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1. 发明申请

US20050036146A1 Sample element qualification 审中-公开
标题翻译：样品单元鉴定
公开(公告)号：US20050036146A1
公开(公告)日：2005-02-17
申请号：US10824933
申请日：2004-04-15
申请人： James Braig , Kenneth Witte , Philip Hartstein , Ken Li , Peter Rule
发明人： James Braig , Kenneth Witte , Philip Hartstein , Ken Li , Peter Rule
IPC分类号： G01N21/03 , G01N21/59 , G01N21/86 , G01N35/00 , G01N21/00
CPC分类号： G01N35/00732 , G01N21/03 , G01N21/5907 , G01N21/8483 , G01N2035/00752 , G01N2035/00762 , G01N2035/00772 , G01N2035/00782
摘要： A sample element includes first and second substantially parallel faces separated by an intermediate member. The parallel faces and the intermediate member at least partially define a sample chamber configured to hold a volume of fluid. The sample element further includes an optical path extending through the parallel faces and the intermediate member, such that electromagnetic radiation can propagate through the sample chamber. The sample element further includes an identifying compound disposed within or on at least one of the parallel faces. The identifying compound has at least one indexed optical absorbance feature, such that spectral analysis of electromagnetic radiation propagated through the sample chamber yields the indexed optical absorbance feature. Detection of the indexed optical absorbance feature in electromagnetic radiation propagated through the sample chamber indicates to an analyte detection system whether the sample element is configured for use with the analyte detection system.
摘要翻译：样品元件包括由中间构件分隔开的第一和第二基本上平行的面。平行面和中间构件至少部分地限定了构造成保持一定体积的流体的样品室。样本元件还包括延伸穿过平行面和中间构件的光路，使得电磁辐射可以传播通过样品室。样本元件还包括设置在至少一个平行面内或之中的识别化合物。识别化合物具有至少一个索引的光吸收特征，使得通过样品室传播的电磁辐射的光谱分析产生索引的光吸收特征。通过样品室传播的电磁辐射中的指示光吸收特征的检测表明分析物检测系统是否将样品元件配置为与分析物检测系统一起使用。

2. 发明申请

US20050037482A1 Dual measurement analyte detection system 审中-公开
标题翻译：双测量分析物检测系统
公开(公告)号：US20050037482A1
公开(公告)日：2005-02-17
申请号：US10826006
申请日：2004-04-15
申请人： James Braig , Peter Rule , Kenneth Witte , Philip Hartstein , Bernhard Sterling
发明人： James Braig , Peter Rule , Kenneth Witte , Philip Hartstein , Bernhard Sterling
IPC分类号： A61B5/00 , C12M1/34
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546
摘要： An analyte detection system is configured to measure concentrations of at least first and second analytes in a single material sample supported by a sample element. The measurement of a second analyte can be conditioned on a quantitative or qualitative result of the first measurement. In one embodiment, the first analyte is glucose and the second analyte is a ketone. According to such an embodiment the ketone is measured if the result of the glucose measurement exceeds a previously-specified value or falls outside of a previously-specified range.
摘要翻译：分析物检测系统被配置为测量由样品元素支持的单个材料样品中的至少第一和第二分析物的浓度。第二分析物的测量可以对第一次测量的定量或定性结果进行调节。在一个实施方案中，第一分析物是葡萄糖，第二分析物是酮。根据这样的实施方案，如果葡萄糖测量结果超过预先规定的值或者超出预先规定的范围，则测量酮。

3. 发明申请

US20060004267A1 Layered spectroscopic sample element with microporous membrane 审中-公开
标题翻译：具有微孔膜的分层光谱样品元件
公开(公告)号：US20060004267A1
公开(公告)日：2006-01-05
申请号：US11173768
申请日：2005-07-01
申请人： Peter Rule , James Braig , Philip Hartstein
发明人： Peter Rule , James Braig , Philip Hartstein
IPC分类号： A61B5/00
CPC分类号： B01L3/5023 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1491 , B01L3/5027 , B01L3/508 , B01L2200/027 , B01L2300/0654 , B01L2300/069 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , G01N21/03 , G01N21/8483 , G01N2021/0346
摘要： A spectroscopic sample holder comprises a microporous sheet. The microporous sheet has a top surface, a bottom surface substantially parallel to the top surface, and at least one side surface oriented substantially perpendicular to the top and bottom surfaces. The side surface forms an exposed transit opening configured to contact a material sample and distribute the contacted material sample into the microporous sheet. The spectroscopic sample holder further comprises a first planar support member positioned on, and substantially parallel to, the top surface of the microporous sheet. The spectroscopic sample holder further comprises a second planar support member positioned on the bottom surface of the microporous sheet, and oriented substantially parallel to the first planar support member.
摘要翻译：光谱样品架包括微孔片。微孔片具有基本平行于顶表面的顶表面，底表面以及基本上垂直于顶表面和底表面取向的至少一个侧表面。侧表面形成暴露的转移开口，其构造成接触材料样品并将接触的材料样品分配到微孔板中。光谱样品架还包括位于微孔板的顶表面上且基本上平行于微孔板的顶表面的第一平面支撑构件。光谱样品架还包括位于微孔板的底表面上并基本上平行于第一平面支撑构件定向的第二平面支撑构件。

4. 发明申请

US20060030790A1 Sample element with barrier material and vacuum 审中-公开
标题翻译：具有阻隔材料和真空的样品元件
公开(公告)号：US20060030790A1
公开(公告)日：2006-02-09
申请号：US10913666
申请日：2004-08-06
申请人： James Braig , Peter Rule , Philip Hartstein , Heidi Smith
发明人： James Braig , Peter Rule , Philip Hartstein , Heidi Smith
IPC分类号： A61B5/00
CPC分类号： A61B5/14546 , A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150213 , A61B5/150221 , A61B5/150274 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/15117 , A61B5/15125 , A61B5/15136 , A61B5/1514 , A61B2562/0295
摘要： Disclosed is a sample element for holding a volume of bodily fluid drawn from the skin of a patient at a withdrawal site. The sample element comprises a housing defining a sample chamber therein, and a barrier. The sample element also comprises a vacuum source. The barrier has a first side configured to contact the skin of the patient at the withdrawal site, and a second side in fluid communication with the sample chamber. The barrier is configured to be pierced by a lance to permit the bodily fluid to pass from the first side to the second side. Additionally, the vacuum source can be actuated to draw the bodily fluid through the barrier and into the sample chamber. Also disclosed is a method of drawing a bodily fluid form the skin of a patient at a withdrawal site. The method comprises placing a first side of a barrier against the skin of the patient at the withdrawal site. The method further comprises forming a first opening through the barrier and a second opening in the skin of the patient at the withdrawal site. The first and second openings are in fluid communication. The method further comprises applying suction at the first opening of the barrier to draw a bodily fluid from the patient.
摘要翻译：公开了一种用于在取出部位保持从患者皮肤抽取的体液体积的样本元件。样品元件包括在其中限定样品室的壳体和屏障。样品元件还包括真空源。屏障具有被配置成在抽出部位接触患者皮肤的第一侧和与样品室流体连通的第二侧。障碍物被构造成被喷枪刺穿以允许体液从第一侧通过到第二侧。此外，可以致动真空源以将体液通过屏障并进入样品室。还公开了一种在抽出部位从患者的皮肤上吸取体液的方法。该方法包括将屏障的第一侧放置在患者的皮肤处于撤出部位。所述方法还包括在所述抽出部位形成穿过所述屏障的第一开口和所述患者皮肤中的第二开口。第一和第二开口处于流体连通状态。该方法还包括在屏障的第一开口处施加抽吸以从患者抽取体液。

5. 发明申请

US20050106749A1 Sample element for use in material analysis 审中-公开
标题翻译：用于材料分析的样品元素
公开(公告)号：US20050106749A1
公开(公告)日：2005-05-19
申请号：US10877965
申请日：2004-06-25
申请人： James Braig , Bernhard Sterling , Peter Rule , Philip Hartstein , Kenneth Li
发明人： James Braig , Bernhard Sterling , Peter Rule , Philip Hartstein , Kenneth Li
IPC分类号： G01N21/03 , G01N21/35 , G01N21/86 , G01N31/22
CPC分类号： G01N21/8483 , G01N21/0303 , G01N21/3577
摘要： A system and method are provided for determining a concentration of an analyte in a material sample. The method includes providing a sample element with a sample chamber at least partially defined by at least one window formed from a material having greater than about 1% wavelength-domain variation in absorbtivity of electromagnetic radiation incident thereon. The method further includes employing the sample element with an analyte detection system which determines the concentration of the analyte with clinically acceptable accuracy.
摘要翻译：提供了用于确定材料样品中分析物浓度的系统和方法。所述方法包括提供样品室，所述样品室至少部分地由至少一个窗口形成，所述至少一个窗口由从其入射的电磁辐射的吸收率具有大于约1％波长域的变化的材料形成。该方法还包括使用样品元件分析物检测系统，其以临床可接受的精度确定分析物的浓度。

6. 发明申请

US20050038674A1 System and method for managing a chronic medical condition 审中-公开
标题翻译：用于管理慢性医疗状况的系统和方法
公开(公告)号：US20050038674A1
公开(公告)日：2005-02-17
申请号：US10826004
申请日：2004-04-15
申请人： James Braig , Peter Rule , Michael Munrow , Philip Hartstein
发明人： James Braig , Peter Rule , Michael Munrow , Philip Hartstein
IPC分类号： G06F19/00 , G06Q50/00 , G06F17/60
CPC分类号： G06F19/3418 , G06F19/3456 , G06Q50/22 , G16H10/60 , G16H40/40
摘要： A system for management of a chronic medical condition generally comprises a plurality of networked physical and/or virtual elements configured to cooperate to aid in management of a chronic medical condition of a patient. The system is configured to provide a primary caregiver with current data relating to the patient's medical condition, and to allow the caregiver to provide appropriate changes to the patient's treatment via an analyte detection meter. The meter is generally configured to calculate a treatment dosage by combining a plurality of patient-affected and caregiver-affected variables. One embodiment relates to a system for management of a diabetic condition in which the primary caregiver is provided with glucose concentration data as well as other information relating to a diabetic condition. The primary caregiver can then make appropriate changes to correction factors to be implemented in an analyte detection meter which is configured to calculate an insulin dosage.
摘要翻译：用于管理慢性医疗状况的系统通常包括多个联网物理和/或虚拟元件，其被配置为协作以帮助管理患者的慢性医疗状况。该系统被配置为向主要照顾者提供与患者的医疗状况相关的当前数据，并且允许护理人员通过分析物检测仪器对患者的治疗提供适当的改变。仪器通常被配置为通过组合多个患者受影响和受照顾者影响的变量来计算治疗剂量。一个实施方案涉及一种用于管理糖尿病状态的系统，其中主要护理者具有葡萄糖浓度数据以及与糖尿病状况有关的其它信息。然后，主要护理者可以对被配置为计算胰岛素剂量的分析物检测计进行校正因子的适当改变。

7. 发明申请

US20050070771A1 Sample adapter 审中-公开
标题翻译：样品适配器
公开(公告)号：US20050070771A1
公开(公告)日：2005-03-31
申请号：US10900062
申请日：2004-07-27
申请人： Peter Rule , James Braig , Philip Hartstein , Jennifer Gable
发明人： Peter Rule , James Braig , Philip Hartstein , Jennifer Gable
IPC分类号： A61B5/00
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/1455 , A61B5/1491
摘要： An adapter presents a sample of bodily fluid, such as whole blood, including an analyte to an analyzer window of a non-invasive monitor. The adapter comprises a base material that comprises a first side and a second side. The adapter also comprises a sample accommodating volume extending between an opening in the second side of the base material and an opening in the first side of the base material.
摘要翻译：适配器将诸如全血的体液样品（包括分析物）提供给非侵入性监测器的分析器窗口。适配器包括包括第一侧和第二侧的基材。适配器还包括在基材的第二侧的开口和基材的第一侧中的开口之间延伸的样品容纳体积。

8. 发明申请

US20060235348A1 Method of extracting and analyzing the composition of bodily fluids 审中-公开
标题翻译：提取和分析体液组成的方法
公开(公告)号：US20060235348A1
公开(公告)日：2006-10-19
申请号：US11314964
申请日：2005-12-21
申请人： David Callicoat , Jennifer Gable , James Braig , Kenneth Witte , Mark Wechsler , Peng Zheng , Peter Rule , Richard Keenan , Richard King
发明人： David Callicoat , Jennifer Gable , James Braig , Kenneth Witte , Mark Wechsler , Peng Zheng , Peter Rule , Richard Keenan , Richard King
IPC分类号： A61M31/00 , A61M37/00 , A61B5/00
CPC分类号： A61B5/157 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/1411 , A61B5/1427 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61B10/0064 , A61B2560/0443 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M5/1723 , A61M5/365 , A61M5/38 , A61M2205/12 , A61M2205/3306 , A61M2230/20 , A61M2230/201 , G01N21/03 , G01N21/3577 , G01N2021/3595 , G01N2201/02 , G01N2201/061 , Y10T137/4478 , Y10T137/7722 , Y10T137/86485 , Y10T436/111666 , Y10T436/2575
摘要： A method of extracting and analyzing bodily fluids from a patient at the point of care for the patient is provided. The method comprises establishing fluid communication between an analyte detection system and a bodily fluid in the patient. A portion of the bodily fluid is drawn from the patient. The drawn portion is separated into a first component of the bodily fluid, while the analyte detection system remains in fluid communication with the patient. The analyte detection system analyzes the first component to measure a concentration of an analyte.
摘要翻译：提供了在患者护理点从患者提取和分析体液的方法。该方法包括在患者体内建立分析物检测系统和体液之间的流体连通。体液的一部分从患者身上抽出。被抽取的部分被分离成体液的第一组分，而分析物检测系统保持与患者的流体连通。分析物检测系统分析第一组分以测量分析物的浓度。

9. 发明申请

US20060189858A1 Analyte detection system for multiple analytes 有权
标题翻译：多种分析物的分析物检测系统
公开(公告)号：US20060189858A1
公开(公告)日：2006-08-24
申请号：US11314176
申请日：2005-12-21
申请人： Bernhard Sterling , James Braig , Kenneth Witte , Peter Rule , Richard Keenan , W. Hall
发明人： Bernhard Sterling , James Braig , Kenneth Witte , Peter Rule , Richard Keenan , W. Hall
IPC分类号： A61B5/00 , A61M31/00
CPC分类号： A61M5/1723 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M2205/12 , A61M2230/20 , A61M2230/201 , G01N1/14 , G01N21/05 , G01N21/274 , G01N21/35 , G01N2021/0346
摘要： An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient; and a pump unit in operative engagement with the fluid handling network. The pump unit has an infusion mode in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus further comprises a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample. In one implementation, the pump unit comprises a first pump operable in the infusion mode but not in the sample draw mode, and a second pump operable in the sample draw mode but not in the infusion mode.
摘要翻译：一种用于分析体液组成的装置。该装置包括流体处理网络，其包括被配置为保持患者体内与体液的流体连通的患者端; 以及与所述流体处理网络操作地接合的泵单元。泵单元具有输注模式，其中泵单元可操作以通过患者端向患者输送输注流体，以及抽样模式，其中泵单元可操作以从患者抽取体液样本，通过病人结束所述设备还包括定位成分析样品的至少一部分的光谱分析仪; 与光谱分析仪通信或并入其中的处理器; 以及可由处理器执行的存储的程序指令，以获得样本的两个或多个属性的测量。在一个实施方案中，泵单元包括可在输液模式中操作但不在样品抽取模式中的第一泵，以及可在样品抽取模式中操作但不在输注模式中的第二泵。

10. 发明申请

US20070060872A1 Apparatus and methods for analyzing body fluid samples 审中-公开
公开(公告)号：US20070060872A1
公开(公告)日：2007-03-15
申请号：US11352956
申请日：2006-02-13
申请人： W. Hall , David Callicoat , Jennifer Gable , James Braig , Kenneth Witte , Mark Wechsler , Peter Rule , Richard Keenan
发明人： W. Hall , David Callicoat , Jennifer Gable , James Braig , Kenneth Witte , Mark Wechsler , Peter Rule , Richard Keenan
IPC分类号： A61M31/00 , A61B5/00 , A61D5/00
CPC分类号： A61B5/14546 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M2230/20
摘要： An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient. The apparatus comprises an infusion line and a catheter configured for insertion into a blood vessel of the patient, and a reversible infusion pump connected between a source of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The sample cell is substantially transmissive to light comprising a wavelength λ. The apparatus further comprises a controller that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The body fluid sample drawn from the patient is disposed such that a first portion of the body fluid sample is in sensing contact with the first sensor of the body fluid sensor assembly, and a second portion of the body fluid sample is disposed within the sample cell of the body fluid sensor assembly. The controller further is configured to monitor the signal provided by the first sensor of the body fluid sensor assembly and to detect a change in the signal indicative of the arrival of the body fluid sample at the first sensor. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction. The signal produced by the first sensor provides an indication of a predetermined parameter of the patient's body fluid when the body fluid sample is in sensing contact with the first sensor.

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