专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US6004777A Vectors having enhanced expression, and methods of making and uses thereof 失效
标题翻译：具有增强表达的载体及其制备和使用方法
公开(公告)号：US6004777A
公开(公告)日：1999-12-21
申请号：US815809
申请日：1997-03-12
申请人： James Tartaglia , Bertram L. Jacobs , Scott J. Goebel , William I. Cox , Russell Robert Gettig , Steven E. Pincus , Enzo Paoletti
发明人： James Tartaglia , Bertram L. Jacobs , Scott J. Goebel , William I. Cox , Russell Robert Gettig , Steven E. Pincus , Enzo Paoletti
IPC分类号： C12N15/09 , A61K35/76 , A61K48/00 , A61P37/04 , C12N15/67 , C12N15/85 , C12P21/02 , C12P21/00 , C12N15/11 , C12N15/63 , C12N15/66
CPC分类号： C12N15/67 , C12N15/85
摘要： Disclosed and claimed are vectors having enhanced expression and methods for making and using them. Enhancement of expression is from substantially co-temporal expression of at least one first nucleic acid molecule and at least one second nucleic acid molecule. The second nucleic acid molecule encodes a translation factor. The contemporaneous expression can be from operably linking the first and second nucleic molecules to a single promoter, or from operably linking the first nucleic acid molecule to a first promoter and the second nucleic molecule to a second promoter wherein the first and second promoters function substantially contemporaneously. Thus, the first and second nucleic acid molecules can be at the same locus in the vector or at different loci. The second nucleic acid molecule can encode encode one translation factor or more than one translation factor. The translation factor can be a K3L open reading frame, an E3L open reading frame, a VAI RNA, an EBER RNA, a sigma 3 open reading frame, a TRBP open reading frame, or combinations thereof. The vector can be a poxvirus such as an attenuated poxvirus; for instance, a NYVAC vaccinia virus or an ALVAC canarypox virus.
摘要翻译：披露和要求保护的是具有增强的表达的载体和用于制备和使用它们的方法。表达的增强来自至少一种第一核酸分子和至少一种第二核酸分子的基本上同时表达。第二核酸分子编码翻译因子。同时表达可以是将第一和第二核酸分子可操作地连接到单个启动子，或者可操作地将第一核酸分子与第一启动子连接，而将第二核酸分子可操作地连接到第二启动子，其中第一和第二启动子基本同时起作用。因此，第一和第二核酸分子可以在载体中或在不同基因座处于相同位点。第二核酸分子可编码编码一个翻译因子或多于一个翻译因子。翻译因子可以是K3L开放阅读框，E3L开放阅读框，VAI RNA，EBER RNA，Sigma 3开放阅读框，TRBP开放阅读框或其组合。载体可以是痘病毒，如减毒痘病毒; 例如，NYVAC痘苗病毒或ALVAC金丝雀痘病毒。

2. 发明申请

US20150191704A1 POXVIRUS-PLASMODIUM RECOMBINANTS, COMPOSITIONS CONTAINING SUCH RECOMBINANTS, USES THEREOF, AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译： POXVIRUS-PLASMODIUM重组体，包含这些重组体的组合物，其用途及其制备方法和使用方法
公开(公告)号：US20150191704A1
公开(公告)日：2015-07-09
申请号：US14576578
申请日：2014-12-19
申请人： Enzo Paoletti , Randall L. Weinberg , Scott J. Goebel
发明人： Enzo Paoletti , Randall L. Weinberg , Scott J. Goebel
IPC分类号： C12N7/00 , A61K39/275
CPC分类号： C12N7/00 , A61K39/015 , A61K39/275 , A61K2039/5256 , C12N15/86 , C12N2710/24021 , C12N2710/24034 , C12N2710/24122 , C12N2710/24134 , C12N2710/24143 , Y02A50/412
摘要： The invention provides a recombinant or synthetic or engineered or non-naturally occurring poxvirus that contains and expresses DNA encoding a heterologous or exogenous antigen, epitope or immunogen and Flagellin or an operable binding portion thereof. The poxvirus can contain or be engineered to contain and express vaccinia host range gene K1L. The poxvirus can be attenuated as to mammals, e.g., NYVAC, NYVAC.1, NYVAC.2, avipox, canarypox, fowlpox, ALVAC, TROVAC, MVA, or MVA-BN. The invention also provides methods for inducing an immunological response involving the poxvirus, and compositions containing the poxvirus. The antigen, epitope or immunogen that the poxvirus expresses can be at least one Plasmodium antigen. The Plasmodium antigen(s), epitope(s) or immunogen(s) can be SERA, ABRA, Pfhsp70, AMA-1, Pfs25, Pfs16, CSP, PfSSP2, LSA-1 repeatless, MSA-1, AMA-1 or combination(s) thereof. Advantageously the poxvirus contains DNA coding for and expresses Plasmodium antigen(s) CSP, PfSSP2, LSA-1-repeatless, MSA-1, SERA, AMA-1 and Pfs25. Also, advantageously, the poxvirus is a NYVAC poxvirus. The invention thus also provides an anti-malarial immunogenic or immunological compositions comprising the poxvirus, and methods for inducing an immunogenic or immunological response against malaria or Plasmodium in a mammal comprising administering to the mammal the poxvirus or an immunological or immunogenic composition containing the poxvirus. The mammal can be a human.
摘要翻译：本发明提供重组或合成或工程化或非天然存在的痘病毒，其含有和表达编码异源或外源抗原，表位或免疫原和鞭毛蛋白或其可操作结合部分的DNA。痘病毒可以包含或被设计成含有和表达痘苗宿主范围基因K1L。痘病毒可以减毒哺乳动物，例如NYVAC，NYVAC.1，NYVAC.2，avipox，金丝雀，禽痘，ALVAC，TROVAC，MVA或MVA-BN。本发明还提供诱导涉及痘病毒的免疫应答的方法和含有痘病毒的组合物。痘病毒表达的抗原，表位或免疫原可以是至少一种疟原虫抗原。疟原虫抗原，表位或免疫原可以是SERA，ABRA，Pfhsp70，AMA-1，Pfs25，Pfs16，CSP，PfSSP2，LSA-1无重复，MSA-1，AMA-1或组合（s）。有利的是，痘病毒含有编码并表达疟原虫抗原CSP，PfSSP2，LSA-1-无重复，MSA-1，SERA，AMA-1和Pfs25的DNA。此外，有利地，痘病毒是NYVAC痘病毒。因此，本发明还提供了包含痘病毒的抗疟疾免疫原性或免疫组合物，以及用于在哺乳动物中诱导针对疟疾或疟原虫的免疫原性或免疫应答的方法，包括向哺乳动物施用痘病毒或含有痘病毒的免疫或免疫原性组合物。哺乳动物可以是一个人。

3. 发明申请

US20210260182A1 RECOMBINANT POXVIRUS BASED VACCINE AGAINST SARS-CoV-2 VIRUS 有权
公开(公告)号：US20210260182A1
公开(公告)日：2021-08-26
申请号：US17187678
申请日：2021-02-26
申请人： Scott J. Goebel , David Evans , Ryan Noyce , Tonix Pharmaceuticals Holding Corp. , The Governors of the University of Alberta
发明人： Seth Lederman , Scott J. Goebel , David Evans , Ryan Noyce
IPC分类号： A61K39/215 , C12N7/00 , C12N15/85
摘要： The invention relates in various aspects to a recombinant poxvirus comprising a nucleic acid encoding a SARS-CoV-2 virus protein, methods for producing such viruses and the use of such viruses. The recombinant poxviruses are well suited, among others, as protective virus vaccines against SARS-CoV-2 virus.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式