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1. 发明公开

EP2360193A4 GRAFT POLYMERIZATION METHOD AND PRODUCT OBTAINED THEREBY 有权转让
标题翻译：移植物和由此得到的产物
公开(公告)号：EP2360193A4
公开(公告)日：2012-05-09
申请号：EP09827629
申请日：2009-11-20
申请人： JAPAN MEDICAL MATERIALS CORP , UNIV TOKYO
发明人： KYOMOTO MASAYUKI , ISHIHARA KAZUHIKO
IPC分类号： C08F283/00 , C08F2/00 , C08F2/48 , C08F283/06 , C08F291/18 , C08J7/04
CPC分类号： C08F291/18 , C08F283/06 , Y10T428/31855 , C08F230/02 , C08F2/48

4. 发明公开

EP2380600A4 POLYMER SLIDING MATERIAL, ARTIFICIAL JOINT MEMBER, MEDICAL APPLIANCE, AND MANUFACTURING METHOD THEREFOR 有权转让
标题翻译：聚合物 - GLEITMATERIAL，KÜNSTLICHESGELENKGLIED，MEDISINISCHESGERÄTUND HERSTELLUNGSVERFAHRENDAFÜR
公开(公告)号：EP2380600A4
公开(公告)日：2013-08-21
申请号：EP09835034
申请日：2009-12-25
申请人： JAPAN MEDICAL MATERIALS CORP , UNIV TOKYO
发明人： KYOMOTO MASAYUKI , ISHIHARA KAZUHIKO
IPC分类号： A61L27/00
CPC分类号： A61L27/18 , C08F2/48 , C08F291/18 , Y10T428/31855 , C08L71/00
摘要： Disclosed is a sliding member with excellent durability and capable of maintaining wear resistance over a long period of time. Further disclosed is an artificial joint member for which the film thickness of the polymer base material is reduced. Further disclosed is an artificial joint which is capable of demonstrating high lubricity, biocompatibility, and resistance to dislocation after introduction into the body. Further disclosed are a medical appliance material and a medical appliance which demonstrate excellent biocompatibility. The sliding material or the medical appliance material is formed by a polymer layer or a biocompatible material layer (B) being provided by coating at least a portion of the surface of a polymer base material (A), the surface of which has a ketone group, and the polymer layer or biocompatible layer (B) is characterized by being formed by surface graft polymerization, wherein the polymer base material (A) is immersed in a reaction system which contains a monomer (C), the polymer base material (A) is exposed to light, and polymerization of the monomer is initiated from the surface of the polymer base material (A). Using the sliding material or medical appliance material, an artificial joint member, an artificial joint, a medical appliance material, and a medical appliance are manufactured.
摘要翻译：公开了具有优异的耐久性并能够长时间保持耐磨性的滑动构件。进一步公开了一种减少聚合物基材的膜厚的人造接头构件。进一步公开了一种人造关节，其能够表现出高的润滑性，生物相容性和在引入体内之后的位错耐性。进一步公开了表现出优异的生物相容性的医疗器具材料和医疗器械。滑动材料或医疗用具材料由聚合物层或生物相容性材料层（B）形成，所述聚合物层或生物相容性材料层（B）通过涂覆聚合物基材（A）的至少一部分表面而提供，所述聚合物基材（A）的表面具有酮基聚合物基材（A）浸渍在含有单体（C），聚合物基材（A）的反应体系中，聚合物基材（A）暴露于光，并且单体的聚合从聚合物基材（A）的表面引发。使用滑动材料或医疗器具材料制造人造关节构件，人造关节，医疗器具材料和医疗器具。

5. 发明公开

EP2468311A4 HIGHLY LUBRICATING SLIDING MEMBER AND ARTIFICIAL JOINT USING SAME 有权转让
标题翻译：在高度润滑滑动ABLE和彪人工关节ORDER
公开(公告)号：EP2468311A4
公开(公告)日：2014-06-25
申请号：EP10809983
申请日：2010-08-18
申请人： JAPAN MEDICAL MATERIALS CORP , UNIV TOKYO
发明人： KYOMOTO MASAYUKI , ISHIHARA KAZUHIKO
IPC分类号： A61L27/00 , A61F2/34
CPC分类号： A61L27/14 , A61F2/30767 , A61F2/32 , A61F2002/30673 , A61L27/18 , A61L27/34 , A61L27/50 , A61L2400/10 , A61L2430/24 , C08L101/02 , C08L71/00 , C08L33/10

6. 发明公开

EP2233159A4 MEDICAL DEVICE AND METHOD FOR MANUFACTURE THEREOF 有权
标题翻译：医疗器械及其制备方法
公开(公告)号：EP2233159A4
公开(公告)日：2013-01-02
申请号：EP08865567
申请日：2008-12-19
申请人： JAPAN MEDICAL MATERIALS CORP , UNIV TOKYO
发明人： KYOMOTO MASAYUKI , ISHIHARA KAZUHIKO , NAKAMURA KOZO , TAKATORI YOSHIO , KAWAGUCHI HIROSHI , MORO TORU
IPC分类号： A61L27/00 , A61K6/00 , A61K6/033 , A61K6/093 , A61L27/34 , A61L31/00 , A61L31/10 , A61L33/00
CPC分类号： A61L33/0076 , A61K6/033 , A61K6/04 , A61L27/34 , A61L31/10 , Y10T428/31667 , A61K6/0023 , C08L33/08 , C08L33/10
摘要： An object is to provide a medical device having excellent antithrombotic and sliding characteristics, which can exert a cell adhesion inhibitory effect. A medical device comprising: a substrate capable of forming hydroxyl groups; and a biocompatible material layer laminated on the substrate at an appropriate position, wherein the hydroxyl groups are formed on a surface of the substrate at least at a required position by a surface treatment, while the biocompatible material layer is formed from a polymer containing phosphorylcholine groups, and wherein the substrate and the biocompatible material layer are joined via a binder layer formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.

7. 发明专利

JP2007260247A Biomaterial, artificial joint using the same and its manufacturing method 有权
标题翻译：生物材料，使用它的人工接头及其制造方法
公开(公告)号：JP2007260247A
公开(公告)日：2007-10-11
申请号：JP2006091544
申请日：2006-03-29
申请人： Japan Medical Materials Corp , Tokyo Medical & Dental Univ , Univ Of Tokyo , 国立大学法人東京医科歯科大学 , 国立大学法人東京大学 , 日本メディカルマテリアル株式会社
发明人： KYOMOTO MASAYUKI , ISHIHARA KAZUHIKO , IWASAKI YASUHIKO , MORO TORU , NAKAMURA KOZO , TAKATORI YOSHIO , KAWAGUCHI HIROSHI , KONNO TOMOHIRO , YAMAWAKI NOBORU
IPC分类号： A61L27/00 , A61F2/34 , A61F2/36 , C22C14/00 , C22C19/07
CPC分类号： A61L27/34 , A61F2/30767 , A61F2/32 , A61F2/34 , A61F2002/30685 , A61F2002/30934 , A61F2002/3611 , A61F2310/00011 , A61F2310/00179 , A61L27/42 , B05D1/18 , B05D3/067 , B23K35/3618 , C22F1/11 , C22F1/183 , Y10T428/24917 , Y10T428/24926 , Y10T428/31536
摘要： PROBLEM TO BE SOLVED: To provide an artificial joint and an artificial joint sliding member capable of suppressing the generation of abrasion powder by suppressing abrasion of a sliding part in repeatedly executing daily actions, and to provide its manufacturing method. SOLUTION: This biomaterial is formed of a base material composed of metal, alloy or ceramic and a biocompatible material layer laminated on appropriate portions of the base material. Also, the biomaterial is characterized in that the base material is formed with a hydroxyl group on at least prescribed portions on its surface by surface treatment; the biocompatible material layer consists of a polymer containing phosphorylcholine group; and the base material and the biocompatible material layer are bound with the hydroxyl group while being joined via a binder layer bound with the biocompatible material. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够通过抑制重复执行日常动作中的滑动部件的磨损来抑制磨损粉末的产生的人造关节和人造关节滑动构件，并提供其制造方法。解决方案：该生物材料由金属，合金或陶瓷构成的基材和层压在基材的适当部分上的生物相容性材料层形成。此外，生物材料的特征在于，通过表面处理在其表面上的至少规定部分上形成基材以形成羟基; 生物相容性材料层由含有磷酸胆碱基团的聚合物组成; 并且所述基材和所述生物相容性材料层通过与所述生物相容性材料结合的粘合剂层而与所述羟基结合。版权所有（C）2008，JPO＆INPIT

9. 发明专利

JP2008148850A Low-wear sliding member and artificial joint making use of the same 有权
标题翻译：低滑动成员和人工接合使用它们
公开(公告)号：JP2008148850A
公开(公告)日：2008-07-03
申请号：JP2006338601
申请日：2006-12-15
申请人： Kazuhiko Ishihara , Japan Medical Materials Corp , Hiroshi Kawaguchi , Tomohiro Konno , Toru Moro , Kozo Nakamura , Yoshio Takatori , 耕三中村 , 浩川口 , 日本メディカルマテリアル株式会社 , 一彦石原 , 徹茂呂 , 智浩金野 , 吉雄高取
发明人： KYOMOTO MASAYUKI , FUTATSUKA TAKESHI , ISHIHARA KAZUHIKO , KONNO TOMOHIRO , NAKAMURA KOZO , KAWAGUCHI HIROSHI , TAKATORI YOSHIO , MORO TORU , HASHIMOTO MASAMI
IPC分类号： A61L27/00 , A61F2/32 , A61F2/38 , A61F2/40 , A61F2/42 , A61F2/44
摘要： PROBLEM TO BE SOLVED: To provide a sliding member that maintains its wear resistance over a prolonged period of time, excelling in durability. SOLUTION: The low-wear sliding member 10 is used in a wet environment, and the sliding member 10 includes a base material 12 molded from a polymer material having a methylene group and a polymer film 30 covering the sliding surface 16 of the base material 12. The polymer film 30 is constituted of a polymer chain having a phosphorylcholine group graft-bonded to the sliding surface 16, and the thickness of the polymer film is 10 to 200 nm. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种在较长时间内保持其耐磨性的滑动构件，耐久性优异。解决方案：低磨损滑动构件10在湿润环境中使用，并且滑动构件10包括由具有亚甲基的聚合物材料模制的基底材料12和覆盖其的滑动表面16的聚合物膜30 基材12.聚合物膜30由与滑动面16接枝的磷酸胆碱基的聚合物链构成，聚合物膜的厚度为10〜200nm。版权所有（C）2008，JPO＆INPIT

10. 发明专利

JP2006345934A REPLACEMENT MATERIAL FOR NUCLEUS PULPOSUS OF INTERVERTEBRAL DISC AND ITS MANUFACTURING METHOD 审中-公开
公开(公告)号：JP2006345934A
公开(公告)日：2006-12-28
申请号：JP2005172672
申请日：2005-06-13
申请人： UNIV KYOTO , JAPAN MEDICAL MATERIALS CORP
发明人： NAKAMURA TAKASHI , GEN JIYOUKIYUU , KYOMOTO MASAYUKI , KONDO MAKOTO
IPC分类号： A61L27/00 , A61F2/44
摘要： PROBLEM TO BE SOLVED: To provide a replacement material for nucleus pulposuses of intervertebral discs which shows relatively high load supporting properties, reduces damage to fibrous rings for the insertion at the surgery, is retained in the fibrous ring stably after the surgery, and prevents the damage caused by the sliding movements against vertebral body cartilage endplates or the fibrous ring around a place where a prosthesis is placed, and its manufacturing method. SOLUTION: The replacement material 4 for nucleus pulposuses of interval discs comprises a PVA (polyvinyl alcohol) gel dried body with a saturated moisture content of 18-50 percent by weight and varies shapes at a rate of shape deformation equal to or more than 150 volume percent when being hydrated. The method of manufacturing the replacement material 4 includes a process of making the PVA with the saturated moisture content of 20-53 percent by weight, of making the PVA into a PVA hydrogel in the hydrated state and forming it into a shape with a hollow part 4a, of irradiating the PVA hydrogel with γ rays of 20-100 kGy, and of drying while the PVA hydrogel is deformed to make the hollow part 4a disappear. COPYRIGHT: (C)2007,JPO&INPIT

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