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1. 发明申请

US20140046173A1 ULTRASOUND VIBROMETRY WITH UNFOCUSED ULTRASOUND 审中-公开
标题翻译：超声波超声波超声波检测
公开(公告)号：US20140046173A1
公开(公告)日：2014-02-13
申请号：US14001604
申请日：2012-02-27
申请人： James F. Greenleaf , Shigao Chen , Armando Manduca , Pengfei Song
发明人： James F. Greenleaf , Shigao Chen , Armando Manduca , Pengfei Song
IPC分类号： A61B8/08 , A61B5/00 , A61B8/00 , G01R33/48
CPC分类号： A61B8/485 , A61B5/0059 , A61B8/461 , A61B8/5223 , G01N21/17 , G01N29/075 , G01N29/221 , G01N29/2456 , G01N2291/02475 , G01N2291/02827 , G01N2291/0422 , G01R33/4814 , G01S7/52042 , G01S15/8927
摘要： Methods for measuring mechanical properties of an object or subject under examination with an ultrasound system and using unfocused ultrasound energy are provided. Shear waves that propagate in the object or subject are produced by applying unfocused ultrasound energy to the object or subject, and measurement data is acquired by applying focused or unfocused ultrasound energy to at least one location in the object or subject at which shear waves are present Mechanical properties are then calculated from the acquired measurement data.
摘要翻译：提供了使用超声系统测量被检查物体或受试者的机械性能并使用未聚焦的超声能量的方法。通过对物体或被摄体施加未聚焦的超声能量来产生在物体或被摄体中传播的剪切波，并且通过将聚焦或未聚焦的超声能量应用于存在剪切波的物体或对象中的至少一个位置来获取测量数据然后从获取的测量数据计算机械性能。

2. 发明授权

US11172910B2 Ultrasound vibrometry with unfocused ultrasound 有权
公开(公告)号：US11172910B2
公开(公告)日：2021-11-16
申请号：US14001604
申请日：2012-02-27
申请人： James F. Greenleaf , Shigao Chen , Armando Manduca , Pengfei Song
发明人： James F. Greenleaf , Shigao Chen , Armando Manduca , Pengfei Song
IPC分类号： A61B8/08 , G01N29/07 , G01N21/17 , G01N29/24 , G01N29/22 , G01S7/52 , A61B5/00 , G01R33/48 , G01S15/89 , A61B8/00
摘要： Methods for measuring mechanical properties of an object or subject under examination with an ultrasound system and using unfocused ultrasound energy are provided. Shear waves that propagate in the object or subject are produced by applying unfocused ultrasound energy to the object or subject, and measurement data is acquired by applying focused or unfocused ultrasound energy to at least one location in the object or subject at which shear waves are present Mechanical properties are then calculated from the acquired measurement data.

3. 发明授权

US09883851B2 System and method for shear wave generation with steered ultrasound push beams 有权
公开(公告)号：US09883851B2
公开(公告)日：2018-02-06
申请号：US14663866
申请日：2015-03-20
申请人： Matthew W. Urban , Alireza Nabavizadehrafsanjani , Pengfei Song , Shigao Chen , James F. Greenleaf
发明人： Matthew W. Urban , Alireza Nabavizadehrafsanjani , Pengfei Song , Shigao Chen , James F. Greenleaf
IPC分类号： A61B8/00 , A61B8/08 , G01S7/52 , G01S15/89
CPC分类号： A61B8/485 , A61B8/4494 , A61B8/54 , G01S7/52022 , G01S7/52042 , G01S15/8915 , G01S15/8927
摘要： A system and method for performing a steered push beam (SPB) technique to create multiple foci generated by the interference of different ultrasound push beams to create shear waves and, based thereon, generate a report indicating mechanical properties about an object.

4. 发明授权

US10624609B2 System and method for shear wave elastography by transmitting ultrasound with subgroups of ultrasound transducer elements 有权
公开(公告)号：US10624609B2
公开(公告)日：2020-04-21
申请号：US14397395
申请日：2013-10-07
申请人： James F. Greenleaf , Shigao Chen , Pengfei Song , Heng Zhao
发明人： James F. Greenleaf , Shigao Chen , Pengfei Song , Heng Zhao
IPC分类号： A61B8/08 , A61B8/00 , G01S7/52 , G01N29/07 , G01N29/26 , G01S15/89
CPC分类号： A61B8/485 , A61B8/08 , A61B8/4488 , A61B8/4494 , A61B8/5223 , G01N29/07 , G01N29/262 , G01S7/5209 , G01S7/52022 , G01S7/52042 , G01S15/8915 , G01S15/8927 , G01N2291/011 , G01N2291/02475 , G01N2291/02827 , G01N2291/0422
摘要： Systems and methods for performing shear wave elastography using push and/or detection ultrasound beams that are generated by subsets of the available number of transducer elements in an ultrasound transducer. These techniques provide several advantages over currently available approaches to shear wave elastography, including the ability to use a standard, low frame rate ultrasound imaging system and the ability to measure shear wave speed throughout the entire field-of-view rather than only those regions where the push beams are not generated.

5. 发明申请

US20150265249A1 SYSTEM AND METHOD FOR SHEAR WAVE GENERATION WITH STEERED ULTRASOUND PUSH BEAMS 有权
标题翻译：具有可变超声波推力的剪切波生成系统和方法
公开(公告)号：US20150265249A1
公开(公告)日：2015-09-24
申请号：US14663866
申请日：2015-03-20
申请人： Matthew W. Urban , Alireza Nabavizadehrafsanjani , Pengfei Song , Shigao Chen , James F. Greenleaf
发明人： Matthew W. Urban , Alireza Nabavizadehrafsanjani , Pengfei Song , Shigao Chen , James F. Greenleaf
IPC分类号： A61B8/08 , A61B8/00
CPC分类号： A61B8/485 , A61B8/4494 , A61B8/54 , G01S7/52022 , G01S7/52042 , G01S15/8915 , G01S15/8927
摘要： A system and method for performing a steered push beam (SPB) technique to create multiple foci generated by the interference of different ultrasound push beams to create shear waves and, based thereon, generate a report indicating mechanical properties about an object.
摘要翻译：一种用于执行转向推波束（SPB）技术的系统和方法，用于产生由不同的超声推波束的干涉产生的多个焦点以产生剪切波，并且基于此产生指示关于物体的机械特性的报告。

6. 发明授权

US10357226B2 System and method for model-independent quantification of tissue viscoelastic properties using ultrasound 有权
公开(公告)号：US10357226B2
公开(公告)日：2019-07-23
申请号：US13795199
申请日：2013-03-12
申请人： Carolina Amador Carrascal , Matthew W. Urban , Shigao Chen , James F. Greenleaf
发明人： Carolina Amador Carrascal , Matthew W. Urban , Shigao Chen , James F. Greenleaf
IPC分类号： A61B8/00 , A61B8/08 , G01S7/52
摘要： A model-independent method for producing a viscoelastic tissue property metric using ultrasound is provided. A mechanical stress, such as an acoustic force, is applied to a tissue using an ultrasound system and tissue displacement resulting from the applied acoustic force is measured. From the tissue displacement measurements, a complex modulus, such as a relative complex modulus, is extracted. A loss tangent is calculated from the extracted complex modulus. Using the calculated loss tangent, viscoelastic tissue property metrics may be calculated.

7. 发明申请

US20110263978A1 Method for Shear Wave Ultrasound Vibrometry with Interleaved Push and Detection Pulses 有权
标题翻译：具有交错推送和检测脉冲的剪切波超声波振动测量方法
公开(公告)号：US20110263978A1
公开(公告)日：2011-10-27
申请号：US13092574
申请日：2011-04-22
申请人： Shigao Chen , James F. Greenleaf
发明人： Shigao Chen , James F. Greenleaf
IPC分类号： A61B8/00
CPC分类号： A61B8/48 , A61B8/485 , G01S7/52022 , G01S7/52042
摘要： A shear wave dispersion ultrasound vibrometry (“SDUV”) method for measuring a mechanical property of a subject is provided. Particularly, a set of ultrasonic vibration tone bursts is applied to a vibration origin in the subject so that harmonic vibratory motion is imparted to a tissue of interest. The set of vibration tone bursts effectively act like a single vibration pulse that imparts vibratory motion at larger amplitudes than achievable with a single pulse. Multiple ultrasonic detection pulses are then applied to two or more locations in the tissue of interest in order to measure shear waves propagating outward from the vibration origin. From these measurements, phase or amplitude information related to the shear wave propagation is determined and used to calculate a shear wave speed. Using the shear wave speed information, mechanical properties of the tissue are calculated.
摘要翻译：提供了用于测量受试者的机械性质的剪切波分散超声波振动测定（“SDUV”）方法。特别地，将一组超声波振动音脉冲施加到被摄体中的振动起点，使得谐波振动运动被赋予感兴趣的组织。这组振动音脉冲有效地像单一的振动脉冲一样，其振幅运动的幅度大于单脉冲可实现的振幅。然后将多个超声波检测脉冲施加到感兴趣的组织中的两个或更多个位置，以便测量从振动源向外传播的剪切波。从这些测量中，确定与剪切波传播相关的相位或振幅信息，并用于计算剪切波速度。使用剪切波速度信息，计算组织的机械性能。

8. 发明授权

US08659975B2 Vibration generation and detection in shear wave dispersion ultrasound vibrometry with large background motions 有权
标题翻译：具有大背景运动的剪切波分散超声波振动的振动产生和检测
公开(公告)号：US08659975B2
公开(公告)日：2014-02-25
申请号：US12992228
申请日：2009-05-15
申请人： James F. Greenleaf , Shigao Chen , Yi Zheng , Aiping Yao
发明人： James F. Greenleaf , Shigao Chen , Yi Zheng , Aiping Yao
IPC分类号： G01S15/00
CPC分类号： A61B8/485 , G01S7/52038
摘要： A method for measuring a mechanical property of a subject includes using an ultrasonic transducer to apply ultrasonic vibration pulses to a vibration origin in the subject in an on-off time sequence in order to impart a harmonic motion at a prescribed frequency to the subject, and when the vibration pulses are off, preferably using the same transducer to apply ultrasonic detection pulses to a motion detection point and to receive echo signals therefrom in order to sense the harmonic motion on the subject at the motion detection point The ultrasonic detection pulses are interspersed with the vibration pulses and can be applied in a non-uniform manner From the received ultrasonic echo signals, a harmonic signal is detected and a characteristic such as amplitude or phase of the detected harmonic signal is calculated using a Kalman filter or interpolation.
摘要翻译：用于测量受试者的机械性质的方法包括使用超声波换能器以开关时间顺序将超声波振动脉冲施加到被检体中的振动起点，以向受检者施加规定频率的谐波运动，以及当振动脉冲关闭时，优选地使用相同的换能器将超声波检测脉冲施加到运动检测点并从其接收回波信号，以便感测在运动检测点处的对象上的谐波运动。超声波检测脉冲分布在可以以不均匀的方式施加振动脉冲从接收到的超声波回波信号中，检测出谐波信号，并且使用卡尔曼滤波器或内插来计算检测到的谐波信号的振幅或相位的特性。

9. 发明授权

US07713201B2 Method and apparatus for shear property characterization from resonance induced by oscillatory radiation force 有权
标题翻译：由振荡辐射力引起的谐振的剪切特性表征的方法和装置
公开(公告)号：US07713201B2
公开(公告)日：2010-05-11
申请号：US10821461
申请日：2004-04-09
申请人： Shigao Chen , James F. Greenleaf , Mostafa Fatemi
发明人： Shigao Chen , James F. Greenleaf , Mostafa Fatemi
IPC分类号： A61B8/00
CPC分类号： G01N29/46 , A61B8/08 , A61B8/0858 , G01N29/07 , G01N29/12 , G01N2291/02475
摘要： A method for determining a shear elasticity and shear viscosity of a material based on resonance characteristics. A focused ultrasound wave is directed at the material to induce oscillations in the material, and a velocity of the material is measured. A spectrum of frequency of oscillation versus velocity is developed, and the resonance characteristics exhibited by the spectrum are used to estimate the shear elasticity and viscosity of the material.
摘要翻译：基于共振特性确定材料的剪切弹性和剪切粘度的方法。聚焦的超声波被引导到材料上以诱导材料中的振荡，并且测量材料的速度。开发了振荡频率与频率的频谱，谱图所示的共振特性用于估计材料的剪切弹性和粘度。

10. 发明授权

US09986973B2 Method for shear wave ultrasound vibrometry with interleaved push and detection pulses 有权
公开(公告)号：US09986973B2
公开(公告)日：2018-06-05
申请号：US13092574
申请日：2011-04-22
申请人： Shigao Chen , James F. Greenleaf
发明人： Shigao Chen , James F. Greenleaf
IPC分类号： A61B8/00 , A61B8/08 , G01S7/52
CPC分类号： A61B8/48 , A61B8/485 , G01S7/52022 , G01S7/52042
摘要： A shear wave dispersion ultrasound vibrometry (“SDUV”) method for measuring a mechanical property of a subject is provided. Particularly, a set of ultrasonic vibration tone bursts is applied to a vibration origin in the subject so that harmonic vibratory motion is imparted to a tissue of interest. The set of vibration tone bursts effectively act like a single vibration pulse that imparts vibratory motion at larger amplitudes than achievable with a single pulse. Multiple ultrasonic detection pulses are then applied to two or more locations in the tissue of interest in order to measure shear waves propagating outward from the vibration origin. From these measurements, phase or amplitude information related to the shear wave propagation is determined and used to calculate a shear wave speed. Using the shear wave speed information, mechanical properties of the tissue are calculated.

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