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1. 发明授权

US08227640B2 Palladium catalysts 失效
标题翻译：钯催化剂
公开(公告)号：US08227640B2
公开(公告)日：2012-07-24
申请号：US12532820
申请日：2007-03-23
申请人： Jackie Y. Ying , Nandanan Erathodiyil
发明人： Jackie Y. Ying , Nandanan Erathodiyil
IPC分类号： C07C209/78 , C07C13/28 , C07C5/03 , B01J23/44 , B01J31/20 , B01J31/02
CPC分类号： B01J23/44 , B01J21/18 , B01J31/1608 , B01J31/1616 , B01J31/1625 , B01J31/1805 , B01J35/04 , B01J35/1019 , B01J35/1047 , B01J35/1061 , B01J2231/4211 , B01J2231/4261 , B01J2231/643 , B01J2231/645 , B01J2531/824 , C07B37/04 , Y02P20/588
摘要： The invention relates to a particulate substance comprising a particulate porous support coupled to a palladium species. The palladium species may comprise palladium nanoclusters. The particulate substance may be used as a catalyst for conducting a carbon-carbon coupling reaction or a reduction.
摘要翻译：本发明涉及包含与钯物质偶联的颗粒状多孔载体的颗粒物质。钯物质可以包括钯纳米团簇。颗粒物质可以用作进行碳 - 碳偶联反应或还原的催化剂。

2. 发明申请

US20120276016A1 POLYMER COATED MAGNETIC PARTICLES 有权
标题翻译：聚合物包覆磁性颗粒
公开(公告)号：US20120276016A1
公开(公告)日：2012-11-01
申请号：US13504736
申请日：2010-10-28
申请人： Jackie Y. Ying , Subramanian T. Selvan , Nandanan Erathodiyil , Alex Wei Haw Lin
发明人： Jackie Y. Ying , Subramanian T. Selvan , Nandanan Erathodiyil , Alex Wei Haw Lin
IPC分类号： C08G75/04 , C12P7/62 , A61K49/12 , B82Y5/00 , B82Y30/00 , B82Y40/00
CPC分类号： C08G63/6856 , A61K49/0019 , A61K49/0054 , A61K49/0067 , A61K49/1857 , A61K49/1863 , B82Y5/00 , C08G63/6886
摘要： The invention relates to a polymer comprising a segment of Formula (I): wherein, R is either absent or a linking group, n is an integer greater than 0; and m is an integer from 1 to 6.
摘要翻译：本发明涉及包含式（I）的片段的聚合物：其中R不存在或连接基团，n为大于0的整数; m为1〜6的整数。

3. 发明授权

US08790633B2 Polymer coated magnetic particles 有权
标题翻译：聚合物涂覆的磁性颗粒
公开(公告)号：US08790633B2
公开(公告)日：2014-07-29
申请号：US13504736
申请日：2010-10-28
申请人： Jackie Y. Ying , Subramanian T. Selvan , Nandanan Erathodiyil , Alex Wei Haw Lin
发明人： Jackie Y. Ying , Subramanian T. Selvan , Nandanan Erathodiyil , Alex Wei Haw Lin
IPC分类号： A61K31/74
CPC分类号： C08G63/6856 , A61K49/0019 , A61K49/0054 , A61K49/0067 , A61K49/1857 , A61K49/1863 , B82Y5/00 , C08G63/6886
摘要： The invention relates to a polymer comprising a segment of Formula (I): wherein, R is either absent or a linking group, n is an integer greater than 0; and m is an integer from 1 to 6.
摘要翻译：本发明涉及包含式（I）的片段的聚合物：其中R不存在或连接基团，n为大于0的整数; m为1〜6的整数。

4. 发明申请

US20120136164A1 NANOSTRUCTURED METALS 审中-公开
标题翻译：纳米结构金属
公开(公告)号：US20120136164A1
公开(公告)日：2012-05-31
申请号：US13260968
申请日：2010-03-30
申请人： Jackie Y. Ying , Nandanan Erathodiyil , Hongwei Gu , Huilin Shao , Jiang Jiang
发明人： Jackie Y. Ying , Nandanan Erathodiyil , Hongwei Gu , Huilin Shao , Jiang Jiang
IPC分类号： C07D307/33 , C07C303/36 , C07C29/145 , B01J35/02 , B01J23/89 , B01J37/04 , C30B7/14 , C07C67/30 , B01J23/42 , B82Y30/00 , B82B1/00 , B82B3/00 , B82Y99/00 , B82Y40/00
CPC分类号： C01G49/00 , B01J23/42 , B01J23/44 , B01J23/462 , B01J23/464 , B01J23/52 , B01J23/8906 , B01J35/002 , B01J35/023 , B01J35/06 , B01J37/086 , B22F1/0025 , B22F9/24 , B82Y30/00 , C01G7/00 , C01G55/00 , C01P2002/85 , C01P2004/04 , C01P2004/16 , C07B31/00 , C07B53/00 , C07B2200/07 , C07C29/143 , C07C67/31 , C07C231/18 , C07C303/40 , C30B7/14 , C30B11/12 , C30B29/02 , C30B29/60 , C07C33/30 , C07C33/20 , C07C33/24 , C07C69/68 , C07C311/19 , C07C235/12
摘要： The invention relates to a nanoparticulate material comprising long ultrathin metal nanowires, and to processes for making it. The nanoparticulate material may be used as a catalyst and, in the presence of a chiral modifier, can catalyse enantioselective reactions.
摘要翻译：本发明涉及包含长超薄金属纳米线的纳米颗粒材料及其制备方法。纳米颗粒材料可以用作催化剂，并且在手性改性剂的存在下可以催化对映选择性反应。

5. 发明申请

US20130023024A1 CONJUGATE OF MAGNETIC PARTICLE AND SURFACE MODIFIER LINKED THROUGH CLEAVABLE PEPTIDE BOND 审中-公开
标题翻译：通过可清除的肽结合连接的磁性颗粒和表面改性剂的结合
公开(公告)号：US20130023024A1
公开(公告)日：2013-01-24
申请号：US13637524
申请日：2011-03-31
申请人： Jackie Y. Ying , Karthikeyan Narayanan , Alex Wei Haw Lin , Andrew Chwee Aun Wan , Yuangang Zheng , Nandanan Erathodiyil
发明人： Jackie Y. Ying , Karthikeyan Narayanan , Alex Wei Haw Lin , Andrew Chwee Aun Wan , Yuangang Zheng , Nandanan Erathodiyil
IPC分类号： C12N13/00 , C12N5/071 , C07K7/06 , B82Y99/00
CPC分类号： B82Y5/00 , G01N33/54326 , G01N33/56966
摘要： A conjugate is provided for cell processing, which comprises a magnetic particle and a surface modifier having specific affinity to a target cell. The particle and modifier are linked through a cleavable peptide bond. In a method of cell processing, the conjugate is attached to a target cell; the target cell attached to the conjugate is subject to magnetic processing; the peptide bond is cleaved to separate the processed target cell from the magnetic particle; the target cell separated from the magnetic particle is attached to a substrate. The magnetic particle may include an iron oxide, and the surface modifier may include a glucosamine. The particle and modifier may be linked by a linker comprising a protease recognition site and a peptide bond. The linker links the surface modifier to the particle, and cleavage of the peptide bond is catalyzed by a specific protease that recognizes the protease recognition site.
摘要翻译：提供了用于细胞处理的缀合物，其包含对靶细胞具有特异性亲和力的磁性颗粒和表面改性剂。颗粒和改性剂通过可切割的肽键连接。在细胞处理方法中，缀合物附着于靶细胞; 附着于缀合物的靶细胞进行磁加工; 肽键被切割以将加工的靶细胞与磁性颗粒分离; 从磁性颗粒分离的靶细胞附着于基材。磁性颗粒可以包括氧化铁，并且表面改性剂可以包括葡糖胺。颗粒和改性剂可以通过包含蛋白酶识别位点和肽键的接头连接。接头将表面改性剂连接到颗粒上，肽键的切割由识别蛋白酶识别位点的特异性蛋白酶催化。

6. 发明申请

US20110243851A1 GLUCOSE-PEG CONJUGATES FOR REDUCING GLUCOSE TRANSPORT INTO A CELL 审中-公开
标题翻译：用于减少葡萄糖输送到细胞中的葡萄糖-PEG结合物
公开(公告)号：US20110243851A1
公开(公告)日：2011-10-06
申请号：US13139170
申请日：2009-12-11
申请人： Karthikeyan Narayanan , Andrew Chwee Aun Wan , Jackie Y. Ying , Nandanan Erathodiyil
发明人： Karthikeyan Narayanan , Andrew Chwee Aun Wan , Jackie Y. Ying , Nandanan Erathodiyil
IPC分类号： A61K49/00 , C07H15/12 , C07H15/26 , C12N5/071 , C12N5/09 , C12Q1/02 , A61K31/7008 , A61P35/00
CPC分类号： C08G65/00 , A61K31/08 , A61K31/16 , A61K31/69 , C07C235/08 , C07H15/08 , G01N33/5091
摘要： There is provided a glucose-PEG conjugate comprising a PEG moiety conjugated to a linear glucose moiety at the C1 position of the glucose moiety. The glucose-PEG conjugate may be used to reduce glucose transport into a cell and may be used to treat a proliferative disorder.
摘要翻译：提供了包含在葡萄糖部分的C1位上与线性葡萄糖部分缀合的PEG部分的葡萄糖-PEG缀合物。葡萄糖-PEG轭合物可用于降低葡萄糖转运至细胞中，并可用于治疗增殖性疾病。

7. 发明申请

US20120128781A1 FUNCTIONALIZATION OF NANOPARTICLES BY GLUCOSAMINE DERIVATIVES 审中-公开
标题翻译：通过葡萄糖胺衍生物对纳米颗粒的功能化
公开(公告)号：US20120128781A1
公开(公告)日：2012-05-24
申请号：US12598410
申请日：2008-05-02
申请人： Jackie Y. Ying , Nikhil R. Jana , Nandanan Erathodiyil
发明人： Jackie Y. Ying , Nikhil R. Jana , Nandanan Erathodiyil
IPC分类号： A61K47/36 , C08B37/08 , A61K9/14 , B82Y5/00 , B82Y30/00 , B82Y40/00
CPC分类号： A61K9/5161 , A61K47/36 , A61K47/61 , A61K47/6923 , A61K47/6929 , B22F1/0018 , B22F1/0062 , B22F2998/00 , B82Y30/00 , C08B37/003 , C08L5/08 , B22F1/0025
摘要： The present invention relates to oligomeric or polymeric saccharide derivatives comprising glucosamine moieties, e.g. derivatives of oligomeric or polymeric glucosamines such as chitosan oligomers or polymers, in which one or more amine groups are substituted by anchoring groups that chemisorb to the surface of a nanoparticle or form an interdigitated bilayer with a surfactant layer surrounding the nanoparticle. The invention also relates to functionalized nanoparticles comprising such derivatives, a method for forming the functionalized particles and to uses thereof as molecular imaging agents, biosensing agents or drug delivery agents, or in the preparation of such agents.
摘要翻译：本发明涉及包含葡糖胺部分的低聚或聚合糖衍生物，例如低分子或聚合葡糖胺的衍生物，例如壳聚糖低聚物或聚合物，其中一个或多个胺基被化学吸附到纳米颗粒表面的锚定基团或与周围纳米颗粒的表面活性剂层形成叉指双层而被取代。本发明还涉及包含这种衍生物的官能化纳米颗粒，形成官能化颗粒的方法及其用作分子显像剂，生物传感剂或药物递送剂，或在制备这些试剂中。

8. 发明申请

US20110014473A1 POLYMER-COATED NANOPARTICLES 审中-公开
标题翻译：聚合物包覆纳米粒子
公开(公告)号：US20110014473A1
公开(公告)日：2011-01-20
申请号：US12449227
申请日：2007-01-31
申请人： Jackie Y. Ying , Nandanan ERATHODIYIL , Nikhil R. JANA
发明人： Jackie Y. Ying , Nandanan ERATHODIYIL , Nikhil R. JANA
IPC分类号： B32B27/00 , B05D3/00 , C07K2/00
CPC分类号： G01N33/54346 , B82Y5/00 , G01N33/54393 , Y10T428/2998
摘要： Polymers for coating nanoparticles (e.g., colloid nanoparticles and quantum dots) and methods associated therewith are provided. Such polymers may be derived from amino acids comprising suitable functional groups for associating the polymer to the nanoparticle. For example, in some embodiments, the polymer includes a polypeptide backbone (e.g., polyaspartic acid) with amino acid side groups (e.g., cysteine and/or methionine). Such a polymer can enable strong binding of the polymer to the nanoparticle surface via its multiple thiol groups, which can lead to excellent colloidal stability. Moreover, the carboxylic acid and amine functional groups of the polymer can facilitate attachment of binding partners (e.g., antibodies) to the polymer, which can allow the polymer-coated nanoparticle to be used in a variety of applications including protein detection and cell labeling.
摘要翻译：提供用于涂覆纳米颗粒的聚合物（例如，胶体纳米颗粒和量子点）以及与之相关的方法。这样的聚合物可以衍生自包含用于将聚合物与纳米颗粒缔合的合适官能团的氨基酸。例如，在一些实施方案中，聚合物包括具有氨基酸侧基（例如半胱氨酸和/或甲硫氨酸）的多肽主链（例如，聚天冬氨酸）。这样的聚合物可以通过其多个硫醇基团实现聚合物与纳米颗粒表面的强烈结合，这可导致优异的胶体稳定性。此外，聚合物的羧酸和胺官能团可促进结合配偶体（例如抗体）与聚合物的连接，这可以使聚合物包被的纳米颗粒用于多种应用，包括蛋白质检测和细胞标记。

9. 发明授权

US09687464B2 Anti-cancer agent delivery vehicles capable of improved loading 有权
公开(公告)号：US09687464B2
公开(公告)日：2017-06-27
申请号：US13634036
申请日：2011-03-11
申请人： Motoichi Kurisawa , Kun Liang , Susi Tan , Joo Eun Chung , Jackie Y. Ying
发明人： Motoichi Kurisawa , Kun Liang , Susi Tan , Joo Eun Chung , Jackie Y. Ying
IPC分类号： A61K31/33 , A61K31/282 , A61K9/00 , A61K9/107 , A61K31/337 , A61K31/353 , A61K31/704 , A61K31/7088 , A61K45/06 , A61K47/48
CPC分类号： A61K31/282 , A61K9/0019 , A61K9/1075 , A61K31/337 , A61K31/353 , A61K31/704 , A61K31/7088 , A61K45/06 , A61K47/48215 , A61K47/60 , A61K2300/00
摘要： There is provided a conjugate of a delivery agent containing a chemical moiety and at least one flavonoid. The flavonoid exists in a monomeric form or dimeric form before conjugation and remains in the monomeric form or dimeric form after conjugation. Preferably, the conjugate comprises two flavonoids. The delivery agent is conjugated at the C6 and/or the C8 position of the A ring of the flavonoid. An anti-cancer agent delivery vehicle comprising an anti-cancer agent and the conjugate is also provided.

10. 再颁专利

USRE44820E1 Nanocrystalline apatites and composites, prostheses incorporating them, and methods of their production 有权
标题翻译：纳米晶磷灰石和复合材料，并入其中的假体及其生产方法
公开(公告)号：USRE44820E1
公开(公告)日：2014-04-01
申请号：US13536924
申请日：2012-06-28
申请人： Jackie Y. Ying , Edward S. Ahn , Atsuski Nakahira
发明人： Jackie Y. Ying , Edward S. Ahn , Atsuski Nakahira
IPC分类号： A61F2/28 , C01B15/16
CPC分类号： A61L27/12 , A61F2/30767 , A61F2310/00239 , A61F2310/00293 , A61F2310/00796 , A61L27/32 , A61L2400/12 , B82Y30/00 , C01B25/32 , C03C4/0007 , C03C14/00 , C04B35/117 , C04B35/447 , C04B35/46 , C04B35/488 , C04B35/6262 , C04B35/62675 , C04B35/645 , C04B2235/3212 , C04B2235/3217 , C04B2235/3225 , C04B2235/3232 , C04B2235/3244 , C04B2235/3246 , C04B2235/5409 , C04B2235/5445 , C04B2235/5454 , C04B2235/549 , C04B2235/608 , C04B2235/656 , C04B2235/6562 , C04B2235/6567 , C04B2235/668 , C04B2235/77 , C04B2235/785 , C04B2235/80 , C04B2235/96 , C04B2235/9653 , F16C2240/64 , Y10S977/776
摘要： Methods for synthesis of nanocrystalline apatites are presented, as well as a series of specific reaction parameters that can be adjusted to tailor, in specific ways, properties in the recovered product. Particulate apatite compositions having average crystal size of less than 150 nm are provided. Products also can have a surface area of at least 40 m2/g and can be of high density.Hydroxyapatite material is investigated in particular detail. Compositions of the invention can be used as prosthetic implants and coatings for prosthetic implants.
摘要翻译：提出了纳米晶磷灰石的合成方法，以及一系列具体的反应参数，可以根据具体方式调整回收产物的特性。提供平均晶体尺寸小于150nm的颗粒状磷灰石组合物。产品还可以具有至少40m 2 / g的表面积，并且可以具有高密度。详细研究了羟基磷灰石材料。本发明的组合物可以用作假体植入物和用于假体植入物的涂层。

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