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1. 发明授权

US09445211B2 Methods for manufacturing high intensity ultrasound transducers 有权
标题翻译：制造高强度超声波换能器的方法
公开(公告)号：US09445211B2
公开(公告)日：2016-09-13
申请号：US11104294
申请日：2005-04-11
申请人： Jack Sliwa , Jonathan L. Podmore , Chris Bagley , John E. Crowe , Michael Holzbaur , Derek Hillstrom , Steve Schellenberg , Peter Goetz , Stephen A. Morse
发明人： Jack Sliwa , Jonathan L. Podmore , Chris Bagley , John E. Crowe , Michael Holzbaur , Derek Hillstrom , Steve Schellenberg , Peter Goetz , Stephen A. Morse
IPC分类号： H04R31/00 , H03H3/02 , H03H3/04 , H03H3/08 , B06B1/06
CPC分类号： H03H3/04 , B06B1/06 , B23K26/351 , B23K2101/36 , G01N29/245 , H03H3/02 , H03H3/08 , H03H2003/0407 , H03H2003/045 , H04R31/00 , Y10T29/42 , Y10T29/49004 , Y10T29/49005
摘要： A method of manufacturing an ultrasound transducer is provided. The ultrasound transducer is activated and the activity across the transducer is measured to determine whether the activity at any area does not meet an acceptance criteria. The transducer is then modified so that the area meets the acceptance criteria. The transducer may be modified with a laser which removes material from the area which does not meet the acceptance criteria.
摘要翻译：提供一种制造超声换能器的方法。激活超声换能器，测量换能器的活动，以确定任何区域的活动是否不符合验收标准。然后对传感器进行修改，使得该区域满足接受标准。传感器可以用激光器进行修改，该激光器从不满足接受标准的区域去除材料。

2. 发明授权

US07338486B2 Methods and devices for ablation 失效
公开(公告)号：US07338486B2
公开(公告)日：2008-03-04
申请号：US10238937
申请日：2002-09-10
申请人： John W. Sliwa , Matthias Vaska , Jonathan L. Podmore , Scott C. Anderson , Gerard Champsaur , John E. Crowe , Stephen A. Morse , Gary Henry Miller
发明人： John W. Sliwa , Matthias Vaska , Jonathan L. Podmore , Scott C. Anderson , Gerard Champsaur , John E. Crowe , Stephen A. Morse , Gary Henry Miller
IPC分类号： A61B19/00 , A61B18/18
CPC分类号： A61B17/22012 , A61B5/0422 , A61B17/2202 , A61B17/2251 , A61B18/00 , A61B18/02 , A61B18/04 , A61B18/1402 , A61B18/148 , A61B18/1482 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B18/20 , A61B18/24 , A61B34/20 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/22077 , A61B2017/2253 , A61B2017/3419 , A61B2018/00005 , A61B2018/00023 , A61B2018/0016 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00285 , A61B2018/00291 , A61B2018/00351 , A61B2018/00363 , A61B2018/00375 , A61B2018/00392 , A61B2018/00577 , A61B2018/00654 , A61B2018/00797 , A61B2018/00839 , A61B2018/00898 , A61B2018/00982 , A61B2018/1213 , A61B2018/142 , A61B2018/1467 , A61B2018/147 , A61B2018/1472 , A61B2018/1861 , A61B2018/2283 , A61B2090/3614 , A61B2090/3782 , A61B2090/395 , A61B2218/002 , A61B2218/007 , A61N1/056 , A61N1/06 , A61N1/362 , A61N7/02 , A61N2007/0078
摘要： An ablating device has a cover which holds an interface material such as a gel. The cover contains the interface material during initial placement of the device. The ablating device may also have a removable tip or a membrane filled with fluid. In still another aspect, the ablating device may be submerged in liquid during operation.

3. 发明授权

US06971394B2 Methods and devices for ablation 失效
公开(公告)号：US06971394B2
公开(公告)日：2005-12-06
申请号：US10238821
申请日：2002-09-10
申请人： John W. Sliwa, Jr. , Matthias Vaska , Jonathan L. Podmore , Scott C. Anderson , Gerard Champsaur , John E. Crowe , Stephen A. Morse , Gary Henry Miller
发明人： John W. Sliwa, Jr. , Matthias Vaska , Jonathan L. Podmore , Scott C. Anderson , Gerard Champsaur , John E. Crowe , Stephen A. Morse , Gary Henry Miller
IPC分类号： A61B5/042 , A61B17/00 , A61B17/22 , A61B17/34 , A61B18/00 , A61B18/02 , A61B18/14 , A61B19/00 , A61N1/06 , A61N1/362 , A61N7/00 , A61N7/02
CPC分类号： A61B17/22012 , A61B5/0422 , A61B17/2202 , A61B17/2251 , A61B18/00 , A61B18/02 , A61B18/04 , A61B18/1402 , A61B18/148 , A61B18/1482 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B18/20 , A61B18/24 , A61B34/20 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/22077 , A61B2017/2253 , A61B2017/3419 , A61B2018/00005 , A61B2018/00023 , A61B2018/0016 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00285 , A61B2018/00291 , A61B2018/00351 , A61B2018/00363 , A61B2018/00375 , A61B2018/00392 , A61B2018/00577 , A61B2018/00654 , A61B2018/00797 , A61B2018/00839 , A61B2018/00898 , A61B2018/00982 , A61B2018/1213 , A61B2018/142 , A61B2018/1467 , A61B2018/147 , A61B2018/1472 , A61B2018/1861 , A61B2018/2283 , A61B2090/3614 , A61B2090/3782 , A61B2090/395 , A61B2218/002 , A61B2218/007 , A61N1/056 , A61N1/06 , A61N1/362 , A61N7/02 , A61N2007/0078
摘要： An ablating device has a cover which holds an interface material such as a gel. The cover contains the interface material during initial placement of the device. The ablating device may also have a removable tip or a membrane filled with fluid. In still another aspect, the ablating device may be submerged in liquid during operation.

4. 发明授权

US06840936B2 Methods and devices for ablation 失效
公开(公告)号：US06840936B2
公开(公告)日：2005-01-11
申请号：US10077470
申请日：2002-02-15
申请人： John W. Sliwa, Jr. , Matthias Vaska , Jonathan L. Podmore , Scott C. Anderson , Gerard Champsaur , John E. Crowe , Stephen A. Morse , Gary Henry Miller
发明人： John W. Sliwa, Jr. , Matthias Vaska , Jonathan L. Podmore , Scott C. Anderson , Gerard Champsaur , John E. Crowe , Stephen A. Morse , Gary Henry Miller
IPC分类号： A61B5/042 , A61B17/00 , A61B17/22 , A61B17/34 , A61B18/00 , A61B18/02 , A61B18/14 , A61B19/00 , A61N1/06 , A61N1/362 , A61N7/00 , A61N7/02 , A61B18/18
CPC分类号： A61B17/22012 , A61B5/0422 , A61B17/2202 , A61B17/2251 , A61B18/00 , A61B18/02 , A61B18/04 , A61B18/1402 , A61B18/148 , A61B18/1482 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B18/20 , A61B18/24 , A61B34/20 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/22077 , A61B2017/2253 , A61B2017/3419 , A61B2018/00005 , A61B2018/00023 , A61B2018/0016 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00285 , A61B2018/00291 , A61B2018/00351 , A61B2018/00363 , A61B2018/00375 , A61B2018/00392 , A61B2018/00577 , A61B2018/00654 , A61B2018/00797 , A61B2018/00839 , A61B2018/00898 , A61B2018/00982 , A61B2018/1213 , A61B2018/142 , A61B2018/1467 , A61B2018/147 , A61B2018/1472 , A61B2018/1861 , A61B2018/2283 , A61B2090/3614 , A61B2090/3782 , A61B2090/395 , A61B2218/002 , A61B2218/007 , A61N1/056 , A61N1/06 , A61N1/362 , A61N7/02 , A61N2007/0078
摘要： An ablating device has a cover which holds an interface material such as a gel. The cover contains the interface material during initial placement of the device. The ablating device may also have a removable tip or a membrane filled with fluid. In still another aspect, the ablating device may be submerged in liquid during operation.

5. 发明授权

US09572953B2 Device having an electroformed pleated region and method of its manufacture 有权
标题翻译：具有电铸褶皱区域的装置及其制造方法
公开(公告)号：US09572953B2
公开(公告)日：2017-02-21
申请号：US13194580
申请日：2011-07-29
申请人： John W. Sliwa , Stephen A. Morse
发明人： John W. Sliwa , Stephen A. Morse
IPC分类号： A61B18/14 , A61M25/00 , A61M25/01 , C25D1/00
CPC分类号： A61M25/001 , A61B18/1492 , A61M25/0074 , A61M25/008 , A61M25/0133 , A61M25/0141 , A61M25/0147 , A61M25/0155 , A61M25/0158 , B23K26/389 , B23K2101/08 , B23K2103/08 , C23C28/021 , C23C28/023 , C25D1/00 , C25D1/02 , C25D1/20 , C25D3/48 , C25D3/50
摘要： A deflectable, flexible device includes an elongate body, a convoluted tip portion at a distal end of the elongate body, and a lumen to receive one or more wires. The convoluted tip portion includes an electroformed pleated region which is formed by electrodepositing a metal on a mandrel having a pleated region. The convoluted tip portion may be hermetically sealed to permit repeated sterilization. The electroformed pleated region may include one or more fluid emission orifices. The convoluted tip portion extends or bends in response to fluid pressure manipulation, contact with tissue, manipulation with an internal spring or wire, or by a user pushing, pulling, or twisting the catheter directly or via an introducer sheath or the like. The convoluted tip portion may further include an RF ablation element or other energy-driven technique to create continuous linear lesions or a sensing element.
摘要翻译：可偏转的柔性装置包括细长主体，在细长主体的远端处的回旋顶端部分和用于接收一根或多根线的内腔。卷曲的末端部分包括电铸褶皱区域，其通过将金属电沉积在具有褶皱区域的心轴上而形成。卷曲的尖端部分可以被气密地密封以允许反复的灭菌。电铸褶皱区域可以包括一个或多个流体排出孔。旋转的尖端部分响应于流体压力操纵，与组织的接触，用内部弹簧或线的操作，或者由使用者直接地或经由导引器鞘或类似物推动，拉动或扭转导管而延伸或弯曲。旋回的尖端部分还可以包括RF消融元件或其他能量驱动技术，以产生连续的线性损伤或感测元件。

6. 发明授权

US09108037B2 Apparatus and method for tissue ablation with near-field cooling 有权
标题翻译：近场冷却组织消融的装置和方法
公开(公告)号：US09108037B2
公开(公告)日：2015-08-18
申请号：US12400198
申请日：2009-03-09
申请人： John W. Sliwa , Stephen A. Morse , John P. Goetz
发明人： John W. Sliwa , Stephen A. Morse , John P. Goetz
IPC分类号： A61B18/04 , A61N7/02 , A61B17/225 , A61B17/00 , A61B18/00
CPC分类号： A61N7/02 , A61B17/2251 , A61B2017/00084 , A61B2018/00011
摘要： A tissue ablation system facilitates lesioning deep tissue while preventing damage to superficial tissue and includes a probe having a distal end portion, at least one transducer carried on the distal end portion, and at least one acoustically transparent heat removal element thermally coupled to a target tissue within the beam path of the transducer. The transducer delivers acoustic energy to the tissue through the heat removal element in order to ablate the tissue; the heat removal element removes sufficient thermal energy from the tissue volume to prevent thermal necrosis in superficial tissue. The heat removal element may be a heat sink or a convective element. An optional temperature sensor provides advisory data to a practitioner and/or is coupled to a feedback control system operable to control delivery of acoustic energy to the tissue and/or a rate of thermal energy removal therefrom.
摘要翻译：组织消融系统便于损伤深部组织，同时防止对表面组织的损伤，并且包括具有远端部分的探针，至少一个在远端部分上承载的传感器，以及至少一个热耦合到靶组织的声透明散热元件在传感器的光束路径内。换能器通过散热元件向组织传递声能以便烧蚀组织; 除热元件从组织体积去除足够的热能以防止表面组织中的热坏死。散热元件可以是散热器或对流元件。可选的温度传感器向从业者提供咨询数据和/或耦合到可操作以控制向组织传递声能的反馈控制系统和/或从其中去除热能的速率。

7. 发明申请

US20100228162A1 Apparatus and Method for Tissue Ablation with Near-Field Cooling 有权
标题翻译：近场冷却组织消融的装置和方法
公开(公告)号：US20100228162A1
公开(公告)日：2010-09-09
申请号：US12400198
申请日：2009-03-09
申请人： John W. Sliwa , Stephen A. Morse , John P. Goetz
发明人： John W. Sliwa , Stephen A. Morse , John P. Goetz
IPC分类号： A61N7/00
CPC分类号： A61N7/02 , A61B17/2251 , A61B2017/00084 , A61B2018/00011
摘要： A tissue ablation system facilitates lesioning deep tissue while preventing damage to superficial tissue and includes a probe having a distal end portion, at least one transducer carried on the distal end portion, and at least one acoustically transparent heat removal element thermally coupled to a target tissue within the beam path of the transducer. The transducer delivers acoustic energy to the tissue through the heat removal element in order to ablate the tissue; the heat removal element removes sufficient thermal energy from the tissue volume to prevent thermal necrosis in superficial tissue. The heat removal element may be a heat sink or a convective element. An optional temperature sensor provides advisory data to a practitioner and/or is coupled to a feedback control system operable to control delivery of acoustic energy to the tissue and/or a rate of thermal energy removal therefrom.
摘要翻译：组织消融系统便于损伤深部组织，同时防止对表面组织的损伤，并且包括具有远端部分的探针，至少一个在远端部分上承载的传感器，以及至少一个热耦合到靶组织的声透明散热元件在传感器的光束路径内。换能器通过散热元件向组织传递声能以便烧蚀组织; 除热元件从组织体积去除足够的热能以防止表面组织中的热坏死。散热元件可以是散热器或对流元件。可选的温度传感器向从业者提供咨询数据和/或耦合到可操作以控制向组织传递声能的反馈控制系统和/或从其中去除热能的速率。

8. 发明授权

US5549601A Delivery of intracorporeal probes 失效
标题翻译：交付体内探针
公开(公告)号：US5549601A
公开(公告)日：1996-08-27
申请号：US321398
申请日：1994-10-11
申请人： John McIntyre , Peter S. Brown , Stephen A. Morse
发明人： John McIntyre , Peter S. Brown , Stephen A. Morse
IPC分类号： A61B17/00 , A61B17/22 , A61B18/24 , A61B19/00 , A61B17/36
CPC分类号： A61B18/24 , A61B17/320758 , A61B2017/00274 , A61B2017/0084 , A61B2017/22072 , A61B2017/22077 , A61B2017/22078 , A61B2018/00547 , A61B90/361
摘要： A system for delivering a probe into a body part to perform a therapeutic or diagnostic procedure therein which includes an elongated probe device which is disposed within a protective sheath and which has a rotary drive unit connected to its proximal extremity to rotate the probe about its longitudinal axis, preferably at a rate above 50 rpms while applying axial pressure thereto to cause the distal end of the probe to penetrate through the patient's tissue to a desired location in the body part where the procedure is to occur. In a presently preferred embodiment, the probe is an optical fiber which is delivered into a male patient's prostate gland through the patient's prostatic urethral wall. The optical fiber is optically connected to a source for laser energy (815 nm) which is emitted from the distal end of the optical fiber to ablate prostatic tissue surrounding the distal end. A sheath is disposed about the optical fiber to support the shaft thereof and to minimize damage to the working channel of a cystoscope through which the device is usually advanced to reach the desired location within the patient's prostatic urethra.
摘要翻译：一种用于将探针输送到身体部分以执行其中的治疗或诊断程序的系统，其包括设置在保护护套内的细长探针装置，并且具有连接到其近端的旋转驱动单元，以围绕其纵向轴，优选地以高于50rpms的速率，同时向其施加轴向压力，以使探针的远端穿过患者组织穿过要进行手术的身体部位中的期望位置。在目前优选的实施方案中，探针是通过患者的前列腺尿道壁输送到男性患者的前列腺中的光纤。光纤被光学连接到从光纤的远端发射的激光能量源（815nm），以消融围绕远端的前列腺组织。护套设置在光纤周围以支撑其轴并且最小化对膀胱镜的工作通道的损伤，通过该护套通常将器械推进到达患者前列腺尿道内的期望位置。

9. 发明申请

US20100168572A1 Apparatus and Methods for Acoustic Monitoring of Ablation Procedures 审中-公开
标题翻译：消融程序声学监测仪器和方法
公开(公告)号：US20100168572A1
公开(公告)日：2010-07-01
申请号：US12636837
申请日：2009-12-14
申请人： John W. Sliwa , Zhenyi Ma , John P. Goetz , Stephen A. Morse
发明人： John W. Sliwa , Zhenyi Ma , John P. Goetz , Stephen A. Morse
IPC分类号： A61B8/00 , A61B18/18
CPC分类号： A61B18/1492 , A61B7/00 , A61B8/0833 , A61B8/0858 , A61B8/0883 , A61B8/12 , A61B8/4472 , A61B8/4483 , A61B8/462 , A61B8/463 , A61B8/5215 , A61B2017/00106 , A61B2018/00577 , A61B2018/00791 , A61B2018/00839 , A61B2018/1861 , A61B2090/065
摘要： A system for ablating tissue includes a catheter having an elongate body, with at least one ablation element (e.g., RF electrode) and at least one acoustic transducer located within the body's tip region. The transducer receives acoustic signals from proximate the tip region. The system also includes a monitoring unit coupled to the transducer to interpret the received acoustic signals as data regarding at least one therapeutic parameter (e.g., pre-pop detection, lesion making progress, tissue interface detection, tissue contact force, tissue contact establishment, bubble spatial distribution, bubble depth, bubble size, bubble size distribution, tissue interface distance, tissue interface position, tissue attenuation, tissue thickness, lesion spectral fingerprint). The monitoring unit is operable to provide feedback to a practitioner, such as graphical, audible, and/or haptic output of sensed data, and may also be operable to control operation of the at least one ablation element in response thereto.
摘要翻译：用于烧蚀组织的系统包括具有细长主体的导管，其具有至少一个消融元件（例如，RF电极）和位于身体尖端区域内的至少一个声学换能器。换能器从尖端区域附近接收声信号。该系统还包括耦合到换能器的监测单元，以将接收到的声学信号解释为关于至少一个治疗参数的数据（例如，预弹头检测，病变进展，组织界面检测，组织接触力，组织接触建立，气泡空间分布，气泡深度，气泡尺寸，气泡尺寸分布，组织界面距离，组织界面位置，组织衰减，组织厚度，病变光谱指纹图）。监测单元可操作以向实践者提供反馈，例如感测数据的图形，可听和/或触觉输出，并且还可操作以响应于此控制至少一个消融元件的操作。

10. 发明授权

US5984937A Orbital dissection cannula and method 失效
标题翻译：轨道解剖套管及方法
公开(公告)号：US5984937A
公开(公告)日：1999-11-16
申请号：US828578
申请日：1997-03-31
申请人： Stephen A. Morse , Peter L. Callas , Geoffrey A. Orth , Andrew G. C. Frazier , Albert K. Chin
发明人： Stephen A. Morse , Peter L. Callas , Geoffrey A. Orth , Andrew G. C. Frazier , Albert K. Chin
IPC分类号： A61B17/00 , A61B17/32 , A61B17/34
CPC分类号： A61B17/00008 , A61B2017/00969 , A61B2017/320044 , A61B2017/3445
摘要： A cannula and method provide manually manipulable orientation of a dissection probe carried eccentricity on the cannula for rotational and translational positioning relative to the field of view of an endoscope at a distal end of the cannula. Rotation of the cannula at fixed axial position relative to the endoscope, and rotational and translational positioning of the dissection probe relative to the distal end of the cannula provide wide-area access within the surgical site for bluntly dissecting connective tissue surrounding a vessel of interest being harvested.
摘要翻译：插管和方法提供了在套管上承载偏心的解剖探针的手动可操纵取向，用于相对于插管的远端处的内窥镜的视场进行旋转和平移定位。插管在相对于内窥镜的固定的轴向位置的旋转以及解剖探针相对于套管的远端的旋转和平移定位提供了在手术部位内的广泛进入，用于直接解剖围绕感兴趣的血管的结缔组织收获。

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