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    • 3. 发明授权
    • Azabicycloalkyl and azatricycloalkyl amides
    • 偶氮二环烷基和氮杂环烷基酰胺
    • US5198435A
    • 1993-03-30
    • US669543
    • 1991-03-14
    • Richard A. MuellerRichard A. PartisJames R. Deason
    • Richard A. MuellerRichard A. PartisJames R. Deason
    • C07D295/185C07D453/02
    • C07D295/185C07D453/02
    • The compounds of this invention are bicyclic, tricyclic, azabicyclic and azatricyclic amides represented by the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ##STR2## group wherein n, m and p are independently an integer of from 1 to 8 provided than n+m+p is equal to or less than 10; x is thio, sulfinyl or sulfonyl; Alk is straight or branched chain lower alkylene; R.sub.3 is selected from the group consisting of a bicycloalkylamino, tricycloalkylamino, azabicycloalkyl, azatricycloalkyl, azabicycloalkylamino, azatricycloalkylamino or dicycloalkylamino. The compounds are useful as anti-inflammatory and anti-allergy agents.
    • 本发明的化合物是由下式表示的双环,三环,氮杂双环和氮杂三环酰胺:其中:R 1和R 2是由卤素,苯基,取代的苯基和取代的苯基组成的组中相同或不同的成员 其中n,m和p独立地为n + m + p等于或小于10提供的1至8的整数; x是硫代,亚磺酰基或磺酰基; Alk是直链或支链低级亚烷基; R 3选自二环烷基氨基,三环烷基氨基,氮杂双环烷基,氮杂环烷基,氮杂双环烷基氨基,氮杂三环烷基氨基或二环烷基氨基。 该化合物可用作抗炎和抗过敏剂。