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1. 发明申请

WO2009062190A3 HYPERPHOTOSYNTHETIC ORGANISMS 审中-公开
标题翻译：超级合成器官
公开(公告)号：WO2009062190A3
公开(公告)日：2009-09-17
申请号：PCT/US2008083056
申请日：2008-11-10
申请人： JOULE BIOTECHNOLOGIES INC , DEVROE ERIC , KOSURI SRIRAM , BERRY DAVID , AFEYAN NOUBAR , SKRALY FRANK , ROBERTSON DAN , GREEN BRIAN , RIDLEY CHRISTIAN
发明人： DEVROE ERIC , KOSURI SRIRAM , BERRY DAVID , AFEYAN NOUBAR , SKRALY FRANK , ROBERTSON DAN , GREEN BRIAN , RIDLEY CHRISTIAN
IPC分类号： C12N1/13 , C12N1/21
CPC分类号： C12N15/74 , C12N9/1007 , C12N15/52 , C12P7/6409 , C12P7/6436 , C12P7/6463 , C12P7/649 , C12Y111/01006 , Y02E50/13 , Y02P60/247
摘要： The present disclosure identifies pathways and mechanisms to confer improved industrial fitness on engineered organisms. It also discloses engineered organisms having improved industrial fitness. Synthetic biologic engineering modules are disclosed that provide for light capture, carbon dioxide fixation, NADH production, NADPH production, thermotolerance, pH tolerance, flue gas tolerance, salt tolerance, nutrient independence and near infrared absorbance. The disclosed engineered organisms can include one or more of these modules. Also provided are methods of using the engineered organism to produce carbon-based products of interest, biomass or pharmaceutical agents.
摘要翻译：本公开识别赋予工程改造的生物体改进的工业适应性的途径和机制。它还公开了具有改进的工业适应性的工程化生物。公开了提供光捕获，二氧化碳固定，NADH产生，NADPH产生，耐热性，pH耐受性，烟气耐受性，耐盐性，营养物独立性和近红外吸收的合成生物工程模块。所公开的工程改造的生物体可以包括这些模块中的一个或多个。还提供了使用工程有机体生产感兴趣的碳基产品，生物质或药剂的方法。

2. 发明申请

WO2009036095A1 ENGINEERED LIGHT-HARVESTING ORGANISMS 审中-公开
标题翻译：工程采光机构
公开(公告)号：WO2009036095A1
公开(公告)日：2009-03-19
申请号：PCT/US2008075899
申请日：2008-09-10
申请人： JOULE BIOTECHNOLOGIES INC , DEVROE ERIC , BERRY DAVID , AFEYAN NOUBAR , ROBERTSON DAN , SKRALY FRANK , RIDLEY CHRISTIAN
发明人： DEVROE ERIC , BERRY DAVID , AFEYAN NOUBAR , ROBERTSON DAN , SKRALY FRANK , RIDLEY CHRISTIAN
IPC分类号： C07K14/195 , C12N5/10 , C12N15/09
CPC分类号： C12N15/70 , C12N9/1205 , C12N15/52 , C12P5/00 , C12P7/00 , C12P19/00 , C12Y207/01019
摘要： The present disclosure identifies pathways and mechanisms to confer photoautotrophic properties to a heterotrophic organism. The resultant engineered cell or organism will uniquely enable efficient conversion of carbon dioxide and light into biomass and carbon-based products of interest.
摘要翻译：本公开标识了赋予异养生物体的光自养性质的途径和机制。所得到的工程细胞或生物将独特地使二氧化碳和光有效转化成生物质和基于碳的产品。

3. 发明专利

JP2014087360A Hyperphotosynthetic organism 有权
标题翻译：高效液相色谱法
公开(公告)号：JP2014087360A
公开(公告)日：2014-05-15
申请号：JP2013269377
申请日：2013-12-26
申请人： Joule Biotechnologies Inc , ジュールアンリミテッドテクノロジーズインコーポレイテッド
发明人： ERIC DEVROE , SRIRAM KOSURI , BERRY DAVID , NOUBAR AFEYAN , FRANK SKRALY , ROBERTSON DAN , BRIAN GREEN , RIDLEY CHRISTIAN
IPC分类号： C12N1/13 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P1/00 , C12P21/02
CPC分类号： C12N15/74 , C12N9/1007 , C12N15/52 , C12P7/6409 , C12P7/6436 , C12P7/6463 , C12P7/649 , C12Y111/01006 , Y02E50/13 , Y02P60/247
摘要： PROBLEM TO BE SOLVED: To provide an engineered organism which has improved industrial adaptability by identifying a route and a mechanism which impart improved industrial adaptability to the engineered organism.SOLUTION: The organism is engineered by artificial biotechnical modules which bring about light capture, carbon dioxide fixation, NADH production, NADPH production, heat resistance, pH resistance, flue gas resistance, salt tolerance, nutrient independence, and near-infrared light absorption. The organism may contain one or more of these modules. In order to produce carbon base products of interest, biomass, or pharmaceutical medicines, the engineered organism is used.
摘要翻译：要解决的问题：提供通过确定赋予工程生物体改善的工业适应性的途径和机制来提高工业适应性的工程生物体。解决方案：生物体由人工生物技术模块工程化，其实现轻捕获，二氧化碳固定，NADH生产，NADPH生产，耐热性，耐pH，烟气耐受性，耐盐性，营养独立性和近红外光吸收。生物体可以包含这些模块中的一个或多个。为了生产感兴趣的碳基产物，生物质或药物，使用工程生物。

4. 发明专利

AU2008323673A1 Hyperphotosynthetic organisms 未知
公开(公告)号：AU2008323673A1
公开(公告)日：2009-05-14
申请号：AU2008323673
申请日：2008-11-10
申请人： JOULE BIOTECHNOLOGIES INC
发明人： RIDLEY CHRISTIAN , DEVROE ERIC , ROBERTSON DAN , GREEN BRIAN , BERRY DAVID , AFEYAN NOUBAR , SKRALY FRANK , KOSURI SRIRAM
IPC分类号： C12N1/13 , C12N1/21
摘要： The present disclosure identifies pathways and mechanisms to confer improved industrial fitness on engineered organisms. It also discloses engineered organisms having improved industrial fitness. Synthetic biologic engineering modules are disclosed that provide for light capture, carbon dioxide fixation, NADH production, NADPH production, thermotolerance, pH tolerance, flue gas tolerance, salt tolerance, nutrient independence and near infrared absorbance. The disclosed engineered organisms can include one or more of these modules. Also provided are methods of using the engineered organism to produce carbon-based products of interest, biomass or pharmaceutical agents.

5. 发明专利

CA2704227A1 HYPERPHOTOSYNTHETIC ORGANISMS 未知
公开(公告)号：CA2704227A1
公开(公告)日：2009-05-14
申请号：CA2704227
申请日：2008-11-10
申请人： JOULE BIOTECHNOLOGIES INC
发明人： DEVROE ERIC , KOSURI SRIRAM , BERRY DAVID , AFEYAN NOUBAR , SKRALY FRANK , ROBERTSON DAN , GREEN BRIAN , RIDLEY CHRISTIAN
IPC分类号： C12N1/13 , C12N1/21
摘要： The present disclosure identifies pathways and mechanisms to confer improved industrial fitness on engineered organisms. It also discloses engineered organisms having improved industrial fitness. Synthetic biologic engineering modules are disclosed that provide for light capture, carbon dioxide fixation, NADH production, NADPH production, thermotolerance, pH tolerance, flue gas tolerance, salt tolerance, nutrient independence and near infrared absorbance. The disclosed engineered organisms can include one or more of these modules. Also provided are methods of using the engineered organism to produce carbon-based products of interest, biomass or pharmaceutical agents.

6. 发明申请

WO2008027501A2 LACCASES FOR PULP BIO-BLEACHING 审中-公开
标题翻译：纸浆生物漂白用的胶乳
公开(公告)号：WO2008027501A2
公开(公告)日：2008-03-06
申请号：PCT/US2007019124
申请日：2007-08-31
申请人： VERENIUM CORP , KEROVUO JANNE SAMULI , HAREMZA SYLKE , KOCH OLIVER , HABICHER TILO , ROBERTSON DAN , DESANTIS GRACE , MCCANN RYAN , LUGINBUHL PETER
发明人： KEROVUO JANNE SAMULI , HAREMZA SYLKE , KOCH OLIVER , HABICHER TILO , ROBERTSON DAN , DESANTIS GRACE , MCCANN RYAN , LUGINBUHL PETER
IPC分类号： C12N9/06
CPC分类号： C12N9/0061 , C12N15/09 , C12P5/00 , C12P7/00 , C12P19/00 , C12Y110/03002 , D21C5/005 , D21C9/005 , D21C9/1063
摘要： Provided herein are isolated laccase enzymes and nucleic acids encoding them. Also provided are mediators for laccase reactions. Also provided herein are methods for using laccases to oxidize lignins and other phenolic and aromatic compounds, such as for bio-bleaching and decolorization of wood pulp under high temperature and pH conditions to facilitate a substantial reduction in use of bleaching chemicals, as well as for treatment of fibers.
摘要翻译：本文提供了分离的漆酶和编码它们的核酸。还提供了用于漆酶反应的介体。本文还提供了使用漆酶氧化木质素和其它酚类和芳族化合物的方法，例如用于在高温和pH条件下木浆的生物漂白和脱色以促进漂白化学品的使用的显着减少，以及用于纤维处理。

7. 发明申请

WO2004066945A3 ENZYMES AND THE NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：酶和核酸编码它们及其制备和使用它们的方法
公开(公告)号：WO2004066945A3
公开(公告)日：2005-12-08
申请号：PCT/US2004002242
申请日：2004-01-26
申请人： DIVERSA CORP , BARTON NELSON , ROBERTSON DAN , CHANG KRISTINE , ELKINS JAMES
发明人： BARTON NELSON , ROBERTSON DAN , CHANG KRISTINE , ELKINS JAMES
IPC分类号： C12N9/00
CPC分类号： C12N9/00
摘要： The invention provides enzymes having a deacetylase, an amidase, a cellulase, an esterase, a glycosidase, a xylanase, an amylase, a transaminase, a laminarinase, a beta-galactosidase, a beta-mannosidase, a pullulanase, and/or a phosphatase activity, and the nucleic acids that encode them, and antibodies that specifically bind to them. This invention provides enzymes for the control of biofilms, polynucleotides and methods of making and using these polynucleotides and polypeptides. The invention provides products comprising these biofilm control compositions. In one aspect, the biofilm-control compositions of the invention have an amidase activity, e.g., the ability to hydrolyze amides, including enzymes having secondary amidase activity, including a peptidase, a protease and/or a hydantoinase activity. In one aspect, the biofilm control compositions of the invention have an amidase, a cellulase, an esterase, a glycosidase, a xylanase, an amylase, a transaminase, a laminarinase, a beta-galactosidase, a beta-mannosidase, a pullulanase, and/or a phosphatase activity.
摘要翻译：本发明提供了具有脱乙酰酶，酰胺酶，纤维素酶，酯酶，糖苷酶，木聚糖酶，淀粉酶，转氨酶，昆布糖酶，β-半乳糖苷酶，β-甘露糖苷酶，支链淀粉酶和/或磷酸酶活性和编码它们的核酸，以及特异性结合它们的抗体。本发明提供了用于控制生物膜，多核苷酸的酶，以及制备和使用这些多核苷酸和多肽的方法。本发明提供包含这些生物膜控制组合物的产品。一方面，本发明的生物膜对照组合物具有酰胺酶活性，例如水解酰胺的能力，包括具有仲酰胺酶活性的酶，包括肽酶，蛋白酶和/或乙内酰脲酶活性。一方面，本发明的生物膜控制组合物具有酰胺酶，纤维素酶，酯酶，糖苷酶，木聚糖酶，淀粉酶，转氨酶，昆布糖酶，β-半乳糖苷酶，β-甘露糖苷酶，支链淀粉酶和 /或磷酸酶活性。

8. 发明申请

WO2004035729A3 ESTERASES, NUCLEIC ACIDS ENCODING THEM AND METHODS OF MAKING AND USING THEM 审中-公开
标题翻译： ESTERASES，NUCLEIC ACID ENCODING THEM AND METHODS OF MAKING AND USING THEM
公开(公告)号：WO2004035729A3
公开(公告)日：2005-08-18
申请号：PCT/US0222336
申请日：2002-07-10
申请人： DIVERSA CORP , ROBERTSON DAN , MURPHY DENNIS , REID JOHN , MAFFIA ANTHONY III , LINK STEVEN , SWANSON RONALD V , WARREN PATRICK V , LENOX ANNA , SHORT JAY M , MATHUR ERIC J
发明人： ROBERTSON DAN , MURPHY DENNIS , REID JOHN , MAFFIA ANTHONY III , LINK STEVEN , SWANSON RONALD V , WARREN PATRICK V , LENOX ANNA , SHORT JAY M , MATHUR ERIC J
IPC分类号： A61K38/00 , C12N9/16 , C12N9/18 , C12P13/04 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/11 , C12N15/55 , C12N15/63
CPC分类号： C12N9/18 , A01K2217/05 , A61K38/00 , C12N9/16 , C12P13/04
摘要： The invention is directed to enzymes having an esterase activity, including thermostable and thermotolerant esterase activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The esterase activities of the enzymes of the invention include lipase activity (in the hydrolysis of lipids), acidolysis reactions (to replace an esterified fatty acid with a free fatty acid), transesterification reactions (exchange of fatty acids between triglycerides), in ester synthesis, and ester interchange reactions. The enzymes of the invention are used in organic synthesis reactions in the manufacture of medicaments, pesticides or intermediates thereof.
摘要翻译：本发明涉及具有酯酶活性的酶，包括耐热和耐热酯酶活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。本发明的酶的酯酶活性包括脂肪酶活性（脂质水解），酸解反应（用游离脂肪酸代替酯化的脂肪酸），酯交换反应（甘油三酯之间的脂肪酸交换），酯合成和酯交换反应。本发明的酶用于制备药物，农药或其中间体的有机合成反应中。

9. 发明申请

WO02068583A2 ENZYMES HAVING DEHALOGENASE ACTIVITY AND METHODS OF USE THEREOF 审中-公开
标题翻译：具有脱氢酶活性的酶及其使用方法
公开(公告)号：WO02068583A2
公开(公告)日：2002-09-06
申请号：PCT/US0145337
申请日：2001-11-30
申请人： DIVERSA CORP , SHORT JAY M , MATHUR ERIC J , RICHARDSON TOBY , ROBERTSON DAN , GRAY KEVIN
发明人： SHORT JAY M , MATHUR ERIC J , RICHARDSON TOBY , ROBERTSON DAN , GRAY KEVIN
IPC分类号： G01N33/53 , B09C1/10 , C02F1/00 , C07K16/40 , C12M1/34 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/14 , C12N15/09 , C12P7/18 , C12P7/20 , C12P7/56 , C12P13/00 , C12P21/08 , C12Q1/34 , C12Q1/68 , G01N33/566 , G06F19/22 , C12N
CPC分类号： C12N9/14 , G06F19/22 , Y10S422/90
摘要： The invention relates to haloalkane dehalogenases and to polynucleotides encoding the haloalkane dehalogenases. In addition methods of designing new dehalogenases and method of use thereof are also provided. The dehalogenases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及卤代烷烃脱卤素酶和编码卤代烷烃脱卤素酶的多核苷酸。另外还提供了设计新的脱卤素酶的方法及其使用方法。脱盐酶在增加的pH和温度下具有增加的活性和稳定性。

10. 发明申请

WO03027315A2 AMIDASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译： AMIDASES，编码它们的核酸以及制备和使用它们的方法
公开(公告)号：WO03027315A2
公开(公告)日：2003-04-03
申请号：PCT/US0231010
申请日：2002-09-27
申请人： DIVERSA CORP , ROBERTSON DAN , MURPHY DENNIS , MATHUR ERIC J , SHORT JAY M
发明人： ROBERTSON DAN , MURPHY DENNIS , MATHUR ERIC J , SHORT JAY M
IPC分类号： C12N9/80 , C12P21/06 , C12Q
CPC分类号： C12P21/06 , C12N9/80
摘要： The invention provides enzymes having an amidase activity, for example, catalyzing the removal of arginine, phenylalanine or methionine from the N-terminal end of polypeptides or peptides, e.g., in peptide or peptidomimetic synthesis. Amidase activities of the enzymes of the invention include deamidating peptide amides or N-terminally protected amino acids, the racemate splitting of N-protected amino acid amides, and for converting amides to carboxylic acids. In one aspect, an enzyme of the invention specifically acts on an (S)-amide; thus, it can be used to stereospecifically convert a mixture of (R)- and (S)-amides to the corresponding enantiomeric (S)-carboxylic acid.
摘要翻译：本发明提供具有酰胺酶活性的酶，例如催化从多肽或肽的N-末端除去精氨酸，苯丙氨酸或甲硫氨酸，例如在肽或肽模拟物合成中。本发明酶的酰胺酶活性包括脱酰胺肽酰胺或N-末端被保护的氨基酸，N-保护的氨基酸酰胺的外消旋分解以及将酰胺转化成羧酸。在一个方面，本发明的酶特异性地作用于（S） - 酰胺; 因此它可用于立体有择地将（R） - 和（S） - 酰胺的混合物转化成相应的对映体（S） - 羧酸。

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