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1. 发明申请

US20060099326A1 Method for attachment of biomolecules to medical device surfaces 审中-公开
公开(公告)号：US20060099326A1
公开(公告)日：2006-05-11
申请号：US11296810
申请日：2005-12-07
申请人： James Keogh , Paul Trescony
发明人： James Keogh , Paul Trescony
IPC分类号： A61K6/083 , B05D3/00
CPC分类号： A61L27/28 , A61L27/22 , A61L27/24 , A61L27/34 , A61L27/3625 , A61L27/3641 , A61L27/3645 , A61L27/54 , A61L29/085 , A61L31/08 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L33/0029 , A61L33/0047 , A61L33/0082 , A61L33/12 , A61L33/128 , A61L33/18 , A61L2300/606 , C08L89/00 , C12N11/02 , C12N11/14 , Y10S530/81 , Y10S530/811 , Y10S530/815 , Y10S530/816
摘要： A method for making a medical device having at least one biomolecule immobilized on a substrate surface is provided. One method of the present invention includes immobilizing a biomolecule comprising an unsubstituted amide moiety on a biomaterial surface. Another method of the present invention includes immobilizing a biomolecule on a biomaterial surface comprising an unsubstituted amide moiety. Still another method of the present invention may be employed to crosslink biomolecules comprising unsubstituted amide moieties immobilized on medical device surfaces. Additionally, one method of the present invention may be employed to crosslink biomolecules comprising unsubstituted amide moieties in solution, thereby forming a crosslinked biomaterial or a crosslinked medical device coating.

2. 发明申请

US20070048352A1 Method for attachment of biomolecules to medical device surfaces 审中-公开
标题翻译：将生物分子附着到医疗器械表面的方法
公开(公告)号：US20070048352A1
公开(公告)日：2007-03-01
申请号：US11507172
申请日：2006-08-21
申请人： James Keogh , Paul Trescony
发明人： James Keogh , Paul Trescony
IPC分类号： B05D3/00
CPC分类号： A61L27/28 , A61L27/22 , A61L27/24 , A61L27/34 , A61L27/3625 , A61L27/3641 , A61L27/3645 , A61L27/54 , A61L29/085 , A61L31/08 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L33/0029 , A61L33/0047 , A61L33/0082 , A61L33/12 , A61L33/128 , A61L33/18 , A61L2300/606 , C08L89/00 , C12N11/02 , C12N11/14 , Y10S530/81 , Y10S530/811 , Y10S530/815 , Y10S530/816
摘要： A method for making a medical device having at least one biomolecule immobilized on a substrate surface is provided. One method of the present invention includes immobilizing a biomolecule comprising an unsubstituted amide moiety on a biomaterial surface. Another method of the present invention includes immobilizing a biomolecule on a biomaterial surface comprising an unsubstituted amide moiety. Still another method of the present invention may be employed to crosslink biomolecules comprising unsubstituted amide moieties immobilized on medical device surfaces. Additionally, one method of the present invention may be employed to crosslink biomolecules comprising unsubstituted amide moieties in solution, thereby forming a crosslinked biomaterial or a crosslinked medical device coating.
摘要翻译：提供一种制造具有固定在基材表面上的至少一种生物分子的医疗装置的方法。本发明的一种方法包括将包含未取代的酰胺部分的生物分子固定在生物材料表面上。本发明的另一种方法包括将生物分子固定在包含未取代的酰胺部分的生物材料表面上。可以使用本发明的另一种方法来交联包含固定在医疗器械表面上的未取代酰胺部分的生物分子。此外，本发明的一种方法可用于交联包含未溶解的酰胺部分的生物分子，由此形成交联的生物材料或交联的医疗器械涂层。

3. 发明申请

US20060193968A1 Method for attachment of biomolecules to medical device surfaces 审中-公开
标题翻译：将生物分子附着到医疗器械表面的方法
公开(公告)号：US20060193968A1
公开(公告)日：2006-08-31
申请号：US11411711
申请日：2006-04-26
申请人： James Keogh , Paul Trescony
发明人： James Keogh , Paul Trescony
IPC分类号： B05D3/02
CPC分类号： A61L27/28 , A61L27/22 , A61L27/24 , A61L27/34 , A61L27/3625 , A61L27/3641 , A61L27/3645 , A61L27/54 , A61L29/085 , A61L31/08 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L33/0029 , A61L33/0047 , A61L33/0082 , A61L33/12 , A61L33/128 , A61L33/18 , A61L2300/606 , C08L89/00 , C12N11/02 , C12N11/14 , Y10S530/81 , Y10S530/811 , Y10S530/815 , Y10S530/816
摘要： A method for making a medical device having at least one biomolecule immobilized on a substrate surface is provided. One method of the present invention includes immobilizing a biomolecule comprising an unsubstituted amide moiety on a biomaterial surface. Another method of the present invention includes immobilizing a biomolecule on a biomaterial surface comprising an unsubstituted amide moiety. Still another method of the present invention may be employed to crosslink biomolecules comprising unsubstituted amide moieties immobilized on medical device surfaces. Additionally, one method of the present invention may be employed to crosslink biomolecules comprising unsubstituted amide moieties in solution, thereby forming a crosslinked biomaterial or a crosslinked medical device coating.
摘要翻译：提供一种制造具有固定在基材表面上的至少一种生物分子的医疗装置的方法。本发明的一种方法包括将包含未取代的酰胺部分的生物分子固定在生物材料表面上。本发明的另一种方法包括将生物分子固定在包含未取代的酰胺部分的生物材料表面上。可以使用本发明的另一种方法来交联包含固定在医疗器械表面上的未取代酰胺部分的生物分子。此外，本发明的一种方法可用于交联包含未溶解的酰胺部分的生物分子，由此形成交联的生物材料或交联的医疗器械涂层。

4. 发明申请

US20120277748A1 BONE PLATE 审中-公开
标题翻译：骨板
公开(公告)号：US20120277748A1
公开(公告)日：2012-11-01
申请号：US13096451
申请日：2011-04-28
申请人： Paul Trescony , Jeffrey Rouleau , Matthew Jolly
发明人： Paul Trescony , Jeffrey Rouleau , Matthew Jolly
IPC分类号： A61B17/80
CPC分类号： A61B17/7059 , A61B17/80
摘要： A plate for connecting a first portion of bone and a second portion of bone is disclosed. The plate comprises a central longitudinal axis, a first end portion extending along the central longitudinal axis and configured to affix to the first portion of bone, a second end portion extending along the central longitudinal axis and configured to affix to the second portion of bone, and an intermediary portion extending along the central longitudinal axis and between the first end portion and the second end portion. The intermediary portion comprises three continuous segments of material, two segments of which extend along a direction substantially parallel to the central longitudinal axis, and one segment of which extends along a direction substantially perpendicular to the central longitudinal axis.
摘要翻译：公开了一种用于连接骨骼的第一部分和骨骼的第二部分的板。板包括中心纵向轴线，第一端部部分沿着中心纵向轴线延伸并且构造成固定到骨头的第一部分;第二端部部分，沿着中心纵向轴线延伸并且构造成固定到骨骼的第二部分，以及沿着中心纵向轴线并且在第一端部和第二端部之间延伸的中间部分。中间部分包括三个连续的材料部分，其两个部分沿着基本上平行于中心纵向轴线的方向延伸，并且其一个部分沿着基本上垂直于中心纵向轴线的方向延伸。

5. 发明申请

US20080103352A1 Implantable Medical Devices Having Recesses 审中-公开
标题翻译：具有凹槽的植入式医疗器械
公开(公告)号：US20080103352A1
公开(公告)日：2008-05-01
申请号：US11971534
申请日：2008-01-09
申请人： Nicolas Rivron , Paul Trescony , Michael Wolf
发明人： Nicolas Rivron , Paul Trescony , Michael Wolf
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/06 , A61F2310/00389
摘要： In general, the invention is directed to devices and methods that are useful for surface preparation of implantable medical devices. In the case of a vascular graft, the invention presents devices and methods that enhance endothelial cell seeding by providing recesses in the luminal surface that can receive endothelial cells. When the device is constructed of a material such as expanded polytetrafluoroethylene (ePTFE), the recesses may be created by physical processing of the microstructures of the material. The physical processing lifts nodes from the surface, forming recesses that can receive endothelial cells.
摘要翻译：通常，本发明涉及可用于可植入医疗装置的表面制备的装置和方法。在血管移植物的情况下，本发明提供了通过在可以接受内皮细胞的腔表面中提供凹陷来增强内皮细胞接种的装置和方法。当装置由诸如膨胀聚四氟乙烯（ePTFE）的材料构成时，可以通过材料的微观结构的物理加工来产生凹陷。物理加工从表面提升节点，形成可以接收内皮细胞的凹槽。

6. 发明申请

US20070020248A1 Process for biological tissue 有权
标题翻译：生物组织过程
公开(公告)号：US20070020248A1
公开(公告)日：2007-01-25
申请号：US11365401
申请日：2006-03-01
申请人： Frank Everaerts , Mark Torrianni , Frans Everaerts , Paul Trescony , Wilfred Hartog
发明人： Frank Everaerts , Mark Torrianni , Frans Everaerts , Paul Trescony , Wilfred Hartog
IPC分类号： A61K48/00 , C12N15/87
CPC分类号： A61K35/34 , A61L27/3604 , A61L27/3625 , A61L27/3683
摘要： The present invention provides an electrophoretic system, apparatus, and method of use thereof for the preparation of a tissue-derived bioprosthesis.
摘要翻译：本发明提供了一种用于制备组织衍生生物假体的电泳系统，装置及其使用方法。

7. 发明申请

US20060199265A1 Seeding implantable medical devices with cells 审中-公开
标题翻译：种植植入式医疗器械与细胞
公开(公告)号：US20060199265A1
公开(公告)日：2006-09-07
申请号：US11071597
申请日：2005-03-02
申请人： Michael Wolf , Laurie Yunker , Paul Trescony
发明人： Michael Wolf , Laurie Yunker , Paul Trescony
IPC分类号： C12N5/00 , C12N5/02
CPC分类号： A61L27/3808 , A61F2/062 , A61L27/16 , A61L27/507 , Y10S623/915 , Y10S623/916 , C08L27/18
摘要： The invention is directed to apparatus and methods for seeding an implantable medical device, such as a vascular prosthesis, with cells, such as endothelial cells. The invention supports techniques for seeding a luminal surface of the device with axial centrifugation. Cells are introduced in suspension into the lumen of the device, and the device is subjected to centrifugation around a longitudinal axis defined by the lumen. Axial centrifugation causes the cells to concentrate toward the luminal surface. Shortly after axial centrifugation, the seeded device can be presented for implantation in a patient.
摘要翻译：本发明涉及用于将可植入医疗装置（例如血管假体）与细胞如内皮细胞接种的装置和方法。本发明支持用轴向离心法将装置的腔表面接种的技术。将细胞以悬浮液的形式引入装置的内腔，并且将该装置围绕由内腔限定的纵向轴线进行离心。轴向离心导致细胞集中到腔表面。在轴向离心后不久，可以将接种的装置用于植入患者体内。

8. 发明授权

US5102402A Releasable coatings on balloon catheters 失效
标题翻译：球囊导管上的可释放涂层
公开(公告)号：US5102402A
公开(公告)日：1992-04-07
申请号：US637436
申请日：1991-01-04
申请人： Michael Dror , Paul Trescony
发明人： Michael Dror , Paul Trescony
IPC分类号： A61M25/00 , A61F2/00 , A61F2/06 , A61F2/84 , A61M25/10 , A61M29/02 , A61M37/00
CPC分类号： A61M25/104 , A61F2/958 , A61L29/16 , A61F2250/0067 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/622 , A61M2025/105 , A61M2025/1081 , A61M2025/1086 , A61M25/1002
摘要： Balloon catheters are prepared to include a coating of body affecting chemicals on the exterior of the balloon. The coating releases from the balloon when the balloon is inflated into contact with the lumen to be treated. The device provides accurate placement of the dosage required at the location in need of treatment. The coating preferably includes drugs in microcapsules or microspheres. The catheters are especially useful in balloon angioplasty procedures.
摘要翻译：气球导管准备包括在气球的外部影响化学物质的身体涂层。当气球膨胀与待处理的内腔接触时，涂层从球囊释放。该装置提供了在需要治疗的位置所需的剂量的准确放置。涂层优选包括微胶囊或微球体中的药物。导管在球囊血管成形术程序中特别有用。

9. 发明申请

US20070059335A1 Seeding implantable medical devices with cells 失效
标题翻译：种植植入式医疗器械与细胞
公开(公告)号：US20070059335A1
公开(公告)日：2007-03-15
申请号：US11515344
申请日：2006-09-01
申请人： Michael Wolf , Laurie Yunker , Paul Trescony
发明人： Michael Wolf , Laurie Yunker , Paul Trescony
IPC分类号： A61F2/02 , C12N5/08
CPC分类号： A61F2/062 , A61L27/16 , A61L27/3616 , A61L27/38 , A61L27/3808 , A61L27/507 , Y10S623/915 , Y10S623/916 , C08L27/18
摘要： Apparatus and methods for seeding an implantable medical device, such as a vascular prosthesis, with cells, such as endothelial cells, are described. The invention supports techniques for seeding a luminal surface of the device with axial centrifugation. Cells are introduced in suspension into the lumen of the device. The introduction of the cells may occur after a blood centrifugation product, such as platelet-poor plasma, is applied to the luminal surface. After the cells are introduced, the device is then subjected to centrifugation around a longitudinal axis defined by the lumen. Axial centrifugation causes the cells to concentrate toward and adhere to the luminal surface. Shortly after axial centrifugation, the seeded device can be presented for implantation in a patient. The implantable medical device may be inserted into a protective sleeve prior to seeding the device with cells, and the sleeve may or may not be removed prior to implantation.
摘要翻译：描述了可植入医疗装置（例如血管假体）与细胞例如内皮细胞接种的装置和方法。本发明支持用轴向离心法将装置的腔表面接种的技术。将细胞悬浮液引入装置的内腔。在血液离心产物（如贫血小板血浆）应用于管腔表面后，细胞的引入可能发生。导入细胞后，将该装置围绕由内腔限定的纵向轴进行离心。轴向离心导致细胞浓缩并附着在管腔表面。在轴向离心后不久，可以将接种的装置用于植入患者体内。可植入的医疗装置可以在将装置与细胞接种之前插入保护套管中，并且在植入之前套筒可以被移除也可以不被移除。

10. 发明申请

US20060210596A1 Seeding implantable medical devices with cells 失效
标题翻译：种植植入式医疗器械与细胞
公开(公告)号：US20060210596A1
公开(公告)日：2006-09-21
申请号：US11367006
申请日：2006-03-02
申请人： Michael Wolf , Laurie Yunker , Paul Trescony
发明人： Michael Wolf , Laurie Yunker , Paul Trescony
IPC分类号： C12N5/08 , C12M3/00 , A61F13/02
CPC分类号： A61L27/3808 , A61F2/062 , A61L27/16 , A61L27/507 , Y10S623/915 , Y10S623/916 , C08L27/18
摘要： Apparatus and methods for seeding an implantable medical device, such as a vascular prosthesis, with cells, such as endothelial cells, are described. The invention supports techniques for seeding a luminal surface of the device with axial centrifugation. Cells are introduced in suspension into the lumen of the device. The introduction of the cells may occur after a blood centrifugation product, such as platelet-poor plasma, is applied to the luminal surface. After the cells are introduced, the device is then subjected to centrifugation around a longitudinal axis defined by the lumen. Axial centrifugation causes the cells to concentrate toward and adhere to the luminal surface. Shortly after axial centrifugation, the seeded device can be presented for implantation in a patient. The implantable medical device may be inserted into a protective sleeve prior to seeding the device with cells, and the sleeve may or may not be removed prior to implantation.
摘要翻译：描述了可植入医疗装置（例如血管假体）与细胞例如内皮细胞接种的装置和方法。本发明支持用轴向离心法将装置的腔表面接种的技术。将细胞悬浮液引入装置的内腔。在血液离心产物（如贫血小板血浆）应用于管腔表面后，细胞的引入可能发生。导入细胞后，将该装置围绕由内腔限定的纵向轴进行离心。轴向离心导致细胞浓缩并附着在管腔表面。在轴向离心后不久，可以将接种的装置用于植入患者体内。可植入的医疗装置可以在将装置与细胞接种之前插入保护套管中，并且在植入之前套筒可以被移除也可以不被移除。

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