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1. 发明授权

US4740615A Process for purified amino acids 失效
标题翻译：纯化氨基酸的工艺
公开(公告)号：US4740615A
公开(公告)日：1988-04-26
申请号：US924393
申请日：1986-10-29
申请人： James W. McManus , Larry D. Forshey
发明人： James W. McManus , Larry D. Forshey
IPC分类号： C07C229/36 , C07C227/40 , C07C99/12
CPC分类号： C07C227/40 , C07C229/36
摘要： A process for the recovery in substantially pure form of an amino acid represented by the formula ##STR1## from an aqueous production mixture by a low pressure temperature gradient chromatographic process is described.

2. 发明授权

US4911239A Method and apparatus for removal of oil well paraffin 失效
标题翻译：去除油井石蜡的方法和装置
公开(公告)号：US4911239A
公开(公告)日：1990-03-27
申请号：US183780
申请日：1988-04-20
申请人： Elmer Winckler , James W. McManus
发明人： Elmer Winckler , James W. McManus
IPC分类号： E21B17/10 , E21B36/00 , E21B36/04 , E21B37/00
CPC分类号： E21B17/1057 , E21B36/006 , E21B36/04 , E21B37/00
摘要： A method and apparatus for reducing the accumulation of paraffin within an oil well that includes forming an electric circuit contact between the oil well sucker rod and tubing and connecting a power source to the sucker rod and tubing. An electric current is applied to the sucker rod in order to generate heat thereat. Preferably a rolling circuit contact is offset from the sucker rod to form a moving contact between the sucker rod and tubing, and in a preferred form a section of the sucker rod and pump is made of a material having a greater electrical resistance to increase the heat generated in a region of high paraffin accumulation. In another embodiment circuit assemblies are provided in the production string to alter the region being heated as the sucker rod reciprocates.
摘要翻译：一种用于减少石油在油井内积聚的方法和装置，其包括在油井抽吸杆和管道之间形成电路接触并将动力源连接到抽油杆和管道。向抽油杆施加电流以在其上产生热量。优选地，滚动回路接触件从抽油杆偏移以在抽油杆和油管之间形成可移动接触，并且在优选形式中，抽油杆和泵的一部分由具有较大电阻的材料制成以增加热量在高石蜡积聚区域产生。在另一个实施例中，电线组件设置在生产线中以改变随着抽油杆往复运动而被加热的区域。

3. 发明授权

US6166213A Omeprazole process and compositions thereof 有权
标题翻译：奥美拉唑方法及其组合物
公开(公告)号：US6166213A
公开(公告)日：2000-12-26
申请号：US169231
申请日：1998-10-09
申请人： Nick Anousis , James W. McManus , Benjamin Newton Banks , Lingwen Zhou , Hui Liu
发明人： Nick Anousis , James W. McManus , Benjamin Newton Banks , Lingwen Zhou , Hui Liu
IPC分类号： A61K31/4184 , A61P1/04 , C07D401/12
CPC分类号： C07D401/12
摘要： The present invention describes an improved process for the preparation, isolation, and purification of the anti-ulcer agent omeprazole whereby the sulfide precursor pyrmetazole is reacted subsurfacely with exactly one molar equivalent of meta-chloroperoxybenzoic acid in methylene chloride or toluene solution; residual organic solvent is removed from the aqueous layer by vacuum distillation; crude product is obtained by reactive crystallization with an alkyl formate and seeding; and pure product is isolated by recrystallization in methanol-water containing aqueous NaOH by subsurface addition of aqueous acetic acid to pH 9.0, seeding, filtration, washing, and drying. Compositions of omeprazole containing no chromatographically detectable levels of residual non-alcoholic organic reaction solvent are also described.
摘要翻译：本发明描述了一种用于制备，分离和纯化抗溃疡剂奥美拉唑的改进方法，其中硫化物前体吡咪唑与正好一摩尔当量的间氯过氧苯甲酸在二氯甲烷或甲苯溶液中地下反应; 通过真空蒸馏从水层除去残留的有机溶剂; 粗产物通过与甲酸烷基酯反应结晶并接种获得; 通过在甲醇 - 含水NaOH水溶液中再次析出纯产物，通过地下加入乙酸水溶液至pH 9.0，接种，过滤，洗涤和干燥。还描述了不含色谱可检测水平的残留非醇有机反应溶剂的奥美拉唑组合物。

4. 发明授权

US6147103A Omeprazole process and compositions thereof 有权
公开(公告)号：US6147103A
公开(公告)日：2000-11-14
申请号：US387945
申请日：1999-09-01
申请人： Nick Anousis , James W. McManus , Benjamin Newton Banks , Lingwen Zhou
发明人： Nick Anousis , James W. McManus , Benjamin Newton Banks , Lingwen Zhou
IPC分类号： A61K31/4184 , A61P1/04 , C07D401/12 , A61K31/415
CPC分类号： C07D401/12
摘要： The present invention describes an improved process for the preparation, isolation, and purification of the anti-ulcer agent omeprazole whereby the sulfide precursor pyrmetazole is reacted subsurfacely with exactly one molar equivalent of meta-chloroperoxybenzoic acid in methylene chloride or toluene solution; residual organic solvent is removed from the aqueous layer by vacuum distillation; crude product is obtained by reactive crystallization with an alkyl formate and seeding; and pure product is isolated by recrystallization in methanol-water containing aqueous NaOH by subsurface addition of aqueous acetic acid to pH 9.0, seeding, filtration, washing, and drying. Compositions of omeprazole containing no chromatographically detectable levels of residual non-alcoholic organic reaction solvent are also described.

5. 发明授权

US4538682A Method and apparatus for removing oil well paraffin 失效
标题翻译：去除油井石蜡的方法和装置
公开(公告)号：US4538682A
公开(公告)日：1985-09-03
申请号：US530366
申请日：1983-09-08
申请人： James W. McManus , Elmer Winckler , James Backus
发明人： James W. McManus , Elmer Winckler , James Backus
IPC分类号： E21B36/04 , E21B37/00
CPC分类号： E21B37/00 , E21B36/04
摘要： A method of removing paraffin build up from an oil well which includes determining the location of a cooler portion of the oil well at which paraffin build up occurs, introducing an inductance heating element down into the annular space between the oil well tubing and the oil well casing, positioning the inductance heating element in the vicinity of the cooler portion and inductance heating the inside surface of the oil well tube to at least the temperature about that of the melting point of paraffin. Preferably, the inside surface of the tube is heated on the down stroke of the oil well sucker rod and at the start of the sucker rod up stroke in order to strip the paraffin from the tubing. The outside surface of the sucker rod is heated on its up stroke and the inductance heater has multiple bands of coil to heat the same general area of the sucker rod as it travels.
摘要翻译：一种从油井中除去石蜡的方法，包括确定发生石蜡堆积的油井的较冷部分的位置，将电感加热元件引入到油井管和油井之间的环形空间中将电感加热元件定位在冷却器部分附近，并且将油井管内表面的电感加热至至少约为石蜡熔点的温度。优选地，管的内表面在油井抽吸杆的下冲程和在抽油杆上升行程开始时被加热，以从管道中剥离石蜡。抽油杆的外表面在其行程上被加热，并且电感加热器具有多个线圈，以加热抽油杆行进时的相同的一般区域。

6. 发明授权

US06191148B1 Omerazole process and compositions thereof 有权
标题翻译：奥美拉唑法及其组合物
公开(公告)号：US06191148B1
公开(公告)日：2001-02-20
申请号：US09461605
申请日：1999-12-15
申请人： James W. McManus , Nick Anousis , Benjamin Newton Banks , Hui Liu , Lingwen Zhou
发明人： James W. McManus , Nick Anousis , Benjamin Newton Banks , Hui Liu , Lingwen Zhou
IPC分类号： A61K314439
CPC分类号： C07D401/12
摘要： The present invention describes an improved process for the preparation, isolation, and purification of the anti-ulcer agent omeprazole whereby the sulfide precursor pyrmetazole is reacted subsurfacely with exactly one molar equivalent of meta-chloroperoxybenzoic acid in a chlorinated aliphatic hydrocarbon or aromatic hydrocarbon solvent, such as methylene chloride or toluene; residual organic solvent is removed from the aqueous layer by vacuum distillation; crude product is obtained by reactive crystallization with an alkyl formate or formic acid solution and seeding; and pure product is isolated by recrystallization in methanol-water containing aqueous NaOH by subsurface addition of aqueous acetic acid to pH 9.0, seeding, filtration, washing, and drying. Omeprazole and compositions of omeprazole containing no chromatographically detectable levels of residual non-alcoholic organic reaction solvent and diminished levels of alcoholic solvent are also described.
摘要翻译：本发明描述了一种用于制备，分离和纯化抗溃疡剂奥美拉唑的改进方法，其中硫化物前体pyrmetazole在氯代脂族烃或芳族烃溶剂中与恰好一摩尔当量的间氯过氧苯甲酸在地下反应，如二氯甲烷或甲苯; 通过真空蒸馏从水层除去残留的有机溶剂; 粗产物通过与甲酸烷基酯或甲酸溶液反应结晶并接种获得; 通过在甲醇 - 含水NaOH水溶液中再次析出纯产物，通过地下加入乙酸水溶液至pH 9.0，接种，过滤，洗涤和干燥。还描述了奥美拉唑和不含色谱可检测水平的残留的非酒精有机反应溶剂和降低的醇溶剂水平的奥美拉唑组合物。

7. 发明授权

US5245069A Process for the preparation of bis(aryl)-phosphorohalidates 失效
标题翻译：制备双（芳基） - 膦酰卤的方法
公开(公告)号：US5245069A
公开(公告)日：1993-09-14
申请号：US966786
申请日：1992-10-27
申请人： James W. McManus
发明人： James W. McManus
IPC分类号： C07D477/02 , C07F9/14
CPC分类号： C07F9/1406 , C07D477/02
摘要： This invention relates to a novel process for preparing bis(aryl)phosphorohalidates which are useful in the synthesis of various enol phosphates. The process of this invention provides a means of producing a high-yield, high-purity product without the need for costly crystallization or impractical, high temperature distillations.
摘要翻译：本发明涉及可用于合成各种烯醇磷酸酯的双（芳基）磷酰卤的新方法。本发明的方法提供了生产高产率，高纯度产品的方法，而不需要昂贵的结晶或不切实际的高温蒸馏。

8. 发明授权

US07199240B2 Reductive alkylation of saturated cyclic amines 失效
标题翻译：饱和环胺的还原烷基化
公开(公告)号：US07199240B2
公开(公告)日：2007-04-03
申请号：US10726091
申请日：2003-12-02
申请人： James W. McManus , Bryan G. Kriel , Michael Stranberg
发明人： James W. McManus , Bryan G. Kriel , Michael Stranberg
IPC分类号： C07D401/06
CPC分类号： C07D213/38
摘要： Saturated cyclic amines (e.g., piperazines and piperidines) are reductively alkylated with an N-containing heteroaryl carbaldehyde using an alkylcarboxylic acid and a borohydride to obtain a product comprising an N-((N-containing heteroaryl)methyl)-substituted cyclic amine and one or more borane complexes thereof, after which the product is treated with a catalytic amount of a Pt or Pd catalyst in the presence of an alcohol to cleave the borane complex(es) and thereby afford the N-((N-containing heteroaryl)methyl)cyclic amine free of borane complex. Saturated cyclic amines are also reductively alkylated by adding an N-containing heteroaryl carbaldehyde and the amine to a tetrahydroborate salt-alkylcarboxylic acid-solvent admixture and aging the resulting reaction mixture to obtain an alkylated product substantially free of borane complex.
摘要翻译：使用烷基羧酸和硼氢化物将饱和环胺（例如哌嗪和哌啶）与含N杂芳基甲醛还原烷基化，得到包含N - （（N）杂芳基）甲基） - 取代的环状胺和一种或更多的硼烷配合物，之后在催化量的Pt或Pd催化剂的存在下，在醇的存在下处理产物以裂解硼烷络合物，由此得到N - （（N）杂芳基）甲基）环胺不含硼烷络合物。饱和环胺也通过将N含杂芳基甲醛和胺加入到四氢硼酸盐 - 烷基羧酸 - 溶剂混合物中进行还原烷基化，并使所得反应混合物老化，得到基本上不含硼烷络合物的烷基化产物。

9. 发明授权

US5550288A Process for the preparation of .alpha.-aminoacylanilides 失效
标题翻译：制备α-氨基酰苯胺的方法
公开(公告)号：US5550288A
公开(公告)日：1996-08-27
申请号：US335806
申请日：1994-11-14
申请人： James W. McManus
发明人： James W. McManus
IPC分类号： C07C231/12 , C07C235/68 , C07C237/06
CPC分类号： C07C231/12
摘要： A novel process for the preparation of .alpha.-aminoacylanilides comprises the treatment of the corresponding .alpha.-haloacylanilides with a solution of ammonium carbamate in aqueous ammonia. The process is especially useful in the preparation of certain active cardiac antiarrhythmic agents, such as tocainide.
摘要翻译： PCT No.PCT / US93 / 05613 371日期：1994年11月14日 102（e）1994年11月14日日期PCT提交1993年6月11日PCT公布。出版物WO93 / 25518 日期：1993年12月23日制备α-氨基酰基酰苯胺的新方法包括用氨基甲酸铵溶液在氨水中处理相应的α-卤代酰苯胺。该方法在制备某些活性心脏抗心律失常药如托卡尼特时特别有用。

10. 发明授权

US4956490A Process for preparing benzylpyruvic acids and esters 失效
标题翻译：苄基丙酮酸和酯的制备方法
公开(公告)号：US4956490A
公开(公告)日：1990-09-11
申请号：US321040
申请日：1989-03-09
申请人： James W. McManus , John F. Genus
发明人： James W. McManus , John F. Genus
IPC分类号： B01J31/12 , C07B61/00 , C07C51/09 , C07C51/347 , C07C51/36 , C07C59/84 , C07C59/90 , C07C205/56 , C07C253/30 , C07C255/57
CPC分类号： C07C51/347 , C07C51/36
摘要： There is disclosed a continuous, non-isolation process for preparing benzylpyruvic acids and benzylpyruvic esters. The benzylpyruvic acids and esters obtained are useful as intermediates to prepare carboxyalkyl dipeptide compounds which are used as angiotension converting enzyme (ACE) inhibitors to treat hypertension.

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