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1. 发明授权

US5911223A Introduction of modifying agents into skin by electroporation 失效
标题翻译：通过电穿孔将改性剂引入皮肤
公开(公告)号：US5911223A
公开(公告)日：1999-06-15
申请号：US695367
申请日：1996-08-09
申请人： James C. Weaver , Tani Chen , Christopher Cullander , Richard Guy , Robert S. Langer , Thomas E. Zewert , Uwe Pliquett , Rita Vanbever , Mark R. Prausnitz
发明人： James C. Weaver , Tani Chen , Christopher Cullander , Richard Guy , Robert S. Langer , Thomas E. Zewert , Uwe Pliquett , Rita Vanbever , Mark R. Prausnitz
IPC分类号： A61B17/00 , A61N1/32 , A61B19/00
CPC分类号： A61N1/0424 , A61N1/325 , A61B2017/00765 , A61N1/0428 , Y10S607/901
摘要： A method of modifying epidermis for transport of a material by electroporation includes applying to epidermis an agent that, upon entry into the epidermis, will modify the epidermis to thereby cause and altered rate of transport of a material across the epidermis. Typically, the altered rate will be an increased rate of transport. The epidermis is electroporated, whereby at least a portion of the modifying agent enters the electroporated epidermis, thereby modifying the epidermis to cause an altered rate of transport of a material across the epidermis. In another embodiment, the modifying agent can modify the epidermis to enable measurement and/or monitoring of physiological conditions or change within or beneath the epidermis. The modifying agents can also be employed to facilitate discharge of fluids from within an organism, such as by providing pathways for discharge of fluids from a tumor. Examples of modifying agents include: oxidizing agents; reducing agents; particles, such as optical indicator beads or beads that include drugs to be released into tissue; electrically-charged particles or molecules; etc. Materials that can be transported by the method of the invention include, for example, proteins, nucleic acids, electrically charged molecules or particles, microorganisms suitable for immunization, etc. Also, tissues other than skin can be employed in the method of the invention.
摘要翻译：通过电穿孔来改变用于运输材料的表皮的方法包括向表皮施加一种在进入表皮时将改变表皮从而引起和改变材料穿过表皮的运输速率的试剂。通常，改变率将是增加的运输速度。表皮被电穿孔，由此至少一部分改性剂进入电穿孔表皮，从而改变表皮，导致材料穿过表皮的转运速率。在另一个实施方案中，修饰剂可以修饰表皮以使得能够测量和/或监测生理条件或在表皮内或下表面的变化。还可以使用改性剂来促进从生物体内排出流体，例如通过提供从肿瘤排出流体的途径。改性剂的实例包括：氧化剂; 还原剂; 颗粒，例如包括要释放到组织中的药物的光学指示剂珠粒或珠粒; 带电粒子或分子; 可以通过本发明的方法传输的材料包括例如蛋白质，核酸，带电分子或颗粒，适合免疫的微生物等。另外，皮肤以外的组织可以用于发明。

2. 发明授权

US5730714A Method for the iontophoretic non-invasive determination of the in vivo concentration level of glucose 失效
标题翻译：离子电渗非侵入性测定葡萄糖体内浓度水平的方法
公开(公告)号：US5730714A
公开(公告)日：1998-03-24
申请号：US312400
申请日：1994-09-26
申请人： Richard Guy , Girish Rao , Peretz Glikfeld , Christopher Cullander , Robert S. Hinz
发明人： Richard Guy , Girish Rao , Peretz Glikfeld , Christopher Cullander , Robert S. Hinz
IPC分类号： A61B5/00 , A61N1/30
CPC分类号： A61B5/411 , A61B5/14532 , A61N1/303 , A61M2037/0007
摘要： The present invention relates to an vitro device for the removal of ionized substances from a membrane sample without mechanical penetration, which device comprises: (a) a positive electrode; (b) a negative electrode, and (c) electrical insulation between subpart (a) and (b), wherein the positive electrode, and the negative electrode, and electrical insulation are positioned on the same side of the membrane sample. The present invention also relates to a device for the removal of or delivery of ionized substances to a mammal through intact skin or mucosal membrane without mechanical penetration, which device comprises: (a) a positive electrode, (b) a negative electrode, and (c) an electrically insulating material between subpart (a) and (b), wherein the positive electrode, negative electrode and insulating material are physically positioned so that each present a common surface of the device for contact with the same surface of the skin or mucosal membrane of the mammal. The present invention also relates to the use of iontophoresis to determine the level of a charged molecule in a living mammal, and with the use of a feedback mechanism, administer appropriate levels of therapeutic substances.
摘要翻译：本发明涉及一种用于从膜样品中除去离子化物质而没有机械穿透的体外装置，该装置包括：（a）正极; （b）负极，（c）部分（a）和（b）之间的电绝缘，其中正电极和负电极以及电绝缘体位于膜样品的同一侧。本发明还涉及一种用于通过完整的皮肤或粘膜除去或递送离子化物质而不机械穿透的装置，该装置包括：（a）正极，（b）负极和（ c）在子部分（a）和（b）之间的电绝缘材料，其中正极，负极和绝缘材料物理地定位，使得每个都存在与皮肤或粘膜的相同表面接触的装置的共同表面哺乳动物的膜。本发明还涉及使用离子电渗法来确定活的哺乳动物中带电分子的水平，并且使用反馈机制来施用适当水平的治疗物质。

3. 发明授权

US06714815B2 Method for the iontophoretic non-invasive determination of the in vivo concentration level of an inorganic or organic substance 失效
标题翻译：离子电渗非侵入性测定无机或有机物质的体内浓度水平的方法
公开(公告)号：US06714815B2
公开(公告)日：2004-03-30
申请号：US10341120
申请日：2003-01-13
申请人： Richard Guy , Girish Rao , Christopher Cullander , Robert S. Hinz , Peretz Glikfeld
发明人： Richard Guy , Girish Rao , Christopher Cullander , Robert S. Hinz , Peretz Glikfeld
IPC分类号： A61N130
CPC分类号： A61B5/411 , A61B5/14532 , A61M2037/0007 , A61N1/303
摘要： The present invention relates to an vitro device for the removal of ionized substances from a membrane sample without mechanical penetration, which device comprises: (a) a positive electrode; (b) a negative electrode, and (c) electrical insulation between subpart (a) and (b), wherein the positive electrode, and the negative electrode, and electrical insulation are positioned on the same side of the membrane sample. The present invention also relates to a device for the removal of or delivery of ionized substances to a mammal through intact skin or mucosal membrane without mechanical penetration, which device comprises: (a) a positive electrode, (b) a negative electrode, and (c) an electrically insulating material between subpart (a) and (b), wherein the positive electrode, negative electrode and insulating material are physically positioned so that each present a common surface of the device for contact with the same surface of the skin or mucosal membrane of the mammal. The present invention also relates to the use of iontophoresis to determine the level of a charged molecule in a living mammal, and with the use of a feedback mechanism, administer appropriate levels of therapeutic substances.
摘要翻译：本发明涉及一种用于从膜样品中除去电离物质而没有机械穿透的体外装置，该装置包括：（a）正极;（b）负极，和（c）子部分）和（b），其中正电极和负电极以及电绝缘体位于膜样品的同一侧。本发明还涉及一种用于将离子化物质除去或递送到哺乳动物的装置通过完整的皮肤或粘膜没有机械穿透，该装置包括：（a）正电极，（b）负电极和（c）子部分（a）和（b）之间的电绝缘材料，其中正电极负极和绝缘材料物理地定位，使得每个都具有与哺乳动物的皮肤或粘膜的相同表面接触的装置的共同表面。本发明还涉及使用离子电渗法来确定活的哺乳动物中带电分子的水平，并且使用反馈机制来施用适当水平的治疗物质。

4. 发明授权

US5279543A Device for iontophoretic non-invasive sampling or delivery of substances 失效
标题翻译：用于离子电渗非侵入性采样或物质运送的装置
公开(公告)号：US5279543A
公开(公告)日：1994-01-18
申请号：US879060
申请日：1992-04-30
申请人： Peretz Glikfeld , Christopher Cullander , Robert S. Hinz , Richard H. Guy
发明人： Peretz Glikfeld , Christopher Cullander , Robert S. Hinz , Richard H. Guy
IPC分类号： A61B10/02 , A61B5/00 , A61B5/145 , A61B5/1477 , A61N1/30
CPC分类号： A61B5/411 , A61B5/14532 , A61N1/303 , A61M2037/0007
摘要： The present invention relates to an vitro device for the removal of ionized substances from a membrane sample without mechanical penetration, which device comprises:(a) a positive electrode;(b) a negative electrode, and(c) electrical insulation between subpart (a) and (b), wherein the positive electrode, and the negative electrode, and electrical insulation are positioned on the same side of the membrane sample.The present invention also relates to a device for the removal of or delivery of ionized substances to a mammal through intact skin or mucosal membrane without mechanical penetration, which device comprises: (a) a positive electrode, (b) a negative electrode, and (c) an electrically insulating material between subpart (a) and (b), wherein the positive electrode, negative electrode and insulating material are physically positioned so that each present a common surface of the device for contact with the same surface of the skin or mucosal membrane of the mammal.The present invention also relates to the use of iontophoresis to determine the level of a charged molecule in a living mammal, and with the use of a feedback mechanism, administer appropriate levels of therapeutic substances.
摘要翻译：本发明涉及一种用于从膜样品中除去离子化物质而没有机械穿透的体外装置，该装置包括：（a）正极; （b）负极，（c）部分（a）和（b）之间的电绝缘，其中正电极和负电极以及电绝缘体位于膜样品的同一侧。本发明还涉及一种用于通过完整的皮肤或粘膜除去或递送离子化物质而不机械穿透的装置，该装置包括：（a）正极，（b）负极和（ c）在子部分（a）和（b）之间的电绝缘材料，其中正极，负极和绝缘材料物理地定位，使得每个都存在与皮肤或粘膜的相同表面接触的装置的共同表面哺乳动物的膜。本发明还涉及使用离子电渗法来确定活的哺乳动物中带电分子的水平，并且使用反馈机制来施用适当水平的治疗物质。

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