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1. 发明申请

US20080194426A1 Flow-thru chip cartridge, chip holder, system & method thereof 审中-公开
标题翻译：流通芯片卡盘，芯片保持器及其系统及方法
公开(公告)号：US20080194426A1
公开(公告)日：2008-08-14
申请号：US12068150
申请日：2008-02-04
申请人： Jack Goodman , Matthew Torres , Hongjun Yang , David G. Mateer , Ian Stuart Richard Smith
发明人： Jack Goodman , Matthew Torres , Hongjun Yang , David G. Mateer , Ian Stuart Richard Smith
IPC分类号： C40B60/12
CPC分类号： G01N21/253 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/502746 , B01L7/00 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/0689 , B01L2300/0636 , B01L2300/0816 , B01L2300/0877 , B01L2300/18 , B01L2300/1822 , B01L2300/1838 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , B01L2400/06 , B01L2400/0622 , G01N21/05 , G01N2021/0346 , G01N2035/00158
摘要： A system for performing hybridization assays comprises a cartridge for housing a flow through device, where the cartridge includes a test fluid chamber for facilitating a substantially uniform flow of a test fluid mixture through the flow through device, and a fluidics station to deliver the test fluid mixture to the cartridge. The cartridge has a chip holder that holds the flow-through device, which has an array of microchannel passages. The chip holder has a support for placement of the flow though device, the test fluid chamber for directing a substantially uniform flow of a test fluid mixture through the array of microchannel passages of the flow through device, and a first port that receives the test fluid mixture. The cartridge has a sealing system for preventing the leakage of the test fluid around the flow through device. The test fluid chamber is defined in part by a spade-like surface having an inlet for the test fluid mixture.
摘要翻译：用于进行杂交测定的系统包括用于容纳流过装置的筒，其中所述筒包括用于促进测试流体混合物通过流动装置的基本均匀流动的测试流体室，以及用于输送测试流体的流体站混合到墨盒。盒具有保持流通装置的芯片保持器，该流通装置具有一组微通道通道。芯片保持器具有用于放置流通装置的支撑件，测试流体室用于引导测试流体混合物的基本上均匀的流动通过流过装置的微通道通道的阵列，以及接收测试流体的第一端口混合物。盒具有用于防止测试流体围绕流过装置的泄漏的密封系统。测试流体室部分地由具有用于测试流体混合物的入口的铲形表面限定。

2. 发明授权

US07326561B2 Flow-thru chip cartridge, chip holder, system and method thereof 有权
标题翻译：流通芯片盒，芯片保持器，系统及其方法
公开(公告)号：US07326561B2
公开(公告)日：2008-02-05
申请号：US09926094
申请日：2000-12-20
申请人： Jack Goodman , Matthew Torres , Hongjun Yang , David G. Mateer , Ian Stuart Richard Smith
发明人： Jack Goodman , Matthew Torres , Hongjun Yang , David G. Mateer , Ian Stuart Richard Smith
IPC分类号： C12M1/36
CPC分类号： G01N21/253 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/502746 , B01L7/00 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/0689 , B01L2300/0636 , B01L2300/0816 , B01L2300/0877 , B01L2300/18 , B01L2300/1822 , B01L2300/1838 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , B01L2400/06 , B01L2400/0622 , G01N21/05 , G01N2021/0346 , G01N2035/00158
摘要： A system for performing hybridization assays comprises a cartridge for housing a flow through device, where the cartridge includes a test fluid chamber for facilitating a substantially uniform flow of a test fluid mixture through the flow through device, and a fluidics station to deliver the test fluid mixture to the cartridge. The cartridge has a chip holder that holds the flow-through device, which has an array of microchannel passages. The chip holder has a support for placement of the flow though device, the test fluid chamber for directing a substantially uniform flow of a test fluid mixture through the array of microchannel passages of the flow through device, and a first port that receives the test fluid mixture. The cartridge has a sealing system for preventing the leakage of the test fluid around the flow through device. The test fluid chamber is defined in part by a spade-like surface having an inlet for the test fluid mixture.
摘要翻译：用于进行杂交测定的系统包括用于容纳流过装置的筒，其中所述筒包括用于促进测试流体混合物通过流动装置的基本均匀流动的测试流体室，以及用于输送测试流体的流体站混合到墨盒。盒具有保持流通装置的芯片保持器，该流通装置具有阵列的微通道通道。芯片保持器具有用于放置流通装置的支撑件，测试流体室用于引导测试流体混合物的基本上均匀的流动通过流过装置的微通道通道的阵列，以及接收测试流体的第一端口混合物。盒具有用于防止测试流体围绕流过装置的泄漏的密封系统。测试流体室部分地由具有用于测试流体混合物的入口的铲形表面限定。

3. 发明申请

US20140299468A1 High-Performance Analytical Instrument and Method 审中-公开
标题翻译：高性能分析仪器及方法
公开(公告)号：US20140299468A1
公开(公告)日：2014-10-09
申请号：US14309896
申请日：2014-06-20
申请人： Hongjun Yang
发明人： Hongjun Yang
IPC分类号： G01N27/327 , G01N21/76
CPC分类号： G01N27/327 , G01N21/66 , G01N21/76 , G01N33/5438
摘要： Apparatus and methods are provided for improving sensitivity, throughput, and efficiency of multi-analyte analytical testing. Specifically, an improved Electrochemiluminescence (ECL) analytical apparatus is provided for analytical chemistry, diagnostics, and environmental applications. The ECL apparatus comprises a 96 or more-well plate, where a microarray of working electrodes is placed in each well for high throughput and multi-analyte testing. The microarray of working electrodes connects with a counter electrode forming a two-electrode electrochemical system. Each well is electrically addressable, thereby controlling ECL reactions in flexible modes. The ECL apparatus further comprises a detector of ECL signals, and the detector employs a CCD-chip assembling matrix. Also provided are methods for high-throughput multi-analyte testing. The methods according to this disclosure are applied in various embodiments to test a broad range of analytes, including chemical compounds, proteins, peptides, DNAs, RNAs, antigens, antibodies, pathogens, contaminants, and derivatives thereof.
摘要翻译：提供了设备和方法来提高多分析物分析测试的灵敏度，产量和效率。具体来说，提供改进的电化学发光（ECL）分析仪器用于分析化学，诊断和环境应用。 ECL装置包括96孔或更多孔板，其中工作电极的微阵列放置在每个孔中用于高通量和多分析物测试。工作电极的微阵列与形成双电极电化学系统的对电极连接。每个井都是电可寻址的，从而以灵活的模式控制ECL反应。 ECL装置还包括ECL信号的检测器，并且检测器采用CCD芯片组装矩阵。还提供了用于高通量多分析物测试的方法。根据本公开的方法应用于各种实施方案中以测试广泛范围的分析物，包括化合物，蛋白质，肽，DNA，RNA，抗原，抗体，病原体，污染物及其衍生物。

4. 发明授权

US07494820B2 Electrochemiluminescence of rare earth metal chelates 失效
标题翻译：稀土金属螯合物的电化学发光
公开(公告)号：US07494820B2
公开(公告)日：2009-02-24
申请号：US11077076
申请日：2005-03-11
申请人： Hongjun Yang , Nicholas Cairns
发明人： Hongjun Yang , Nicholas Cairns
IPC分类号： G01N21/76 , G01N33/532 , G01N33/533 , G01N33/24 , C07K1/10
CPC分类号： C07F5/003 , G01N33/582 , Y10S436/806 , Y10T436/13
摘要： Luminescent chemical reagents that include complexes of rare earth metals with ligands such as aromatic heterocyclic nitrogen-containing compounds and semi-aromatic oxygen-containing compounds are used to detect small quantities of complex substances such as pharmaceuticals, metabolites, and microorganisms in complex sample mixtures.
摘要翻译：包括稀土金属络合物与芳族杂环含氮化合物和半芳族含氧化合物等配体的发光化学试剂用于检测复杂样品混合物中的少量复合物质，如药物，代谢物和微生物。

5. 发明申请

US20090197349A1 ELECTROCHEMILUMINESCENCE OF RARE EARTH METAL CHELATES 审中-公开
公开(公告)号：US20090197349A1
公开(公告)日：2009-08-06
申请号：US12354698
申请日：2009-01-15
申请人： Hongjun Yang , Nicholas Cairns
发明人： Hongjun Yang , Nicholas Cairns
IPC分类号： G01N33/53 , G01N33/20 , C07F19/00
CPC分类号： C07F5/003 , G01N33/582 , Y10S436/806 , Y10T436/13
摘要： Luminescent chemical reagents that include complexes of rare earth metals with ligands such as aromatic heterocyclic nitrogen-containing compounds and semi-aromatic oxygen-containing compounds are used to detect small quantities of complex substances such as pharmaceuticals, metabolites, and microorganisms in complex sample mixtures.

6. 发明授权

US06403382B1 Attachment chemistry for organic molecules to silicon 有权
标题翻译：有机分子与硅的附着化学
公开(公告)号：US06403382B1
公开(公告)日：2002-06-11
申请号：US09456556
申请日：1999-12-08
申请人： Xiaoyang Zhu , Hongjun Yang
发明人： Xiaoyang Zhu , Hongjun Yang
IPC分类号： G01N3368
CPC分类号： B82Y30/00 , B05D1/185 , B05D1/60 , B82Y40/00 , C07B61/00 , G01N33/552 , Y10T436/2525
摘要： A simple chemical approach for the covalent assembly of organic molecules on silicon surfaces via robust linkages is provided. This is achieved by the efficient reaction between a nucleophilic functional group and a halogenated Si surface. The nucleophile anchor is the bridge between two surface Si atoms. The resulting organic layer is thermally stable. The method demonstrated herein is generally applicable for the assembly of a variety of functional organic molecules under vacuum environment or in solution phase.
摘要翻译：提供了一种用于通过稳定连接在硅表面上共价组装有机分子的简单化学方法。这是通过亲核官能团和卤化Si表面之间的有效反应来实现的。亲核试剂锚是两个表面Si原子之间的桥梁。所得有机层是热稳定的。本文所示的方法通常适用于在真空环境或溶液相中组装各种功能性有机分子。

7. 发明授权

US09181374B2 Process for preparing branched polymer 有权
标题翻译：制备支链聚合物的方法
公开(公告)号：US09181374B2
公开(公告)日：2015-11-10
申请号：US14353112
申请日：2012-08-14
申请人： Bibiao Jiang , Wenyan Huang , Hongjun Yang , Xiaoqiang Xue
发明人： Bibiao Jiang , Wenyan Huang , Hongjun Yang , Xiaoqiang Xue
IPC分类号： C08F220/30 , C08F12/08 , C08G83/00 , C08F220/28 , C08L101/00
CPC分类号： C08F220/30 , C08F12/08 , C08F220/28 , C08G83/005 , C08L101/005 , C08F4/34 , C08F212/08 , C08F220/18 , C08F2220/281 , C08F218/08 , C08F220/14
摘要： A polymer synthesis process wherein a vinyl monomer, such as styrene, toluene (benzene, xylene) as a solvent, is subjected to a self-initiated free radical polymerization at 60˜100° C. with a compound (methyl(meth)acrylate peroxide) as the initiator and the branched monomer containing both polymerizable double bond and peroxide bond. The degree of branching of the polymer can be adjusted by adjusting the molar ratio of the compound to polymerizable monomer. The process for preparing a branched polymer is carried out under the conditions of conventional free radical polymerization without the addition of the branched monomer and other assist initiators.
摘要翻译：聚合物合成方法，其中乙烯基单体如苯乙烯，甲苯（苯，二甲苯）作为溶剂，在60〜100℃下用化合物（（甲基）丙烯酸甲酯过氧化物）进行自引发的自由基聚合）作为引发剂和含有可聚合双键和过氧化物键的支化单体。可以通过调节化合物与可聚合单体的摩尔比来调节聚合物的支化度。制备支化聚合物的方法在常规自由基聚合的条件下进行，而不加入支化单体和其它辅助引发剂。

8. 发明申请

US20080254155A1 Use of Ginkgo Biloba Extract in Preparation of a Composition for Lowering Cholesterol 审中-公开
标题翻译：使用银杏叶提取物制备降低胆固醇的组合物
公开(公告)号：US20080254155A1
公开(公告)日：2008-10-16
申请号：US12091701
申请日：2006-10-23
申请人： Xiaomei Gu , Delong Xie , Qinghua Zhang , Qi Gao , Gang Liu , Guoan Zhang , Huasheng Xiao , Hongjun Yang , Guoping Zhao , Lu Zhang
发明人： Xiaomei Gu , Delong Xie , Qinghua Zhang , Qi Gao , Gang Liu , Guoan Zhang , Huasheng Xiao , Hongjun Yang , Guoping Zhao , Lu Zhang
IPC分类号： A61K36/16 , A61K31/7048 , A61K31/19 , A61K31/352 , A61P3/00 , C12Q1/68
CPC分类号： A61K36/16
摘要： The use of ginkgo biloba extract in preparation of a composition for lowering cholesterol is provided. Furthermore, the use of ginkgo biloba extract in preparation of a composition for modulating the gene expressions of key enzymes associated with cholesterol metabolism in vivo is provided. Also the use of a set of changes in gene expressions at the level of genes and proteins.
摘要翻译：提供了银杏叶提取物在制备用于降低胆固醇的组合物中的用途。此外，提供了银杏叶提取物在制备用于调节与体内胆固醇代谢相关的关键酶的基因表达的组合物中的用途。还可以在基因和蛋白质水平上使用一组基因表达的变化。

9. 发明申请

US20140256898A1 PROCESS FOR PREPARING BRANCHED POLYMER 有权
标题翻译：制备分支聚合物的方法
公开(公告)号：US20140256898A1
公开(公告)日：2014-09-11
申请号：US14353112
申请日：2012-08-14
申请人： Bibiao Jiang , Wenyan Huang , Hongjun Yang , Xiaoqiang Xue
发明人： Bibiao Jiang , Wenyan Huang , Hongjun Yang , Xiaoqiang Xue
IPC分类号： C08F220/30 , C08F220/28
CPC分类号： C08F220/30 , C08F12/08 , C08F220/28 , C08G83/005 , C08L101/005 , C08F4/34 , C08F212/08 , C08F220/18 , C08F2220/281 , C08F218/08 , C08F220/14
摘要： A process for preparing a branched polymer, belonging to the fields of polymer synthesis and preparation of functional polymers. A vinyl monomer, such as styrene, toluene (benzene, xylene) as a solvent, is subjected to a self-initiated free radical polymerization at 60˜100° C. with a new type of compound (methyl (meth)acrylate peroxide) as the initiator and the branched monomer containing both polymerisable double bond and peroxide bond, which can be used to synthesize the branched polymers. The degree of branching of the polymer can be adjusted by adjusting the molar ratio of the new type of compound to polymerisable monomer. The process for preparing a branched polymer is carried out under the conditions of conventional free radical polymerization without the addition of the branched monomer and other assist initiators. The polymerization is simple and feasible, has a high monomer conversion, a controllable degree of branching for the polymer, and is highly suitable for synthesizing branched polymers from various monomers. Another advantage of this process is its low production cost.
摘要翻译：一种制备支链聚合物的方法，属于聚合物合成领域和官能聚合物的制备。将乙烯基单体如苯乙烯，甲苯（苯，二甲苯）作为溶剂，在60〜100℃下用新型的化合物（甲基（甲基）丙烯酸酯过氧化物）进行自引发的自由基聚合，如含有可聚合双键和过氧化物键的引发剂和支链单体，其可用于合成支化聚合物。可以通过调节新型化合物与可聚合单体的摩尔比来调节聚合物的支化度。制备支化聚合物的方法在常规自由基聚合的条件下进行，而不加入支化单体和其它辅助引发剂。聚合是简单和可行的，具有高的单体转化率，聚合物的可控度支化度，并且非常适用于从各种单体合成支链聚合物。该方法的另一个优点是其低的生产成本。

10. 外观设计

USD687564S1 Combined sample container and processor with screw cap 有权
标题翻译：组合样品容器和带螺帽的处理器
公开(公告)号：USD687564S1
公开(公告)日：2013-08-06
申请号：US29371856
申请日：2011-10-31
申请人： Hongjun Yang , Zhifeng Long
设计人： Hongjun Yang , Zhifeng Long

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