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1. 发明授权

US5601079A Non-invasive quantification of glucose control, aging, and advanced maillard products by stimulated fluorescence 失效
标题翻译：通过刺激荧光对葡萄糖控制，衰老和晚期美拉德产品进行非侵入性定量
公开(公告)号：US5601079A
公开(公告)日：1997-02-11
申请号：US307125
申请日：1994-09-16
申请人： Jacob Y. Wong , Bent Formby , Charles M. Peterson
发明人： Jacob Y. Wong , Bent Formby , Charles M. Peterson
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455 , A61B5/1495 , G01N21/27 , A61B6/00
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/6826
摘要： An apparatus for measuring the concentration of selected solute in a solution. This apparatus is particulary suitable for measuring the concentration of blood components, such as blood late Maillard products. A beam of exposing light is imaged through a wall of a containment vessel onto a region of the sample adjacent to this wall to induce from said selected solute emission of light that includes at least one emission peak that can be used to calculate the concentration of this solute. At least one detector is positioned to maximize the strength of detected signal, if other components of this solution strongly absorb the emitted light. The exposing light is directed such that the detected signal is maximized as a function of the path of this exposing light. A particular embodiment is a low-cost, non-invasive blood Maillard products concentration detector. In this embodiment, the containment vessel is preferably one of the patient's fingers. At least two additional detected signals are monitored and processed at wavenumbers suitable for eliminating temperatures and pressure effects on the calculated blood glucose levels.
摘要翻译：一种用于测量溶液中所选溶质浓度的装置。该装置特别适用于测量血液成分的浓度，如血后期美拉德产品。将曝光光束通过容纳容器的壁成像到与该壁相邻的样品的区域上，以诱导所述选定的溶质发射光，其包括至少一个可用于计算该浓度的发射峰溶质。如果该解决方案的其他组件强烈地吸收发射的光，则至少设置一个检测器以使检测到的信号的强度最大化。引导曝光光使得检测到的信号被最大化为该曝光光的路径的函数。一个特定的实施方案是低成本，无创血液美拉德产品浓度检测器。在该实施例中，容纳容器优选为患者手指之一。在适于消除对计算出的血糖水平的温度和压力影响的波数下监测和处理至少两个附加的检测信号。

2. 发明授权

US5370114A Non-invasive blood chemistry measurement by stimulated infrared relaxation emission 失效
标题翻译：通过受刺激的红外弛豫发射进行非侵入性血液化学测量
公开(公告)号：US5370114A
公开(公告)日：1994-12-06
申请号：US852085
申请日：1992-03-12
申请人： Jacob Y. Wong , Bent Formby , Charles M. Peterson
发明人： Jacob Y. Wong , Bent Formby , Charles M. Peterson
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455 , A61B5/1495 , G01N21/27 , A61B6/00
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/6826
摘要： An apparatus for measuring the concentration of a selected solute in a solution. This apparatus is particularly suitable for measuring the concentration of blood components, such as blood glucose. A beam of exposing light is imaged through a wall of a containment vessel onto a region of the sample adjacent to this wall to induce from said selected solute emission of light that includes at least one emission peak that can be used to calculate the concentration of this solute. At least one detector is positioned to maximize the strength of detected signal, if other components of this solution strongly absorb the emitted light. The exposing light is directed such that the detected signal is maximized as a function of the path of this exposing light. A particular embodiment is a non-invasive blood glucose tester that can be used painlessly by diabetics to monitor their blood glucose levels. In this embodiment, the containment vessel is preferably one of the patient's fingers. At least two additional detected signals are monitored and processed at wavenumbers suitable for eliminating temperature and pressure effects on the calculated blood glucose levels.
摘要翻译：一种用于测量溶液中选定溶质的浓度的装置。该装置特别适用于测定血液成分浓度，例如血糖。将曝光光束通过容纳容器的壁成像到与该壁相邻的样品的区域上，以诱导所述选定的溶质发射光，其包括至少一个可用于计算该浓度的发射峰溶质。如果该解决方案的其他组件强烈地吸收发射的光，则至少设置一个检测器以使检测到的信号的强度最大化。引导曝光光使得检测到的信号被最大化为该曝光光的路径的函数。一个特定的实施方案是可以由糖尿病患者无痛地用于监测其血糖水平的非侵入性血糖测试仪。在该实施例中，容纳容器优选为患者手指之一。在适于消除对计算出的血糖水平的温度和压力影响的波数处监测和处理至少两个额外的检测信号。

3. 发明授权

US06389306B1 Method for determining lipid and protein content of tissue 失效
标题翻译：确定组织脂质和蛋白质含量的方法
公开(公告)号：US06389306B1
公开(公告)日：2002-05-14
申请号：US09420867
申请日：1999-10-19
申请人： Joseph Chaiken , Charles M. Peterson
发明人： Joseph Chaiken , Charles M. Peterson
IPC分类号： A61B600
CPC分类号： A61B5/6826 , A61B5/0053 , A61B5/0059 , A61B5/14552 , A61B5/1491 , A61B5/6838 , A61B2562/0242 , G01N21/65
摘要： Disclosed is a method of modulating temperature of tissue in a subject to be spectroscopically probed. In a preferred embodiment, the method comprises applying a tissue modulation device of the invention to the tissue, passing current through the temperature regulating element so as to elevate or lower the temperature of the tissue, and passing electromagnetic radiation through the window of the device. Preferably, spectroscopic probing is performed when the temperature of the tissue has been elevated or lowered and when the temperature of the tissue is not elevated or lowered. The method can further comprise collecting Raman spectra emitted by the tissue. The invention also provides a method for determining phase transition, and a method for determining lipid content and identity and protein content and identity in a tissue of a subject.
摘要翻译：公开了一种调节受试者的组织的光谱探测温度的方法。在优选实施例中，该方法包括将本发明的组织调节装置应用于组织，使电流通过温度调节元件，以提升或降低组织的温度，并使电磁辐射通过该装置的窗口。优选地，当组织的温度升高或降低时以及当组织的温度不升高或降低时进行光谱探测。该方法还可以包括收集组织发射的拉曼光谱。本发明还提供了一种用于确定相变的方法，以及用于确定受试者的组织中的脂质含量和身份以及蛋白质含量和身份的方法。

4. 发明授权

US4279533A Roadway expansion joint 失效
标题翻译：巷道伸缩接头
公开(公告)号：US4279533A
公开(公告)日：1981-07-21
申请号：US122920
申请日：1980-02-20
申请人： Charles M. Peterson , Frank M. Lymburner
发明人： Charles M. Peterson , Frank M. Lymburner
IPC分类号： E01D19/06 , E01C11/06 , E01C11/12
CPC分类号： E01D19/06 , E01D19/067
摘要： A roadway sealed expansion joint between roadway sections spaced by an expansion slot, the roadway sections having recesses adjacent and extending longitudinally of the slot. A metal plate bridges the slot and is secured to the bottom of the recess in one of the sections and is movable relative to the bottom of the recess in the other of the sections. Overlying the metal plate is a unitary elastomeric slab with its upper surface aligned with the upper surfaces of the concrete sections and with its edges bonded to the sides of the recesses, this elastomeric slab having a center premolded portion of relatively high elasticity and edge portions which are molded in situ and which are of relatively low elasticity.
摘要翻译：在由扩张槽隔开的道路区段之间的道路密封的膨胀接头，所述道路段具有与所述槽的纵向相邻并延伸的凹部。金属板桥接槽，并且在其中一个部分中固定到凹部的底部，并且可以在另一个部分中相对于凹部的底部移动。金属板上面是整体的弹性体板，其上表面与混凝土部分的上表面对准，并且其边缘与凹部的侧面相结合，该弹性体板具有相对高弹性的中心预成型部分和边缘部分，原位成型并且具有相对低的弹性。

5. 发明授权

US07440044B2 Color display device and method 失效
标题翻译：彩色显示装置及方法
公开(公告)号：US07440044B2
公开(公告)日：2008-10-21
申请号：US10997994
申请日：2004-11-29
申请人： Charles M. Peterson , Gene Koch , Sanji Arisawa , Yuichi Aoki
发明人： Charles M. Peterson , Gene Koch , Sanji Arisawa , Yuichi Aoki
IPC分类号： G02F1/1335
CPC分类号： G02F1/133617 , G02F1/13362
摘要： A color display having a monochromatic light source, an optical switch and an array of pixels formed of anisotropically emitting photoluminescent material may be combined such that large losses often associated with color filter and polarizers are avoided such that a high efficient display results. The optical switch may be a liquid crystal device that is tuned to the wavelength of the monochromatic light source. The monochromatic light source may be made from OLED material that emits in the violet, near UV or blue spectrum and may be polarized. The array of pixels may include a transmissive pixel when the backlight spectrum is the same as the color of one of the pixels.
摘要翻译：可以组合具有单色光源，光开关和由各向异性发射的光致发光材料形成的像素阵列的彩色显示器，从而避免通常与滤色器和偏振器相关联的大损耗，从而导致高效显示。光开关可以是被调谐到单色光源的波长的液晶器件。单色光源可以由在紫色，接近UV或蓝色光谱中发射并且可以被极化的OLED材料制成。当背光光谱与像素之一的颜色相同时，像素阵列可以包括透射像素。

6. 发明授权

US07050842B2 Method of tissue modulation for noninvasive measurement of an analyte 失效
公开(公告)号：US07050842B2
公开(公告)日：2006-05-23
申请号：US10332748
申请日：2001-07-11
申请人： Joseph Chaiken , Karen P. Peterson , Charles M. Peterson
发明人： Joseph Chaiken , Karen P. Peterson , Charles M. Peterson
IPC分类号： A61B5/00
CPC分类号： A61B5/6826 , A61B5/0053 , A61B5/0059 , A61B5/14532 , A61B5/14552 , A61B5/6838
摘要： Disclosed are a device and methods for obtaining signals related to blood analytes and bone features by collecting spectra, such as fluorescence and Raman spectra, through the nail of a finger or toe. The invention additionally provides methods of modulating blood flow in a tissue of a subject.

7. 发明授权

US5670377A Method of diagnosing gestational diabetes 失效
标题翻译：诊断妊娠糖尿病的方法
公开(公告)号：US5670377A
公开(公告)日：1997-09-23
申请号：US615973
申请日：1996-03-14
申请人： Charles M. Peterson , Lois G. Peterson
发明人： Charles M. Peterson , Lois G. Peterson
IPC分类号： G01N33/68 , G01N33/50
CPC分类号： G01N33/689 , G01N2800/368 , Y10S436/811 , Y10T436/144444
摘要： Methods of diagnosis of gestational diabetes mellitus are disclosed. In preferred embodiments, a blood sample is obtained from a pregnant female in the 24th to 28th week of pregnancy after an overnight fast, after a 1-hour 50-gram glucose challenge test, or at the 1-hour time point during a 3-hour 100-gram oral glucose tolerance test. The concentrations of fasting plasma glucose and glycosylated plasma proteins in this blood sample are then determined. A fasting plasma glucose concentration equal to or exceeding 90 mg/dL is 100% sensitive and 64% specific in predicting glucose-related macrosomia (i.e., birth weight above 4000 grams). A glycosylated plasma protein concentration equal to or exceeding 23% is 100% sensitive and 52% specific in predicting glucose-related macrosomia. A fasting plasma protein value equal to or exceeding 90 mg/dL and a glycosylated plasma protein value equal to or exceeding 23% is 100% sensitive and 93% specific in predicting glucose-related macrosomia.
摘要翻译：公开了妊娠糖尿病诊断方法。在优选的实施方案中，在1小时的50g葡萄糖激发试验后，或在3小时的时间点，在怀孕24周至28周之后，在快速过夜之后或在1小时时间内从孕妇获得血液样品，小时100克口服葡萄糖耐量试验。然后测定该血样中空腹血浆葡萄糖和糖基化血浆蛋白的浓度。等于或超过90mg / dL的空腹血浆葡萄糖浓度在预测葡萄糖相关巨大儿病（即，出生体重在4000克以上）时是100％敏感性和64％特异性。等于或超过23％的糖基化血浆蛋白浓度对于预测葡萄糖相关巨大儿症是100％敏感性和52％特异性。等于或超过90mg / dL的空腹血浆蛋白质值和等于或超过23％的糖基化血浆蛋白质值是预测葡萄糖相关巨大儿症的100％敏感性和93％特异性。

8. 发明授权

US06880948B2 Illuminant and method 失效
公开(公告)号：US06880948B2
公开(公告)日：2005-04-19
申请号：US10319631
申请日：2002-12-16
申请人： Gene C. Koch , Charles M. Peterson
发明人： Gene C. Koch , Charles M. Peterson
IPC分类号： F21V8/00 , H01L51/52 , F21V7/04
CPC分类号： G02B6/0036 , G02B3/0068 , G02B5/003 , G02B5/0231 , G02B6/0038 , G02B6/005 , H01L51/5265
摘要： An illuminant that also functions as decorative wallpaper or as an architectural decoration is disclosed. The illuminant may include a light generation part such as an organic light emitting material, a light guide such as a tapered light guide, and a surface pattern. The light source generates the light that is guided to small opening in the surface pattern to provide illumination. The surface pattern may be formed as a decoration or subsequently processed to form the decoration.

9. 发明授权

US06377828B1 Method for non-invasive measurement of an analyte 有权
标题翻译：非侵入性测量分析物的方法
公开(公告)号：US06377828B1
公开(公告)日：2002-04-23
申请号：US09480375
申请日：2000-01-10
申请人： Joseph Chaiken , Charles M. Peterson
发明人： Joseph Chaiken , Charles M. Peterson
IPC分类号： A61B500
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14553 , G01N21/49 , G01N21/65
摘要： Disclosed is a method and apparatus for measuring an analyte in a tissue of a subject. The method comprises contacting the tissue with electromagnetic radiation having a first excitation wavelength, wherein the first excitation wavelength is substantially equal to an absorption wavelength of a temperature probe within the tissue. The temperature probe and the analyte are sufficiently proximate to one another that energy deposited into one by absorption of radiation is transferred to the other. The Raman spectra emitted by the tissue are collected and analyzed to determine a concentration of analyte present in the tissue. The analysis can comprise measuring the Raman spectra associated with the temperature probe. In addition, the method can include simultaneously contacting the tissue with electromagnetic radiation having the first excitation wavelength and with electromagnetic radiation having a second excitation wavelength, wherein the second excitation wavelength is substantially equal to an absorption wavelength of the analyte. The analysis comprises comparing the spectra emitted in response to the first excitation wavelength in the presence and in the absence of the second excitation wavelength. In another embodiment, the analysis comprises measuring the anti-Stokes component of the Raman spectra associated with the analyte. The method provides a non-invasive measurement of blood glucose, using hemoglobin as the temperature probe.
摘要翻译：公开了一种用于测量受试者的组织中的分析物的方法和装置。该方法包括使组织与具有第一激发波长的电磁辐射接触，其中第一激发波长基本上等于组织内温度探针的吸收波长。温度探针和分析物彼此足够接近，通过吸收辐射而沉积成一个的能量传递到另一个。收集和分析由组织发出的拉曼光谱，以确定存在于组织中的分析物的浓度。该分析可以包括测量与温度探针相关的拉曼光谱。此外，该方法可以包括同时使组织与具有第一激发波长的电磁辐射和具有第二激发波长的电磁辐射接触，其中第二激发波长基本上等于分析物的吸收波长。分析包括在存在和不存在第二激发波长的情况下比较响应于第一激发波长发射的光谱。在另一个实施方案中，分析包括测量与分析物相关的拉曼光谱的反斯托克斯分量。该方法使用血红蛋白作为温度探针提供血糖的非侵入性测量。

10. 发明授权

US5255980A Black body TRD temperature sensor 失效
标题翻译：黑体TRD温度传感器
公开(公告)号：US5255980A
公开(公告)日：1993-10-26
申请号：US882826
申请日：1992-05-14
申请人： David C. Thomas , Stephen C. Jensen , Gerald R. Cucci , Charles M. Peterson , Shelle D. Tilstra , Steven J. Rychnovsky
发明人： David C. Thomas , Stephen C. Jensen , Gerald R. Cucci , Charles M. Peterson , Shelle D. Tilstra , Steven J. Rychnovsky
IPC分类号： G01K11/20 , G01K17/00
CPC分类号： G01K11/20
摘要： A temperature sensing system has a signal means which provides a signal representative of a temperature responsive luminescence, where the luminescence has a characteristic time-rate-of-decay. A means for comparison is connected to the signal means and samples the signal during two time intervals, the first interval overlapping the second. The averages of the samples are compared to provide a difference signal representative of the difference between the two measured averages. Control means coupled to the comparison means provide an output representing the temperature as a function of the time-rate-of-decay, by adjusting the overlapping intervals so that the difference signal converges to a preselected limit.
摘要翻译：温度感测系统具有提供表示温度响应发光的信号的信号装置，其中发光具有特征的衰减衰减速率。用于比较的装置连接到信号装置并且在两个时间间隔期间对信号进行采样，第一间隔与第二间隔重叠。将样本的平均值进行比较，以提供表示两个测量平均值之间的差的差分信号。耦合到比较装置的控制装置通过调整重叠间隔来提供表示作为衰减时间率的函数的温度的输出，使得差信号收敛到预选极限。

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