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1. 发明专利

JP2008076409A Method for controlling quality of incubated tissue 有权
标题翻译：控制组织质量的方法
公开(公告)号：JP2008076409A
公开(公告)日：2008-04-03
申请号：JP2007279001
申请日：2007-10-26
申请人： Japan Tissue Engineering:Kk , Mitsuo Ochi , 株式会社ジャパン・ティッシュ・エンジニアリング , 光夫越智
发明人： OCHI MITSUO , IWASA JUNJI , HIDA MASATOSHI , KATO MASAKAZU , YAMAMOTO TAKAYUKI , FUKUSHIMA RIKA , KURUSHIMA TOYOICHI
IPC分类号： G01N3/40
摘要： PROBLEM TO BE SOLVED: To enable easy and appropriate control of quality of incubated tissue without destroying the incubated tissue. SOLUTION: In the method, hardness information of in-vitro incubated tissue, having a three-dimensional structure in which hardness or elasticity thereof changes with passing of a cultivation period, is measured; the states of cell multiplication and the quantity of a product substrate are grasped from the measurement results; and transplantation aptitude of the incubated tissue judged from the states. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：使得能够容易且适当地控制孵育的组织的质量而不破坏孵育的组织。解决方案：在该方法中，测量其中硬度或弹性随培养时间过去而改变的三维结构的体外培养组织的硬度信息; 从测量结果中掌握细胞倍增状态和产品底物的数量; 和从状态判断的孵化组织的移植能力。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2007151605A Magnetic induction device and guide system of magnetic complex 审中-公开
标题翻译：磁感应装置及磁性复合导向系统
公开(公告)号：JP2007151605A
公开(公告)日：2007-06-21
申请号：JP2005346911
申请日：2005-11-30
申请人： Mitsuo Ochi , Tamakawa Co Ltd , 株式会社玉川製作所 , 光夫越智
发明人： OCHI MITSUO , TAMAGAWA KATSUNORI
IPC分类号： A61M37/00 , A61B17/56 , A61B19/00
摘要： PROBLEM TO BE SOLVED: To provide a magnetic induction device and a guide system of a magnetic complex facilitating the moving, installed in a small space compared with a conventional one and reducing the manufacturing cost. SOLUTION: A support part 12 is movable with its supporting a solenoid coil. The support part 12 has a guide rail 15 provided extending vertically, a height adjusting means 16 provided to adjust the height of the solenoid coil, and an angle adjusting means provided to adjust an angle formed between an axis of the solenoid coil and the horizontal plane. The height adjusting means 16 has a ball screw 23 being in parallel to the guide rail 15, a worm gear 24 threadedly engaged with the ball screw 23 and a handle 25 capable of rotating the warm gear 24. The solenoid coil is movable along the guide rail 15 by the rotation of the ball screw 23. The magnetic complex includes an internal effective substance and a micromagnetic material and is movable by a magnetic field generated by the solenoid coil. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种磁传感装置和便于移动的磁性复合体的引导系统，其安装在与常规的相比较的空间中，并降低制造成本。
解决方案：支撑部件12可以通过支撑螺线管线圈而移动。支撑部分12具有垂直延伸设置的导轨15，设置用于调节螺线管线圈高度的高度调节装置16和用于调节螺线管线圈的轴线与水平面之间形成的角度的角度调节装置。高度调节装置16具有与导轨15平行的滚珠丝杠23，与滚珠丝杠23螺纹接合的蜗轮24和能够使暖齿轮24旋转的手柄25.螺线管线圈可沿导向件磁性复合体包括内部有效物质和微磁材料，并可通过螺线管线圈产生的磁场移动。版权所有（C）2007，JPO＆INPIT

3. 发明专利

JP2005261610A Member for cartilage formation and cartilage formation method 有权
标题翻译：纸质成型和成型方法的会员
公开(公告)号：JP2005261610A
公开(公告)日：2005-09-29
申请号：JP2004077425
申请日：2004-03-18
申请人： Mmt:Kk , Mitsuo Ochi , Toshiba Ceramics Co Ltd , 東芝セラミックス株式会社 , 株式会社エム・エム・ティー , 光夫越智
发明人： OCHI MITSUO
IPC分类号： A61L27/00
摘要： PROBLEM TO BE SOLVED: To provide a member for cartilage formation which is to be the culture base material of cartilage cells by itself, has sufficient strength to be planted to a cartilage deletion part and can fix and regenerate the cartilage and bones in an early stage in cartilage formation treatment, and a cartilage formation method using the member. SOLUTION: By using the member for the cartilage formation in which a holding part for holding a gel-like body for the cartilage formation is provided on a part of the surface of a calcium phosphate ceramic porous body and the gel-like body for the cartilage formation is held by the holding part, the cartilage cell is reproduced by bringing the gel-like body for the cartilage formation into contact with a culture solution, and then the member for the cartilage formation is implanted to the joint of a living body. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：为了提供作为软骨细胞本身的培养基材料的软骨形成成分，具有足够的强度来种植到软骨缺失部分，并且可以固定和再生软骨和骨骼中的软骨和骨骼软骨形成治疗的早期阶段，以及使用该成员的软骨形成方法。解决方案：通过使用用于软骨形成的构件，其中在钙磷酸钙陶瓷多孔体的表面的一部分上提供用于保持用于软骨形成的凝胶状体的保持部，并且凝胶状体由于软骨形成由保持部保持，通过使软骨形成用凝胶状体与培养液接触来再生软骨细胞，然后将软骨形成用部件植入生物体的接合体身体。版权所有（C）2005，JPO＆NCIPI

4. 发明专利

JP2004129814A Biological member 有权
公开(公告)号：JP2004129814A
公开(公告)日：2004-04-30
申请号：JP2002296923
申请日：2002-10-10
申请人： Mmt:Kk , Mitsuo Ochi , Toshiba Ceramics Co Ltd , 東芝セラミックス株式会社 , 株式会社エム・エム・ティー , 越智光夫
发明人： OCHI MITSUO
IPC分类号： A61L27/00
CPC分类号： A61F2/28 , A61F2002/30001
摘要： PROBLEM TO BE SOLVED: To provide a biological member composed of ceramics which is excellent in cell infiltration and its adhesion and excellent in a strength property and is allowed to be formed in any desired size and shape easily. SOLUTION: This biological member is formed combinationably from a porous ceramic part comprising hydroxyapatite and a dense ceramic part comprising hydroxyapatite. These ceramics parts are combined and formed in any desired shape by being fastened and sintered to be integrated. COPYRIGHT: (C)2004,JPO

5. 发明专利

JP2004298566A Member for living body 有权
公开(公告)号：JP2004298566A
公开(公告)日：2004-10-28
申请号：JP2003098299
申请日：2003-04-01
申请人： Mmt:Kk , Mitsuo Ochi , Toshiba Ceramics Co Ltd , 東芝セラミックス株式会社 , 株式会社エム・エム・ティー , 光夫越智
发明人： OCHI MITSUO
IPC分类号： A61L27/00 , A61F2/28
摘要： PROBLEM TO BE SOLVED: To provide a member for the living bodies which achieves the easier guiding of the blood vessels into the center part of the member when used as an artificial bone or the like to promote the regeneration of the bone and moreover, the easier production thereof. SOLUTION: The member for the living bodies to be used as the bone or the like has at least three cylindrical ceramics bar-like bodies 1 each with the cross section of 1 mm or more to 10 mm or less in diameter which each comprises a ceramic porous element having pores communicating with each other inside and are housed into a titanium gauze 11 to be integrated. COPYRIGHT: (C)2005,JPO&NCIPI

6. 发明专利

JP2004298565A Member for living body 有权
公开(公告)号：JP2004298565A
公开(公告)日：2004-10-28
申请号：JP2003098298
申请日：2003-04-01
申请人： Mmt:Kk , Mitsuo Ochi , Toshiba Ceramics Co Ltd , 東芝セラミックス株式会社 , 株式会社エム・エム・ティー , 光夫越智
发明人： OCHI MITSUO
IPC分类号： A61L27/00 , A61F2/28 , C04B35/447
CPC分类号： A61F2/28 , A61F2002/30001
摘要： PROBLEM TO BE SOLVED: To provide a member for the living bodies which achieves an easier guiding of the blood vessels into the center part of the member when used as an artificial bone or the like to promote the regeneration of the bone and moreover, the easier production thereof. SOLUTION: The member for the living bodies to be used as the artificial bone or the like has at least three ceramics bar-like bodies 1 each with the cross section of 1 mm or more to 10 mm or less in diameter which each comprises a ceramics porous element having pores communicating with each other inside and are bundled at several points with a titanium belt 2 to be integrated. COPYRIGHT: (C)2005,JPO&NCIPI

7. 发明授权

US07971592B2 Magnetic cell and method of using the same 有权
标题翻译：磁性细胞及其使用方法
公开(公告)号：US07971592B2
公开(公告)日：2011-07-05
申请号：US10554259
申请日：2004-06-25
申请人： Mitsuo Ochi
发明人： Mitsuo Ochi
IPC分类号： A61B19/00
CPC分类号： C12N5/0006 , A61K41/00 , A61K47/6901
摘要： In the present invention, because no examples are known of binding of magnetic particle to mesenchymal cell or chondrocyte which might be used in regenerative medicine, whether or not a cell having the magnetic particle bound thereto is retained in local by external magnetism after administration and whether or not the cell can exhibit intrinsic activity is studied. According to the present invention, a magnetic cell comprising mesenchymal cell or cultured chondrocyte having magnetic particle bound to the surface thereof is provided, and when the cell is administered in vivo and an external magnetic field is applied, the cell can be retained for a long time at a disease site. Moreover, a drug delivery system can be constructed by causing the magnetic cells to contain a drug.
摘要翻译：在本发明中，由于没有将磁性粒子与可能用于再生医学中的间充质细胞或软骨细胞结合的实例，是否具有与其结合的磁性粒子的细胞是否在给药后通过外部磁力保持在局部，以及是否或者不能细胞可以表现出内在的活性被研究。根据本发明，提供了包含具有与其表面结合的磁性粒子的间充质细胞或培养的软骨细胞的磁性细胞，并且当细胞在体内施用并施加外部磁场时，细胞可以保持长时间在疾病现场的时间。此外，可以通过使磁性细胞含有药物来构建药物递送系统。

8. 发明申请

US20070172812A1 Tissue equivalent for transplantation and method for producing same 审中-公开
标题翻译：移植组织等价物及其生产方法
公开(公告)号：US20070172812A1
公开(公告)日：2007-07-26
申请号：US11727521
申请日：2007-03-27
申请人： Mitsuo Ochi , Yuji Uchio , Kenzo Kawasaki , Masakazu Katoh , Takeyuki Yamamoto , Rika Fukushima , Toyokazu Kurushima
发明人： Mitsuo Ochi , Yuji Uchio , Kenzo Kawasaki , Masakazu Katoh , Takeyuki Yamamoto , Rika Fukushima , Toyokazu Kurushima
IPC分类号： A01N1/02 , C12N5/08 , C12N5/06
CPC分类号： A61L27/3821 , A61L27/3633 , A61L27/3817 , A61L27/3895
摘要： A tissue equivalent for transplantation having a three-dimensional structure which is cultured in vitro, contains cells to be transplanted and which can be transplanted into a living body after the culture, characterized by including a scaffold layer mainly culturing a scaffold constituting the three-dimensional structure and a cell layer which is localized at least in a part of the surface of the tissue equivalent for transplantation continuously with the scaffold layer and which contains the cells to be transplanted or extra cellular matrix in a larger amount than the scaffold layer. This tissue equivalent is appropriately employed as a tissue equivalent for transplantation in a relatively large size. This tissue equivalent enables realization of prompt fixation to the neighborhood of the transplanted tissue and prevention of falling off.
摘要翻译：具有体外培养的具有三维结构的移植组织当量含有待移植的细胞，并且可以在培养后移植到生物体中，其特征在于包括主要培养构成三维的支架的支架层结构和细胞层，其至少在组织的表面的一部分中等同于与支架层连续移植，并且其含有比支架层更大量的要移植的细胞或细胞外基质。这种组织当量适当地用作相对较大尺寸移植的组织当量。这种组织等效使得能够实现对移植组织附近的迅速固定并防止脱落。

9. 发明申请

US20060264690A1 Magnetic cell and method of using the same 有权
标题翻译：磁性细胞及其使用方法
公开(公告)号：US20060264690A1
公开(公告)日：2006-11-23
申请号：US10554259
申请日：2004-06-25
申请人： Mitsuo Ochi
发明人： Mitsuo Ochi
IPC分类号： A61N2/00 , A61B19/00 , A61B17/52
CPC分类号： C12N5/0006 , A61K41/00 , A61K47/6901
摘要： In the present invention, because no examples are known of binding of magnetic particle to mesenchymal cell or chondrocyte which might be used in regenerative medicine, whether or not a cell having the magnetic particle bound thereto is retained in local by external magnetism after administration and whether or not the cell can exhibit intrinsic activity is studied. According to the present invention, a magnetic cell comprising mesenchymal cell or cultured chondrocyte having magnetic particle bound to the surface thereof is provided, and when the cell is administered in vivo and an external magnetic field is applied, the cell can be retained for a long time at a disease site. Moreover, a drug delivery system can be constructed by causing the magnetic cells to contain a drug.
摘要翻译：在本发明中，由于没有将磁性粒子与可能用于再生医学中的间充质细胞或软骨细胞结合的实例，是否具有与其结合的磁性粒子的细胞是否在给药后通过外部磁力保持在局部，以及是否或者不能细胞可以表现出内在的活性被研究。根据本发明，提供了包含具有与其表面结合的磁性粒子的间充质细胞或培养的软骨细胞的磁性细胞，并且当细胞在体内施用并施加外部磁场时，细胞可以保持长时间在疾病现场的时间。此外，可以通过使磁性细胞含有药物来构建药物递送系统。

10. 发明申请

US20020115060A1 Methods for measuring stiffness of cultured tissue, for determining transplant compatibility, for quality control, and for preparing transplant-compatible cultured tissue 失效
标题翻译：用于测量培养组织的硬度，确定移植物兼容性，质量控制以及制备移植相容的培养组织的方法
公开(公告)号：US20020115060A1
公开(公告)日：2002-08-22
申请号：US10083583
申请日：2002-02-27
申请人： MITSUO OCHI and JAPAN TISSUE ENGINEERING CO., LTD.
发明人： Mitsuo Ochi , Junji Iwasa , Masatoshi Tobita , Masakazu Katoh , Takeyuki Yamamoto , Rika Fukushima , Toyokazu Kurushima
IPC分类号： C12Q001/00 , C12M001/34
CPC分类号： G01N3/32 , G01N3/405 , G01N2203/0005 , G01N2203/0051 , G01N2203/0676 , G01N2203/0682 , G01N2203/0688
摘要： To determine the transplant compatibility of an in vitro cultured tissue, a method measures the stiffness of the cultured tissue by using a stiffness measuring device, which stiffness measuring device includes a detecting unit and calculation means, the detecting unit includes a contact unit, a vibrator connected to the contact unit, and a vibration detecting unit for detecting the vibration of the vibrator, and the calculation means determines stiffness information by calculation based on the detected result from the vibration detecting element; and by bringing the contact unit into contact with the cultured tissue. With this method the transplant compatibility of the cultured tissue can be nondestructively and easily determined easily and the quality of the cultured tissue can be appropriately controlled.
摘要翻译：为了确定体外培养的组织的移植相容性，一种方法通过使用刚度测量装置测量培养组织的刚度，所述刚度测量装置包括检测单元和计算装置，所述检测单元包括接触单元，振动器连接到所述接触单元的振动检测单元，以及用于检测所述振动器的振动的振动检测单元，并且所述计算单元基于来自所述振动检测元件的检测结果，通过计算来确定刚度信息; 并使接触单元与培养的组织接触。通过这种方法，培养的组织的移植相容性可以非破坏性且容易地确定，并且可以适当地控制培养的组织的质量。

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