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1. 发明授权

US10357226B2 System and method for model-independent quantification of tissue viscoelastic properties using ultrasound 有权
公开(公告)号：US10357226B2
公开(公告)日：2019-07-23
申请号：US13795199
申请日：2013-03-12
申请人： Carolina Amador Carrascal , Matthew W. Urban , Shigao Chen , James F. Greenleaf
发明人： Carolina Amador Carrascal , Matthew W. Urban , Shigao Chen , James F. Greenleaf
IPC分类号： A61B8/00 , A61B8/08 , G01S7/52
摘要： A model-independent method for producing a viscoelastic tissue property metric using ultrasound is provided. A mechanical stress, such as an acoustic force, is applied to a tissue using an ultrasound system and tissue displacement resulting from the applied acoustic force is measured. From the tissue displacement measurements, a complex modulus, such as a relative complex modulus, is extracted. A loss tangent is calculated from the extracted complex modulus. Using the calculated loss tangent, viscoelastic tissue property metrics may be calculated.

2. 发明授权

US08602994B2 Method for ultrasound vibrometry using orthogonal basis functions 有权
标题翻译：使用正交基函数的超声波振幅测量方法
公开(公告)号：US08602994B2
公开(公告)日：2013-12-10
申请号：US13254227
申请日：2010-03-09
申请人： Yi Zheng , Aiping Yao , James F. Greenleaf , Shigao Chen , Matthew W. Urban
发明人： Yi Zheng , Aiping Yao , James F. Greenleaf , Shigao Chen , Matthew W. Urban
IPC分类号： A61B8/00 , G01H1/00
CPC分类号： G01S7/52036 , A61B8/485 , G01S7/52022 , G01S15/8952
摘要： A method for measuring a mechanical property of a subject includes using an ultrasound transducer to apply ultrasonic vibration pulses to a location in a subject in order to induce shear waves at multiple prescribed orthogonal frequencies in the subject. The ultrasound transducer is directed by an excitation signal that is composed of multiple orthogonal basis functions, each having a given frequency component corresponding to the prescribed orthogonal frequencies. The power level of each orthogonal basis function is independently adjustable. The excitation signal can be sparsely sampled, or portions of the excitation signal can be removed in order to improve tissue vibration and to provide for the interleaving ultrasonic vibration and detection pulses. Ultrasonic detection pulses are applied to at least one motion detection point, from which echo signals are received. From the received echo signals, a motion signal is determined, from which mechanical properties of the subject are calculated.
摘要翻译：用于测量受试者的机械性质的方法包括使用超声波换能器将超声波振动脉冲施加到受试者中的位置，以便在受试者中以多个规定的正交频率诱发剪切波。超声换能器由多个正交基函数组成的激励信号引导，每个正交基函数具有对应于规定正交频率的给定频率分量。每个正交基函数的功率电平是独立可调的。励磁信号可以被稀疏地采样，或者可以去除激励信号的部分，以便改善组织振动并提供交织超声波振动和检测脉冲。超声波检测脉冲被施加到至少一个运动检测点，从该运动检测点接收回波信号。从所接收的回波信号中，确定运动信号，从而计算被摄体的机械性质。

3. 发明申请

US20130237821A1 System and Method for Model-Independent Quantification of Tissue Viscoelastic Properties Using Ultrasound 审中-公开
标题翻译：使用超声波模型独立定量组织粘弹性的系统和方法
公开(公告)号：US20130237821A1
公开(公告)日：2013-09-12
申请号：US13795199
申请日：2013-03-12
申请人： Carolina Amador Carrascal , Matthew W. Urban , Shigao Chen , James F. Greenleaf
发明人： Carolina Amador Carrascal , Matthew W. Urban , Shigao Chen , James F. Greenleaf
IPC分类号： A61B8/08
CPC分类号： A61B8/485 , A61B8/085 , A61B8/5223 , G01S7/52042
摘要： A model-independent method for producing a viscoelastic tissue property metric using ultrasound is provided. A mechanical stress, such as an acoustic force, is applied to a tissue using an ultrasound system and tissue displacement resulting from the applied acoustic force is measured. From the tissue displacement measurements, a complex modulus, such as a relative complex modulus, is extracted. A loss tangent is calculated from the extracted complex modulus. Using the calculated loss tangent, viscoelastic tissue property metrics may be calculated.
摘要翻译：提供了一种使用超声波产生粘弹性组织性能量度的模型无关方法。使用超声系统将机械应力（例如声力）施加到组织，并且测量由施加的声力引起的组织位移。从组织位移测量中，提取复数模量，例如相对复数模量。从提取的复数模数计算损耗角正切值。使用计算的损耗角正切，可以计算粘弹性组织性质指标。

4. 发明申请

US20150265249A1 SYSTEM AND METHOD FOR SHEAR WAVE GENERATION WITH STEERED ULTRASOUND PUSH BEAMS 有权
标题翻译：具有可变超声波推力的剪切波生成系统和方法
公开(公告)号：US20150265249A1
公开(公告)日：2015-09-24
申请号：US14663866
申请日：2015-03-20
申请人： Matthew W. Urban , Alireza Nabavizadehrafsanjani , Pengfei Song , Shigao Chen , James F. Greenleaf
发明人： Matthew W. Urban , Alireza Nabavizadehrafsanjani , Pengfei Song , Shigao Chen , James F. Greenleaf
IPC分类号： A61B8/08 , A61B8/00
CPC分类号： A61B8/485 , A61B8/4494 , A61B8/54 , G01S7/52022 , G01S7/52042 , G01S15/8915 , G01S15/8927
摘要： A system and method for performing a steered push beam (SPB) technique to create multiple foci generated by the interference of different ultrasound push beams to create shear waves and, based thereon, generate a report indicating mechanical properties about an object.
摘要翻译：一种用于执行转向推波束（SPB）技术的系统和方法，用于产生由不同的超声推波束的干涉产生的多个焦点以产生剪切波，并且基于此产生指示关于物体的机械特性的报告。

5. 发明申请

US20110319756A1 Method for Ultrasound Vibrometry Using Orthogonal Basis Functions 有权
标题翻译：使用正交基函数的超声波振幅法
公开(公告)号：US20110319756A1
公开(公告)日：2011-12-29
申请号：US13254227
申请日：2010-03-09
申请人： Yi Zheng , Aiping Yao , James F. Greenleaf , Shigao Chen , Matthew W. Urban
发明人： Yi Zheng , Aiping Yao , James F. Greenleaf , Shigao Chen , Matthew W. Urban
IPC分类号： A61B8/00
CPC分类号： G01S7/52036 , A61B8/485 , G01S7/52022 , G01S15/8952
摘要： A method for measuring a mechanical property of a subject includes using an ultrasound transducer to apply ultrasonic vibration pulses to a location in a subject in order to induce shear waves at multiple prescribed orthogonal frequencies in the subject. The ultrasound transducer is directed by an excitation signal that is composed of multiple orthogonal basis functions, each having a given frequency component corresponding to the prescribed orthogonal frequencies. The power level of each orthogonal basis function is independently adjustable. The excitation signal can be sparsely sampled, or portions of the excitation signal can be removed in order to improve tissue vibration and to provide for the interleaving ultrasonic vibration and detection pulses. Ultrasonic detection pulses are applied to at least one motion detection point, from which echo signals are received. From the received echo signals, a motion signal is determined, from which mechanical properties of the subject are calculated.
摘要翻译：用于测量受试者的机械性质的方法包括使用超声波换能器将超声波振动脉冲施加到受试者中的位置，以便在受试者中以多个规定的正交频率诱发剪切波。超声换能器由多个正交基函数组成的激励信号引导，每个正交基函数具有对应于规定正交频率的给定频率分量。每个正交基函数的功率电平是独立可调的。励磁信号可以被稀疏地采样，或者可以去除激励信号的部分，以便改善组织振动并提供交织超声波振动和检测脉冲。超声波检测脉冲被施加到至少一个运动检测点，从该运动检测点接收回波信号。从所接收的回波信号中，确定运动信号，从而计算被摄体的机械性质。

6. 发明授权

US09883851B2 System and method for shear wave generation with steered ultrasound push beams 有权
公开(公告)号：US09883851B2
公开(公告)日：2018-02-06
申请号：US14663866
申请日：2015-03-20
申请人： Matthew W. Urban , Alireza Nabavizadehrafsanjani , Pengfei Song , Shigao Chen , James F. Greenleaf
发明人： Matthew W. Urban , Alireza Nabavizadehrafsanjani , Pengfei Song , Shigao Chen , James F. Greenleaf
IPC分类号： A61B8/00 , A61B8/08 , G01S7/52 , G01S15/89
CPC分类号： A61B8/485 , A61B8/4494 , A61B8/54 , G01S7/52022 , G01S7/52042 , G01S15/8915 , G01S15/8927
摘要： A system and method for performing a steered push beam (SPB) technique to create multiple foci generated by the interference of different ultrasound push beams to create shear waves and, based thereon, generate a report indicating mechanical properties about an object.

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