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1. 发明授权

US10022236B2 Internal joint cavity expander 有权
公开(公告)号：US10022236B2
公开(公告)日：2018-07-17
申请号：US15121229
申请日：2015-02-10
申请人： JAPAN TISSUE ENGINEERING CO., LTD. , Mitsuo Ochi
发明人： Mitsuo Ochi
IPC分类号： A61F2/38 , A61B17/64
摘要： An internal joint cavity expander includes femur-side magnets, tibia-side magnets, and magnetic shield-members. Each femur-side magnet has a plate curved into an arc and fixed to a femur. Each tibia-side magnet has length smaller than the femur-side magnet length and having a plate curved into arc concentric with the femur-side magnet arc. Each tibia-side magnet is fixed to a tibia. The pole on the convex surface of each femur-side magnet is same as the pole on the concave surface corresponding tibia-side magnet. The convex surface of each femur-side magnet faces the concave surface of corresponding tibia-side magnet. Each magnetic shield-member covers the surface of corresponding femur-side magnet and tibia-side magnet facing the skin throughout range in which the femur-side magnet moves relative to the tibia-side magnet. Each magnetic shield-member prevents magnetism of corresponding magnets and from leaking outside without hindering the femur-side magnet movement relative to the tibia-side magnet.

2. 发明申请

US20120289764A1 MAGNETIC INDUCTION SYSTEM AND OPERATING METHOD FOR SAME INCORPORATION BY REFERENCE 有权
标题翻译：磁感应系统及其作为参考用途的操作方法
公开(公告)号：US20120289764A1
公开(公告)日：2012-11-15
申请号：US13503255
申请日：2010-10-25
申请人： Masato Murakami , Mitsuo Ochi
发明人： Masato Murakami , Mitsuo Ochi
IPC分类号： A61B17/52 , G01R33/035 , H01F6/00
CPC分类号： A61N2/002 , A61B34/73 , A61N2/02 , H01F6/00
摘要： The invention provides a magnetic induction system and an operating method for it in which the magnetic force can be made to act deeply and widely in any desired direction. The magnetic induction system of the invention contains multiple magnetic field generation means formed of a superconductive bulk magnet, a drive means for arranging the magnetic field generation means at a desired site and angle, and a drive control means for driving the driving means and controlling the position and the angle of the multiple magnetic field generation means so that a magnetic complex can be inducted to the desired position in a body by the synthetic magnetic field formed by the multiple magnetic field generation means, whereby the magnetic complex is inducted to be concentrated in the cartilage defected part.
摘要翻译：本发明提供一种磁感应系统及其操作方法，其中可以使磁力在任何所需方向上深入地和广泛地作用。本发明的磁感应系统包含由超导体磁体形成的多个磁场产生装置，用于将磁场产生装置配置在期望的位置和角度的驱动装置，以及驱动控制装置，用于驱动驱动装置并控制位置和多个磁场产生装置的角度，使得磁性复合体可以通过由多个磁场产生装置形成的合成磁场被感应到身体中的期望位置，由此磁性复合体被引入以集中在软骨缺损部位。

3. 发明申请

US20050019748A1 Method for measuring stiffness of a cultured tissue, using a stiffness measurement device having a vibration detective unit 有权
标题翻译：使用具有振动检测单元的刚度测量装置测量培养组织的刚度的方法
公开(公告)号：US20050019748A1
公开(公告)日：2005-01-27
申请号：US10921339
申请日：2004-08-19
申请人： Mitsuo Ochi , Junji Iwasa , Masatoshi Tobita , Masakazu Katoh , Takeyuki Yamamoto , Rika Fukushima , Toyokazu Kurushima
发明人： Mitsuo Ochi , Junji Iwasa , Masatoshi Tobita , Masakazu Katoh , Takeyuki Yamamoto , Rika Fukushima , Toyokazu Kurushima
IPC分类号： G01N3/00 , G01N3/06 , G01N3/32 , G01N3/40 , C12Q1/00
CPC分类号： G01N3/32 , G01N3/405 , G01N2203/0005 , G01N2203/0051 , G01N2203/0676 , G01N2203/0682 , G01N2203/0688
摘要： To determine the transplant compatibility of an in vitro cultured tissue, a method measures the stiffness of the cultured tissue by using a stiffness measuring device, which stiffness measuring device includes a detecting unit and calculation means, the detecting unit includes a contact unit, a vibrator connected to the contact unit, and a vibration detecting unit for detecting the vibration of the vibrator, and the calculation means determines stiffness information by calculation based on the detected result from the vibration detecting element; and by bringing the contact unit into contact with the cultured tissue. With this method the transplant compatibility of the cultured tissue can be nondestructively and easily determined easily and the quality of the cultured tissue can be appropriately controlled.
摘要翻译：为了确定体外培养的组织的移植相容性，一种方法通过使用刚度测量装置测量培养组织的刚度，所述刚度测量装置包括检测单元和计算装置，所述检测单元包括接触单元，振动器连接到所述接触单元的振动检测单元，以及用于检测所述振动器的振动的振动检测单元，并且所述计算单元基于来自所述振动检测元件的检测结果，通过计算来确定刚度信息; 并使接触单元与培养的组织接触。通过这种方法，培养的组织的移植相容性可以非破坏性且容易地确定，并且可以适当地控制培养的组织的质量。

4. 发明授权

US07971592B2 Magnetic cell and method of using the same 有权
标题翻译：磁性细胞及其使用方法
公开(公告)号：US07971592B2
公开(公告)日：2011-07-05
申请号：US10554259
申请日：2004-06-25
申请人： Mitsuo Ochi
发明人： Mitsuo Ochi
IPC分类号： A61B19/00
CPC分类号： C12N5/0006 , A61K41/00 , A61K47/6901
摘要： In the present invention, because no examples are known of binding of magnetic particle to mesenchymal cell or chondrocyte which might be used in regenerative medicine, whether or not a cell having the magnetic particle bound thereto is retained in local by external magnetism after administration and whether or not the cell can exhibit intrinsic activity is studied. According to the present invention, a magnetic cell comprising mesenchymal cell or cultured chondrocyte having magnetic particle bound to the surface thereof is provided, and when the cell is administered in vivo and an external magnetic field is applied, the cell can be retained for a long time at a disease site. Moreover, a drug delivery system can be constructed by causing the magnetic cells to contain a drug.
摘要翻译：在本发明中，由于没有将磁性粒子与可能用于再生医学中的间充质细胞或软骨细胞结合的实例，是否具有与其结合的磁性粒子的细胞是否在给药后通过外部磁力保持在局部，以及是否或者不能细胞可以表现出内在的活性被研究。根据本发明，提供了包含具有与其表面结合的磁性粒子的间充质细胞或培养的软骨细胞的磁性细胞，并且当细胞在体内施用并施加外部磁场时，细胞可以保持长时间在疾病现场的时间。此外，可以通过使磁性细胞含有药物来构建药物递送系统。

5. 发明申请

US20070172812A1 Tissue equivalent for transplantation and method for producing same 审中-公开
标题翻译：移植组织等价物及其生产方法
公开(公告)号：US20070172812A1
公开(公告)日：2007-07-26
申请号：US11727521
申请日：2007-03-27
申请人： Mitsuo Ochi , Yuji Uchio , Kenzo Kawasaki , Masakazu Katoh , Takeyuki Yamamoto , Rika Fukushima , Toyokazu Kurushima
发明人： Mitsuo Ochi , Yuji Uchio , Kenzo Kawasaki , Masakazu Katoh , Takeyuki Yamamoto , Rika Fukushima , Toyokazu Kurushima
IPC分类号： A01N1/02 , C12N5/08 , C12N5/06
CPC分类号： A61L27/3821 , A61L27/3633 , A61L27/3817 , A61L27/3895
摘要： A tissue equivalent for transplantation having a three-dimensional structure which is cultured in vitro, contains cells to be transplanted and which can be transplanted into a living body after the culture, characterized by including a scaffold layer mainly culturing a scaffold constituting the three-dimensional structure and a cell layer which is localized at least in a part of the surface of the tissue equivalent for transplantation continuously with the scaffold layer and which contains the cells to be transplanted or extra cellular matrix in a larger amount than the scaffold layer. This tissue equivalent is appropriately employed as a tissue equivalent for transplantation in a relatively large size. This tissue equivalent enables realization of prompt fixation to the neighborhood of the transplanted tissue and prevention of falling off.
摘要翻译：具有体外培养的具有三维结构的移植组织当量含有待移植的细胞，并且可以在培养后移植到生物体中，其特征在于包括主要培养构成三维的支架的支架层结构和细胞层，其至少在组织的表面的一部分中等同于与支架层连续移植，并且其含有比支架层更大量的要移植的细胞或细胞外基质。这种组织当量适当地用作相对较大尺寸移植的组织当量。这种组织等效使得能够实现对移植组织附近的迅速固定并防止脱落。

6. 发明申请

US20060264690A1 Magnetic cell and method of using the same 有权
标题翻译：磁性细胞及其使用方法
公开(公告)号：US20060264690A1
公开(公告)日：2006-11-23
申请号：US10554259
申请日：2004-06-25
申请人： Mitsuo Ochi
发明人： Mitsuo Ochi
IPC分类号： A61N2/00 , A61B19/00 , A61B17/52
CPC分类号： C12N5/0006 , A61K41/00 , A61K47/6901
摘要： In the present invention, because no examples are known of binding of magnetic particle to mesenchymal cell or chondrocyte which might be used in regenerative medicine, whether or not a cell having the magnetic particle bound thereto is retained in local by external magnetism after administration and whether or not the cell can exhibit intrinsic activity is studied. According to the present invention, a magnetic cell comprising mesenchymal cell or cultured chondrocyte having magnetic particle bound to the surface thereof is provided, and when the cell is administered in vivo and an external magnetic field is applied, the cell can be retained for a long time at a disease site. Moreover, a drug delivery system can be constructed by causing the magnetic cells to contain a drug.
摘要翻译：在本发明中，由于没有将磁性粒子与可能用于再生医学中的间充质细胞或软骨细胞结合的实例，是否具有与其结合的磁性粒子的细胞是否在给药后通过外部磁力保持在局部，以及是否或者不能细胞可以表现出内在的活性被研究。根据本发明，提供了包含具有与其表面结合的磁性粒子的间充质细胞或培养的软骨细胞的磁性细胞，并且当细胞在体内施用并施加外部磁场时，细胞可以保持长时间在疾病现场的时间。此外，可以通过使磁性细胞含有药物来构建药物递送系统。

7. 发明授权

US09242117B2 Magnetic induction system and operating method for same incorporation by reference 有权
标题翻译：磁感应系统及其相关操作方法
公开(公告)号：US09242117B2
公开(公告)日：2016-01-26
申请号：US13503255
申请日：2010-10-25
申请人： Masato Murakami , Mitsuo Ochi
发明人： Masato Murakami , Mitsuo Ochi
IPC分类号： A61N2/02 , A61N2/00 , H01F6/00 , A61B19/00
CPC分类号： A61N2/002 , A61B34/73 , A61N2/02 , H01F6/00
摘要： The invention provides a magnetic induction system and an operating method for it in which the magnetic force can be made to act deeply and widely in any desired direction. The magnetic induction system of the invention contains multiple magnetic field generation means formed of a superconductive bulk magnet, a drive means for arranging the magnetic field generation means at a desired site and angle, and a drive control means for driving the driving means and controlling the position and the angle of the multiple magnetic field generation means so that a magnetic complex can be inducted to the desired position in a body by the synthetic magnetic field formed by the multiple magnetic field generation means, whereby the magnetic complex is inducted to be concentrated in the cartilage defected part.
摘要翻译：本发明提供一种磁感应系统及其操作方法，其中可以使磁力在任何所需方向上深入地和广泛地作用。本发明的磁感应系统包含由超导体磁体形成的多个磁场产生装置，用于将磁场产生装置配置在期望的位置和角度的驱动装置，以及驱动控制装置，用于驱动驱动装置并控制位置和多个磁场产生装置的角度，使得磁性复合体可以通过由多个磁场产生装置形成的合成磁场被感应到身体中的期望位置，由此磁性复合体被引入以集中在软骨缺损部位。

8. 发明授权

US08701676B2 Magnetic cell and method of using the same 有权
标题翻译：磁性细胞及其使用方法
公开(公告)号：US08701676B2
公开(公告)日：2014-04-22
申请号：US12702163
申请日：2010-02-08
申请人： Mitsuo Ochi
发明人： Mitsuo Ochi
IPC分类号： A61N2/10
CPC分类号： C12N5/0006 , A61K41/00 , A61K47/6901
摘要： In the present invention, because no examples are known of binding of magnetic particle to mesenchymal cell or chondrocyte which might be used in regenerative medicine, whether or not a cell having the magnetic particle bound thereto is retained in local by external magnetism after administration and whether or not the cell can exhibit intrinsic activity is studied. According to the present invention, a magnetic cell comprising mesenchymal cell or cultured chondrocyte having magnetic particle bound to the surface thereof is provided, and when the cell is administered in vivo and an external magnetic field is applied, the cell can be retained for a long time at a disease site. Moreover, a drug delivery system can be constructed by causing the magnetic cells to contain a drug.
摘要翻译：在本发明中，由于没有将磁性粒子与可能用于再生医学中的间充质细胞或软骨细胞结合的实例，是否具有与其结合的磁性粒子的细胞是否在给药后通过外部磁力保持在局部，以及是否或者不能细胞可以表现出内在的活性被研究。根据本发明，提供了包含具有与其表面结合的磁性粒子的间充质细胞或培养的软骨细胞的磁性细胞，并且当细胞在体内施用并施加外部磁场时，细胞可以保持长时间在疾病现场的时间。此外，可以通过使磁性细胞含有药物来构建药物递送系统。

9. 发明申请

US20070274966A1 Neural regeneration with transplanted AC133 positive cells 审中-公开
标题翻译：神经再生移植AC133阳性细胞
公开(公告)号：US20070274966A1
公开(公告)日：2007-11-29
申请号：US11711898
申请日：2007-02-28
申请人： Masakazu Ishikawa , Mitsuo Ochi , Takayuki Asahara
发明人： Masakazu Ishikawa , Mitsuo Ochi , Takayuki Asahara
IPC分类号： A61K35/12 , A61P25/00 , A61P25/02
CPC分类号： A61K35/28
摘要： We focused attention on AC133 positive cells as a cell source. AC133 positive cells were transplanted to an injured sciatic nerve model and an injured spinal cord model and were found to have very intensive neural regeneration ability. Such AC133 positive cells are easily available from the peripheral blood with reduced burden on a donor. In addition, they are free from ethical questions and are found to be used as a very useful cell source in neural regenerative treatments with transplanted cells. According to this invention, there is provided a cell source for neural regenerative treatments with transplanted cells, which is more easily available and has a higher neural regeneration ability than equivalents.
摘要翻译：我们集中注意AC133阳性细胞作为细胞来源。将AC133阳性细胞移植到受伤的坐骨神经模型和受损的脊髓模型，发现其具有非常强的神经再生能力。这种AC133阳性细胞容易从外周血中获得，而捐赠者负担减轻。此外，它们没有伦理问题，被发现用作具有移植细胞的神经再生治疗中非常有用的细胞来源。根据本发明，提供了一种用于具有移植细胞的神经再生治疗的细胞源，其更容易获得并且具有比等同物更高的神经再生能力。

10. 发明授权

US07198908B2 Method for measuring stiffness of a cultured tissue, using a stiffness measurement device having a vibration detective unit 有权
标题翻译：使用具有振动检测单元的刚度测量装置测量培养组织的刚度的方法
公开(公告)号：US07198908B2
公开(公告)日：2007-04-03
申请号：US10921339
申请日：2004-08-19
申请人： Mitsuo Ochi , Junji Iwasa , Masatoshi Tobita , Masakazu Katoh , Takeyuki Yamamoto , Rika Fukushima , Toyokazu Kurushima
发明人： Mitsuo Ochi , Junji Iwasa , Masatoshi Tobita , Masakazu Katoh , Takeyuki Yamamoto , Rika Fukushima , Toyokazu Kurushima
IPC分类号： C12P1/00
CPC分类号： G01N3/32 , G01N3/405 , G01N2203/0005 , G01N2203/0051 , G01N2203/0676 , G01N2203/0682 , G01N2203/0688
摘要： To determine the transplant compatibility of an in vitro cultured tissue, a method measures the stiffness of the cultured tissue by using a stiffness measuring device, which stiffness measuring device includes a detecting unit and calculation means, the detecting unit includes a contact unit, a vibrator connected to the contact unit, and a vibration detecting unit for detecting the vibration of the vibrator, and the calculation means determines stiffness information by calculation based on the detected result from the vibration detecting element; and by bringing the contact unit into contact with the cultured tissue. With this method the transplant compatibility of the cultured tissue can be nondestructively and easily determined easily and the quality of the cultured tissue can be appropriately controlled.
摘要翻译：为了确定体外培养的组织的移植相容性，一种方法通过使用刚度测量装置测量培养组织的刚度，所述刚度测量装置包括检测单元和计算装置，所述检测单元包括接触单元，振动器连接到所述接触单元的振动检测单元，以及用于检测所述振动器的振动的振动检测单元，并且所述计算单元基于来自所述振动检测元件的检测结果，通过计算来确定刚度信息; 并使接触单元与培养的组织接触。通过这种方法，培养的组织的移植相容性可以非破坏性且容易地确定，并且可以适当地控制培养的组织的质量。

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