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1. 发明申请

US20150191704A1 POXVIRUS-PLASMODIUM RECOMBINANTS, COMPOSITIONS CONTAINING SUCH RECOMBINANTS, USES THEREOF, AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译： POXVIRUS-PLASMODIUM重组体，包含这些重组体的组合物，其用途及其制备方法和使用方法
公开(公告)号：US20150191704A1
公开(公告)日：2015-07-09
申请号：US14576578
申请日：2014-12-19
申请人： Enzo Paoletti , Randall L. Weinberg , Scott J. Goebel
发明人： Enzo Paoletti , Randall L. Weinberg , Scott J. Goebel
IPC分类号： C12N7/00 , A61K39/275
CPC分类号： C12N7/00 , A61K39/015 , A61K39/275 , A61K2039/5256 , C12N15/86 , C12N2710/24021 , C12N2710/24034 , C12N2710/24122 , C12N2710/24134 , C12N2710/24143 , Y02A50/412
摘要： The invention provides a recombinant or synthetic or engineered or non-naturally occurring poxvirus that contains and expresses DNA encoding a heterologous or exogenous antigen, epitope or immunogen and Flagellin or an operable binding portion thereof. The poxvirus can contain or be engineered to contain and express vaccinia host range gene K1L. The poxvirus can be attenuated as to mammals, e.g., NYVAC, NYVAC.1, NYVAC.2, avipox, canarypox, fowlpox, ALVAC, TROVAC, MVA, or MVA-BN. The invention also provides methods for inducing an immunological response involving the poxvirus, and compositions containing the poxvirus. The antigen, epitope or immunogen that the poxvirus expresses can be at least one Plasmodium antigen. The Plasmodium antigen(s), epitope(s) or immunogen(s) can be SERA, ABRA, Pfhsp70, AMA-1, Pfs25, Pfs16, CSP, PfSSP2, LSA-1 repeatless, MSA-1, AMA-1 or combination(s) thereof. Advantageously the poxvirus contains DNA coding for and expresses Plasmodium antigen(s) CSP, PfSSP2, LSA-1-repeatless, MSA-1, SERA, AMA-1 and Pfs25. Also, advantageously, the poxvirus is a NYVAC poxvirus. The invention thus also provides an anti-malarial immunogenic or immunological compositions comprising the poxvirus, and methods for inducing an immunogenic or immunological response against malaria or Plasmodium in a mammal comprising administering to the mammal the poxvirus or an immunological or immunogenic composition containing the poxvirus. The mammal can be a human.
摘要翻译：本发明提供重组或合成或工程化或非天然存在的痘病毒，其含有和表达编码异源或外源抗原，表位或免疫原和鞭毛蛋白或其可操作结合部分的DNA。痘病毒可以包含或被设计成含有和表达痘苗宿主范围基因K1L。痘病毒可以减毒哺乳动物，例如NYVAC，NYVAC.1，NYVAC.2，avipox，金丝雀，禽痘，ALVAC，TROVAC，MVA或MVA-BN。本发明还提供诱导涉及痘病毒的免疫应答的方法和含有痘病毒的组合物。痘病毒表达的抗原，表位或免疫原可以是至少一种疟原虫抗原。疟原虫抗原，表位或免疫原可以是SERA，ABRA，Pfhsp70，AMA-1，Pfs25，Pfs16，CSP，PfSSP2，LSA-1无重复，MSA-1，AMA-1或组合（s）。有利的是，痘病毒含有编码并表达疟原虫抗原CSP，PfSSP2，LSA-1-无重复，MSA-1，SERA，AMA-1和Pfs25的DNA。此外，有利地，痘病毒是NYVAC痘病毒。因此，本发明还提供了包含痘病毒的抗疟疾免疫原性或免疫组合物，以及用于在哺乳动物中诱导针对疟疾或疟原虫的免疫原性或免疫应答的方法，包括向哺乳动物施用痘病毒或含有痘病毒的免疫或免疫原性组合物。哺乳动物可以是一个人。

2. 发明授权

US6004777A Vectors having enhanced expression, and methods of making and uses thereof 失效
标题翻译：具有增强表达的载体及其制备和使用方法
公开(公告)号：US6004777A
公开(公告)日：1999-12-21
申请号：US815809
申请日：1997-03-12
申请人： James Tartaglia , Bertram L. Jacobs , Scott J. Goebel , William I. Cox , Russell Robert Gettig , Steven E. Pincus , Enzo Paoletti
发明人： James Tartaglia , Bertram L. Jacobs , Scott J. Goebel , William I. Cox , Russell Robert Gettig , Steven E. Pincus , Enzo Paoletti
IPC分类号： C12N15/09 , A61K35/76 , A61K48/00 , A61P37/04 , C12N15/67 , C12N15/85 , C12P21/02 , C12P21/00 , C12N15/11 , C12N15/63 , C12N15/66
CPC分类号： C12N15/67 , C12N15/85
摘要： Disclosed and claimed are vectors having enhanced expression and methods for making and using them. Enhancement of expression is from substantially co-temporal expression of at least one first nucleic acid molecule and at least one second nucleic acid molecule. The second nucleic acid molecule encodes a translation factor. The contemporaneous expression can be from operably linking the first and second nucleic molecules to a single promoter, or from operably linking the first nucleic acid molecule to a first promoter and the second nucleic molecule to a second promoter wherein the first and second promoters function substantially contemporaneously. Thus, the first and second nucleic acid molecules can be at the same locus in the vector or at different loci. The second nucleic acid molecule can encode encode one translation factor or more than one translation factor. The translation factor can be a K3L open reading frame, an E3L open reading frame, a VAI RNA, an EBER RNA, a sigma 3 open reading frame, a TRBP open reading frame, or combinations thereof. The vector can be a poxvirus such as an attenuated poxvirus; for instance, a NYVAC vaccinia virus or an ALVAC canarypox virus.
摘要翻译：披露和要求保护的是具有增强的表达的载体和用于制备和使用它们的方法。表达的增强来自至少一种第一核酸分子和至少一种第二核酸分子的基本上同时表达。第二核酸分子编码翻译因子。同时表达可以是将第一和第二核酸分子可操作地连接到单个启动子，或者可操作地将第一核酸分子与第一启动子连接，而将第二核酸分子可操作地连接到第二启动子，其中第一和第二启动子基本同时起作用。因此，第一和第二核酸分子可以在载体中或在不同基因座处于相同位点。第二核酸分子可编码编码一个翻译因子或多于一个翻译因子。翻译因子可以是K3L开放阅读框，E3L开放阅读框，VAI RNA，EBER RNA，Sigma 3开放阅读框，TRBP开放阅读框或其组合。载体可以是痘病毒，如减毒痘病毒; 例如，NYVAC痘苗病毒或ALVAC金丝雀痘病毒。

3. 发明授权

US6017542A Nucleotide and amino acid sequences of canine herpesvirus GD and uses therefor 失效
标题翻译：犬疱疹病毒GD的核苷酸和氨基酸序列，并用于其
公开(公告)号：US6017542A
公开(公告)日：2000-01-25
申请号：US473446
申请日：1995-06-07
申请人： Enzo Paoletti , Keith J. Limbach
发明人： Enzo Paoletti , Keith J. Limbach
IPC分类号： C12N15/09 , A61K39/00 , A61K39/12 , A61K39/245 , A61P31/12 , A61P31/22 , C07H21/04 , C07K14/03 , C12N15/38 , C12P21/02 , C12N7/01
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/14143 , C12N2710/16722
摘要： Disclosed and claimed are nucleotides for genes encoding the canine herpesvirus (CHV) gB, gC and gD homologues. These genes encode polypeptides of 879, 459 and 345 amino acids, respectively, which are also disclosed and claimed. The genes are useful as DNA probes or, for preparing PCR primers. The polypeptides are useful in antigenic, immunological or vaccine compositions. The nucleotides can be expressed in any suitable vector system, allowing for production of the polypeptides. Additionally, the vector system containing any or any combination of the nucleotides can be employed in an antigenic, immunological or vaccine composition, such as a poxvirus vector system, e.g., a CHV-vaccinia or avipox virus recombinant, as can the products from expression, i.e., the gB, gC and gD glycoproteins. Antibodies elicited by the glycoproteins or from expression of the vector containing the nucleotide(s) are also useful. Methods for making and using the composition are also disclosed and claimed. Also, specific canarypox-CHV gB, gC and gD recombinants vCP 320, vCP322 and vCP294 and methods for making and using them are also disclosed and claimed.
摘要翻译：公开并要求保护的是用于编码犬疱疹病毒（CHV）gB，gC和gD同系物的基因的核苷酸。这些基因分别编码879,459和345个氨基酸的多肽，其也被公开和要求保护。这些基因可用作DNA探针，或用于制备PCR引物。多肽可用于抗原性，免疫学或疫苗组合物。核苷酸可以在任何合适的载体系统中表达，允许产生多肽。另外，含有任何或任何组合的核苷酸的载体系统可以用于抗原性，免疫学或疫苗组合物，例如痘病毒载体系统，例如CHV-痘苗或Avipox病毒重组体，以及来自表达的产物，即gB，gC和gD糖蛋白。由糖蛋白引起的抗体或含有该核苷酸的载体的表达也是有用的。还公开并要求保护和使用组合物的方法。此外，还公开并要求保护特定的金丝雀痘-GV，gC和gD重组体vCP 320，vCP322和vCP294及其制备和使用方法。

4. 发明授权

US5990091A Vectors having enhanced expression, and methods of making and uses thereof 失效
标题翻译：具有增强表达的载体及其制备和使用方法
公开(公告)号：US5990091A
公开(公告)日：1999-11-23
申请号：US816155
申请日：1997-03-12
申请人： James Tartaglia , William I. Cox , Russell Robert Gettig , Hector Martinez , Enzo Paoletti , Steven E. Pincus
发明人： James Tartaglia , William I. Cox , Russell Robert Gettig , Hector Martinez , Enzo Paoletti , Steven E. Pincus
IPC分类号： C12N15/09 , A61K35/76 , A61K48/00 , A61P37/04 , C12N15/67 , C12N15/85 , C12N15/863 , C12N15/86
CPC分类号： C12N15/86 , A61K48/00 , C12N15/67 , C12N15/85 , C12N2710/24043 , C12N2710/24143 , C12N2830/00 , C12N2830/60 , C12N2840/00
摘要： Disclosed and claimed are vectors having enhanced expression and methods for making and using them. Enhancement of expression is from substantially co-temporal expression of at least one first nucleic acid molecule and at least one second nucleic acid molecule. The second nucleic acid molecule encodes a transcription factor or a translation factor or a transcription factor and a translation factor. The contemporaneous expression can be from operably linking the first and second nucleic molecules to a single promoter, or from operably linking the first nucleic acid molecule to a first promoter and the second nucleic molecule to a second promoter wherein the first and second promoters function substantially contemporaneously. Thus, the first and second nucleic acid molecules can be at the same locus in the vector, or at different loci. The second nucleic acid molecule can encode: one transcription factor or more than one transcription factor; or one translation factor or more than one translation factor; or at least one transcription factor and at least one translation factor. The transcription factor can be from vaccinia H4L, D6, A7, G8R, A1L, A2L, H5R, or combinations thereof. The translation factor can be from a K3L open reading frame, an E3L open reading frame, a VAI RNA, an EBER RNA, a sigma 3 open reading frame, a TRBP open reading frame, or combinations thereof. The vector can be a poxvirus such as an attenuated poxvirus, e.g., NYVAC, or ALVAC.
摘要翻译：披露和要求保护的是具有增强的表达的载体和用于制备和使用它们的方法。表达的增强来自至少一种第一核酸分子和至少一种第二核酸分子的基本上同时表达。第二核酸分子编码转录因子或翻译因子或转录因子和翻译因子。同时表达可以是将第一和第二核酸分子可操作地连接到单个启动子，或者可操作地将第一核酸分子与第一启动子连接，而将第二核酸分子可操作地连接到第二启动子，其中第一和第二启动子基本同时起作用。因此，第一和第二核酸分子可以在载体中的相同基因座处或在不同的基因座处。第二核酸分子可编码：一种转录因子或多于一种转录因子; 或一个翻译因子或多于一个翻译因子; 或至少一个转录因子和至少一个翻译因子。转录因子可以来自牛痘H4L，D6，A7，G8R，A1L，A2L，H5R或其组合。翻译因子可以来自K3L开放阅读框，E3L开放阅读框，VAI RNA，EBER RNA，西格玛3开放阅读框，TRBP开放阅读框或其组合。载体可以是痘病毒，例如减毒痘病毒，例如NYVAC或ALVAC。

5. 发明授权

US5766597A Malaria recombinant poxviruses 失效
标题翻译：疟疾重症痘病毒
公开(公告)号：US5766597A
公开(公告)日：1998-06-16
申请号：US257073
申请日：1994-06-09
申请人： Enzo Paoletti , Charles de Taisne , John A. Tine
发明人： Enzo Paoletti , Charles de Taisne , John A. Tine
IPC分类号： A61K38/00 , A61K39/00 , A61K39/015 , A61K39/275 , A61K39/285 , C07K14/445 , C12N7/01
CPC分类号： C07K14/445 , A61K38/00 , A61K39/00
摘要： What is described is a recombinant poxvirus, such as vaccinia or canarypox virus, containing foreign DNA from Plasmodium such as coding for at least one of CSP, PfSSP2, LSA-1, LSA-1-repeatless, MSA-1, SERA, AMA-1, Pfs25, MSA-1 N-terminal p83 and MSA-1 C-terminal gp42. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine. Preferred recombinants have attenuated virulence. In certain embodiments the vaccinia has deleted or disrupted the thymidine kinase gene, the hemorrhagic region, the A type inclusion body region, the host range gene region and, the large subunit, ribonucleotide reductase; and, contains coding sequences for CSP, PfSSP2, LSA-1-repeatless, MSA-1, SERA, AMA-1 and Pfs25. That embodiment is termed NYVAC-Pf7 and is a multicomponent, multistage vaccine since it codes for and expresses sporozoite proteins, liver stage proteins, blood stage proteins and, sexual stage proteins.
摘要翻译：描述的是重组痘病毒，例如痘苗或金丝雀痘病毒，其含有来自疟原虫的外来DNA，例如编码CSP，PfSSP2，LSA-1，LSA-1-无重复，MSA-1，SERA，AMA- 1，Pfs25，MSA-1 N端p83和MSA-1 C端gp42。还描述了含有用于在接种疫苗的宿主动物中诱导免疫应答的重组痘病毒的疫苗。优选的重组体具有减毒毒力。在某些实施方案中，痘苗已经缺失或破坏了胸苷激酶基因，出血区域，A型包涵体区域，宿主范围基因区域和大亚基核糖核苷酸还原酶; 并且包含用于CSP，PfSSP2，LSA-1-无重复，MSA-1，SERA，AMA-1和Pfs25的编码序列。该实施方案称为NYVAC-Pf7，并且是多组分多级疫苗，因为其编码并表达子孢子蛋白，肝阶段蛋白质，血液阶段蛋白质和性阶段蛋白质。

6. 发明授权

US5756102A Poxvirus-canine distemper virus (CDV) recombinants and compositions and methods employing the recombinants 失效
标题翻译：疱疹病毒 - 犬瘟热病毒（CDV）重组体和使用重组体的组合物和方法
公开(公告)号：US5756102A
公开(公告)日：1998-05-26
申请号：US224657
申请日：1994-04-06
申请人： Enzo Paoletti , James Tartaglia , Jill Taylor
发明人： Enzo Paoletti , James Tartaglia , Jill Taylor
IPC分类号： C12N15/09 , A61K39/175 , A61K39/275 , A61K39/285 , A61P31/12 , C07K14/11 , C07K14/115 , C07K14/12 , C07K14/125 , C07K14/13 , C07K14/145 , C12N7/01 , C12N7/04 , C12N15/863 , C12P21/02
CPC分类号： C12N15/86 , C07K14/005 , C12N2710/24043 , C12N2710/24143 , C12N2760/16122 , C12N2760/18122 , C12N2760/18422 , C12N2760/18722 , C12N2760/20122
摘要： Attenuated recombinant viruses containing DNA coding for a canine distemper virus antigen, as well as methods and compositions employing the viruses, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The DNA can code for at least one of: canine distemper virus fusion protein and canine distemper virus hemagglutinin glycoprotein. The recombinant viruses and gene products therefrom are useful for eliciting protection against canine distemper virus.
摘要翻译：含有编码犬瘟热病毒抗原的DNA的减毒重组病毒以及使用该病毒的方法和组合物被公开并要求保护。重组病毒可以是NYVAC或ALVAC重组病毒。 DNA可编码以下至少一种：犬瘟热病毒融合蛋白和犬瘟热病毒血凝素糖蛋白。重组病毒及其基因产物可用于引发针对犬瘟热病毒的保护。

7. 发明授权

US5744140A Flavivirus recombinant poxvirus vaccine 失效
公开(公告)号：US5744140A
公开(公告)日：1998-04-28
申请号：US224391
申请日：1994-04-07
申请人： Enzo Paoletti , Steven Elliot Pincus
发明人： Enzo Paoletti , Steven Elliot Pincus
IPC分类号： C12N7/00 , A61K35/76 , A61K39/00 , A61K39/12 , A61K48/00 , A61P31/12 , C07K14/015 , C07K14/02 , C07K14/03 , C07K14/035 , C07K14/045 , C07K14/05 , C07K14/06 , C07K14/065 , C07K14/07 , C07K14/11 , C07K14/12 , C07K14/125 , C07K14/145 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/175 , C07K14/18 , C07K14/33 , C12N7/08 , C12N15/00 , C12N15/09 , C12N15/863 , A61K39/275 , A61K39/295 , C12N7/01
CPC分类号： C12N15/86 , C07K14/005 , C07K14/33 , A61K2039/5254 , A61K39/00 , C07K2319/00 , C12N2710/16222 , C12N2710/16622 , C12N2710/16722 , C12N2710/24022 , C12N2710/24043 , C12N2710/24122 , C12N2710/24143 , C12N2730/10122 , C12N2740/13022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2750/14322 , C12N2760/12022 , C12N2760/16122 , C12N2760/18122 , C12N2760/18722 , C12N2760/20022 , C12N2770/24022 , C12N2770/24043 , C12N2770/24122 , C12N2770/24143
摘要： What is described is a recombinant poxvirus, such as vaccinia virus, fowlpox virus and canarypox virus, containing foreign DNA from flavivirus, such as Japanese encephalitis virus, yellow fever virus and Dengue virus. In a preferred embodiment, the recombinant poxvirus generates an extracellular particle containing flavivirus E and M proteins capable of inducing neutralizing antibodies, hemagglutination-inhibiting antibodies and protective immunity against flavivirus infection. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine.

8. 发明授权

US5583028A Recombinant vaccinia virus as DNA constructs encoding HSV glycoproteins 失效
标题翻译：重组痘苗病毒作为编码HSV糖蛋白的DNA构建体
公开(公告)号：US5583028A
公开(公告)日：1996-12-10
申请号：US306259
申请日：1994-09-13
申请人： Enzo Paoletti , Dennis Panicali
发明人： Enzo Paoletti , Dennis Panicali
IPC分类号： C12N15/09 , A61K39/00 , A61K39/285 , C07H21/04 , C07K14/035 , C07K14/11 , C12N5/10 , C12N7/00 , C12N15/00 , C12N15/63 , C12N15/863 , C12P21/00 , C12Q1/70 , C12R1/19 , C12R1/91 , C12R1/92 , C12N7/01 , C12N15/86
CPC分类号： C12N15/86 , C07K14/005 , A61K39/00 , C12N2710/16622 , C12N2710/24143 , C12N2760/16122
摘要： Disclosed and claimed are DNA constructs encoding HSV glycoproteins. The constructs are recombinant vaccinia virus, and host cells infected by the recombinant vaccinia virus are also disclosed and claimed.
摘要翻译：披露和要求的是编码HSV糖蛋白的DNA构建体。构建体是重组痘苗病毒，并且还公开并要求保护由重组痘苗病毒感染的宿主细胞。

9. 发明授权

US5529780A Nucleotide and amino acid sequences of canine herpesvirus gB and gC 失效
标题翻译：犬疱疹病毒gB和gC的核苷酸和氨基酸序列
公开(公告)号：US5529780A
公开(公告)日：1996-06-25
申请号：US220151
申请日：1994-03-30
申请人： Enzo Paoletti , Keith J. Limbach
发明人： Enzo Paoletti , Keith J. Limbach
IPC分类号： A61K39/00 , C07K14/03 , A61K39/245 , C12N7/01 , C12N15/38 , C12P21/02
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/14143 , C12N2710/16722
摘要： Disclosed and claimed are nucleotides for genes encoding the canine herpesvirus (CHV) gB, gC and gD homologues. These genes encode polypeptides of 879, 459 and 345 amino acids, respectively, which are also disclosed. The nucleotides can be expressed in any suitable vector system, allowing for production of the polypeptides. Additionally, the vector system containing any or any combination of the nucleotides can be employed in an antigenic, immunological or vaccine composition, such as a poxvirus vector system, e.g., a CHV-vaccinia or avipox virus recombinant, as can the products from expression, i.e., the gB, gC and gD glycoproteins. Antibodies elicited by the glycoproteins or from expression of the vector containing the nucleotide are also useful. Methods for making and using the composition are also disclosed and claimed.
摘要翻译：公开并要求保护的是用于编码犬疱疹病毒（CHV）gB，gC和gD同系物的基因的核苷酸。这些基因分别编码879,459和345个氨基酸的多肽，其也被公开。核苷酸可以在任何合适的载体系统中表达，允许产生多肽。另外，含有任何或任何组合的核苷酸的载体系统可以用于抗原性，免疫学或疫苗组合物，例如痘病毒载体系统，例如CHV-痘苗或Avipox病毒重组体，以及来自表达的产物，即gB，gC和gD糖蛋白。由糖蛋白引起的抗体或含有该核苷酸的载体的表达也是有用的。还公开并要求保护和使用组合物的方法。

10. 发明授权

US5514375A Flavivirus recombinant poxvirus vaccine 失效
标题翻译：黄病毒重组痘病毒疫苗
公开(公告)号：US5514375A
公开(公告)日：1996-05-07
申请号：US714687
申请日：1991-06-13
申请人： Enzo Paoletti , Steven E. Pincus
发明人： Enzo Paoletti , Steven E. Pincus
IPC分类号： A61K39/00 , C07K14/015 , C07K14/02 , C07K14/03 , C07K14/035 , C07K14/045 , C07K14/05 , C07K14/06 , C07K14/065 , C07K14/07 , C07K14/11 , C07K14/12 , C07K14/125 , C07K14/145 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/175 , C07K14/18 , C07K14/33 , C12N15/863 , A61K39/285 , A61K39/295 , C12N7/01
CPC分类号： C12N15/86 , C07K14/005 , C07K14/33 , A61K2039/5254 , A61K39/00 , C07K2319/00 , C12N2710/16222 , C12N2710/16622 , C12N2710/16722 , C12N2710/24022 , C12N2710/24122 , C12N2710/24143 , C12N2730/10122 , C12N2740/13022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2750/14322 , C12N2760/12022 , C12N2760/16122 , C12N2760/18122 , C12N2760/18722 , C12N2760/20022 , C12N2770/24022 , C12N2770/24122 , Y10S530/826
摘要： What is described is a recombinant poxvirus, such as vaccinia virus, fowlpox virus and canarypox virus, containing foreign DNA from flavivirus, such as Japanese encephalitis virus, yellow fever virus and Dengue virus. In a preferred embodiment, the recombinant poxvirus generates an extracellular particle containing flavivirus E and M proteins capable of inducing neutralizing antibodies, hemagglutination-inhibiting antibodies and protective immunity against flavivirus infection. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine.
摘要翻译：描述的是重组痘病毒，例如痘苗病毒，禽痘病毒和金丝雀痘病毒，其含有来自黄病毒的外源DNA，例如日本脑炎病毒，黄热病病毒和登革热病毒。在优选的实施方案中，重组痘病毒产生含有能够诱导中和抗体，血细胞凝集抑制性抗体和针对黄病毒感染的保护性免疫的黄病毒E和M蛋白的细胞外颗粒。还描述了含有用于在接种疫苗的宿主动物中诱导免疫应答的重组痘病毒的疫苗。

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