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1. 发明申请

US20090198231A1 METHODS TO TREAT UNWANTED TISSUE WITH ELECTRIC PULSES 审中-公开
标题翻译：用电脉冲处理不需要的组织的方法
公开(公告)号：US20090198231A1
公开(公告)日：2009-08-06
申请号：US12329571
申请日：2008-12-06
申请人： Axel T. Esser , Thiruvallur R. Gowrishankar , Kyle C. Smith , Stephen K. Burns , James C. Weaver
发明人： Axel T. Esser , Thiruvallur R. Gowrishankar , Kyle C. Smith , Stephen K. Burns , James C. Weaver
IPC分类号： A61B18/14
CPC分类号： A61N1/327 , A61B2018/00613
摘要： Provided are methods for selecting parameters of an electrical pulse for electroporation to induce apoptosis in a tissue in need of therapeutic removal in a patient. Also provided are methods and apparatuses for treating a disease by inducing apoptosis in a tissue in need of therapeutic removal in a patient. Further provided are computer-readable media having instructions for selecting parameters of an electrical pulse for electroporation to induce apoptosis in a tissue in need of therapeutic removal in a patient.
摘要翻译：提供了用于选择用于电穿孔的电脉冲的参数以诱导需要在患者中进行治疗性移除的组织中的细胞凋亡的方法。还提供了通过在患者中需要治疗性去除的组织中诱导细胞凋亡来治疗疾病的方法和装置。还提供了具有用于选择用于电穿孔的电脉冲的参数以诱导需要在患者中进行治疗性移除的组织中的凋亡的指令的计算机可读介质。

2. 发明授权

US5650441A Method of assaying CD4 glycoproteins by using certain azo dyes 失效
标题翻译：通过使用某些偶氮染料测定CD4糖蛋白的方法
公开(公告)号：US5650441A
公开(公告)日：1997-07-22
申请号：US320852
申请日：1994-10-11
申请人： Adorjan Aszalos , James C. Weaver , P. Scott Pine
发明人： Adorjan Aszalos , James C. Weaver , P. Scott Pine
IPC分类号： A61K31/655 , A61K31/17
CPC分类号： A61K31/655
摘要： Antiviral compositions useful for the inhibition of HIV include various azo dye compounds which have the ability of inhibiting the binding of HIV rgp120 to CD4 cells on peripheral blood lymphocytes and affecting HIV replication. Also disclosed are methods for treating HIV viral infections with these compositions.
摘要翻译：可用于抑制HIV的抗病毒组合物包括各种偶氮染料化合物，其具有抑制HIV rgp120与外周血淋巴细胞上的CD4细胞结合并影响HIV复制的能力。还公开了用这些组合物治疗HIV病毒感染的方法。

3. 发明授权

US5055390A Process for chemical manipulation of non-aqueous surrounded microdroplets 失效
标题翻译：非水包围微滴的化学处理方法
公开(公告)号：US5055390A
公开(公告)日：1991-10-08
申请号：US185156
申请日：1988-04-22
申请人： James C. Weaver , Gregory B. Williams , Jonathan G. Bliss
发明人： James C. Weaver , Gregory B. Williams , Jonathan G. Bliss
IPC分类号： C12Q1/00 , C12Q1/18 , C12Q1/24 , G01N33/50
CPC分类号： C12Q1/00 , C12Q1/18 , C12Q1/24 , G01N33/50 , Y10T428/2984
摘要： A process for the chemical manipulation of liquid and gel microdroplets is disclosed. The process involves providing first microdroplets having aqueous interiors, such that the first microdroplets are surrounded by a non-aqueous fluid. The aqueous interior chemical composition of the first microdroplets is then manipulated by exposure to compounds soluble in both the non-aqueous and aqueous phases, or by exposure to emulsions or suspensions of second microdroplets such that contact between the first and second microdroplets is made. This allows chemical manipulation to be accomplished without removing the first microdroplets from a non-aqueous fluid environment.
摘要翻译：公开了一种用于化学操作液体和凝胶微滴的方法。该方法包括提供具有水性内部的第一微滴，使得第一微滴被非水性流体包围。然后通过暴露于可溶于非水相和水相的化合物，或通过暴露于第二微滴的乳液或悬浮液来操作第一微滴的含水内部化学组成，使得形成第一和第二微滴之间的接触。这允许在不从非水性流体环境中去除第一微滴的情况下进行化学操作。

4. 发明授权

US4959301A Process for rapidly enumerating viable entities 失效
标题翻译：快速列举可行实体的过程
公开(公告)号：US4959301A
公开(公告)日：1990-09-25
申请号：US185083
申请日：1988-04-22
申请人： James C. Weaver , Jonathan G. Bliss , Gregory B. Williams , Kevin T. Powell , Gail I. Harrison
发明人： James C. Weaver , Jonathan G. Bliss , Gregory B. Williams , Kevin T. Powell , Gail I. Harrison
IPC分类号： C12Q1/00 , C12Q1/18 , C12Q1/24 , G01N33/50
CPC分类号： C12Q1/24 , C12Q1/00 , C12Q1/18 , G01N33/50
摘要： A process for rapidly enumerating viable biological entities is disclosed, wherein viability is determined by the critierion of growth of biological entities contained in microdroplets. Alternatively, in some cases, viability is determined by use of vital staining of biological entities contained in microdroplets. The process involves formation of microdroplets, which are very small volume liquid or gel particles, such that some of the microdroplets contain biololgical entities, followed by measurements of biological entities and of microdroplet volumes, such that use of statistical analysis can be used self-consistently to determine the number of viable entities per volume of a sample.
摘要翻译：公开了一种用于快速计数活的生物实体的方法，其中生存力由微滴中包含的生物实体的生长指标决定。或者，在一些情况下，通过使用包含在微滴中的生物实体的生物染色来确定存活力。该方法包括形成微滴体，其是非常小体积的液体或凝胶颗粒，使得一些微滴含有生物实体，随后是生物体和微滴体积的测量，使得统计分析的使用可以自发地使用以确定每体积样本的活体数。

5. 发明授权

US4401755A Process for measuring microbiologically active material 失效
标题翻译：微生物活性物质测定方法
公开(公告)号：US4401755A
公开(公告)日：1983-08-30
申请号：US229483
申请日：1981-01-29
申请人： James C. Weaver
发明人： James C. Weaver
IPC分类号： C12N1/00 , C12P1/00 , C12Q1/00 , C12Q1/04 , C12M1/34 , C12Q1/06 , C12Q1/18
CPC分类号： C12Q1/00 , C12N1/00 , C12P1/00 , Y10S435/808
摘要： The activity of a microbiologically active material is measured by suspending the material in a liquid medium capable of forming a gel. The resultant suspension is formed into small liquid droplets which droplets are caused to gel. The gel microdroplets (GMDs) are treated to effect desirable alteration of the microbiologically active material and the amount of metabolites or reaction products of the desired alteration within each get droplet is measured. Alternatively, incubation is carried out such that each GMD initially containing one cell contains many, a microcolony, which can be tested for desirable properties while retaining sufficient viable cells for with growth and harvesting for further testing and/or production.
摘要翻译：通过将材料悬浮在能够形成凝胶的液体介质中来测量微生物活性材料的活性。所得悬浮液形成小液滴，使液滴凝胶化。处理凝胶微滴（GMD）以实现微生物活性物质的理想改变，并且测量每个获得的液滴内所需改变的代谢物或反应产物的量。或者，进行温育，使得最初含有一个细胞的每个GMD含有许多微小菌落，其可以测试所需的性质，同时保留足够的活细胞用于生长和收获用于进一步测试和/或生产。

6. 发明授权

US4379802A Stampable reinforced thermoplastic polyester sheet with improved surface finish 失效
标题翻译：具有改善表面光洁度的可冲压增强热塑性聚酯薄片
公开(公告)号：US4379802A
公开(公告)日：1983-04-12
申请号：US370319
申请日：1982-04-21
申请人： James C. Weaver , Robert W. Seymour
发明人： James C. Weaver , Robert W. Seymour
IPC分类号： B32B27/12 , B32B15/00 , B32B17/00
CPC分类号： B32B37/00 , B32B27/12 , Y10T428/252 , Y10T428/256 , Y10T428/259 , Y10T428/273 , Y10T428/31786 , Y10T428/31794 , Y10T428/31797 , Y10T442/67
摘要： Stampable sheet of reinforced thermoplastic material having a plurality of layers of polymeric material and a plurality of layers of fibrous reinforcing material alternating with the layers of polymeric material, the polymeric material layers having minimum crystallization half-times upon heating of one minute or less with the fifth layer of the sheet being polymeric material having a shrinkage of less than 2% as determined in accordance with ASTM Method D-955, and the first or outer layer and the third layer of the sheet being polymeric material layers having about 5 to about 50 weight percent fillers; with all of the layers being integrally formed together and possessing a smooth surface, essentially free of fiber "read-through", and having more uniform reinforcement in the sheet, and of the type required of exterior automotive-type appearance parts; and a stamped sheet formed from the stampable sheet and having a heat deflection temperature under 264 psi. load greater than T.sub.m -50.degree. C., where T.sub.m is the melting point in the outer layers of the sheet.
摘要翻译：增强热塑性材料的可冲压片材具有多层聚合物材料和多层纤维增强材料，与聚合物材料层交替，聚合物材料层在加热1分钟或更短时间内具有最小结晶半倍片材的第五层是根据ASTM方法D-955测定的具有小于2％的收缩率的聚合物材料，并且片材的第一层或外层和第三层是聚合材料层，其具有约5至约50 填料重量百分比其中所有的层整体地形成在一起并且具有光滑的表面，基本上不含纤维“直通”，并且在片材中具有更均匀的增强和外部汽车型外观部件所需的类型; 以及由冲压片材形成并具有264psi以下的热变形温度的冲压片材。负载大于Tm-50℃，其中Tm是片材外层中的熔点。

7. 发明授权

US4263364A Stampable reinforced thermoplastic polyester sheets 失效
标题翻译：可冲压增强热塑性聚酯薄片
公开(公告)号：US4263364A
公开(公告)日：1981-04-21
申请号：US103806
申请日：1979-12-14
申请人： Robert W. Seymour , James C. Weaver , Benny W. Wright
发明人： Robert W. Seymour , James C. Weaver , Benny W. Wright
IPC分类号： B29C51/00 , B32B27/34
CPC分类号： B32B27/34 , B29C51/002 , B32B37/00 , Y10T428/24995 , Y10T428/31616
摘要： The object of the invention is to provide a stampable sheet of reinforced thermoplastic material, the sheet being composed of a plurality of layers of polyester material and a plurality of layers of reinforcing material integrally formed together, the central layer or layers of polyester material being of more slowly crystallizing material than the outer layers. The polyester layers are all substantially amorphous and are made of polyester polymers selected from poly(ethylene terephthalate), selected copolymers of poly(ethylene terephthalate), poly(1,4-cyclohexylenedimethylene terephthalate), selected copolymers of poly(1,4-cyclohexylenedimethylene terephthalate), blends of poly(ethylene terephthalate) and any of the aforementioned selected copolymers, and blends of poly(1,4-cyclohexylenedimethylene terephthalate) and any of the aforementioned selected copolymers, The central polyester layer or layers are polyester polymers selected from the aforementioned selected copolymers and blends.Another object of the invention is to provide a stamped sheet from the stampable sheet of reinforced thermoplastic material, the stamped sheet having a heat deflection temperature under 264 psi. load greater than T.sub.m -50.degree. C.
摘要翻译：本发明的目的是提供一种加强热塑性材料的可冲压片材，该片材由多层聚酯材料和多层增强材料组成，整体形成在一起，聚酯材料的中心层或多层是比外层更缓慢地结晶材料。聚酯层全部基本上是无定形的，并且由聚对苯二甲酸乙二醇酯，聚（对苯二甲酸乙二醇酯），聚（1,4-环己烯二亚甲基对苯二甲酸酯）的选择共聚物，聚（1,4-环己烯二甲基亚甲基）聚对苯二甲酸乙二醇酯）和任何上述选择的共聚物的共混物，以及聚（1,4-环己烯二亚甲基对苯二甲酸酯）和任何上述选择的共聚物的共混物。中心聚酯层或聚酯聚酯选自上述选择的共聚物和共混物。本发明的另一个目的是提供一种来自加强热塑性材料的可冲压片材的冲压片材，冲压片材的热变形温度在264psi以下。负载大于Tm -50℃

8. 发明授权

US4197369A Method for measuring reactant concentrations and quantities 失效
标题翻译：测量反应物浓度和数量的方法
公开(公告)号：US4197369A
公开(公告)日：1980-04-08
申请号：US967037
申请日：1978-12-06
申请人： James C. Weaver
发明人： James C. Weaver
IPC分类号： C12M1/34 , C12M1/40 , C12Q1/00 , C12Q1/58
CPC分类号： C12Q1/58 , C12M21/18 , C12M23/24 , C12M25/02 , C12M41/32 , C12Q1/00 , Y10S435/807
摘要： A method and apparatus is provided for determining the concentration or quantity of enzyme molecules, microorganisms or substrate molecules by monitoring directly the concentration and/or the quantity of vaporous by-product produced from the selective reaction of the molecule catalyzed with a known amount of substrate or of an enzyme or a microorganism. The apparatus comprises a membrane permeable to the vaporous product or substrate, a known amount of microorganism or an enzyme adjacent to the membrane, means for introducing a liquid sample into contact with the microorganism or enzyme within a small volume adjacent the membrane and means for measuring the amount of vaporous by-product passing through the membrane. A mass spectrometer located adjacent the membrane surface is suitable for measuring the amount of vaporous product or substrate passing through the membrane. The process is conducted by first calibrating the apparatus with a known concentration of substrate or of enzyme, and thereafter contacting a sample containing an unknown concentration of enzyme or microorganism with the substrates, or substrate with the enzyme or microorganism.
摘要翻译：提供了一种方法和装置，用于通过直接监测由已知量的底物催化的分子的选择性反应产生的蒸气副产物的浓度和/或量来确定酶分子，微生物或底物分子的浓度或数量或酶或微生物。该装置包括对蒸气产物或底物可渗透的膜，已知量的微生物或与膜相邻的酶，用于将液体样品与邻近膜的小体积内的微生物或酶接触的装置和用于测量的装置蒸气副产物通过膜的量。位于膜表面附近的质谱仪适用于测量通过膜的蒸气产物或底物的量。该方法通过首先用已知浓度的底物或酶校准装置进行，然后使含有未知浓度的酶或微生物的样品与底物或底物与酶或微生物接触。

9. 发明授权

US4088709A Phosphorus stabilized-polyester-polycarbonate molding compositions 失效
标题翻译：磷稳定聚酯 - 聚碳酸酯模塑组合物
公开(公告)号：US4088709A
公开(公告)日：1978-05-09
申请号：US812934
申请日：1977-07-01
申请人： Robert W. Seymour , James C. Weaver , Theodore F. Gray, Jr.
发明人： Robert W. Seymour , James C. Weaver , Theodore F. Gray, Jr.
IPC分类号： C08K5/524 , C08L67/02 , C08L67/00
CPC分类号： C08K5/524 , C08L67/02
摘要： Disclosed is a composition comprised of an admixture of poly(tetramethylene terephthalate), bisphenol A polycarbonate and selected phosphorous compounds.
摘要翻译：公开了由聚对苯二甲酸丁二醇酯，双酚A聚碳酸酯和选择的磷化合物的混合物组成的组合物。

10. 发明授权

US3948731A Method and apparatus for measuring reactant concentrations and quantities 失效
标题翻译：用于测量反应物浓度和数量的方法和设备
公开(公告)号：US3948731A
公开(公告)日：1976-04-06
申请号：US517422
申请日：1974-10-24
申请人： James C. Weaver
发明人： James C. Weaver
IPC分类号： C12M1/34 , C12Q1/00 , C12Q1/32 , C12Q1/58 , G01N7/10 , C12K1/04
CPC分类号： C12Q1/00 , C12M41/34 , C12M41/36 , C12M41/46 , C12Q1/32 , C12Q1/58 , G01N7/10 , Y10S435/807 , Y10S435/839 , Y10S435/849
摘要： A method and apparatus is provided for determining the concentration or quantity of substrate molecules by monitoring directly the concentration and/or the quantity of vaporous byproduct produced from the selective reaction of the molecule catalyzed with a known amount of an enzyme or a microorganism. The apparatus comprises a membrane permeable to the vaporous by-product, a known amount of microorganism or an enzyme immobilized adjacent to the membrane, means for introducing a liquid sample into contact with the microorganism or enzyme and means for measuring the amount of vaporous by-product passing through the membrane. A mass spectrometer located adjacent the membrane surface having the immobilized enzyme or microorganism is suitable for measuring the amount of vaporous by-product passing through the membrane. The process is conducted by first calibrating the apparatus with a known concentration of substrate and thereafter contacting a sample containing an unknown concentration of substrate with the enzyme or microorganism.
摘要翻译：提供了一种方法和装置，用于通过直接监测由已知量的酶或微生物催化的分子的选择性反应产生的蒸气副产物的浓度和/或量来确定底物分子的浓度或数量。该装置包括对蒸气副产物可渗透的膜，已知量的微生物或邻近膜固定的酶，用于将液体样品与微生物或酶接触的装置，以及用于测量蒸气副产物的量的装置，产品通过膜。位于具有固定化酶或微生物的膜表面附近的质谱仪适用于测量通过膜的蒸气副产物的量。该方法通过首先用已知浓度的底物校准该装置，然后使含有未知浓度的底物的样品与酶或微生物接触。

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