for delivery through a catheter is described herein. The stent delivery assembly can deliver and place a stent within tortuous regions of the body which are accessible to guidewires but inaccessible to stenting catheters. The assembly comprises a guidewire covered in part by a retractable sheath and a radially expandable stent near or at the distal end of the guidewire. The whole assembly is advanced through conventional catheters or it may be used alone. In either case, when the stent is adjacent to a treatment site within the body, the sheath is retracted proximally to expose the stent for radial expansion into contact with the vessel wall. Radio-opaque marker bands are optionally located on either side or both sides of the stent on the guidewire body to aid in visual placement. The assembly can optionally include an expandable balloon on the guidewire for different treatment modalities.

7. 发明授权

US08679148B2 Distal protection device 有权
标题翻译：远端保护装置
公开(公告)号：US08679148B2
公开(公告)日：2014-03-25
申请号：US13608890
申请日：2012-09-10
申请人： James F. McGuckin, Jr. , Marc-Alan Levine , James Erich Bressler
发明人： James F. McGuckin, Jr. , Marc-Alan Levine , James Erich Bressler
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/008
摘要： A distal protection device comprising a catheter having a first strut movable from a collapsed configuration to an expanded configuration having a first dimension and a second strut movable from a collapsed configuration to an expanded configuration having a second dimension larger than the first dimension. Movement of the first strut deploys filter material to a first position having a first deployed dimension and movement of the second strut to a first position deploys filter material to a second deployed dimension larger than the first expanded dimension.
摘要翻译：一种远端保护装置，其包括导管，该导管具有可从折叠构型移动到具有第一尺寸的扩张构型的第一支柱和可从折叠构型移动到具有大于第一尺寸的第二尺寸的扩张构型的第二支柱。第一支柱的运动将过滤材料部署到具有第一展开尺寸的第一位置，并且将第二支柱移动到第一位置将过滤材料展开到大于第一展开尺寸的第二展开尺寸。

8. 发明申请

US20130006296A1 DISTAL PROTECTION DEVICE 有权
标题翻译：远程保护装置
公开(公告)号：US20130006296A1
公开(公告)日：2013-01-03
申请号：US13608890
申请日：2012-09-10
申请人： James F. McGuckin, JR. , Marc-Alan Levine , James Erich Bressler
发明人： James F. McGuckin, JR. , Marc-Alan Levine , James Erich Bressler
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/008
摘要： A distal protection device comprising a catheter having a first strut movable from a collapsed configuration to an expanded configuration having a first dimension and a second strut movable from a collapsed configuration to an expanded configuration having a second dimension larger than the first dimension. Movement of the first strut deploys filter material to a first position having a first deployed dimension and movement of the second strut to a first position deploys filter material to a second deployed dimension larger than the first expanded dimension.
摘要翻译：一种远端保护装置，其包括导管，该导管具有可从折叠构型移动到具有第一尺寸的扩张构型的第一支柱和可从折叠构型移动到具有大于第一尺寸的第二尺寸的扩张构型的第二支柱。第一支柱的运动将过滤材料部署到具有第一展开尺寸的第一位置，并且将第二支柱移动到第一位置将过滤材料展开到大于第一展开尺寸的第二展开尺寸。

9. 发明申请

US20120239066A1 ROTATIONAL THROMBECTOMY WIRE COUPLER 有权
标题翻译：旋转式色差电感耦合器
公开(公告)号：US20120239066A1
公开(公告)日：2012-09-20
申请号：US13456555
申请日：2012-04-26
申请人： Marc-Alan Levine , Nicholas Ciccarelli , Michael Leedle , John D. Leedle
发明人： Marc-Alan Levine , Nicholas Ciccarelli , Michael Leedle , John D. Leedle
IPC分类号： A61B17/22
CPC分类号： A61B17/320758 , A61B2017/00398 , A61B2017/00477 , A61B2017/00734 , A61B2017/00876 , A61B2017/22038 , A61B2017/320032 , A61B2017/320733 , A61B2017/320775 , A61B2090/031
摘要： An assembly for breaking up vascular thrombus or other obstructive material including a motor housing having a motor, a motor shaft extending from the motor, a first housing positioned at a distal end of the motor shaft, a rotational thrombectomy wire and a second housing positioned at a proximal end of the wire. The first housing has a first magnet positioned therein and recessed from the distal edge of the first housing which has a first plurality of teeth. The second housing has a second magnet positioned therein and recessed from a proximal edge of the second housing which has a second plurality of teeth intermeshing with the first plurality of teeth when the wire is coupled to the motor shaft. The first and second plurality of teeth slip when a torque of the motor shaft exceeds a predetermined value.
摘要翻译：一种用于分解血管血栓或其他阻塞物质的组件，包括具有马达的马达壳体，从马达延伸的马达轴，位于马达轴远端的第一壳体，旋转血栓切除线和位于线的近端。第一壳体具有定位在其中的第一磁体并且具有第一多个齿的第一壳体的远端边缘凹陷。第二壳体具有定位在其中的第二磁体并且从第二壳体的近侧边缘凹入，当第二壳体与电动机轴联接时，该第二磁体具有与第一多个齿啮合的第二多个齿。当电动机轴的扭矩超过预定值时，第一和第二多个齿滑动。

10. 发明申请

US20090024205A1 Radially Expandable Stent 有权
标题翻译：径向可扩展支架
公开(公告)号：US20090024205A1
公开(公告)日：2009-01-22
申请号：US11948928
申请日：2007-11-30
申请人： Stephen Hebert , Marc-Alan Levine
发明人： Stephen Hebert , Marc-Alan Levine
IPC分类号： A61F2/82
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91533 , A61F2002/9155 , A61F2002/91558 , A61F2002/91583 , A61F2230/0054
摘要： A highly compressible stent is described. The stent includes a plurality of circumferentially offset and interconnected undulating rings having intermediate struts disposed between at least some of the undulating ring struts.
摘要翻译：描述了高度可压缩的支架。支架包括多个周向偏移和相互连接的起伏环，其具有设置在至少一些起伏环支柱之间的中间支柱。

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