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    • 3. 发明授权
    • Filtration system
    • 过滤系统
    • US4080294A
    • 1978-03-21
    • US753961
    • 1976-12-23
    • James H. EdwardsBernard R. DantiWayne S. Merrill
    • James H. EdwardsBernard R. DantiWayne S. Merrill
    • B01D29/13B01D29/23B01D31/00C02B3/02
    • B01D29/23B01D2201/088B01D2201/34
    • A filtration system is provided that directs a fluid to be filtered through a disposable tubular filtration element, supports the filtration element, and accommodates for "wet growth" of the filtration element. The system operates with an inside-to-outside forced fluid flow through the filtration element and includes a generally cylindrical housing with a fluid inlet and outlet. A perforated outer support screen is mounted within the housing and surrounds the walls of the tubular filtration element with slight clearance. Under the influence of the fluid pressure and the wet growth, the walls of the filtration element bear against the screen. A sealing and support assembly having upstream and downstream fluid guides, each carrying, in a preferred form, a pair of resilient sealing members, is positioned inside the filtration element. A rigid inner member bridges the opposing faces of the resilient member pairs. A rod and nut arrangement draws the flow guides towards one another to apply a longitudinal compressive force on the resilient members caught between a flange on the flow guides and the rigid inner member. This compressive force deforms the resilient members in a radially outward direction to seal the filtration element to the housing and isolate the filtered fluid. In a preferred form, the adjacent faces of each pair of resilient members are aligned with the interior edge of an impregnated end portion of the filtration element. In addition, a tubular prefiltration element may be positioned inside the rigid inner member.
    • 提供了一种过滤系统,其引导待过滤的流体通过一次性管状过滤元件,支撑过滤元件,并适应过滤元件的“湿增长”。 该系统通过内部至外部强制流体流动通过过滤元件并且包括具有流体入口和出口的大致圆柱形壳体。 穿孔的外部支撑屏幕安装在壳体内并且以轻微的间隙围绕管状过滤元件的壁。 在流体压力和湿增长的影响下,过滤元件的壁抵靠屏幕。 具有上游和下游流体引导件的密封和支撑组件位于过滤元件内部,每个流体引导件以优选形式承载一对弹性密封件。 刚性内部构件桥接弹性构件对的相对面。 杆和螺母装置将流动引导件朝向彼此拉动,以将纵向压缩力施加在捕获在流动引导件上的凸缘和刚性内部构件之间的弹性构件上。 这种压缩力使弹性构件在径向向外的方向变形,以将过滤元件密封到壳体并隔离被过滤的流体。 在优选形式中,每对弹性构件的相邻面与过滤元件的浸渍端部的内边缘对准。 此外,管状预过滤元件可以位于刚性内部构件的内部。
    • 6. 发明授权
    • Anti-short bushing
    • 防短套管
    • US4752652A
    • 1988-06-21
    • US903402
    • 1986-09-03
    • Bernard R. DantiJoel A. HamiltonDavid P. WilliamsPaul W. Suprono
    • Bernard R. DantiJoel A. HamiltonDavid P. WilliamsPaul W. Suprono
    • H01B7/24H02G3/06H01B17/58
    • H01B7/24H02G3/0691Y10T16/063
    • An anti-short bushing, for use between a tubular metal sheath and an electrical conductor carried within the metal sheath, comprising a tubular insulative unit configured to be inserted between the sheath and the conductor. The tubular insulative unit is formed as a single molded piece having three connected segments. Two of the segments are generally semi-cylindrical and each has a shoulder projecting radially therefrom at one end. The two segments are connected by an elongated hinge which permits them to be folded relative to one another to form a tubular configuration with their shoulders forming a partial circumferential shoulder. The third segment is connected to the elongated hinge by a second hinge to permit the third segment to be rotated to project radially outwardly so as to form with the two shoulders of the other two segments a complete circumferential shoulder.
    • 用于管状金属护套和承载在金属护套内的电导体之间的防短衬套,包括构造成插入护套和导体之间的管状绝缘单元。 管状绝缘单元形成为具有三个连接段的单个模制件。 两个片段通常是半圆柱形的,并且每个片段的一端具有从其径向突出的肩部。 两个部分通过细长的铰链连接,这允许它们相对于彼此折叠以形成其肩部形成部分周向肩部的管状构造。 第三段通过第二铰链连接到细长铰链,以允许第三段旋转以径向向外突出,以便与其他两个段的两个肩部形成完整的周向肩部。
    • 7. 发明授权
    • Cell culture system
    • 细胞培养系统
    • US4661458A
    • 1987-04-28
    • US697864
    • 1984-10-02
    • Eric S. BerryBernard R. Danti
    • Eric S. BerryBernard R. Danti
    • C12M1/02C12M1/04C12M1/12C12M3/06C12M3/00C12N5/00
    • C12M29/04C12M23/34C12M23/44
    • A device is described which provides a totally enclosed and secure environment for the culture of cells and for the production of biologicals, pharmaceuticals, and other cell-derived products of commercial value. The device comprises several modules of differing functions: regulating the cellular growth environment, providing a suitable cell growth substrate or environment, or separating of desired product form interfering substances. Each module comprises a series of membranes separated by a solid support material which is channeled to provide a series of parallel capillaries for the flow of nutrients, environmental regulating fluids, or gas exchange. The structure and composition of the separating membranes limits the nature, rate, and size of the particular material exchanged across an individual membrane into or from an adjacent compartment. The capillaries are so dimensioned that the nutrients and gases are diffused over distances typical of human tissue.
    • PCT No.PCT / US84 / 01350 Sec。 371日期1984年10月2日第 102(e)日期1984年10月2日PCT提交1984年8月22日PCT公布。 公开号WO85 / 01062 日期为1985年3月14日。描述了一种装置,其为细胞培养和用于生产具有商业价值的生物制品,药物和其它细胞衍生产品提供完全封闭和安全的环境。 该装置包括具有不同功能的几个模块:调节细胞生长环境,提供合适的细胞生长底物或环境,或分离所需产物形式的干扰物质。 每个模块包括由固体支撑材料分离的一系列膜,其被引导以提供用于营养物流动,环境调节流体或气体交换的一系列平行毛细管。 分离膜的结构和组成限制了通过单个膜在相邻隔室进入或离开的特定材料的性质,速率和尺寸。 毛细血管的尺寸如此,使得营养物和气体在人体组织的典型的距离上扩散。
    • 10. 发明授权
    • Tubular filtration element and method of making it
    • 管状过滤元件及其制作方法
    • US4101423A
    • 1978-07-18
    • US769763
    • 1977-02-17
    • Wayne S. MerrillJames H. EdwardsBernard R. Danti
    • Wayne S. MerrillJames H. EdwardsBernard R. Danti
    • B01D29/11B01D29/13B01D63/06B01D69/10B01D27/00B01D29/06
    • B01D69/10B01D29/111B01D63/062B01D63/063B01D2201/0407B01D2201/188
    • A tubular element for removing particulate matter and bacteria of dimensions in excess of a predetermined value from a fluid flowing from the interior to the exterior of the filtration element has a first inner layer of a highly porous material that has a low coefficient of sliding friction, and a second layer of a microporous filtration material having pores of substantially uniform size. The element may include an outer support layer of a porous material that is not subject to shedding. In a preferred form, the inner layer is formed from a high wet strength paper, the microporous filtration layer has sufficiently small pores to remove all bacteria from the fluid, and the outer layer may be a fine porous plastic sheet material or a high wet strength, high porosity paper that is impregnated with the polymeric material that forms the microporous filtration material. The fine pore structure of the outer layer supports the fragile filtration layer. In a preferred form, both ends of the tubular element are impregnated with a suitable sealing material such as a polyurethane potting compound. The ends are preferably dipped in the sealing material to a predetermined depth. When cured, these end portions provide additional mechanical support for the tube ends and block the passage of particulate matter and bacteria past the filtration layer at its edge. A fabrication process for the filtration element that does not damage the fragile microporous filtration layer involves helically wrapping the inner layer on a fixed mandrel to act as a carrier, and helically wrapping an overlying layer of the microporous filtration material. If an outer layer is used this is wrapped on the microporous material. All layers move in unison along the longitudinal axis of the mandrel. Each layer is self-overlapping and at least the filtration layer is sealed in the area of the overlap.
    • 用于从从内部流到过滤元件的流体流动的流体中去除颗粒物质和尺寸超过预定值的细菌的管状元件具有第一内层,其具有低的滑动摩擦系数, 以及具有基本均匀尺寸的孔的微孔过滤材料的第二层。 元件可以包括不会脱落的多孔材料的外部支撑层。 在优选的形式中,内层由高湿强纸形成,微孔过滤层具有足够小的孔以从流体中除去所有细菌,外层可以是细多孔塑料片材或高湿强度 ,高孔隙率纸,其被形成微孔过滤材料的聚合材料浸渍。 外层的细孔结构支撑脆性过滤层。 在优选形式中,管状元件的两端用合适的密封材料浸渍,例如聚氨酯灌封化合物。 优选将端部浸入密封材料中至预定的深度。 当固化时,这些端部为管端提供额外的机械支撑,并阻止颗粒物质和细菌通过其边缘处的过滤层。 用于过滤元件的不会损坏易碎微孔过滤层的制造方法包括将内层螺旋地缠绕在固定的心轴上以充当载体,并螺旋地缠绕微孔过滤材料的上层。 如果使用外层,则将其包裹在微孔材料上。 所有层沿心轴的纵向轴线一致移动。 每个层都是自重叠的,并且至少过滤层被密封在重叠的区域中。