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    • 1. 发明授权
    • Substituted lactones of amino acids
    • 取代的氨基酸内酯
    • US4513139A
    • 1985-04-23
    • US393812
    • 1982-06-30
    • Jacques MartelJean TessierAndre Teche
    • Jacques MartelJean TessierAndre Teche
    • C07D307/33C07D207/16C07D307/93C07D405/04
    • C07D207/16
    • Novel substituted lactones of amino acids in all their possible stereoisomeric forms or mixtures thereof of the formula ##STR1## wherein A is a hydrocarbon chain of 1 to 10 chain members containing one or more heteroatoms and one or more unsaturations and the chain members being a mono- or polycyclic system or comprises a system of spiro or endo type and may contain one or more chiral atoms or the lactone copula can present a supplementary chirality due to the asymetric spatial configuration of the molecule make up and R is selected from the group consisting of ##STR2## wherein Z is the organic remainder of an amino acid of the formula ##STR3## Y is derived from a primary, secondary or tertiary alcohol of the formula Y--OH and B is the remainder of a heterocyclic amino acid of 3 to 6 carbon atoms of the formula ##STR4## and their preparation and their use for the resolution of amino acids.
    • 新颖的氨基酸的取代的内酯以其所有可能的立体异构体形式或其混合物,其中A为具有1至10个含有一个或多个杂原子和一个或多个不饱和基团的链成员的烃链,链成员为 单环或多环系统或包含螺或内型的系统,并且可以含有一个或多个手性原子,或由于分子组成的不对称空间构型,内酯共聚物可呈现辅助手性,并且R选自 其中Z是下式的氨基酸的有机剩余部分:III1衍生自式Y-OH的伯,仲或叔醇,B是杂环氨基酸的剩余部分3 至6个碳原子,它们的制备及其用于分解氨基酸的用途。
    • 2. 发明授权
    • Substituted pyridine methyl esters of dimethyl cyclopropane carboxylic
acids and their use as insecticides
    • 二甲基环丙烷羧酸的取代吡啶甲酯及其作为杀虫剂的用途
    • US4357335A
    • 1982-11-02
    • US280547
    • 1981-07-06
    • Jacques MartelJean TessierAndre TecheJean-Pierre Demoute
    • Jacques MartelJean TessierAndre TecheJean-Pierre Demoute
    • A01N53/04A01N53/00A01N53/08A61K31/44C07D213/64C07D213/643C07D213/647C07D213/70C07D405/12C07D409/12C07D213/55
    • C07D213/643A01N53/00A61K31/44C07D213/647C07D213/70
    • Novel esters in all possible isomeric forms and mixtures thereof of the formula ##STR1## wherein A is selected from the group consisting of ##STR2## R is selected from the group consisting of hydrogen, --CN and --C.tbd.CH, Y is selected from the group consisting of oxygen and sulfur, Z is selected from the group consisting of alkyl and alkoxy of 1 to 4 carbon atoms, alkylthio and alkylsulfonyl of 1 to 4 carbon atoms, cycloalkyl of 3 to 4 carbon atoms, 3,4-methylenedioxy, chlorine, fluorine and bromine, n is an integer of 0, 1 or 2, Z.sub.1 and Z.sub.2 may both be methyl or Z.sub.1 is hydrogen and Z.sub.2 is ##STR3## R.sub.3 is selected from the group consisting of hydrogen and halogen, R.sub.1 and R.sub.2 are individually alkyl of 1 to 8 carbon atoms or taken together with the carbon they are attached to form cycloalkyl of 3 to 6 carbon atoms or ##STR4## X is selected from the group consisting of oxygen and sulfur, T is at least one member of the group consisting of halogen, alkyl of 1 to 8 carbon atoms, alkoxy of 1 to 8 carbon atoms optionally substituted with at least one halogen and --CF.sub.3 and m is an integer from 0, 1 or 2 having insecticidal activity as well as nematocidal and acaricidal activity.
    • 所有可能的异构体形式的新型酯及其下式的混合物,其中A选自由下列组成的组:R 1选自氢,-CN和-C 3位CH,Y选自 Z为选自由1至4个碳原子的烷基和烷氧基组成的组,1至4个碳原子的烷硫基和烷基磺酰基,3至4个碳原子的环烷基,3,4-亚甲二氧基 ,氯,氟和溴,n是0,1或2的整数,Z1和Z2都可以是甲基或Z1是氢,Z2是选自氢和卤素,R1和R2 具有1至8个碳原子的单独烷基或与它们所连接的碳一起形成3至6个碳原子的环烷基,或者X选自氧和硫,T是至少一个 由卤素,1至8个碳原子的烷基,1至8个的烷氧基组成的组 任选被至少一个卤素和-CF 3取代的碳原子,m是具有杀虫活性以及杀线虫和杀螨活性的0,1或2的整数。
    • 4. 发明授权
    • Process for resolving amino acids using substituted lactones
    • 使用取代的内酯拆分氨基酸的方法
    • US5136050A
    • 1992-08-04
    • US154799
    • 1988-02-11
    • Jacques MartelJean TessierAndre Teche
    • Jacques MartelJean TessierAndre Teche
    • C07D207/16
    • C07D207/16
    • Novel substituted lactones of amino acids in all their possible stereoisomeric forms or mixtures thereof of the formula ##STR1## wherein A is a hydrocarbon chain of 1 to 10 chain members containing one or more heteroatoms and one or more unsaturations and the chain members being a mono- or polycyclic system or comprises a system of spiro or endo type and may contain one or more chiral atoms or the lactone copula can present a supplementary chirality due to the asymetric spatial configuration of the molecule make up and R is selected from the group consisting of ##STR2## wherein Z is the organic remainder of an amino acid of the formula ##STR3## Y is derived from a primary, secondary or tertiary alcohol of the formula Y-OH and B is the remainder of a heterocycle amino acid of 3 to 6 carbon atoms of the formula ##STR4## and their preparation and their use for the resolution of amino acids.
    • 新颖的氨基酸的取代的内酯以其所有可能的立体异构体形式或其混合物,其中A为具有1至10个含有一个或多个杂原子和一个或多个不饱和基团的链成员的烃链,链成员为 单环或多环系统或包含螺或内型的系统,并且可以含有一个或多个手性原子,或由于分子组成的不对称空间构型,内酯共聚物可呈现辅助手性,并且R选自 其中Z是下式的氨基酸的有机剩余部分III1衍生自式Y-OH的伯,仲或叔醇,B是 其余的具有式(III)III2的3至6个碳原子的杂环氨基酸及其制备及其在分解氨基酸中的用途。
    • 5. 发明授权
    • Certain cyclopropanedicarboxylates with an unsaturated side chain having
insecticidal activity
    • US4883806A
    • 1989-11-28
    • US100284
    • 1987-09-23
    • Jacques MartelJean TessierAndre Teche
    • Jacques MartelJean TessierAndre Teche
    • A01N53/00A23K1/16A61K31/22C07D209/48C07D213/64C07D213/647C07D233/72C07D307/20C07D307/45C07D309/12
    • C07D213/647A01N53/00A23K20/105A23K20/111A23K20/132A61K31/22C07D209/48C07D233/72C07D307/20C07D307/42C07D309/12
    • Novel isomers and mixtures thereof of cyclopropane carboxylic acid derivatives with a 3-unsaturated side chain of the formula ##STR1## wherein A' is selected from the group consisting of (1) alkyl of 1 to 18 carbon atoms, (2) benzyl optionally substituted with at least one member of the group consisting of alkyl of 1 to 4 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkenyloxy of 2 to 6 carbon atoms, alkadienyl of 4 to 8 carbon atoms, methylenedioxy or halogen, ##STR2## wherein R.sub.1 is selected from the group consisting of hydrogen and methyl and R.sub.2 is selected from the group consisting of --CH.sub.2 --C.tbd.CH and monocyclic aryl, ##STR3## wherein a is selected from the group consisting of hydrogen and methyl and R.sub.3 is an aliphatic group of 2 to 6 carbon atoms containing at least one carbon-carbon unsaturation ##STR4## wherein a and and R.sub.3 have the above definition and R.sub.1 ' and R.sub.2 ' are individually selected from the group consisting of hydrogen, halogen, alkyl of 1 to 6 carbon atoms, aryl of 6 to 10 carbon atoms, cyano and alkoxy carbonyl of 2 to 5 carbon atoms, (6) ##STR5## wherein B is selected from the group consisting of ##STR6## --O-- and --S--, R.sub.4 is selected from the group consisting of hydrogen, --CH.sub.3, --C.tbd.N--CONH.sub.2, --CSNH.sub.2 and --C.tbd.CH, n is an integer form 0, 1 or 2 and R.sub.5 is selected from the group consisting of halogen and --CH.sub.3 ##STR7## wherein R.sub.6, R.sub.7 , R.sub.8 and R.sub.9 are selected from the group consisting of hydrogen, chlorine and methyl and S/I symbolizes an aromatic ring or dihydro or tetrahydro ring, ##STR8## wherein R.sub.10 is selected from the group consisting of hydrogen and --CN, R.sub.12 is selected from the group consisting of --CH.sub.2 -- and --O-- and R.sub.11 is selected from the group consisting of thiazolyl and thiadiazolyl with the bond the bond to ##STR9## being in anyone of the positions, R.sub.12 being bonded to R.sub.11 by the carbon atom included between a sulfur atom and a nitrogen atom, ##STR10## wherein R.sub.13 is selected from the group consisting of hydrogen and --CN ##STR11## wherein R.sub.13 has the above definition and the benzoyl is in the 3- or 4-position; ##STR12## wherein R.sub.14 is; selected from the group consisting of hydrogen, methyl, ethynyl and --CN and R.sub.15 and R.sub.16 are individually selected from the group consisting of hydrogen, bromine and fluorine and ##STR13## wherein R.sub.14 has the above definition, p is 0, 1 or 2, each R.sub.17 is selected from the group consisting of alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio of 1 to 4 carbon atoms, alkylsulfonyl of 1 to 4 carbon atoms, --CF.sub.3 3,4-methylenedioxy, chlorine, bromine and fluorine, B is selected from the group consisting of --O-- and --S-- and R is selected from the group consisting of alkyl of 1 to 18 carbon atoms substituted with one or more, optionally different functional groups, aryl of 6 to 14 carbon atoms optionally substituted with one or more optionally different functional groups, the double bond having Z or E geometry having insecticidal and nematocidal activity as well as plant and animal acaricidal activity and their preparation.
    • 10. 发明授权
    • Cyclopropane carboxylic esters and acids
    • 环丙烷羧酸酯和酸
    • US4808749A
    • 1989-02-28
    • US932179
    • 1986-11-18
    • Jacques MartelJean TessierAndre Teche
    • Jacques MartelJean TessierAndre Teche
    • A01N53/00A01N53/02A23K1/16A61K31/22A61K31/225C07D213/64C07D213/647C07D233/74C07F9/40C07C121/46C07C53/134
    • C07D213/647A01N53/00A23K20/105A23K20/111A61K31/22A61K31/225C07D233/74C07F9/4006
    • Novel esters in all possible isomeric forms of the formula ##STR1## wherein R is selected from the group consisting of (a) optionally unsaturated alkyl of 1 to 8 carbon atoms and optionally unsaturated cycloalkyl or cycloalkyl-alkyl of 3 to 8 carbon atoms optionally substituted with at least one member of the group consisting of halogen, --OH, --SH, --OR', --SR', --NO.sub.2, ##STR2## --CN, --SO.sub.3 H, --PO.sub.4 H.sub.2, ##STR3## --SO.sub.2 AlK.sub.2, --SO.sub.3 AlK.sub.3, aryl optionally substituted with at least one member of the group consisting of --OH, alkoxy of 1 to 8 carbon atoms, alkyl of 1 to 8 carbon atoms, halogen, --CF.sub.3, --OCF.sub.3, --SCF.sub.3 and ##STR4## R' is alkyl of 1 to 8 carbon atoms, R" and R"' are individually selected from the group consisting of hydrogen and alkyl of 1 to 8 carbon atoms, AlK.sub.1, AlK.sub.2 and AlK.sub.3 are individually alkyl of 1 to 18 carbon atoms, (b) aryl of 6 to 14 carbon atoms optionally substituted with at least one substitutent selected from the group consisting of --OH, alkoxy of 1 to 8 carbon atoms, alkyl of 1 to 8 carbon atoms, halogen, --OCF.sub.3, --CF.sub.3 and --SCF.sub.3 and (c) heterocycle optionally substituted with at least one member of the group consisting of --OH, alkoxy of 1 to 8 carbon atoms, alkyl of 1 to 8 carbon atoms, halogen, --CF.sub.3, --OCF.sub.3 and --SCF.sub.3, B is selected from the group consisting of optionally unsaturated alkyl of 1 to 18 carbon atoms, optionally unsaturated cycloalkyl of 3 to 18 carbon atoms and the remainder of an alcohol used in synthesis of pyrethrinoid esters, X is halogen and the ethylenic double bond may have Z or E geometry having parasitic activity, especially insecticidal acaricidal and nematocidal activity.
    • 式(Ⅰ)的所有可能异构体形式的新型酯,其中R选自(a)1-8个碳原子的任选不饱和烷基和任选不饱和的环烷基或3-8个碳原子的环烷基 - 烷基, 被至少一个由卤素,-OH,-SH,-OR',-SR',-NO 2,-CN,-SO 3 H,-PO 4 H 2,-SO 2 AlK 2,-SO 3 AlK 3 任选被-OH,1-8个碳原子的烷氧基,1-8个碳原子的烷基,卤素,-CF 3,-OCF 3,-SCF 3和R'中的至少一个成员取代的芳基是 1至8个碳原子的烷基,R“和R”'分别选自氢和1至8个碳原子的烷基,AlK1,AlK2和AlK3分别为1至18个碳原子的烷基( b)6至14个碳原子的芳基,任选被至少一个选自-OH,1至8个碳原子的烷氧基,1〜 8个碳原子,卤素,-OCF 3,-CF 3和-SCF 3和(c)任选被至少一个选自-OH,1-8个碳原子的烷氧基,1至8个碳原子的烷基取代的杂环, 卤素,-CF 3,-OCF 3和-SCF 3,B选自任选不饱和的1至18个碳原子的烷基,任选地具有3至18个碳原子的不饱和环烷基,剩余的用于合成除虫菊酯的醇 X是卤素,烯键式双键可具有具有寄生活性的Z或E几何形状,特别是杀虫杀螨和杀线虫活性。