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1. 发明申请

US20080314480A1 Martensitic Stainless Steel Strengthened By Ni3tin-Phase Precipitation 有权
标题翻译：通过Ni3tin相析出强化马氏体不锈钢
公开(公告)号：US20080314480A1
公开(公告)日：2008-12-25
申请号：US11814780
申请日：2006-01-25
申请人： James Wright , Jin-Won Jung
发明人： James Wright , Jin-Won Jung
IPC分类号： C22C38/52
CPC分类号： C22C38/004 , C21D6/004 , C21D6/007 , C21D2211/008 , C22C38/06 , C22C38/44 , C22C38/50 , C22C38/52
摘要： A precipitation-hardened stainless maraging steel which exhibits a combination of strength, toughness, and corrosion resistance comprises by weight about: 8 to 15% chromium (Cr), 2 to 15% cobalt (Co), 7 to 14% nickel (Ni), and up to about 0.7% aluminum (Al), less than about 0.4% copper (Cu), 0.5% to 2.5% molybdenum (Mo), 0.4 to 0.75% titanium (Ti), up to about 0.5% tungsten (W), and up to about 120 wppm carbon (C), the balance essentially iron (Fe) and incidental elements and impurities, characterized in that the alloy has a predominantly lath martensite microstructure essentially without topologically close packed intermetallic phases and strengthened primarily by a dispersion of intermetallic particles primarily of the eta-Ni3Ti phase and wherein the titanium and carbon (Ti) and (C) levels are controlled such that C can be dissolved during a homogenization step and subsequently precipitated during forging to provide a grain-pinning dispersion.
摘要翻译：表现出强度，韧性和耐腐蚀性的组合的沉淀硬化的不锈钢马氏体时效钢包含约8〜15％的铬（Cr），2〜15％的钴（Co），7〜14％的镍（Ni），高达约0.7％的铝（Al），小于约0.4％的铜（Cu），0.5％至2.5％的钼（Mo），0.4至0.75％的钛（Ti），至多约0.5％的钨（W），和高达约120wppm的碳（C），余量基本上为铁（Fe）和附带元素和杂质，其特征在于该合金主要具有板条马氏体组织，基本上没有拓扑密实的金属间相，并主要通过主要是eta-Ni3Ti相的金属间化合物颗粒，其中控制钛和碳（Ti）和（C）水平，使得C在均匀化步骤期间可以溶解，随后在锻造期间沉淀以提供颗粒钉扎分散体。

2. 发明授权

US07879159B2 Martensitic stainless steel strengthened by Ni3Ti η-phase precipitation 有权
标题翻译：通过Ni3Ti和相变析出强化马氏体不锈钢
公开(公告)号：US07879159B2
公开(公告)日：2011-02-01
申请号：US11814780
申请日：2006-01-25
申请人： James Wright , Jin-Won Jung
发明人： James Wright , Jin-Won Jung
IPC分类号： C22C38/50 , C22C38/52 , C22C38/44
CPC分类号： C22C38/004 , C21D6/004 , C21D6/007 , C21D2211/008 , C22C38/06 , C22C38/44 , C22C38/50 , C22C38/52
摘要： A precipitation-hardened stainless maraging steel which exhibits a combination of strength, toughness, and corrosion resistance comprises by weight about: 8 to 15% chromium (Cr), 2 to 15% cobalt (Co), 7 to 14% nickel (Ni), and up to about 0.7% aluminum (Al), less than about 0.4% copper (Cu), 0.5 to 2.6% molybdenum (Mo), 0.4 to less than about 0.75% titanium (Ti), up to about 0.5% tungsten (W), and up to about 120 wppm carbon (C), the balance essentially iron (Fe) and incidental elements and impurities, characterized in that the alloy has predominantly lath martensite microstructure essentially without topologically close packed intermetallic phases and strengthened primarily by a dispersion of intermetallic particles primarily of the eta-Ni3Ti phase and wherein the titanium and carbon (Ti) and (C) levels are controlled such that C can be dissolved during a homogenization step and subsequently precipitated during forging to provide a grain-pinnning dispersion.
摘要翻译：表现出强度，韧性和耐腐蚀性的组合的沉淀硬化的不锈钢马氏体时效钢包含约8〜15％的铬（Cr），2〜15％的钴（Co），7〜14％的镍（Ni），高达约0.7％的铝（Al），小于约0.4％的铜（Cu），0.5至2.6％的钼（Mo），0.4至小于约0.75％的钛（Ti），至多约0.5％的钨 W）和高达约120wppm的碳（C），余量基本上是铁（Fe）和附带的元素和杂质，其特征在于该合金主要具有板条马氏体组织，基本上没有拓扑密实的金属间相，并且主要由分散体主要由eta-Ni3Ti相组成的金属间化合物颗粒，其中控制钛和碳（Ti）和（C）的含量，使C在均匀化步骤中可以溶解，随后在锻造期间沉淀，从而提供颗粒沉淀分散体。

3. 发明授权

US09308179B2 Long circulating nanoparticles for sustained release of therapeutic agents 有权
公开(公告)号：US09308179B2
公开(公告)日：2016-04-12
申请号：US13556647
申请日：2012-07-24
申请人： Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright
发明人： Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright
IPC分类号： A61K9/51 , A61K47/34 , B82Y5/00 , A61K9/00 , A61K47/48
CPC分类号： A61K9/5153 , A61K9/0019 , A61K9/1641 , A61K31/337 , A61K31/436 , A61K31/475 , A61K31/519 , A61K47/542 , A61K47/593 , A61K47/60 , A61K47/6925 , A61K47/6937 , B82Y5/00
摘要： The present disclosure is directed in part to a biocompatible nanoparticle composition comprising a plurality of non-colloidal long circulating nanoparticles, each comprising a α-hydroxy polyester-co-polyether and a therapeutic agent, wherein such disclosed compositions provide a therapeutic effect for at least 12 hours.

4. 发明授权

US08518963B2 Therapeutic polymeric nanoparticle compositions with high glass transition temperature or high molecular weight copolymers 有权
标题翻译：具有高玻璃化转变温度或高分子量共聚物的治疗性聚合物纳米颗粒组合物
公开(公告)号：US08518963B2
公开(公告)日：2013-08-27
申请号：US13372036
申请日：2012-02-13
申请人： Mir Mukkaram Ali , Abhimanyu Sabnis , David Dewitt , Greg Troiano , James Wright , Maria Figueiredo , Michael Figa , Christina Van Geen Hoven , Young-Ho Song , Jason Auer , Tarikh Christopher Campbell
发明人： Mir Mukkaram Ali , Abhimanyu Sabnis , David Dewitt , Greg Troiano , James Wright , Maria Figueiredo , Michael Figa , Christina Van Geen Hoven , Young-Ho Song , Jason Auer , Tarikh Christopher Campbell
IPC分类号： A61K9/50 , A61K31/44
CPC分类号： G01N25/4866 , A61K9/0019 , A61K9/146 , A61K9/5153 , A61K31/00 , A61K31/337 , A61K31/427 , A61K31/436 , A61K31/475 , A61K31/573 , A61K31/58 , A61K31/585 , A61K31/69 , A61K47/34
摘要： The present disclosure relates in part to pharmaceutical compositions comprising polymeric nanoparticles having certain glass transition temperatures. Other aspects of the invention include methods of making such nanoparticles.
摘要翻译：本公开部分涉及包含具有某些玻璃化转变温度的聚合物纳米颗粒的药物组合物。本发明的其它方面包括制备这种纳米颗粒的方法。

5. 发明申请

US20130023898A9 MINIMALLY INVASIVE SURGICAL TRAINING USING ROBOTICS AND TELECOLLABORATION 有权
公开(公告)号：US20130023898A9
公开(公告)日：2013-01-24
申请号：US12173963
申请日：2008-07-16
申请人： Yulun Wang , Modjtaba Ghodoussi , Darrin Uecker , James Wright , Amante Mangaser , Ranjan Mukherjee
发明人： Yulun Wang , Modjtaba Ghodoussi , Darrin Uecker , James Wright , Amante Mangaser , Ranjan Mukherjee
IPC分类号： A61B19/00
CPC分类号： G09B23/28 , A61B34/30 , A61B34/35 , A61B34/37 , A61B34/70 , A61B34/76 , A61B34/77 , A61B90/06 , A61B90/361 , A61B2017/00707 , A61B2034/305 , A61B2090/064 , G05B15/02 , G06F19/00 , G06F19/3418
摘要： A medical system that allows a mentor to teach a pupil how to use a robotically controlled medical instrument. The system may include a first handle that can be controlled by a mentor to move the medical instrument. The system may further have a second handle that can be moved by a pupil to control the same instrument. Deviations between movement of the handles by the mentor and the pupil can be provided as force feedback to the pupil and mentor handles. The force feedback pushes the pupil's hand to correspond with the mentor's handle movement. The force feedback will also push the mentor's hand to provide information to the mentor on pupil's movements. The mentor is thus able to guide the pupil's hands through force feedback of the pupil handles to teach the pupil how to use the system.

6. 发明授权

US08318211B2 Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of making and using same 有权
标题翻译：包括长春花生物碱的治疗性聚合物纳米颗粒及其制备和使用方法
公开(公告)号：US08318211B2
公开(公告)日：2012-11-27
申请号：US12485467
申请日：2009-06-16
申请人： Stephen E. Zale , Greg Troiano , Mir Mukkaram Ali , Jeff Hrkach , James Wright
发明人： Stephen E. Zale , Greg Troiano , Mir Mukkaram Ali , Jeff Hrkach , James Wright
IPC分类号： A61K9/50 , A61K31/44 , A01N43/42
CPC分类号： A61K9/1647 , A61K9/14 , A61K9/1694 , A61K9/19 , A61K9/5153 , A61K31/4745 , A61K31/475 , A61K31/55 , A61K47/26
摘要： The present disclosure generally relates to therapeutic nanoparticles. Exemplary nanoparticles disclosed herein may include about 1 to about 20 weight percent of a vinca alkaloid; and about 50 to about 99 weight percent biocompatible polymer.
摘要翻译：本公开一般涉及治疗性纳米颗粒。本文公开的示例性纳米颗粒可包括约1至约20重量％的长春花生物碱; 和约50至约99重量％的生物相容性聚合物。

7. 发明申请

US20120288541A1 Drug Loaded Polymeric Nanoparticles and Methods of Making and Using Same 有权
标题翻译：药物负载的聚合物纳米颗粒及其制备和使用方法
公开(公告)号：US20120288541A1
公开(公告)日：2012-11-15
申请号：US13553210
申请日：2012-07-19
申请人： Stephen E. Zale , Greg Troiano , Mir Mukkaram Ali , Jeff Hrkach , James Wright
发明人： Stephen E. Zale , Greg Troiano , Mir Mukkaram Ali , Jeff Hrkach , James Wright
IPC分类号： A61K9/14 , A61P35/00 , A61K31/337 , B82Y5/00
CPC分类号： A61K47/34 , A61J3/00 , A61K9/10 , A61K9/107 , A61K9/1647 , A61K9/19 , A61K9/5146 , A61K9/5153 , A61K31/337 , A61K31/4355 , A61K31/436 , A61K31/437 , A61K31/439 , A61K31/475 , A61K31/704 , A61K31/7068 , A61K47/6915 , A61K47/6925 , A61K47/6937 , B82Y5/00 , C07C59/08 , Y10S977/773
摘要： The present disclosure generally relates to nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol. Other aspects of the invention include methods of making such nanoparticles.
摘要翻译：本公开内容通常涉及具有约0.2至约35重量％的治疗剂的纳米颗粒; 和约10至约99重量％的生物相容性聚合物，例如二嵌段聚（乳酸） - 聚（乙烯）二醇。本发明的其它方面包括制备这种纳米颗粒的方法。

8. 发明授权

US07785320B2 Method for operating a medical robotic system by stopping movement of a surgical instrument about a pivot point or issuing a warning if the pivot point moves beyond a threshold value 有权
标题翻译：用于通过停止手术器械关于枢转点的运动来操作医疗机器人系统的方法或者如果枢转点移动超过阈值则发出警告
公开(公告)号：US07785320B2
公开(公告)日：2010-08-31
申请号：US12051957
申请日：2008-03-20
申请人： Yulun Wang , Darrin R Uecker , Jeff Wilson , Keith Philip Laby , Steve Jordan , James Wright
发明人： Yulun Wang , Darrin R Uecker , Jeff Wilson , Keith Philip Laby , Steve Jordan , James Wright
IPC分类号： A61B17/00
CPC分类号： A61B17/11 , A61B17/0469 , A61B17/29 , A61B34/30 , A61B34/35 , A61B34/37 , A61B34/70 , A61B34/71 , A61B34/72 , A61B34/75 , A61B34/76 , A61B34/77 , A61B46/10 , A61B50/00 , A61B90/361 , A61B2017/00199 , A61B2017/00243 , A61B2017/00252 , A61B2017/0046 , A61B2017/00477 , A61B2017/00703 , A61B2017/00973 , A61B2017/1107 , A61B2017/1135 , A61B2017/2927 , A61B2017/2929 , A61B2034/2059 , A61B2034/742 , A61B2090/064 , B25J9/1689 , G05B2219/45119
摘要： A system for performing minimally invasive cardiac procedures. The system includes a pair of surgical instruments that are coupled to a pair of robotic arms. The instruments have end effectors that can be manipulated to hold and suture tissue. The robotic arms are coupled to pair of master handles by a controller. The handles can be moved by the surgeon to produce a corresponding movement of the end effectors. The controller controls and limits movement of robotic arms relative to the patient.
摘要翻译：用于执行微创心脏手术的系统。该系统包括耦合到一对机器人臂的一对外科器械。仪器具有能够被操纵以保持和缝合组织的末端效应器。机器臂通过控制器耦合到一对主手柄。手柄可由外科医生移动以产生末端执行器的相应运动。控制器控制和限制机器人臂相对于患者的运动。

9. 发明申请

US20100216804A1 Long Circulating Nanoparticles for Sustained Release of Therapeutic Agents 审中-公开
标题翻译：用于持续释放治疗剂的长循环纳米颗粒
公开(公告)号：US20100216804A1
公开(公告)日：2010-08-26
申请号：US12638297
申请日：2009-12-15
申请人： Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright , Susan Low
发明人： Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright , Susan Low
IPC分类号： A61K9/14 , A61K31/337 , A61K31/4745 , A61K31/519 , A61K31/436 , A61P35/00
CPC分类号： A61K9/5153 , A61K9/0019 , A61K9/1641 , A61K31/337 , A61K31/436 , A61K31/475 , A61K31/519 , A61K47/542 , A61K47/593 , A61K47/60 , A61K47/6925 , A61K47/6937 , B82Y5/00
摘要： The present disclosure is directed in part to a biocompatible nanoparticle composition comprising a plurality of non-colloidal long circulating nanoparticles, each comprising a α-hydroxy polyester-co-polyether and a therapeutic agent, wherein such disclosed compositions provide a therapeutic effect for at least 12 hours.
摘要翻译：本公开部分地涉及生物相容性纳米颗粒组合物，其包含多个非胶体长循环纳米颗粒，每个非胶体长循环纳米颗粒包含α-羟基聚酯 - 共聚醚和治疗剂，其中所述公开的组合物至少提供治疗效果 12小时。

10. 发明申请

US20090012544A1 GASTROINTESTINAL BYPASS SLEEVE AS AN ADJUNCT TO BARIATRIC SURGERY 审中-公开
标题翻译：胃肠外套管作为对手术治疗的补充
公开(公告)号：US20090012544A1
公开(公告)日：2009-01-08
申请号：US12135989
申请日：2008-06-09
申请人： Chris Thompson , Mitchell Roslin , Mitchell Dann , Greg Fluet , James Wright
发明人： Chris Thompson , Mitchell Roslin , Mitchell Dann , Greg Fluet , James Wright
IPC分类号： A61B17/11
CPC分类号： A61B17/1114 , A61B17/11 , A61B2017/00557 , A61B2017/0647 , A61F2002/045
摘要： Disclosed herein are systems and methods for treating a patient that has undergone a bariatric surgical procedure, to promote weight loss in the patient. The systems and methods can involve positioning a gastrointestinal bypass sleeve within a portion of the altered GI anatomy to create or restore a restriction, and/or create a malabsorptive effect via a gastric and partial intestinal bypass. The bypass sleeve can include a proximal attachment element for attaching the proximal end of the sleeve in a penetrating or non-penetrating manner at the gastroesophageal junction, stomach, neo-stomach, or other locations. The bypass can be placed during the same operative session as the bariatric surgical procedure, or alternatively at a later date.
摘要翻译：本文公开了用于治疗已经进行减肥手术的患者的系统和方法，以促进患者的体重减轻。系统和方法可以包括将胃肠旁路套管定位在改变的GI解剖结构的一部分内以产生或恢复限制，和/或通过胃和部分肠旁路产生吸收不良的作用。旁路套管可以包括用于以穿透或非穿透方式在胃食管接合部，胃，新胃或其他位置附接套筒的近端的近端附接元件。旁路可以在与减肥手术相同的手术期间放置，或者在稍后的日期。

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