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1. 发明申请

US20070136002A1 Method and system for synchronizing protein information of PPI network DB 审中-公开
标题翻译： PPI网络数据库的蛋白质信息同步方法和系统
公开(公告)号：US20070136002A1
公开(公告)日：2007-06-14
申请号：US11635579
申请日：2006-12-08
申请人： Jae Choi , Jong Park , Myung Lim , Seon Park
发明人： Jae Choi , Jong Park , Myung Lim , Seon Park
IPC分类号： G06F19/00
CPC分类号： G16B50/00 , G16B20/00
摘要： A method and system for keeping a protein-protein interaction (PPI) network database (DB) up-to-date by synchronizing protein information present in the PPI network DB with protein information present in a public DB which is frequently updated and is provided to the public are provided. The method of synchronizing protein information of a protein-protein interaction (PPI) network database (DB) includes: (a) choosing a protein from a PPI network DB which stores a plurality of pieces of PPI information; (b) receiving up-to-date protein information corresponding to the chosen protein from a global protein DB which stores a plurality of pieces of up-to-date protein information that can be provided to the public, and keeping the local protein DB up-to-date by performing a global synchronization operation on a local protein DB such that protein information which corresponds to the chosen protein and is present in the local protein DB can be updated with the received up-to-date protein information, the local protein DB storing a plurality of pieces of protein information corresponding to the PPI network DB; and (c) receiving updated protein information obtained through the global synchronization operation from the local protein DB, and keeping the PPI network up-to-date by performing a local synchronization operation on the PPI network DB such that protein information which corresponds to the chosen protein and is present in the PPI network DB can be updated with the received updated protein information.
摘要翻译：通过将PPI网络DB中存在的蛋白质信息与存在于公共DB中的蛋白质信息同步来保持蛋白质 - 蛋白质相互作用（PPI）网络数据库（DB）的最新方法和系统，所述蛋白质信息经常被更新并提供给公众提供。蛋白质 - 蛋白质相互作用（PPI）网络数据库（DB）的同步蛋白质信息的方法包括：（a）从存储多条PPI信息的PPI网络DB中选择蛋白质; （b）从全球蛋白质DB接收对应于所选择的蛋白质的最新蛋白质信息，其存储可以提供给公众的多条最新蛋白质信息，并保持局部蛋白质DB向上通过对局部蛋白质DB进行全局同步操作，使得可以用接收到的最新蛋白质信息来更新对应于所选蛋白质并存在于局部蛋白质DB中的蛋白质信息，局部蛋白质 DB存储对应于PPI网络DB的多条蛋白质信息; 和（c）从本地蛋白质DB接收通过全局同步操作获得的更新的蛋白质信息，并且通过对PPI网络DB执行本地同步操作来保持PPI网络是最新的，使得与所选择的蛋白质信息相对应的蛋白质信息蛋白质并存在于PPI网络DB中，可以用接收到的更新的蛋白质信息进行更新。

2. 发明申请

US20070136003A1 Method and system of verifying protein-protein interaction using protein homology relationship 审中-公开
标题翻译：使用蛋白质同源关系验证蛋白质 - 蛋白质相互作用的方法和系统
公开(公告)号：US20070136003A1
公开(公告)日：2007-06-14
申请号：US11635581
申请日：2006-12-08
申请人： Jae Choi , Jong Park , Seon Park
发明人： Jae Choi , Jong Park , Seon Park
IPC分类号： G06F19/00
CPC分类号： G16B20/00 , G16B30/00
摘要： Provided are a method and system for verifying a protein-protein interaction of a species by using a homology relationship between proteins of the species and proteins of other species. The method includes generating one or more protein homology relationships between source proteins of a species and heterogeneous proteins of one or more other species, generating one or more heterogeneous protein interactions corresponding to a specific source protein interaction using the generated one or more protein homology relationships, and determining whether the generated one or more heterogeneous protein interactions are present between the heterogeneous proteins of one or more species. Accordingly, a protein-protein interaction of a specific high-rank organism can be automatically verified by using protein-protein interactions of a low-rank organism that can be easily determined at low costs, without an expensive biological experiment.
摘要翻译：提供了一种通过使用物种的蛋白质和其他物种的蛋白质之间的同源性关系来验证物种的蛋白质 - 蛋白质相互作用的方法和系统。该方法包括在物种的源蛋白质和一种或多种其他物种的异质蛋白质之间产生一种或多种蛋白质同源性关系，使用所产生的一种或多种蛋白质同源性关系产生对应于特定来源蛋白质相互作用的一种或多种异质蛋白质相互作用，以及确定所产生的一种或多种异质蛋白质相互作用是否存在于一种或多种物质的异质蛋白质之间。因此，通过使用可以以低成本容易地测定的低等级生物体的蛋白质 - 蛋白质相互作用，可以自动验证特定高级生物体的蛋白质 - 蛋白质相互作用，而无需昂贵的生物实验。

3. 发明申请

US20060147999A1 Method and apparatus for homology-based complex detection in a protein-protein interaction network 审中-公开
标题翻译：蛋白质 - 蛋白质相互作用网络中基于同源性复合物检测的方法和装置
公开(公告)号：US20060147999A1
公开(公告)日：2006-07-06
申请号：US11296886
申请日：2005-12-07
申请人： Jae Choi , Jong Park , Jae Jung , Seon Park
发明人： Jae Choi , Jong Park , Jae Jung , Seon Park
IPC分类号： G01N33/53 , G06F19/00
CPC分类号： G16B20/00
摘要： Provided are a method and a apparatus for detecting a protein complex using a similarity between different proteins in a protein-protein interaction network. The method includes: (a) producing a virtual complex of a specific organism by mapping proteins contained in a complex of a different organism into proteins of the specific organism using homology information between different proteins; and (b) searching for the produced virtual complex in the protein-protein interaction network of the specific organism.
摘要翻译：提供了使用蛋白质 - 蛋白质相互作用网络中的不同蛋白质之间的相似性来检测蛋白质复合物的方法和装置。该方法包括：（a）使用不同蛋白质之间的同源性信息，通过将不同生物体的复合物中包含的蛋白质映射到特定生物体的蛋白质来产生特定生物体的虚拟复合物; 和（b）搜索特定生物体的蛋白质 - 蛋白质相互作用网络中产生的虚拟复合物。

4. 发明申请

US20060136452A1 Method of generating database schema to provide integrated view of dispersed data and data integrating system 审中-公开
标题翻译：生成数据库模式以提供分散数据和数据集成系统的集成视图的方法
公开(公告)号：US20060136452A1
公开(公告)日：2006-06-22
申请号：US11184623
申请日：2005-07-19
申请人： Myung Lim , Myung Chung , Myung Bae , Seon Park
发明人： Myung Lim , Myung Chung , Myung Bae , Seon Park
IPC分类号： G06F17/00
CPC分类号： G06F16/84 , G06F16/211
摘要： A method for generating a database schema in order to generate an integrated view capable of obtaining desired data from data resources dispersed and stored in different formats in different locations, and an data integrating system are provided. The method includes rules for parsing the structure and contents of an database described in a specification language, generating a schema semantically corresponding to the database, and defining data items required for generating an integrated view. Also, in order to generate a global schema expressing an integrated view, part of XQuery grammar is introduced for local schemas expressing a single database, and a definition of standard expression for expressing a data view is included. Accordingly, an data integrating system can generate an integrated view for a variety of heterogeneous databases dispersed on a network by using a specification language, and post a query in real time.
摘要翻译：一种用于生成数据库模式的方法，以便产生能够从不同位置以不同格式分散和存储的数据资源获得所需数据的集成视图，以及数据集成系统。该方法包括用于解析在规范语言中描述的数据库的结构和内容的规则，生成与数据库对应的语义模式，以及定义生成集成视图所需的数据项。此外，为了生成表达集成视图的全局模式，引入了表示单个数据库的本地模式的XQuery语法的一部分，并且包括用于表达数据视图的标准表达式的定义。因此，数据集成系统可以通过使用规范语言生成分散在网络上的各种异构数据库的集成视图，并实时发布查询。

5. 发明申请

US20070150458A1 System for extending data query using ontology, and method therefor 审中-公开
标题翻译：使用本体扩展数据查询的系统及其方法
公开(公告)号：US20070150458A1
公开(公告)日：2007-06-28
申请号：US11635446
申请日：2006-12-07
申请人： Myung Chung , Myung Lim , Myung Bae , Seon Park
发明人： Myung Chung , Myung Lim , Myung Bae , Seon Park
IPC分类号： G06F17/30
CPC分类号： H04N21/438 , G06F16/24526 , G06F16/25 , H04N5/44543 , H04N5/50 , H04N21/4345 , H04N21/482 , H04N21/485
摘要： Provided are an information query extension system and method, and more particularly, a method for efficiently managing heterogeneous data using a defined specification language to represent information distributed on the Internet, and extending a conceptual query which is a criteria for integration for a specific purpose.
摘要翻译：提供了一种信息查询扩展系统和方法，更具体地，涉及一种使用定义的规范语言有效地管理异构数据以表示分布在因特网上的信息的方法，并且扩展作为用于特定目的的集成标准的概念查询。

6. 发明申请

US20050137808A1 Method for conceptualizing protein interaction networks using gene ontology 审中-公开
标题翻译：使用基因本体概念化蛋白质相互作用网络的方法
公开(公告)号：US20050137808A1
公开(公告)日：2005-06-23
申请号：US10971872
申请日：2004-10-22
申请人： Jae Choi , Seon Park
发明人： Jae Choi , Seon Park
IPC分类号： G01N33/68 , G06F19/00 , G01N33/48 , G01N33/50
CPC分类号： G16B5/00 , G16B20/00 , G16B45/00 , G16B50/00
摘要： Provided is a method for conceptualizing protein interaction networks. The method conceptualizes and simplifies complicated and enormous protein interaction networks wherein the method comprises the steps of (a) conceptualizing protein nodes that form the protein interaction network as gene ontology concepts to reconfigure the network; (b) integrating nodes including the same concepts in the reconfigured network into one node to generate the network by means of exact match; and (c) integrating several nodes having similar concepts in the generated network into one node to reconfigure the generated network by means of approximate match.
摘要翻译：提供了一种用于概念化蛋白质相互作用网络的方法。该方法概念化并简化了复杂和巨大的蛋白质相互作用网络，其中该方法包括以下步骤：（a）将构成蛋白质相互作用网络的蛋白质节点概念化为基因本体概念以重新配置网络; （b）将包括相同概念的节点在重新配置的网络中集成到一个节点中，以通过精确匹配来生成网络; 以及（c）将具有类似概念的几个节点集成到一个节点中，以通过近似匹配来重构所生成的网络。

7. 发明申请

US20060221550A1 Method for manufacturing dielectric ceramic powder, and multilayer ceramic capacitor obtained by using the ceramic powder 审中-公开
标题翻译：制造电介质陶瓷粉末的方法和使用陶瓷粉末得到的多层陶瓷电容器
公开(公告)号：US20060221550A1
公开(公告)日：2006-10-05
申请号：US11353120
申请日：2006-02-14
申请人： Sung Ryu , Seon Park , Sang Lee , Dong Sinn , Sang Lee , Dang Yoon
发明人： Sung Ryu , Seon Park , Sang Lee , Dong Sinn , Sang Lee , Dang Yoon
IPC分类号： H01G4/06
CPC分类号： C04B35/4682 , B82Y30/00 , C01G23/006 , C01P2004/04 , C01P2004/62 , C01P2004/64 , C01P2006/12 , C04B35/6261 , C04B35/62625 , C04B35/62675 , C04B2235/3208 , C04B2235/3215 , C04B2235/3225 , C04B2235/3239 , C04B2235/3263 , C04B2235/528 , C04B2235/5409 , C04B2235/5436 , C04B2235/5463 , C04B2235/761 , C04B2235/765 , H01G4/1227
摘要： The invention relates to a method for manufacturing dielectric ceramic powder and a multilayer ceramic capacitor using the ceramic powder. According to the invention, BaCO3 powder is dispersed into a solution of solvent and dispersant to prepare BaCO3 slurry and then the resultant BaCO3 slurry is wet-milled. Also, TiO2 powder slurry is mixed into the wet-milled BaCO3 slurry to form mixed slurry and then the mixed slurry is dried into mixed powder. Finally, the dried mixed powder is calcined to produce BaTiO3 powder.
摘要翻译：本发明涉及使用陶瓷粉末制造电介质陶瓷粉末的方法和多层陶瓷电容器。根据本发明，将BaCO 3粉末分散在溶剂和分散剂的溶液中以制备BaCO 3浆料，然后将所得的BaCO 3浆料被湿磨。此外，将TiO 2粉末浆料混合到湿磨的BaCO 3浆料中以形成混合的浆料，然后将混合的浆料干燥成混合粉末。最后，将干燥的混合粉末煅烧以制备BaTiO 3 N 3粉末。

8. 发明申请

US20060136147A1 Biological relationship event extraction system and method for processing biological information 审中-公开
标题翻译：生物关系事件提取系统和处理生物信息的方法
公开(公告)号：US20060136147A1
公开(公告)日：2006-06-22
申请号：US11304030
申请日：2005-12-15
申请人： Hyun-Chul Jang , Hyun-Sook Lee , Jae-Soo Lim , Soo-Jun Park , Seon Park
发明人： Hyun-Chul Jang , Hyun-Sook Lee , Jae-Soo Lim , Soo-Jun Park , Seon Park
IPC分类号： G01N33/48
CPC分类号： G16B50/00
摘要： A biological relationship extraction system including a biological named entity substitution unit substituting a biological named entity in a biological document with a predetermined substitution name; a structure analyzing unit parsing the biological named entity in the biological document containing the substituted biological named entity; a relationship analyzing unit analyzing a relationship between biological named entities from the biological literature parsed by the structure analyzing unit and selecting relationship candidates; a relationship determining unit determining whether the relationship candidates delivered from the relationship analyzing unit are biologically meaningful and determining a relationship between biological named entities; and a biological named entity assignment storage unit storing the biological named entity and a substitution name corresponding to the biological named entity and providing a substitution name or a biological named entity.
摘要翻译：一种生物关系提取系统，其包括用具有预定取代名称的生物文献中的生物命名实体取代生物命名实体取代单元; 解析包含取代的生物命名实体的生物文件中的生物命名实体的结构分析单元; 关系分析单元，从结构分析单元解析的生物学文献中分析生物命名实体之间的关系，并选择关系候选; 关系确定单元，确定从关系分析单元传递的关系候选是否具有生物学意义，并确定生物命名实体之间的关系; 以及生物命名实体分配存储单元，其存储生物命名实体和与生物命名实体相对应的替代名称，并提供替代名称或生物命名实体。

9. 发明申请

US20070134756A1 Method and system of verifying protein-protein interaction using text mining 审中-公开
标题翻译：使用文本挖掘验证蛋白质 - 蛋白质相互作用的方法和系统
公开(公告)号：US20070134756A1
公开(公告)日：2007-06-14
申请号：US11601620
申请日：2006-11-20
申请人： Jae Lim , Hyun Jang , Joon Lim , Soo Park , Seon Park
发明人： Jae Lim , Hyun Jang , Joon Lim , Soo Park , Seon Park
IPC分类号： G06F19/00 , C12Q1/37
CPC分类号： G01N33/6845
摘要： Provided are a method and system for verifying a protein-protein interaction according to a text mining method. The method includes extracting protein-protein interaction information from protein-related documents searched for from a bio-information document database, according to a text mining method, mapping the protein-protein interaction information to corresponding ontology identifications, and filtering the mapped protein-protein interaction information according to a frequency of the information and an impact factor of a corresponding protein-related document in order to obtain highly-weighted information.
摘要翻译：提供了一种根据文本挖掘方法验证蛋白质 - 蛋白质相互作用的方法和系统。该方法包括从生物信息文献数据库中搜索的蛋白质相关文献中提取蛋白质 - 蛋白质相互作用信息，根据文本挖掘方法，将蛋白质 - 蛋白质相互作用信息映射到相应的本体标识，并过滤映射的蛋白质 - 蛋白质根据信息的频率和相应的蛋白质相关文献的影响因子的交互信息，以获得高度加权的信息。

10. 发明申请

US20070134705A1 Method and apparatus for predicting regulation of multiple transcription factors 审中-公开
标题翻译：用于预测多种转录因子调节的方法和装置
公开(公告)号：US20070134705A1
公开(公告)日：2007-06-14
申请号：US11634922
申请日：2006-12-07
申请人： Ho Jung , Ji Kim , Seon Park
发明人： Ho Jung , Ji Kim , Seon Park
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G16B25/00 , G16B40/00 , G16B45/00
摘要： Provided are a method and apparatus for predicting a regulation of multiple transcription factors which can predict a regulation correlation between the multiple transcription factors and a target gene, wherein the regulation correlation is used in a method of manipulating a gene inside an actual cell. The method includes: separating gene expression profile data into expression profile data of a gene which expresses a transcription factor and an expression profile data of a target gene; clustering all pairs which can be combined, one pair including one transcription factor and one target gene; showing a result of the clustering using an interval graph; and calculating a optimum subset of the transcription factors, which occupies the maximum expression section of the target gene with the minimum number of transcription factors.
摘要翻译：提供了一种用于预测可以预测多种转录因子与靶基因之间的调节相关性的多种转录因子的调节的方法和装置，其中所述调节相关性用于操纵实际细胞内的基因的方法。该方法包括：将基因表达谱数据分离为表达转录因子的基因和靶基因的表达谱数据的表达谱数据; 聚合可以组合的所有对，一对包括一个转录因子和一个靶基因; 使用间隔图显示聚类的结果; 并计算转录因子的最佳子集，其以最少数量的转录因子占据靶基因的最大表达部分。

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