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    • 1. 发明授权
    • Color display device and method
    • 彩色显示装置及方法
    • US07440044B2
    • 2008-10-21
    • US10997994
    • 2004-11-29
    • Charles M. PetersonGene KochSanji ArisawaYuichi Aoki
    • Charles M. PetersonGene KochSanji ArisawaYuichi Aoki
    • G02F1/1335
    • G02F1/133617G02F1/13362
    • A color display having a monochromatic light source, an optical switch and an array of pixels formed of anisotropically emitting photoluminescent material may be combined such that large losses often associated with color filter and polarizers are avoided such that a high efficient display results. The optical switch may be a liquid crystal device that is tuned to the wavelength of the monochromatic light source. The monochromatic light source may be made from OLED material that emits in the violet, near UV or blue spectrum and may be polarized. The array of pixels may include a transmissive pixel when the backlight spectrum is the same as the color of one of the pixels.
    • 可以组合具有单色光源,光开关和由各向异性发射的光致发光材料形成的像素阵列的彩色显示器,从而避免通常与滤色器和偏振器相关联的大损耗,从而导致高效显示。 光开关可以是被调谐到单色光源的波长的液晶器件。 单色光源可以由在紫色,接近UV或蓝色光谱中发射并且可以被极化的OLED材料制成。 当背光光谱与像素之一的颜色相同时,像素阵列可以包括透射像素。
    • 2. 发明授权
    • Projection system and method
    • 投影系统和方法
    • US07210792B2
    • 2007-05-01
    • US10997999
    • 2004-11-29
    • Charles M. PetersonGene Koch
    • Charles M. PetersonGene Koch
    • G03B21/14G03B21/56
    • G02B5/201G03B21/10G03B21/204G03B21/60H04N9/3129H04N9/3141
    • A micromechanical mirror combined with a photoluminescent screen is able to efficiently use light from the light source. In such a device, the light source produces light that is directed onto the micromechanical mirror. The micromechanical mirror then selectively reflects the light onto a photoluminescent screen. The light excites the photoluminescent screen to produce the desired picture. The photoluminescent screen may include sets of pixels that convert light from the light source to provide the desired picture. Typically, each pixel set includes a red, green and blue portion although any suitable combination of colors and number of pixels may be used. Each pixel set portion converts the light received from the light source into its respective color by photoluminescence. Alternatively, the photoluminescent screen may include transparent and/or scattering portions instead of photoluminescent portions of a certain color when the light source has a spectrum which is limited to one color.
    • 与光致发光屏组合的微机械镜能够有效地使用来自光源的光。 在这种装置中,光源产生被引导到微机械反射镜上的光。 微机械镜然后选择性地将光反射到光致发光屏幕上。 光激发光致发光屏以产生所需的图像。 光致发光屏幕可以包括转换来自光源的光以提供所需图像的像素组。 通常,每个像素组包括红色,绿色和蓝色部分,尽管可以使用颜色和像素数量的任何合适的组合。 每个像素组部分通过光致发光将从光源接收的光转换成其相应的颜色。 或者,当光源具有限于一种颜色的光谱时,光致发光屏可以包括透明和/或散射部分而不是特定颜色的光致发光部分。
    • 3. 发明授权
    • Method for determining lipid and protein content of tissue
    • 确定组织脂质和蛋白质含量的方法
    • US06389306B1
    • 2002-05-14
    • US09420867
    • 1999-10-19
    • Joseph ChaikenCharles M. Peterson
    • Joseph ChaikenCharles M. Peterson
    • A61B600
    • A61B5/6826A61B5/0053A61B5/0059A61B5/14552A61B5/1491A61B5/6838A61B2562/0242G01N21/65
    • Disclosed is a method of modulating temperature of tissue in a subject to be spectroscopically probed. In a preferred embodiment, the method comprises applying a tissue modulation device of the invention to the tissue, passing current through the temperature regulating element so as to elevate or lower the temperature of the tissue, and passing electromagnetic radiation through the window of the device. Preferably, spectroscopic probing is performed when the temperature of the tissue has been elevated or lowered and when the temperature of the tissue is not elevated or lowered. The method can further comprise collecting Raman spectra emitted by the tissue. The invention also provides a method for determining phase transition, and a method for determining lipid content and identity and protein content and identity in a tissue of a subject.
    • 公开了一种调节受试者的组织的光谱探测温度的方法。 在优选实施例中,该方法包括将本发明的组织调节装置应用于组织,使电流通过温度调节元件,以提升或降低组织的温度,并使电磁辐射通过该装置的窗口。 优选地,当组织的温度升高或降低时以及当组织的温度不升高或降低时进行光谱探测。 该方法还可以包括收集组织发射的拉曼光谱。 本发明还提供了一种用于确定相变的方法,以及用于确定受试者的组织中的脂质含量和身份以及蛋白质含量和身份的方法。
    • 4. 发明授权
    • Roadway expansion joint
    • 巷道伸缩接头
    • US4279533A
    • 1981-07-21
    • US122920
    • 1980-02-20
    • Charles M. PetersonFrank M. Lymburner
    • Charles M. PetersonFrank M. Lymburner
    • E01D19/06E01C11/06E01C11/12
    • E01D19/06E01D19/067
    • A roadway sealed expansion joint between roadway sections spaced by an expansion slot, the roadway sections having recesses adjacent and extending longitudinally of the slot. A metal plate bridges the slot and is secured to the bottom of the recess in one of the sections and is movable relative to the bottom of the recess in the other of the sections. Overlying the metal plate is a unitary elastomeric slab with its upper surface aligned with the upper surfaces of the concrete sections and with its edges bonded to the sides of the recesses, this elastomeric slab having a center premolded portion of relatively high elasticity and edge portions which are molded in situ and which are of relatively low elasticity.
    • 在由扩张槽隔开的道路区段之间的道路密封的膨胀接头,所述道路段具有与所述槽的纵向相邻并延伸的凹部。 金属板桥接槽,并且在其中一个部分中固定到凹部的底部,并且可以在另一个部分中相对于凹部的底部移动。 金属板上面是整体的弹性体板,其上表面与混凝土部分的上表面对准,并且其边缘与凹部的侧面相结合,该弹性体板具有相对高弹性的中心预成型部分和边缘部分, 原位成型并且具有相对低的弹性。
    • 6. 发明授权
    • Method of diagnosing gestational diabetes
    • 诊断妊娠糖尿病的方法
    • US5670377A
    • 1997-09-23
    • US615973
    • 1996-03-14
    • Charles M. PetersonLois G. Peterson
    • Charles M. PetersonLois G. Peterson
    • G01N33/68G01N33/50
    • G01N33/689G01N2800/368Y10S436/811Y10T436/144444
    • Methods of diagnosis of gestational diabetes mellitus are disclosed. In preferred embodiments, a blood sample is obtained from a pregnant female in the 24th to 28th week of pregnancy after an overnight fast, after a 1-hour 50-gram glucose challenge test, or at the 1-hour time point during a 3-hour 100-gram oral glucose tolerance test. The concentrations of fasting plasma glucose and glycosylated plasma proteins in this blood sample are then determined. A fasting plasma glucose concentration equal to or exceeding 90 mg/dL is 100% sensitive and 64% specific in predicting glucose-related macrosomia (i.e., birth weight above 4000 grams). A glycosylated plasma protein concentration equal to or exceeding 23% is 100% sensitive and 52% specific in predicting glucose-related macrosomia. A fasting plasma protein value equal to or exceeding 90 mg/dL and a glycosylated plasma protein value equal to or exceeding 23% is 100% sensitive and 93% specific in predicting glucose-related macrosomia.
    • 公开了妊娠糖尿病诊断方法。 在优选的实施方案中,在1小时的50g葡萄糖激发试验后,或在3小时的时间点,在怀孕24周至28周之后,在快速过夜之后或在1小时时间内从孕妇获得血液样品, 小时100克口服葡萄糖耐量试验。 然后测定该血样中空腹血浆葡萄糖和糖基化血浆蛋白的浓度。 等于或超过90mg / dL的空腹血浆葡萄糖浓度在预测葡萄糖相关巨大儿病(即,出生体重在4000克以上)时是100%敏感性和64%特异性。 等于或超过23%的糖基化血浆蛋白浓度对于预测葡萄糖相关巨大儿症是100%敏感性和52%特异性。 等于或超过90mg / dL的空腹血浆蛋白质值和等于或超过23%的糖基化血浆蛋白质值是预测葡萄糖相关巨大儿症的100%敏感性和93%特异性。
    • 8. 发明授权
    • Method for non-invasive measurement of an analyte
    • 非侵入性测量分析物的方法
    • US06377828B1
    • 2002-04-23
    • US09480375
    • 2000-01-10
    • Joseph ChaikenCharles M. Peterson
    • Joseph ChaikenCharles M. Peterson
    • A61B500
    • A61B5/1455A61B5/14532A61B5/14553G01N21/49G01N21/65
    • Disclosed is a method and apparatus for measuring an analyte in a tissue of a subject. The method comprises contacting the tissue with electromagnetic radiation having a first excitation wavelength, wherein the first excitation wavelength is substantially equal to an absorption wavelength of a temperature probe within the tissue. The temperature probe and the analyte are sufficiently proximate to one another that energy deposited into one by absorption of radiation is transferred to the other. The Raman spectra emitted by the tissue are collected and analyzed to determine a concentration of analyte present in the tissue. The analysis can comprise measuring the Raman spectra associated with the temperature probe. In addition, the method can include simultaneously contacting the tissue with electromagnetic radiation having the first excitation wavelength and with electromagnetic radiation having a second excitation wavelength, wherein the second excitation wavelength is substantially equal to an absorption wavelength of the analyte. The analysis comprises comparing the spectra emitted in response to the first excitation wavelength in the presence and in the absence of the second excitation wavelength. In another embodiment, the analysis comprises measuring the anti-Stokes component of the Raman spectra associated with the analyte. The method provides a non-invasive measurement of blood glucose, using hemoglobin as the temperature probe.
    • 公开了一种用于测量受试者的组织中的分析物的方法和装置。 该方法包括使组织与具有第一激发波长的电磁辐射接触,其中第一激发波长基本上等于组织内温度探针的吸收波长。 温度探针和分析物彼此足够接近,通过吸收辐射而沉积成一个的能量传递到另一个。 收集和分析由组织发出的拉曼光谱,以确定存在于组织中的分析物的浓度。 该分析可以包括测量与温度探针相关的拉曼光谱。 此外,该方法可以包括同时使组织与具有第一激发波长的电磁辐射和具有第二激发波长的电磁辐射接触,其中第二激发波长基本上等于分析物的吸收波长。 分析包括在存在和不存在第二激发波长的情况下比较响应于第一激发波长发射的光谱。 在另一个实施方案中,分析包括测量与分析物相关的拉曼光谱的反斯托克斯分量。 该方法使用血红蛋白作为温度探针提供血糖的非侵入性测量。
    • 10. 发明授权
    • Methods and apparatus for obtaining enhanced spectroscopic information from living tissue
    • 从活体组织获得增强的光谱信息的方法和装置
    • US06681133B2
    • 2004-01-20
    • US09998036
    • 2001-11-30
    • Joseph ChaikenCharles M. PetersonKaren P. Peterson
    • Joseph ChaikenCharles M. PetersonKaren P. Peterson
    • A61B600
    • A61B5/444A61B5/0059A61B5/0062A61B5/0068A61B5/0071A61B5/0075A61B5/0091A61B5/442A61B5/7239A61B2562/0242G01N21/65
    • Disclosed is a method for obtaining feedback to drive a servo system for aligning and maintaining alignment in optical systems that bring light to an in vivo skin sample, for adjusting the focus of the optical system, and for adjusting the net depth of focus of the optical system within the in vivo system under characterization. These methods comprise adjusting the angle of incidence of electromagnetic radiation and/or providing a shielding lens to block scattered incident light, or otherwise limiting the field of view of the Raman scattered radiation collection system to exclude optical surfaces of the excitation delivery portion of the optical system. In one embodiment, the method comprises discriminating between Raman signals originating on outer portions of skin from signals originating from substances deeper within the skin or other tissues. In another embodiment, the invention provides a method for detecting skin abnormalities and for assessing the aging of skin and related tissues.
    • 公开了一种用于获得反馈的方法,用于驱动伺服系统,用于对准并保持对体内皮肤样品带来光的光学系统中的对准,用于调整光学系统的焦点,并用于调整光学系统的净焦深度 系统内的体内系统表征。 这些方法包括调整电磁辐射的入射角和/或提供屏蔽透镜以阻挡散射的入射光,或以其它方式限制拉曼散射辐射收集系统的视野,以排除光学的激发传递部分的光学表面 系统。 在一个实施方案中,该方法包括鉴别来自皮肤或其他组织内更深处物质的信号,来源于皮肤的外部部分的拉曼信号。 在另一个实施方案中,本发明提供了一种用于检测皮肤异常和评估皮肤和相关组织的老化的方法。