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1. 发明申请

US20130109578A1 DIFFERENTIATION OF ISOBARIC AMINO ACIDS AND OTHER SPECIES 有权
标题翻译： ISOBARIC氨基酸和其他物种的差异
公开(公告)号：US20130109578A1
公开(公告)日：2013-05-02
申请号：US13386333
申请日：2009-07-22
申请人： James R. Heath , Su Seong Lee , Jaehong Lim , Junhoe Cha , Sylvia Tan , Shi Yun Yeo
发明人： James R. Heath , Su Seong Lee , Jaehong Lim , Junhoe Cha , Sylvia Tan , Shi Yun Yeo
IPC分类号： G01N33/68 , C07K1/13
CPC分类号： G01N33/6848 , C07B2200/11 , C07K1/047 , C07K1/13 , C07K7/06 , C40B50/16 , G01N33/6812 , G01N33/6818
摘要： Techniques for differentiating isobaric species are described. An isobaric species may be substituted with a tagging species identified using mass spectrometry. The isobaric species may be a subunit of a first polymer having a defined sequence, e.g., the isobaric species may be an amino acid in a protein or a peptide sequence. A tagging species may be substituted for the isobaric species in a second polymer having an otherwise identical sequence as the first polymer. The second polymer may have the same number of sequences as the first polymer, and substantially the same sequence of subunits, with a few exceptions such as the tagging species for the isobaric species. The first polymer and the second polymer may be prepared in the same reaction vessel. A polymer/protein of defined subunit sequence containing an isobaric species or a tagging species may be analyzed by mass spectrometry to determine the sequence.
摘要翻译：描述了用于区分等压物种的技术。同量异位物质可以用用质谱鉴定的标记物种代替。等压异构物可以是具有确定的序列的第一聚合物的亚单位，例如，同量异位物质可以是蛋白质或肽序列中的氨基酸。在具有与第一聚合物相同的序列的第二聚合物中，标记物质可以代替同量异位物质。第二聚合物可以具有与第一聚合物相同数量的序列，以及基本上相同的亚基序列，只有少数例外，例如同量异序物种的标记物种。第一聚合物和第二聚合物可以在相同的反应容器中制备。可以通过质谱分析含有等压物种或标记物质的限定亚单位序列的聚合物/蛋白质来确定序列。

2. 发明申请

US20120122711A1 SCREENING OF BIOPOLYMERS 审中-公开
标题翻译：生物聚合物筛选
公开(公告)号：US20120122711A1
公开(公告)日：2012-05-17
申请号：US13384510
申请日：2010-07-15
申请人： James R. Heath , Su Seong Lee , Jaehong Lim , Junhoe Cha , Sylvia Tan , Shi Yun Yeo , Yi Li Ang , Yiran Zhang
发明人： James R. Heath , Su Seong Lee , Jaehong Lim , Junhoe Cha , Sylvia Tan , Shi Yun Yeo , Yi Li Ang , Yiran Zhang
IPC分类号： C40B30/00 , C40B50/18 , C40B40/12 , C40B40/06 , C40B40/10
CPC分类号： G01N33/6845
摘要： Described herein are inventive compositions and methods relating to sampling of biopolymers and, in particular, to fractional sampling of biopolymers. In one aspect, embodiments are generally related to unique biopolymer species where a fraction of each biopolymer species contains a cleavable linker. The biopolymer species may, in some embodiments, be attached to a surface. For example, the biopolymer species may be attached to beads. In some embodiments, a portion of a unique biopolymer species may be sampled by cleaving the cleavable linker. In some cases, the sample may be analyzed to determine the sequence of the biopolymer.
摘要翻译：本文描述了与生物聚合物的取样有关的本发明组合物和方法，特别是生物聚合物的分数取样。在一个方面，实施方案通常涉及独特的生物聚合物种类，其中每个生物聚合物种类的一部分含有可切割的连接体。在一些实施方案中，生物聚合物物质可附着于表面。例如，生物聚合物物质可以连接到珠粒上。在一些实施方案中，可以通过切割可切割接头来采样一部分独特的生物聚合物种类。在一些情况下，可以分析样品以确定生物聚合物的顺序。

3. 发明授权

US09863956B2 Differentiation of isobaric amino acids and other species 有权
公开(公告)号：US09863956B2
公开(公告)日：2018-01-09
申请号：US13386333
申请日：2009-07-22
申请人： James R. Heath , Su Seong Lee , Jaehong Lim , Junhoe Cha , Sylvia Tan , Shi Yun Yeo
发明人： James R. Heath , Su Seong Lee , Jaehong Lim , Junhoe Cha , Sylvia Tan , Shi Yun Yeo
IPC分类号： G01N33/68 , C07K1/04 , C07K7/06 , C40B50/16 , C07K1/13
CPC分类号： G01N33/6848 , C07B2200/11 , C07K1/047 , C07K1/13 , C07K7/06 , C40B50/16 , G01N33/6812 , G01N33/6818
摘要： Techniques for differentiating isobaric species are described. An isobaric species may be substituted with a tagging species identified using mass spectrometry. The isobaric species may be a subunit of a first polymer having a defined sequence, e.g., the isobaric species may be an amino acid in a protein or a peptide sequence. A tagging species may be substituted for the isobaric species in a second polymer having an otherwise identical sequence as the first polymer. The second polymer may have the same number of sequences as the first polymer, and substantially the same sequence of subunits, with a few exceptions such as the tagging species for the isobaric species. The first polymer and the second polymer may be prepared in the same reaction vessel. A polymer/protein of defined subunit sequence containing an isobaric species or a tagging species may be analyzed by mass spectrometry to determine the sequence.

4. 发明授权

US08586348B2 Lateral flow microfluidic assaying device and related method 有权
标题翻译：侧流微流体测定装置及相关方法
公开(公告)号：US08586348B2
公开(公告)日：2013-11-19
申请号：US13240347
申请日：2011-09-22
申请人： Jun Wang , James R. Heath
发明人： Jun Wang , James R. Heath
IPC分类号： C12M1/00 , C12M1/34 , C12Q1/68 , G01N33/53 , G01N33/00 , G01N15/06 , G01N30/96
CPC分类号： G01N33/54386 , B01L3/502753 , B01L3/502776 , B01L2300/0681 , B01L2300/0816 , B01L2300/087 , B01L2300/0883 , B01L2400/0406 , B01L2400/0487 , B01L2400/0633 , B01L2400/086
摘要： Provided herein is a microfluidic device and related method for controlling flow of different fluid components of a fluid. The microfluidic device comprises an input channel, focusing channel and an assaying channel. The microfluidic device is adapted to separate a fluid into at least two fluid components, and is further adapted to detect a target material comprised within one of the fluid components. The method comprises providing a channel, the channel having a dimension which is a function of a dimension of one of the fluid components and deliver the fluid through the channel at a set flow rate.
摘要翻译：本文提供了用于控制流体的不同流体组分的流动的微流体装置和相关方法。微流体装置包括输入通道，聚焦通道和测定通道。微流体装置适于将流体分离成至少两个流体组分，并且还适于检测包含在流体组分之一内的目标材料。该方法包括提供通道，通道具有作为流体部件中的一个的尺寸的函数的尺寸，并以设定的流速输送通过通道的流体。

5. 发明申请

US20120097204A1 NANOMESH PHONONIC STRUCTURES FOR LOW THERMAL CONDUCTIVITY AND THERMOELECTRIC ENERGY CONVERSION MATERIALS 有权
标题翻译：用于低导热性和热电能转换材料的纳米微波结构
公开(公告)号：US20120097204A1
公开(公告)日：2012-04-26
申请号：US13278074
申请日：2011-10-20
申请人： Jen-Kan Yu , Slobodan Mitrovic , James R. Heath
发明人： Jen-Kan Yu , Slobodan Mitrovic , James R. Heath
IPC分类号： H01L35/02 , H01L21/265 , B32B3/24 , H01L21/22
CPC分类号： H01L35/26 , B82Y10/00 , B82Y30/00 , B82Y40/00 , Y10T428/24273 , Y10T428/24298
摘要： A nanomesh phononic structure includes: a sheet including a first material, the sheet having a plurality of phononic-sized features spaced apart at a phononic pitch, the phononic pitch being smaller than or equal to twice a maximum phonon mean free path of the first material and the phononic size being smaller than or equal to the maximum phonon mean free path of the first material.
摘要翻译：纳米级声子结构包括：包括第一材料的片材，该片材具有以声子间距间隔开的多个声子大小的特征，声子间距小于或等于第一材料的最大声子平均自由程的两倍并且声子尺寸小于或等于第一材料的最大声子平均自由程。

6. 发明授权

US07948271B1 Molecular wire crossbar logic (MWCL) 有权
标题翻译：分子线交叉逻辑（MWCL）
公开(公告)号：US07948271B1
公开(公告)日：2011-05-24
申请号：US09282045
申请日：1999-03-29
申请人： Philip J. Kuekes , James R. Heath
发明人： Philip J. Kuekes , James R. Heath
IPC分类号： H03K19/20 , H03K19/082
CPC分类号： H03K19/20 , B82Y10/00 , H01L27/101 , H01L27/1021 , H01L27/285 , H01L29/0665 , H01L29/0673
摘要： A programmable logic array (PLA) comprising a two-dimensional array of a plurality of nanometer-scale switches is provided. Each switch comprises a pair of crossed wires which form a junction where one wire crosses another and at least one connector species connecting the pair of crossed wires in the junction. The connector species comprises a bi-stable molecule. A plurality of switches is configurable as an AND gate and a plurality of switches is configurable as an OR gate.
摘要翻译：提供了包括多个纳米级开关的二维阵列的可编程逻辑阵列（PLA）。每个开关包括一对交叉的线，其形成一条线与另一条线交叉的连接处，以及至少一个在连接处连接一对交叉线的连接器种类。连接器种类包括双稳态分子。多个开关可配置为与门，并且多个开关可配置为或门。

7. 发明申请

US20110039717A1 METHODS AND SYSTEMS FOR DETECTING AND/OR SORTING TARGETS 有权
标题翻译：用于检测和/或分配目标的方法和系统
公开(公告)号：US20110039717A1
公开(公告)日：2011-02-17
申请号：US12652000
申请日：2010-01-04
申请人： Gabriel A. Kwong , Ryan C. Bailey , Rong Fan , James R. Heath
发明人： Gabriel A. Kwong , Ryan C. Bailey , Rong Fan , James R. Heath
IPC分类号： C40B30/04
CPC分类号： G01N33/6845 , C12Q1/6834 , C12Q2563/131
摘要： Provided herein are methods and systems for detecting and/or sorting targets in a sample based on the combined use of polynucleotide-encoded protein and substrate polynucleotides. The polynucleotide-encoded protein is comprised of a protein that specifically binds to a predetermined target and of an encoding polynucleotide that specifically binds to a substrate polynucleotide, wherein the substrate polynucleotide is attached to a substrate.
摘要翻译：本文提供了用于基于多核苷酸编码的蛋白质和底物多核苷酸的组合使用来检测和/或分选样品中靶标的方法和系统。所述多核苷酸编码的蛋白质由特异性结合预定靶标的蛋白质和特异性结合底物多核苷酸的编码多核苷酸组成，其中所述底物多核苷酸附着于底物。

8. 发明授权

US06903366B2 Chemically synthesized and assembled electronic devices 失效
标题翻译：化学合成和组装电子器件
公开(公告)号：US06903366B2
公开(公告)日：2005-06-07
申请号：US10699172
申请日：2003-10-31
申请人： James R. Heath , R. Stanley Williams , Philip J. Kuekes
发明人： James R. Heath , R. Stanley Williams , Philip J. Kuekes
IPC分类号： B81B7/04 , B82B1/00 , G01R31/28 , G11C13/02 , H01L21/00 , H01L23/532 , H01L27/10 , H01L29/861 , H01L51/00 , H01L51/05 , H01L51/30 , H01L51/40 , H01L29/06
CPC分类号： H01L27/10 , B82B1/00 , B82Y10/00 , B82Y30/00 , G11C13/0009 , G11C13/0014 , G11C13/02 , G11C2213/72 , G11C2213/77 , G11C2213/81 , H01L51/0595 , Y10S977/704 , Y10S977/705 , Y10S977/936
摘要： A route to the fabrication of electronic devices is provided, in which the devices consist of two crossed wires sandwiching an electrically addressable molecular species. The approach is extremely simple and inexpensive to implement, and scales from wire dimensions of several micrometers down to nanometer-scale dimensions. The device of the present invention can be used to produce crossbar switch arrays, logic devices, memory devices, and communication and signal routing devices. The present invention enables construction of molecular electronic devices on a length scale than can range from micrometers to nanometers via a straightforward and inexpensive chemical assembly procedure. The device is either partially or completely chemically assembled, and the key to the scaling is that the location of the devices on the substrate are defined once the devices have been assembled, not prior to assembly.
摘要翻译：提供了制造电子器件的途径，其中器件由夹着电可寻址分子种类的两条交叉导线组成。该方法实现起来非常简单和便宜，并且从几微米的线尺寸缩小到纳米级尺寸。本发明的装置可用于产生交叉开关阵列，逻辑器件，存储器件以及通信和信号路由器件。本发明能够通过直接且廉价的化学组装程序在长度尺度上构建分子电子器件，其尺寸范围可以从微米到纳米。该装置部分或完全化学地组装，并且缩放的关键在于，一旦装置组装而不是装配之前，基板上的装置的位置被定义。

9. 发明授权

US06756296B2 Method for lithographic processing on molecular monolayer and multilayer thin films 失效
标题翻译：分子单层和多层薄膜的平版印刷加工方法
公开(公告)号：US06756296B2
公开(公告)日：2004-06-29
申请号：US10015063
申请日：2001-12-11
申请人： James R. Heath , Charles P. Collier , Yi Luo , Erica DeIonno , Patricia A. Beck
发明人： James R. Heath , Charles P. Collier , Yi Luo , Erica DeIonno , Patricia A. Beck
IPC分类号： H01L214763
CPC分类号： H01L27/285 , B82Y10/00 , H01L51/0052 , H01L51/0067 , H01L51/0591 , H01L51/0595 , Y10T428/12542 , Y10T428/24917 , Y10T428/31663
摘要： Methods for making electronic devices where a molecular monolayer or multilayer is sandwiched between top and bottom electrodes at electrode intersections. The molecular layer has an electrical characteristic such as bistable switching. A layer of electrically conductive material is used to protect the molecular layer during formation of the top electrode pattern. The electrically conductive material remains sandwiched between the top and bottom electrodes at the electrode intersections in the final electronic device.
摘要翻译：制造电子器件的方法，其中分子单层或多层被夹在电极交叉处的顶部和底部电极之间。分子层具有诸如双稳态切换的电特性。在形成顶部电极图案期间，使用一层导电材料来保护分子层。导电材料保持夹在最终电子设备中的电极交叉处的顶部和底部电极之间。

10. 发明授权

US06459095B1 Chemically synthesized and assembled electronics devices 失效
标题翻译：化学合成和组装的电子器件
公开(公告)号：US06459095B1
公开(公告)日：2002-10-01
申请号：US09282048
申请日：1999-03-29
申请人： James R. Heath , R. Stanley Williams , Philip J. Kuekes
发明人： James R. Heath , R. Stanley Williams , Philip J. Kuekes
IPC分类号： H01L2906
CPC分类号： H01L27/10 , B82B1/00 , B82Y10/00 , B82Y30/00 , G11C13/0009 , G11C13/0014 , G11C13/02 , G11C2213/72 , G11C2213/77 , G11C2213/81 , H01L51/0595 , Y10S977/704 , Y10S977/705 , Y10S977/936
摘要： A route to the fabrication of electronic devices is provided, in which the devices consist of two crossed wires sandwiching an electrically addressable molecular species. The approach is extremely simple and inexpensive to implement, and scales from wire dimensions of several micrometers down to nanometer-scale dimensions. The device of the present invention can be used to produce crossbar switch arrays, logic devices, memory devices, and communication and signal routing devices. The present invention enables construction of molecular electronic devices on a length scale than can range from micrometers to nanometers via a straightforward and inexpensive chemical assembly procedure. The device is either partially or completely chemically assembled, and the key to the scaling is that the location of the devices on the substrate are defined once the devices have been assembled, not prior to assembly.
摘要翻译：提供了制造电子器件的途径，其中器件由夹着电可寻址分子种类的两条交叉导线组成。该方法实现起来非常简单和便宜，并且从几微米的线尺寸缩小到纳米级尺寸。本发明的装置可用于产生交叉开关阵列，逻辑器件，存储器件以及通信和信号路由器件。本发明能够通过直接且廉价的化学组装程序在比例范围从微米到纳米的范围内构建分子电子器件。该装置部分或完全化学地组装，并且缩放的关键在于，一旦装置组装而不是装配之前，基板上的装置的位置被定义。

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