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1. 发明授权

US09108037B2 Apparatus and method for tissue ablation with near-field cooling 有权
标题翻译：近场冷却组织消融的装置和方法
公开(公告)号：US09108037B2
公开(公告)日：2015-08-18
申请号：US12400198
申请日：2009-03-09
申请人： John W. Sliwa , Stephen A. Morse , John P. Goetz
发明人： John W. Sliwa , Stephen A. Morse , John P. Goetz
IPC分类号： A61B18/04 , A61N7/02 , A61B17/225 , A61B17/00 , A61B18/00
CPC分类号： A61N7/02 , A61B17/2251 , A61B2017/00084 , A61B2018/00011
摘要： A tissue ablation system facilitates lesioning deep tissue while preventing damage to superficial tissue and includes a probe having a distal end portion, at least one transducer carried on the distal end portion, and at least one acoustically transparent heat removal element thermally coupled to a target tissue within the beam path of the transducer. The transducer delivers acoustic energy to the tissue through the heat removal element in order to ablate the tissue; the heat removal element removes sufficient thermal energy from the tissue volume to prevent thermal necrosis in superficial tissue. The heat removal element may be a heat sink or a convective element. An optional temperature sensor provides advisory data to a practitioner and/or is coupled to a feedback control system operable to control delivery of acoustic energy to the tissue and/or a rate of thermal energy removal therefrom.
摘要翻译：组织消融系统便于损伤深部组织，同时防止对表面组织的损伤，并且包括具有远端部分的探针，至少一个在远端部分上承载的传感器，以及至少一个热耦合到靶组织的声透明散热元件在传感器的光束路径内。换能器通过散热元件向组织传递声能以便烧蚀组织; 除热元件从组织体积去除足够的热能以防止表面组织中的热坏死。散热元件可以是散热器或对流元件。可选的温度传感器向从业者提供咨询数据和/或耦合到可操作以控制向组织传递声能的反馈控制系统和/或从其中去除热能的速率。

2. 发明申请

US20100228162A1 Apparatus and Method for Tissue Ablation with Near-Field Cooling 有权
标题翻译：近场冷却组织消融的装置和方法
公开(公告)号：US20100228162A1
公开(公告)日：2010-09-09
申请号：US12400198
申请日：2009-03-09
申请人： John W. Sliwa , Stephen A. Morse , John P. Goetz
发明人： John W. Sliwa , Stephen A. Morse , John P. Goetz
IPC分类号： A61N7/00
CPC分类号： A61N7/02 , A61B17/2251 , A61B2017/00084 , A61B2018/00011
摘要： A tissue ablation system facilitates lesioning deep tissue while preventing damage to superficial tissue and includes a probe having a distal end portion, at least one transducer carried on the distal end portion, and at least one acoustically transparent heat removal element thermally coupled to a target tissue within the beam path of the transducer. The transducer delivers acoustic energy to the tissue through the heat removal element in order to ablate the tissue; the heat removal element removes sufficient thermal energy from the tissue volume to prevent thermal necrosis in superficial tissue. The heat removal element may be a heat sink or a convective element. An optional temperature sensor provides advisory data to a practitioner and/or is coupled to a feedback control system operable to control delivery of acoustic energy to the tissue and/or a rate of thermal energy removal therefrom.
摘要翻译：组织消融系统便于损伤深部组织，同时防止对表面组织的损伤，并且包括具有远端部分的探针，至少一个在远端部分上承载的传感器，以及至少一个热耦合到靶组织的声透明散热元件在传感器的光束路径内。换能器通过散热元件向组织传递声能以便烧蚀组织; 除热元件从组织体积去除足够的热能以防止表面组织中的热坏死。散热元件可以是散热器或对流元件。可选的温度传感器向从业者提供咨询数据和/或耦合到可操作以控制向组织传递声能的反馈控制系统和/或从其中去除热能的速率。

3. 发明申请

US20100168572A1 Apparatus and Methods for Acoustic Monitoring of Ablation Procedures 审中-公开
标题翻译：消融程序声学监测仪器和方法
公开(公告)号：US20100168572A1
公开(公告)日：2010-07-01
申请号：US12636837
申请日：2009-12-14
申请人： John W. Sliwa , Zhenyi Ma , John P. Goetz , Stephen A. Morse
发明人： John W. Sliwa , Zhenyi Ma , John P. Goetz , Stephen A. Morse
IPC分类号： A61B8/00 , A61B18/18
CPC分类号： A61B18/1492 , A61B7/00 , A61B8/0833 , A61B8/0858 , A61B8/0883 , A61B8/12 , A61B8/4472 , A61B8/4483 , A61B8/462 , A61B8/463 , A61B8/5215 , A61B2017/00106 , A61B2018/00577 , A61B2018/00791 , A61B2018/00839 , A61B2018/1861 , A61B2090/065
摘要： A system for ablating tissue includes a catheter having an elongate body, with at least one ablation element (e.g., RF electrode) and at least one acoustic transducer located within the body's tip region. The transducer receives acoustic signals from proximate the tip region. The system also includes a monitoring unit coupled to the transducer to interpret the received acoustic signals as data regarding at least one therapeutic parameter (e.g., pre-pop detection, lesion making progress, tissue interface detection, tissue contact force, tissue contact establishment, bubble spatial distribution, bubble depth, bubble size, bubble size distribution, tissue interface distance, tissue interface position, tissue attenuation, tissue thickness, lesion spectral fingerprint). The monitoring unit is operable to provide feedback to a practitioner, such as graphical, audible, and/or haptic output of sensed data, and may also be operable to control operation of the at least one ablation element in response thereto.
摘要翻译：用于烧蚀组织的系统包括具有细长主体的导管，其具有至少一个消融元件（例如，RF电极）和位于身体尖端区域内的至少一个声学换能器。换能器从尖端区域附近接收声信号。该系统还包括耦合到换能器的监测单元，以将接收到的声学信号解释为关于至少一个治疗参数的数据（例如，预弹头检测，病变进展，组织界面检测，组织接触力，组织接触建立，气泡空间分布，气泡深度，气泡尺寸，气泡尺寸分布，组织界面距离，组织界面位置，组织衰减，组织厚度，病变光谱指纹图）。监测单元可操作以向实践者提供反馈，例如感测数据的图形，可听和/或触觉输出，并且还可操作以响应于此控制至少一个消融元件的操作。

4. 发明授权

US09572953B2 Device having an electroformed pleated region and method of its manufacture 有权
标题翻译：具有电铸褶皱区域的装置及其制造方法
公开(公告)号：US09572953B2
公开(公告)日：2017-02-21
申请号：US13194580
申请日：2011-07-29
申请人： John W. Sliwa , Stephen A. Morse
发明人： John W. Sliwa , Stephen A. Morse
IPC分类号： A61B18/14 , A61M25/00 , A61M25/01 , C25D1/00
CPC分类号： A61M25/001 , A61B18/1492 , A61M25/0074 , A61M25/008 , A61M25/0133 , A61M25/0141 , A61M25/0147 , A61M25/0155 , A61M25/0158 , B23K26/389 , B23K2101/08 , B23K2103/08 , C23C28/021 , C23C28/023 , C25D1/00 , C25D1/02 , C25D1/20 , C25D3/48 , C25D3/50
摘要： A deflectable, flexible device includes an elongate body, a convoluted tip portion at a distal end of the elongate body, and a lumen to receive one or more wires. The convoluted tip portion includes an electroformed pleated region which is formed by electrodepositing a metal on a mandrel having a pleated region. The convoluted tip portion may be hermetically sealed to permit repeated sterilization. The electroformed pleated region may include one or more fluid emission orifices. The convoluted tip portion extends or bends in response to fluid pressure manipulation, contact with tissue, manipulation with an internal spring or wire, or by a user pushing, pulling, or twisting the catheter directly or via an introducer sheath or the like. The convoluted tip portion may further include an RF ablation element or other energy-driven technique to create continuous linear lesions or a sensing element.
摘要翻译：可偏转的柔性装置包括细长主体，在细长主体的远端处的回旋顶端部分和用于接收一根或多根线的内腔。卷曲的末端部分包括电铸褶皱区域，其通过将金属电沉积在具有褶皱区域的心轴上而形成。卷曲的尖端部分可以被气密地密封以允许反复的灭菌。电铸褶皱区域可以包括一个或多个流体排出孔。旋转的尖端部分响应于流体压力操纵，与组织的接触，用内部弹簧或线的操作，或者由使用者直接地或经由导引器鞘或类似物推动，拉动或扭转导管而延伸或弯曲。旋回的尖端部分还可以包括RF消融元件或其他能量驱动技术，以产生连续的线性损伤或感测元件。

5. 发明授权

US07338486B2 Methods and devices for ablation 失效
公开(公告)号：US07338486B2
公开(公告)日：2008-03-04
申请号：US10238937
申请日：2002-09-10
申请人： John W. Sliwa , Matthias Vaska , Jonathan L. Podmore , Scott C. Anderson , Gerard Champsaur , John E. Crowe , Stephen A. Morse , Gary Henry Miller
发明人： John W. Sliwa , Matthias Vaska , Jonathan L. Podmore , Scott C. Anderson , Gerard Champsaur , John E. Crowe , Stephen A. Morse , Gary Henry Miller
IPC分类号： A61B19/00 , A61B18/18
CPC分类号： A61B17/22012 , A61B5/0422 , A61B17/2202 , A61B17/2251 , A61B18/00 , A61B18/02 , A61B18/04 , A61B18/1402 , A61B18/148 , A61B18/1482 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B18/20 , A61B18/24 , A61B34/20 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/22077 , A61B2017/2253 , A61B2017/3419 , A61B2018/00005 , A61B2018/00023 , A61B2018/0016 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00285 , A61B2018/00291 , A61B2018/00351 , A61B2018/00363 , A61B2018/00375 , A61B2018/00392 , A61B2018/00577 , A61B2018/00654 , A61B2018/00797 , A61B2018/00839 , A61B2018/00898 , A61B2018/00982 , A61B2018/1213 , A61B2018/142 , A61B2018/1467 , A61B2018/147 , A61B2018/1472 , A61B2018/1861 , A61B2018/2283 , A61B2090/3614 , A61B2090/3782 , A61B2090/395 , A61B2218/002 , A61B2218/007 , A61N1/056 , A61N1/06 , A61N1/362 , A61N7/02 , A61N2007/0078
摘要： An ablating device has a cover which holds an interface material such as a gel. The cover contains the interface material during initial placement of the device. The ablating device may also have a removable tip or a membrane filled with fluid. In still another aspect, the ablating device may be submerged in liquid during operation.

6. 发明授权

US06971394B2 Methods and devices for ablation 失效
公开(公告)号：US06971394B2
公开(公告)日：2005-12-06
申请号：US10238821
申请日：2002-09-10
申请人： John W. Sliwa, Jr. , Matthias Vaska , Jonathan L. Podmore , Scott C. Anderson , Gerard Champsaur , John E. Crowe , Stephen A. Morse , Gary Henry Miller
发明人： John W. Sliwa, Jr. , Matthias Vaska , Jonathan L. Podmore , Scott C. Anderson , Gerard Champsaur , John E. Crowe , Stephen A. Morse , Gary Henry Miller
IPC分类号： A61B5/042 , A61B17/00 , A61B17/22 , A61B17/34 , A61B18/00 , A61B18/02 , A61B18/14 , A61B19/00 , A61N1/06 , A61N1/362 , A61N7/00 , A61N7/02
CPC分类号： A61B17/22012 , A61B5/0422 , A61B17/2202 , A61B17/2251 , A61B18/00 , A61B18/02 , A61B18/04 , A61B18/1402 , A61B18/148 , A61B18/1482 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B18/20 , A61B18/24 , A61B34/20 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/22077 , A61B2017/2253 , A61B2017/3419 , A61B2018/00005 , A61B2018/00023 , A61B2018/0016 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00285 , A61B2018/00291 , A61B2018/00351 , A61B2018/00363 , A61B2018/00375 , A61B2018/00392 , A61B2018/00577 , A61B2018/00654 , A61B2018/00797 , A61B2018/00839 , A61B2018/00898 , A61B2018/00982 , A61B2018/1213 , A61B2018/142 , A61B2018/1467 , A61B2018/147 , A61B2018/1472 , A61B2018/1861 , A61B2018/2283 , A61B2090/3614 , A61B2090/3782 , A61B2090/395 , A61B2218/002 , A61B2218/007 , A61N1/056 , A61N1/06 , A61N1/362 , A61N7/02 , A61N2007/0078
摘要： An ablating device has a cover which holds an interface material such as a gel. The cover contains the interface material during initial placement of the device. The ablating device may also have a removable tip or a membrane filled with fluid. In still another aspect, the ablating device may be submerged in liquid during operation.

7. 发明申请

US20100168569A1 IMAGE-GUIDED ABLATION SYSTEM AND METHOD FOR MONITORING AN ABLATION PROCEDURE 有权
标题翻译：图像引导系统及其监测方法
公开(公告)号：US20100168569A1
公开(公告)日：2010-07-01
申请号：US12346132
申请日：2008-12-30
申请人： John W. Sliwa , Stephen A. Morse
发明人： John W. Sliwa , Stephen A. Morse
IPC分类号： A61B8/00 , A61B18/14
CPC分类号： A61B8/12 , A61B8/00 , A61B8/0841 , A61B8/4245 , A61B8/445 , A61B8/463 , A61B18/02 , A61B18/14 , A61B18/18 , A61B18/20 , A61B2090/3782 , A61B2090/3784 , A61N7/02 , A61N7/022
摘要： An ablation system comprises a tool including an shaft having proximal and distal end portions, a handle at the proximal end portion, and a lumen extending between the proximal and distal end portions. The system further includes an ablation subsystem comprised of an ablation element at the distal end portion of the shaft, and an ablation source connected to the ablation element. The system further includes an imaging subsystem comprising an ultrasound imaging transducer disposed proximate the ablation element. The transducer is pivotally attached to the shaft or the ablation element to allow the transducer to articulate between stowed and deployed positions. The imaging subsystem further comprises a processor connected to the transducer configured to receive image data acquired by the transducer, and to generate an image corresponding thereto. The imaging subsystem still further includes a display connected to the processor configured to display the generated image.
摘要翻译：消融系统包括工具，其包括具有近端部分和远端部分的轴，在近端部分处的手柄以及在近端部分和远端部分之间延伸的内腔。该系统还包括消融子系统，其包括在轴的远端部分处的消融元件和连接到消融元件的消融源。该系统还包括成像子系统，其包括邻近消融元件设置的超声成像换能器。换能器枢转地附接到轴或消融元件，以允许换能器在收起位置和展开位置之间铰接。成像子系统还包括连接到换能器的处理器，其被配置为接收由换能器获取的图像数据，并且生成与其对应的图像。成像子系统还包括连接到处理器的显示器，其被配置为显示生成的图像。

8. 发明授权

US06840936B2 Methods and devices for ablation 失效
公开(公告)号：US06840936B2
公开(公告)日：2005-01-11
申请号：US10077470
申请日：2002-02-15
申请人： John W. Sliwa, Jr. , Matthias Vaska , Jonathan L. Podmore , Scott C. Anderson , Gerard Champsaur , John E. Crowe , Stephen A. Morse , Gary Henry Miller
发明人： John W. Sliwa, Jr. , Matthias Vaska , Jonathan L. Podmore , Scott C. Anderson , Gerard Champsaur , John E. Crowe , Stephen A. Morse , Gary Henry Miller
IPC分类号： A61B5/042 , A61B17/00 , A61B17/22 , A61B17/34 , A61B18/00 , A61B18/02 , A61B18/14 , A61B19/00 , A61N1/06 , A61N1/362 , A61N7/00 , A61N7/02 , A61B18/18
CPC分类号： A61B17/22012 , A61B5/0422 , A61B17/2202 , A61B17/2251 , A61B18/00 , A61B18/02 , A61B18/04 , A61B18/1402 , A61B18/148 , A61B18/1482 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B18/20 , A61B18/24 , A61B34/20 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/22077 , A61B2017/2253 , A61B2017/3419 , A61B2018/00005 , A61B2018/00023 , A61B2018/0016 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00285 , A61B2018/00291 , A61B2018/00351 , A61B2018/00363 , A61B2018/00375 , A61B2018/00392 , A61B2018/00577 , A61B2018/00654 , A61B2018/00797 , A61B2018/00839 , A61B2018/00898 , A61B2018/00982 , A61B2018/1213 , A61B2018/142 , A61B2018/1467 , A61B2018/147 , A61B2018/1472 , A61B2018/1861 , A61B2018/2283 , A61B2090/3614 , A61B2090/3782 , A61B2090/395 , A61B2218/002 , A61B2218/007 , A61N1/056 , A61N1/06 , A61N1/362 , A61N7/02 , A61N2007/0078
摘要： An ablating device has a cover which holds an interface material such as a gel. The cover contains the interface material during initial placement of the device. The ablating device may also have a removable tip or a membrane filled with fluid. In still another aspect, the ablating device may be submerged in liquid during operation.

9. 发明申请

US20140276692A1 Pressure Sensing of Irrigant Backpressure for Aligning Directional Medical Devices with Target Tissue 有权
标题翻译：用于对准具有目标组织的定向医疗装置的刺激背压的压力感测
公开(公告)号：US20140276692A1
公开(公告)日：2014-09-18
申请号：US13837964
申请日：2013-03-15
申请人： John W. Sliwa , Zhenyi Ma , Stephen A. Morse
发明人： John W. Sliwa , Zhenyi Ma , Stephen A. Morse
IPC分类号： A61B17/32 , A61B18/24 , A61B18/18
CPC分类号： A61B17/320068 , A61B18/1492 , A61B18/18 , A61B90/37 , A61B2018/00577 , A61B2090/064 , A61B2090/0807 , A61B2090/3782 , A61B2090/3784 , A61B2217/007 , A61N7/00 , A61N2007/0047
摘要： The present disclosure relates generally to systems and methods for aligning directionally operable medical devices with and upon target tissue. In particular, the instant disclosure relates to systems and methods for aligning medical devices such as directional ablation catheters to and upon target tissue by monitoring irrigant backpressure.
摘要翻译：本公开一般涉及用于使可定向操作的医疗装置与目标组织上和之间的对准的系统和方法。特别地，本公开涉及通过监测冲洗背压来将诸如定向消融导管的医疗装置与目标组织对准的系统和方法。

10. 发明申请

US20120172843A1 DEVICE HAVING AN ELECTROFORMED PLEATED REGION AND METHOD OF ITS MANUFACTURE 有权
标题翻译：具有电气化区域的装置及其制造方法
公开(公告)号：US20120172843A1
公开(公告)日：2012-07-05
申请号：US13194580
申请日：2011-07-29
申请人： John W. Sliwa , Stephen A. Morse
发明人： John W. Sliwa , Stephen A. Morse
IPC分类号： A61M25/00 , C25D1/02 , A61B18/18
CPC分类号： A61M25/001 , A61B18/1492 , A61M25/0074 , A61M25/008 , A61M25/0133 , A61M25/0141 , A61M25/0147 , A61M25/0155 , A61M25/0158 , B23K26/389 , B23K2101/08 , B23K2103/08 , C23C28/021 , C23C28/023 , C25D1/00 , C25D1/02 , C25D1/20 , C25D3/48 , C25D3/50
摘要： A deflectable, flexible device includes an elongate body, a convoluted tip portion at a distal end of the elongate body, and a lumen to receive one or more wires. The convoluted tip portion includes an electroformed pleated region which is formed by electrodepositing a metal on a mandrel having a pleated region. The convoluted tip portion may be hermetically sealed to permit repeated sterilization. The electroformed pleated region may include one or more fluid emission orifices. The convoluted tip portion extends or bends in response to fluid pressure manipulation, contact with tissue, manipulation with an internal spring or wire, or by a user pushing, pulling, or twisting the catheter directly or via an introducer sheath or the like. The convoluted tip portion may further include an RF ablation element or other energy-driven technique to create continuous linear lesions or a sensing element.
摘要翻译：可偏转的柔性装置包括细长主体，在细长主体的远端处的回旋顶端部分和用于接收一根或多根线的内腔。卷曲的末端部分包括电铸褶皱区域，其通过将金属电沉积在具有褶皱区域的心轴上而形成。卷曲的尖端部分可以被气密地密封以允许反复的灭菌。电铸褶皱区域可以包括一个或多个流体排出孔。旋转的尖端部分响应于流体压力操纵，与组织的接触，用内部弹簧或线的操作，或者由使用者直接地或经由导引器鞘或类似物推动，拉动或扭转导管而延伸或弯曲。旋回的尖端部分还可以包括RF消融元件或其他能量驱动技术，以产生连续的线性损伤或感测元件。

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