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1. 发明授权

US08255033B2 Oxygen enhancing membrane systems for implantable devices 有权
公开(公告)号：US08255033B2
公开(公告)日：2012-08-28
申请号：US11410392
申请日：2006-04-25
申请人： James Petisce , Mark A. Tapsak , Peter C. Simpson , Victoria Carr-Brendel , James H. Brauker
发明人： James Petisce , Mark A. Tapsak , Peter C. Simpson , Victoria Carr-Brendel , James H. Brauker
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/1473 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/14735 , A61B5/14865
摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.

2. 发明授权

US08255030B2 Oxygen enhancing membrane systems for implantable devices 有权
公开(公告)号：US08255030B2
公开(公告)日：2012-08-28
申请号：US11410555
申请日：2006-04-25
申请人： James Petisce , Mark A. Tapsak , Peter C. Simpson , Victoria Carr-Brendel , James H. Brauker
发明人： James Petisce , Mark A. Tapsak , Peter C. Simpson , Victoria Carr-Brendel , James H. Brauker
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/1473 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/14735 , A61B5/14865
摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.

3. 发明申请

US20100145172A1 OXYGEN ENHANCING MEMBRANE SYSTEMS FOR IMPLANTABLE DEVICES 有权
标题翻译：用于可植入设备的氧气增强膜系统
公开(公告)号：US20100145172A1
公开(公告)日：2010-06-10
申请号：US12688763
申请日：2010-01-15
申请人： James Petisce , Mark A. Tapsak , Peter C. Simpson , Victoria Carr-Brendel , James H. Brauker
发明人： James Petisce , Mark A. Tapsak , Peter C. Simpson , Victoria Carr-Brendel , James H. Brauker
IPC分类号： A61B5/1468
CPC分类号： A61B5/1473 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/14735 , A61B5/14865
摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
摘要翻译：本发明一般涉及用于增加可植入装置的氧气可用性的系统和方法。优选的实施方案提供了一种膜系统，其被配置为提供该装置与生物环境的保护和/或用于实现酶反应的催化剂，其中所述膜系统包括由高氧可溶性材料形成的聚合物。高氧可溶性聚合物材料与可植入装置上的氧气源相邻设置，以便在缺氧期间动态地保持氧利用源的高氧可利用性。优选实施方案的膜系统对于具有氧利用源的可植入装置和/或在低氧环境中起作用，例如基于酶的电化学传感器和细胞移植装置是有用的。

4. 发明授权

US07379765B2 Oxygen enhancing membrane systems for implantable devices 有权
标题翻译：用于可植入装置的氧增强膜系统
公开(公告)号：US07379765B2
公开(公告)日：2008-05-27
申请号：US10896639
申请日：2004-07-21
申请人： James Petisce , Mark A. Tapsak , Peter C. Simpson , Victoria Carr-Brendel , James H. Brauker
发明人： James Petisce , Mark A. Tapsak , Peter C. Simpson , Victoria Carr-Brendel , James H. Brauker
IPC分类号： A61B5/05 , A61B5/00 , C12M1/00 , C12N9/00 , C12N11/00 , G01N27/26 , G01N17/00 , C12Q1/00 , G01F1/64
CPC分类号： A61B5/1473 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/14735 , A61B5/14865
摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
摘要翻译：本发明一般涉及用于增加可植入装置的氧气可用性的系统和方法。优选的实施方案提供了一种膜系统，其被配置为提供该装置与生物环境的保护和/或用于实现酶反应的催化剂，其中所述膜系统包括由高氧可溶性材料形成的聚合物。高氧可溶性聚合物材料与可植入装置上的氧气源相邻设置，以便在缺氧期间动态地保持氧利用源的高氧可利用性。优选实施方案的膜系统对于具有氧利用源的可植入装置和/或在低氧环境中起作用，例如基于酶的电化学传感器和细胞移植装置是有用的。

5. 发明申请

US20110275919A1 OXYGEN ENHANCING MEMBRANE SYSTEMS FOR IMPLANTABLE DEVICES 有权
标题翻译：用于可植入设备的氧气增强膜系统
公开(公告)号：US20110275919A1
公开(公告)日：2011-11-10
申请号：US13187277
申请日：2011-07-20
申请人： James Petisce , Mark A. Tapsak , Peter C. Simpson , Victoria Carr-Brendel
发明人： James Petisce , Mark A. Tapsak , Peter C. Simpson , Victoria Carr-Brendel
IPC分类号： A61B5/1468
CPC分类号： A61B5/1473 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/14735 , A61B5/14865
摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
摘要翻译：本发明一般涉及用于增加可植入装置的氧气可用性的系统和方法。优选的实施方案提供了一种膜系统，其被配置为提供该装置与生物环境的保护和/或用于实现酶反应的催化剂，其中所述膜系统包括由高氧可溶性材料形成的聚合物。高氧可溶性聚合物材料与可植入装置上的氧气源相邻设置，以便在缺氧期间动态地保持氧利用源的高氧可利用性。优选实施方案的膜系统对于具有氧利用源的可植入装置和/或在低氧环境中起作用，例如基于酶的电化学传感器和细胞移植装置是有用的。

6. 发明申请

US20100041971A1 IMPLANTABLE ANALYTE SENSOR 审中-公开
标题翻译：可分析分析仪
公开(公告)号：US20100041971A1
公开(公告)日：2010-02-18
申请号：US12608872
申请日：2009-10-29
申请人： Paul V. Goode, JR. , Arnold L. Holmquist , Mark A. Tapsak , Mark Shults , Victoria Carr-Brendel , James H. Brauker , Paul V. Neale , Jason D. McClure , Mark Brister , Peter C. Simpson , Rathbun K. Rhodes
发明人： Paul V. Goode, JR. , Arnold L. Holmquist , Mark A. Tapsak , Mark Shults , Victoria Carr-Brendel , James H. Brauker , Paul V. Neale , Jason D. McClure , Mark Brister , Peter C. Simpson , Rathbun K. Rhodes
IPC分类号： A61B5/1468 , H01R43/00
CPC分类号： A61B5/0031 , A61B5/076 , A61B5/14532 , A61B5/14865 , A61B2560/04 , A61B2560/0462 , H04B1/03 , Y10T29/49117
摘要： An implantable analyte sensor including a sensing region for measuring the analyte and a non-sensing region for immobilizing the sensor body in the host. The sensor is implanted in a precisely dimensioned pocket to stabilize the analyte sensor in vivo and enable measurement of the concentration of the analyte in the host before and after formation of a foreign body capsule around the sensor. The sensor further provides a transmitter for RF transmission through the sensor body, electronic circuitry, and a power source optimized for long-term use in the miniaturized sensor body.
摘要翻译：包括用于测量分析物的感测区域和用于将传感器主体固定在主机中的非感测区域的可植入分析物传感器。将传感器植入精确尺寸的袋中以在体内稳定分析物传感器，并且能够在形成传感器周围的异物胶囊之前和之后测量主体中分析物的浓度。传感器还提供用于通过传感器主体，电子电路和为在小型化传感器主体中长期使用而优化的电源的RF传输的发射器。

7. 发明授权

US07108778B2 Electrochemical sensors including electrode systems with increased oxygen generation 有权
标题翻译：电化学传感器包括增加氧气产生的电极系统
公开(公告)号：US07108778B2
公开(公告)日：2006-09-19
申请号：US10897377
申请日：2004-07-21
申请人： Peter C. Simpson , Paul Goode , Mark A. Tapsak , Victoria Carr-Brendel
发明人： Peter C. Simpson , Paul Goode , Mark A. Tapsak , Victoria Carr-Brendel
IPC分类号： G01N27/327
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/14546 , C12Q1/003 , G01N27/3272
摘要： The present invention relates generally to systems and methods for increasing oxygen generation in electrochemical sensors in order to overcome the oxygen limitations. The preferred embodiments employ electrode systems with at least two electrodes in relatively close proximity to each other; wherein at least one electrode is configured to generate oxygen and at least one other electrode is configured to sense an analyte or a product of a reaction indicative of the concentration of analyte. The oxygen generated by the oxygen-generating electrode is available to the catalyst within a membrane system and/or the counter electrode, thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions.
摘要翻译：本发明一般涉及用于增加电化学传感器中的氧气产生的系统和方法，以克服氧限制。优选实施例采用电极系统，其中至少两个电极彼此相对靠近; 其中至少一个电极被配置为产生氧，并且至少一个其它电极被配置为感测分析物或指示分析物浓度的反应的产物。由氧发生电极产生的氧气可用于膜系统和/或对电极内的催化剂，从而使得优选实施方案的电化学传感器能够在缺血状态下起作用。

8. 发明授权

US07828728B2 Analyte sensor 有权
标题翻译：分析物传感器
公开(公告)号：US07828728B2
公开(公告)日：2010-11-09
申请号：US11675063
申请日：2007-02-14
申请人： Robert Boock , Monica Rixman , James H. Brauker , James R. Petisce , Peter C. Simpson , Mark Brister , Mark A. Tapsak , Victoria Carr-Brendel
发明人： Robert Boock , Monica Rixman , James H. Brauker , James R. Petisce , Peter C. Simpson , Mark Brister , Mark A. Tapsak , Victoria Carr-Brendel
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/14532 , A61B5/418 , B33Y70/00
摘要： The present invention relates generally to membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel silicone-hydrophilic polymer blend membranes, and to devices and implantable devices including these membranes.
摘要翻译：本发明一般涉及与可植入装置一起使用的膜，例如用于检测生物样品中分析物浓度的装置。更具体地说，本发明涉及新的有机硅 - 亲水性聚合物共混膜，以及包括这些膜的装置和可植入装置。

9. 发明申请

US20110313543A1 POROUS MEMBRANES FOR USE WITH IMPLANTABLE DEVICES 审中-公开
标题翻译：多孔膜与可植入的器件一起使用
公开(公告)号：US20110313543A1
公开(公告)日：2011-12-22
申请号：US13210338
申请日：2011-08-15
申请人： James H. Brauker , Victoria Carr-Brendel , Mark A. Tapsak
发明人： James H. Brauker , Victoria Carr-Brendel , Mark A. Tapsak
IPC分类号： A61F2/02 , A61B5/00
CPC分类号： A61L31/146 , A61L31/10 , A61L31/14
摘要： A membrane for implantation in soft tissue comprising a first domain that supports tissue ingrowth, disrupts contractile forces typically found in a foreign body response, encourages vascularity, and interferes with barrier cell layer formation, and a second domain that is resistant to cellular attachment, is impermeable to cells and cell processes, and allows the passage of analytes. The membrane allows for long-term analyte transport in vivo and is suitable for use as a biointerface for implantable analyte sensors, cell transplantation devices, drug delivery devices, and/or electrical signal delivering or measuring devices. The membrane architecture, including cavity size, depth, and interconnectivity, provide long-term robust functionality of the membrane in vivo.
摘要翻译：用于植入软组织中的膜包括支撑组织向内生长的第一结构域，破坏通常在异物反应中发现的收缩力，促进血管分布，并妨碍阻隔细胞层的形成，以及抵抗细胞附着的第二结构域是对细胞和细胞过程不可渗透，并允许分析物通过。该膜允许体内长期的分析物输送，并且适用于可植入分析物传感器，细胞移植装置，药物递送装置和/或电信号传递或测量装置的生物界面。膜结构，包括腔体尺寸，深度和互连性，在体内提供膜的长期稳定的功能。

10. 发明授权

US07881763B2 Optimized sensor geometry for an implantable glucose sensor 有权
标题翻译：优化的植入式葡萄糖传感器的传感器几何
公开(公告)号：US07881763B2
公开(公告)日：2011-02-01
申请号：US11415631
申请日：2006-05-02
申请人： James H. Brauker , Victoria Carr-Brendel , Paul V. Neale , Laura A. Martinson , Mark A. Tapsak
发明人： James H. Brauker , Victoria Carr-Brendel , Paul V. Neale , Laura A. Martinson , Mark A. Tapsak
IPC分类号： A61B5/1473
CPC分类号： A61B5/6882 , A61B5/0031 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/415 , A61B5/418 , A61B2562/187
摘要： An implantable sensor for use in measuring a concentration of an analyte such as glucose in a bodily fluid, including a body with a sensing region adapted for transport of analytes between the sensor and the bodily fluid, wherein the sensing region is located on a curved portion of the body such that when a foreign body capsule forms around the sensor, a contractile force is exerted by the foreign body capsule toward the sensing region. The body is partially or entirely curved, partially or entirely covered with an anchoring material for supporting tissue ingrowth, and designed for subcutaneous tissue implantation. The geometric design, including curvature, shape, and other factors minimize chronic inflammatory response at the sensing region and contribute to improved performance of the sensor in vivo.
摘要翻译：一种用于测量体液中诸如葡萄糖的分析物的浓度的植入式传感器，其包括具有适于在所述传感器和所述体液之间输送分析物的感测区域的身体，其中所述感测区域位于弯曲部分上使得当异物体胶囊围绕传感器形成时，异物胶囊朝向感测区域施加收缩力。身体部分或完全弯曲，部分或完全覆盖有用于支撑组织向内生长的锚固材料，并被设计用于皮下组织植入。几何设计，包括曲率，形状和其他因素最大限度地减少传感区域的慢性炎症反应，并有助于改善体内传感器的性能。

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