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1. 发明申请

WO2010053990A3 CRHR2 PEPTIDE AGONISTS AND USES THEREOF 审中-公开
标题翻译： CRHR2肽激动剂及其用途
公开(公告)号：WO2010053990A3
公开(公告)日：2010-07-01
申请号：PCT/US2009063276
申请日：2009-11-04
申请人： JANSSEN PHARMACEUTICA NV , SWANSON RONALD V , SHANKLEY NIGEL P , MORENO VERONICA , GENGO PETER
发明人： SWANSON RONALD V , SHANKLEY NIGEL P , MORENO VERONICA , GENGO PETER
IPC分类号： C07K14/575 , A61K38/22 , C07K16/18 , C12N15/12
CPC分类号： C07K14/57509 , A61K38/00
摘要： The present invention relates to novel peptides that are selective corticotropin releasing hormone receptor type 2 (CRHR2) agonists and compositions thereof for the treatment, amelioration or inhibition of cardiovascular conditions, including but not limited to heart failure. The novel peptide agonist preferably comprise modifications that include pegylated peptides. Furthermore, the present invention also relates to methods for the treatment and prevention of a disease or disorder related to CRHR2 activity.
摘要翻译：本发明涉及作为选择性促肾上腺皮质激素释放激素受体2型（CRHR2）激动剂的新型肽及其组合物，用于治疗，改善或抑制心血管疾病，包括但不限于心力衰竭。新型肽激动剂优选包含包括聚乙二醇化肽的修饰。此外，本发明还涉及用于治疗和预防与CRHR2活性有关的疾病或病症的方法。

2. 发明申请

WO2010021874A2 ENGINEERED ANTI-IL-13 ANTIBODIES, COMPOSITIONS, METHODS AND USES 审中-公开
标题翻译：工程抗IL-13抗体，组合物，方法和用途
公开(公告)号：WO2010021874A2
公开(公告)日：2010-02-25
申请号：PCT/US2009/053425
申请日：2009-08-11
申请人： CENTOCOR ORTHO BIOTECH INC. , SWANSON, Ronald, V. , CHI, Ellen , RAGHUNATHAN, Gopalan , ZHAO, Shanrong , FRANSSON, Johan , CORDIER, Wendy , ALMAGRO, Juan, C. , HYUN, Linus , GILES-KOMAR, Jill , O'NEIL, Karyn, T. , CARTON, Jill, M. , ZHOU, Hong, Mimi , TEPLYAKOV, Alexey, V. , FENG, Yiqing
发明人： SWANSON, Ronald, V. , CHI, Ellen , RAGHUNATHAN, Gopalan , ZHAO, Shanrong , FRANSSON, Johan , CORDIER, Wendy , ALMAGRO, Juan, C. , HYUN, Linus , GILES-KOMAR, Jill , O'NEIL, Karyn, T. , CARTON, Jill, M. , ZHOU, Hong, Mimi , TEPLYAKOV, Alexey, V. , FENG, Yiqing
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/21 , G01N2333/5437
摘要： The present invention relates to engineered antibodies immunospecific for human interleukin-13 (IL- 13) protein or fragment thereof, as well as methods of making and using thereof, including therapeutic indications.
摘要翻译：本发明涉及针对人白细胞介素-13（IL-13）蛋白或其片段免疫特异性的工程化抗体，以及其制备和使用方法，包括治疗适应症。

3. 发明申请

WO2004035729A2 ESTERASES, NUCLEIC ACIDS ENCODING THEM AND METHODS OF MAKING AND USING THEM 审中-公开
标题翻译： ESTERASES，NUCLEIC ACID ENCODING THEM AND METHODS OF MAKING AND USING THEM
公开(公告)号：WO2004035729A2
公开(公告)日：2004-04-29
申请号：PCT/US2002/022336
申请日：2002-07-10
申请人： DIVERSA CORPORATION , ROBERTSON, Dan , MURPHY, Dennis , REID, John , MAFFIA, Anthony, III. , LINK, Steven , SWANSON, Ronald, V. , WARREN, Patrick, V. , LENOX, Anna , SHORT, Jay, M. , MATHUR, Eric, J.
发明人： ROBERTSON, Dan , MURPHY, Dennis , REID, John , MAFFIA, Anthony, III. , LINK, Steven , SWANSON, Ronald, V. , WARREN, Patrick, V. , LENOX, Anna , SHORT, Jay, M. , MATHUR, Eric, J.
IPC分类号： C12N
CPC分类号： C12N9/18 , A01K2217/05 , A61K38/00 , C12N9/16 , C12P13/04
摘要： The invention is directed to enzymes having an esterase activity, including thermostable and thermotolerant esterase activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The esterase activities of the enzymes of the invention include lipase activity (in the hydrolysis of lipids), acidolysis reactions (to replace an esterified fatty acid with a free fatty acid), transesterification reactions (exchange of fatty acids between triglycerides), in ester synthesis, and ester interchange reactions. The enzymes of the invention are used in organic synthesis reactions in the manufacture of medicaments, pesticides or intermediates thereof.
摘要翻译：本发明涉及具有酯酶活性的酶，包括耐热和耐热酯酶活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。本发明的酶的酯酶活性包括脂肪酶活性（脂质水解），酸解反应（用游离脂肪酸代替酯化的脂肪酸），酯交换反应（甘油三酯之间的脂肪酸交换），酯合成和酯交换反应。本发明的酶用于制备药物，农药或其中间体的有机合成反应中。

4. 发明申请

WO1997030160A1 ESTERASES 审中-公开
标题翻译：酯酶
公开(公告)号：WO1997030160A1
公开(公告)日：1997-08-21
申请号：PCT/US1997002039
申请日：1997-02-11
申请人： RECOMBINANT BIOCATALYSIS, INC. , ROBERTSON, Dan, E. , MURPHY, Dennis , REID, John , MAFFIA, Anthony, M. , LINK, Steven , SWANSON, Ronald, V. , WARREN, Patrick, V. , KOSMOTKA, Anna , CALLEN, Walter
发明人： RECOMBINANT BIOCATALYSIS, INC.
IPC分类号： C12N15/55
CPC分类号： C12N9/16 , C12N9/18 , C12P13/04
摘要： Esterase enzymes derived from various Staphylothermus, Pyrodictium, Archaeoglobus, Aquifex, M11TL, Thermococcus, Teredinibacter and Sulfolobus organisms are disclosed. The enzymes are produced from native or recombinant host cells and can be utilized in the pharmaceutical, agricultural and other industries.
摘要翻译：公开了衍生自各种葡萄球菌，火炬蒿，古细血管，Aquifex，M11TL，Thermococcus，Teredinibacter和Sulfolobus生物体的酯酶。酶由天然或重组宿主细胞产生，可用于制药，农业和其他工业。

5. 发明申请

WO2004035729A3 ESTERASES, NUCLEIC ACIDS ENCODING THEM AND METHODS OF MAKING AND USING THEM 审中-公开
标题翻译： ESTERASES，NUCLEIC ACID ENCODING THEM AND METHODS OF MAKING AND USING THEM
公开(公告)号：WO2004035729A3
公开(公告)日：2005-08-18
申请号：PCT/US0222336
申请日：2002-07-10
申请人： DIVERSA CORP , ROBERTSON DAN , MURPHY DENNIS , REID JOHN , MAFFIA ANTHONY III , LINK STEVEN , SWANSON RONALD V , WARREN PATRICK V , LENOX ANNA , SHORT JAY M , MATHUR ERIC J
发明人： ROBERTSON DAN , MURPHY DENNIS , REID JOHN , MAFFIA ANTHONY III , LINK STEVEN , SWANSON RONALD V , WARREN PATRICK V , LENOX ANNA , SHORT JAY M , MATHUR ERIC J
IPC分类号： A61K38/00 , C12N9/16 , C12N9/18 , C12P13/04 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/11 , C12N15/55 , C12N15/63
CPC分类号： C12N9/18 , A01K2217/05 , A61K38/00 , C12N9/16 , C12P13/04
摘要： The invention is directed to enzymes having an esterase activity, including thermostable and thermotolerant esterase activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The esterase activities of the enzymes of the invention include lipase activity (in the hydrolysis of lipids), acidolysis reactions (to replace an esterified fatty acid with a free fatty acid), transesterification reactions (exchange of fatty acids between triglycerides), in ester synthesis, and ester interchange reactions. The enzymes of the invention are used in organic synthesis reactions in the manufacture of medicaments, pesticides or intermediates thereof.
摘要翻译：本发明涉及具有酯酶活性的酶，包括耐热和耐热酯酶活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。本发明的酶的酯酶活性包括脂肪酶活性（脂质水解），酸解反应（用游离脂肪酸代替酯化的脂肪酸），酯交换反应（甘油三酯之间的脂肪酸交换），酯合成和酯交换反应。本发明的酶用于制备药物，农药或其中间体的有机合成反应中。

6. 发明申请

WO1998024799A1 GLYCOSIDASE ENZYMES 审中-公开
标题翻译：谷氨酰胺酶
公开(公告)号：WO1998024799A1
公开(公告)日：1998-06-11
申请号：PCT/US1997022623
申请日：1997-12-08
申请人： DIVERSA CORPORATION , BYLINA, Edward, J. , SWANSON, Ronald, V. , MATHUR, Eric, J. , LAM, David, E.
发明人： DIVERSA CORPORATION
IPC分类号： C07H21/04
CPC分类号： C12N9/2491 , C12N9/2402 , C12N9/2445 , C12N9/2454 , C12N9/2457 , C12N9/2465 , C12N9/2468 , C12N9/2494 , C12P19/02 , C12Y302/01021 , C12Y302/01022 , C12Y302/01023 , C12Y302/01025 , C12Y302/01041
摘要： Thermostable glycosidase enzymes derived from various Thermococcus, Staphylothermus and Pyrococcus organisms is disclosed. The enzymes are produced from native or recombinant host cells and can be utilized in the food processing industry, pharmaceutical industry and in the textile industry, detergent industry and in the baking industry.
摘要翻译：公开了源自各种热球菌属，葡萄球菌属和热球菌属的热稳定性糖苷酶。酶由天然或重组宿主细胞产生，可用于食品加工业，制药工业，纺织工业，洗涤剂行业和烘焙行业。

7. 发明申请

WO2010021874A3 ENGINEERED ANTI-IL-13 ANTIBODIES, COMPOSITIONS, METHODS AND USES 审中-公开
标题翻译：工程抗IL-13抗体，组合物，方法和用途
公开(公告)号：WO2010021874A3
公开(公告)日：2016-03-24
申请号：PCT/US2009053425
申请日：2009-08-11
申请人： CENTOCOR ORTHO BIOTECH INC , SWANSON RONALD V , CHI ELLEN , RAGHUNATHAN GOPALAN , ZHAO SHANRONG , FRANSSON JOHAN , CORDIER WENDY , ALMAGRO JUAN C , HYUN LINUS , GILES-KOMAR JILL , O'NEIL KARYN T , CARTON JILL M , ZHOU HONG MIMI , TEPLYAKOV ALEXEY V , FENG YIQING
发明人： SWANSON RONALD V , CHI ELLEN , RAGHUNATHAN GOPALAN , ZHAO SHANRONG , FRANSSON JOHAN , CORDIER WENDY , ALMAGRO JUAN C , HYUN LINUS , GILES-KOMAR JILL , O'NEIL KARYN T , CARTON JILL M , ZHOU HONG MIMI , TEPLYAKOV ALEXEY V , FENG YIQING
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/21 , G01N2333/5437
摘要： The present invention relates to engineered antibodies immunospecific for human interleukin-13 (IL- 13) protein or fragment thereof, as well as methods of making and using thereof, including therapeutic indications.
摘要翻译：本发明涉及针对人白细胞介素-13（IL-13）蛋白或其片段免疫特异性的工程化抗体，以及其制备和使用方法，包括治疗适应症。

8. 发明申请

WO2003068910A3 GLYCOSIDASES, NUCLEIC ACIDS ENCODING THEM AND METHODS OF MAKING AND USING THEM 审中-公开
公开(公告)号：WO2003068910A3
公开(公告)日：2003-08-21
申请号：PCT/US2002/023550
申请日：2002-07-22
申请人： DIVERSA CORPORATION , SHORT, Jay, M. , SWANSON, Ronald, V. , BYLINA, Edward , MATHUR, Eric, J. , LAM, DAvid, E.
发明人： SHORT, Jay, M. , SWANSON, Ronald, V. , BYLINA, Edward , MATHUR, Eric, J. , LAM, DAvid, E.
IPC分类号： C12P21/06
摘要： The invention is directed to enzymes having a glycosidase activity, including thermostable and thermotolerant glycosidase activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The glycosidase activities of the enzymes of the invention include the hydrolysis of any glycosidic linkages. For example, a glycosidase activity of an enzyme of the invention includes hydrolysis of a beta-anomeric configuration of a glycosidic linkage, such as the hydrolysis of beta-glucosides, beta-fucosides and beta-galactosides. Another glycosidase activity of an enzyme of the invention includes alpha-galactosidase activity, e.g., catalysis of the hydrolysis of galactose groups on a polysaccharide backbone or catalyzing the hydrolysis of the cleavage of di- or oligosaccharides comprising galactose. Another glycosidase activity of an enzyme of the invention includes catalysis of the hydrolysis of mannose groups internally on a polysaccharide backbone or hydrolysis of the cleavage of di-or oligosaccharides comprising mannose groups. Beta-mannosidases of the invention can hydrolyze non-reducing, terminal mannose residues on a mannose-containing polysaccharide and catalyze the cleavage of di- or oligosaccharides comprising mannose groups.

9. 发明申请

WO03068910A2 GLYCOSIDASES, NUCLEIC ACIDS ENCODING THEM AND METHODS OF MAKING AND USING THEM 审中-公开
标题翻译：糖苷酸，编码它们的核酸及其制备和使用方法
公开(公告)号：WO03068910A2
公开(公告)日：2003-08-21
申请号：PCT/US0223550
申请日：2002-07-22
申请人： DIVERSA CORP , SHORT JAY M , SWANSON RONALD V , BYLINA EDWARD , MATHUR ERIC J , LAM DAVID E
发明人： SHORT JAY M , SWANSON RONALD V , BYLINA EDWARD , MATHUR ERIC J , LAM DAVID E
IPC分类号： C12N9/24 , C12N9/38 , C12N9/46 , C12N
CPC分类号： C12N9/2468 , C12N9/2402 , C12N9/2437 , C12N9/2454 , C12N9/2457 , C12N9/2465 , C12N9/2494 , C12Y302/01004 , C12Y302/01022 , C12Y302/01025 , C12Y302/01041 , C12Y302/01078
摘要： The invention is directed to enzymes having a glycosidase activity, including thermostable and thermotolerant glycosidase activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The glycosidase activities of the enzymes of the invention include the hydrolysis of any glycosidic linkages. For example, a glycosidase activity of an enzyme of the invention includes hydrolysis of a beta-anomeric configuration of a glycosidic linkage, such as the hydrolysis of beta-glucosides, beta-fucosides and beta-galactosides. Another glycosidase activity of an enzyme of the invention includes alpha-galactosidase activity, e.g., catalysis of the hydrolysis of galactose groups on a polysaccharide backbone or catalyzing the hydrolysis of the cleavage of di- or oligosaccharides comprising galactose. Another glycosidase activity of an enzyme of the invention includes catalysis of the hydrolysis of mannose groups internally on a polysaccharide backbone or hydrolysis of the cleavage of di-or oligosaccharides comprising mannose groups. Beta-mannosidases of the invention can hydrolyze non-reducing, terminal mannose residues on a mannose-containing polysaccharide and catalyze the cleavage of di- or oligosaccharides comprising mannose groups.
摘要翻译：本发明涉及具有糖苷酶活性的酶，包括耐热和耐热糖苷酶活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。本发明的酶的糖苷酶活性包括任何糖苷键的水解。例如，本发明的酶的糖苷酶活性包括糖苷键的β-端基异构构型的水解，例如β-葡糖苷，β-岩藻糖苷和β-半乳糖苷的水解。本发明的酶的另一种糖苷酶活性包括α-半乳糖苷酶活性，例如催化多糖主链上的半乳糖基团的水解或催化水解包含半乳糖的二糖或寡糖的裂解。本发明的酶的另一种糖苷酶活性包括在多糖骨架内部水解甘露糖基团或水解包含甘露糖基团的二糖或寡糖的水解。本发明的β-甘露糖苷酶可以在含甘露糖的多糖上水解非还原性末端甘露糖残基，并催化包含甘露糖基团的二糖或寡糖的切割。

10. 发明申请

WO1997029187A1 TRANSAMINASES AND AMINOTRANSFERASES 审中-公开
标题翻译：多胺和氨基转移酶
公开(公告)号：WO1997029187A1
公开(公告)日：1997-08-14
申请号：PCT/US1997001094
申请日：1997-01-21
申请人： RECOMBINANT BIOCATALYSIS, INC. , WARREN, Patrick, V. , SWANSON, Ronald, V.
发明人： RECOMBINANT BIOCATALYSIS, INC.
IPC分类号： C12N09/10
CPC分类号： C12N9/00 , C12N9/1096 , C12N9/16 , C12Y206/01001 , Y10S435/822
摘要： Thermostable transaminase and aminotransferase enzymes derived from various ammonifex, aquifex and pyrobaculum organisms are disclosed. The enzymes are produced from native or recombinant host cells and can be utilized in the pharmaceutical, agricultural and other industries.
摘要翻译：公开了衍生自各种氨，含水和火腿菌生物体的热稳定转氨酶和氨基转移酶。酶由天然或重组宿主细胞产生，可用于制药，农业和其他工业。

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