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1. 发明专利

JPH01150755A METHOD OF CONTROLLING OPERATION OF CRYOGENIC REFRIGERATOR 失效
公开(公告)号：JPH01150755A
公开(公告)日：1989-06-13
申请号：JP30753387
申请日：1987-12-07
申请人： JAPAN ATOMIC ENERGY RES INST , HITACHI LTD
发明人： SHIBANUMA KIYOSHI , SHIBATA TAKEYORI , MURAKAMI SEI , SASAKI KIYOSHI , MATSUMOTO KOZO
IPC分类号： F25B9/02 , F25B9/00 , F25B9/06
摘要： PURPOSE: To properly maintain the travel of an inlet valve of an expansion device throughout pre-cooling and stable operations in a cryogenic freezer by selecting the minimum of travels of an expansion device inlet valve obtained from controlled variables of temperature and pressure at the inlet and outlet of the expansion device to operate the valve. CONSTITUTION: An expansion turbine inlet valve 70 that is the expansion device inlet valve is, in this case, controlled on a basis of control variables, that is, inlet pressure P1 of a first expansion turbine 40 detected by a pressure detector 80, inlet pressure P2 of a second expansion turbine 41 detected by a pressure detector 81 and inlet temperature T1 of the second expansion turbine 41 detected by a temperature detector 82. In the case of employing the inlet pressure P2 of the second expansion turbine 41 for the controlled variable, the expansion turbine inlet valve 70 is excessively opened during the last half period of the pre-cooling operation and the stable operation to lower the inlet temperature of the second expansion turbine 41. Therefore, the travel of the expansion turbine inlet valve 70 can be properly maintained throughout the pre-cooling and stable operations by selecting the minimum of control inputs obtained from these controlled variables or the travels of the expansion turbine inlet valve 70 for the actual control input.

2. 发明专利

JPH01127862A METHOD OF CONTROLLING EXPANSION VALVE IN CRYOGENIC REFRIGERATOR 失效
公开(公告)号：JPH01127862A
公开(公告)日：1989-05-19
申请号：JP28536487
申请日：1987-11-13
申请人： JAPAN ATOMIC ENERGY RES INST , HITACHI LTD
发明人： SHIBANUMA KIYOSHI , MURAKAMI SEI , KAJIWARA HIROTAKE
IPC分类号： F25B9/02
摘要： PURPOSE: To control the operation to an optimum expansion valve opening at all times independently from types of operation modes of liquefaction operation and freezing operation by controlling the expansion valve opening on the basis of a flow rate of low pressure return gas from an article to be cooled. CONSTITUTION: A freezing circuit is adapted such that a high pressure refrigerant raised in pressure in a refrigerant compressor 1 is cooled and then branched with low pressure return gas after passage through a heat exchanger 3, one of which is expanded and cooled in expansion machines 5, 6, 7 and is joined with a low pressure return gas line 18 and is returned to the compressor 1 after recovery of temperature, and while the other branched high pressure refrigerant is liquefied through an expansion valve 11 and is sent to an article 13 to be cooled, and further the low pressure return gas from the article 13 is returned to the refrigerant compressor after passage through heat exchangers 10, 9, 6, 8, 3 and a pressure reduction pump 14. Herein, an opening of the expansion valve 11 is controlled with the aid of a flow rate meter 15 provided at an inlet of the pressure reduction pump 14 whereby the opening of the expansion valve 14 is controlled to an optimum value calculated with a specific formula from an optimum CV value in both liquefaction and freezing operation modes, a pressure reduction pump flow rate upon freezing operation mode, and a flow rate upon actual operation.

3. 发明专利

DE4002994A1 Cultivating cells and their biological prods. with fermenter - and controlled membrane sepn. of unwanted components 未知
公开(公告)号：DE4002994A1
公开(公告)日：1990-08-16
申请号：DE4002994
申请日：1990-02-01
申请人： HITACHI LTD
发明人： NAKANO RYUSEI , TAKAI MASAO , SASAKI KIYOSHI , MATSUZAKI HARUMI , ISHIDA MASASHIKO , FURUKAWA TOKINOBU , MURAKAMI SEI , KATOH KENJI
IPC分类号： C12M3/02 , C12N5/02
摘要： Prior to return to a fermenter, cells cultivated in a broth are sepd. by a hydrophobic membrane, made e.g. of hollow fibres and sterilisable by steam. The membrane is suitable for materials of specific molecular wt. ranges. While waste prods. are similarly removed, together with materials which could impede cell growth, one or more medium components of a useful substance produced by the cell and whose molecular wt. is less than that of the medium component(s), are similarly removed and returned to the fermenter. These include expensive high molecular wt. medium components of sera, whose return facilitates high density cell cultivation to reduce operating costs. Between upper and lower ends of a container, cultivation is accelerated by the intensive mixing derived by internal jets delivering fast gas streams, without damaging cells. USE/ADVANTAGE - Produces wide range of useful prods., e.g. Interferon, enzymes, and immunoglobin in economically desirable amts.

4. 发明专利

CA2061905A1 APPARATUS AND METHOD FOR APPLYING A LASER BEAM THROUGH A MICROSCOPE 未知
公开(公告)号：CA2061905A1
公开(公告)日：1992-08-28
申请号：CA2061905
申请日：1992-02-26
申请人： HITACHI LTD
发明人： MURAKAMI SEI , TAKAI MASAO , NAKANO RYUSEI , KIMURA NOBUO
IPC分类号： G02B21/00 , G02B21/06
摘要： The present invention relates to an inverted microscope which is adapted so that a specimen thereon, e.g. cells, can be irradiated by a laser beam. The laser beam is guided from a laser source by a series of adjustably movable reflectors which introduce it into the microscope optical pathway at a parallel-beam region thereof, and through the objective lens of the microscope. A point to be irradiated can be selected by moving the reflectors which may be galvanometricallymovable. The laser beam can be focused together with the microscope image. The movable reflectors are kept within 200 mm behind the objective lens principal plane to ensure that the laser can be applied all over the microscope viewing field.

5. 发明专利

SG11201800936WA SINGLE-USE CELL CULTURING APPARATUS AND CULTURING BAG 未知
公开(公告)号：SG11201800936WA
公开(公告)日：2018-03-28
申请号：SG11201800936W
申请日：2016-07-01
申请人： HITACHI LTD , FUJIMORI KOGYO CO LTD
发明人： NANBA MASARU , ANDOU TAKASHI , SUGITA YUI , MURAKAMI SEI , MATSUDA HIROYUKI
IPC分类号： C12M1/02 , C12M1/06 , C12M3/00
摘要： A single-use cell culturing apparatus and a culturing bag are provided, each of which can improve efficiency of stirring a culture solution and further reduce a possibility of leakage of the culture solution. The single-use cell culturing apparatus of the present invention includes a housing that accommodates the culturing bag which is flexible and can seal the culture solution inside thereof. The housing has, on an inner surface thereof, a curved convex-shaped protrusion provided at a portion of a contact face at which the housing is in contact with the culturing bag. The culturing bag of the present invention is accommodated in the housing of the single-use cell culturing apparatus; is flexible; and can seal the culture solution inside thereof. The culturing bag includes a concave portion having a shape corresponding to the curved convex protrusion disposed on a part of the housing.

6. 发明公开

EP3045521A4 CELL CULTURING APPARATUS AND CELL CULTURING METHOD 有权
标题翻译： ZELLKULTURVORRICHTUNG UND ZELLKULTURVERFAHREN
公开(公告)号：EP3045521A4
公开(公告)日：2017-04-26
申请号：EP14842701
申请日：2014-08-01
申请人： HITACHI LTD
发明人： NANBA MASARU , HAGA RYOUICHI , MURAKAMI SEI , SUZUKI HARUO
IPC分类号： C12M1/00 , C12M1/34
CPC分类号： C12M41/30 , C12M23/14 , C12M23/22 , C12M23/26 , C12M37/00 , C12M41/36
摘要： A cell culture apparatus is provided which can continuously and accurately measure turbidity of a cell culture solution and culture a cell, without inserting a turbidity sensor from outside into a sterile bag. The cell culture apparatus (1) includes: a flexible and transparent sterile bag (2) that is installed at a prescribed position in the cell culture apparatus and in which a cell contained in a cell culture solution (4) is cultured; and a turbidity sensor (3) that includes a light emitter (31) which emits light to the cell culture solution (4) in the sterile bag (2) via a portion (2a) of the sterile bag (2), a light receiver (32) which receives the light transmitted through the cell culture solution (4) via another portion (2b) of the sterile bag (2), and that is configured to place the light emitter (31), the portion (2a) of the sterile bag (2), another portion (2b) of the sterile bag (2), and the light receiver (32), optically on a same straight line.
摘要翻译：提供了一种细胞培养装置，其能够连续且准确地测量细胞培养液的浊度并培养细胞，而无需将浊度传感器从外部插入无菌袋中。细胞培养装置（1）具有：设置于细胞培养装置内的规定位置且培养细胞培养液（4）中含有的细胞的柔软且透明的无菌袋（2）和浊度传感器（3），所述浊度传感器包括经由无菌袋（2）的一部分（2a）向无菌袋（2）中的细胞培养液（4）发光的光发射器（31），光接收器（32），其经由所述无菌袋（2）的另一部分（2b）接收透过所述细胞培养液（4）的光，并且被配置为放置所述光发射器（31），所述光发射器无菌袋（2），无菌袋（2）的另一部分（2b）和光接收器（32）在光学上位于同一直线上。

7. 发明公开

EP3018475A4 SEPARATION DEVICE AND SEPARATION METHOD 有权转让
标题翻译： TRENNVORRICHTUNG UND TRENNVERFAHREN
公开(公告)号：EP3018475A4
公开(公告)日：2017-03-15
申请号：EP14820358
申请日：2014-06-19
申请人： HITACHI LTD
发明人： SHIBUYA KEISUKE , TADA YASUHIKO , KONDO TAKEYUKI , MURAKAMI SEI
IPC分类号： G01N30/46 , B01D15/08 , B01D15/20 , B01D15/22 , C07K1/22 , G01N30/26 , G01N30/88
CPC分类号： B01D15/22 , B01D15/08 , B01D15/1821 , B01D15/1885 , B01D15/20 , C07K1/22 , G01N2030/8813

8. 发明专利

JP2015052552A 液漏れ検知部材、有用物質製造装置、および有用物質製造システム审中-公开
标题翻译：液体泄漏检测部件，有用的材料生产装置和系统
公开(公告)号：JP2015052552A
公开(公告)日：2015-03-19
申请号：JP2013186036
申请日：2013-09-09
申请人：株式会社日立製作所 , Hitachi Ltd
发明人： SHIBUYA KEISUKE , TADA YASUHIKO , MATSUO TOSHIAKI , SUZUKI HARUO , MURAKAMI SEI
IPC分类号： G01N31/00 , C12M1/00 , G01N31/22
摘要：【課題】培養や分離精製の際に生じる微量な液漏れの検出が可能な液漏れ検知部材、有用物質製造装置、および有用物質製造システムを提供する。【解決手段】培養処理および分離精製処理のうち少なくとも1つの処理において使用する有用物質製造装置120または前記有用物質製造装置に接続される配管の外側表面に付され、前記有用物質製造装置120または前記配管から外部に漏れる液体と接触することにより反応して性質が変化することを特徴とする液漏れ検知部材10により上記課題を解決する。【選択図】図2
摘要翻译：要解决的问题：提供一种能够检测在培养和分离精炼期间产生的痕量的液体泄漏的液体泄漏检测构件，并提供有用的材料生产装置和有用的材料生产系统。解决方案：提供了一种有用的用于至少一种处理和分离精炼处理的处理材料生产装置120，或者设置在与有用材料生产装置连接的管道的外表面上的液体泄漏检测构件10，其接触从有用材料生产泄漏的液体装置120或来自外部的管，并且与液体反应以改变构件的性质，从而解决问题。

9. 发明专利

JP2015050983A 細胞培養装置及び細胞培養方法有权
标题翻译：细胞培养装置和细胞培养方法
公开(公告)号：JP2015050983A
公开(公告)日：2015-03-19
申请号：JP2013186430
申请日：2013-09-09
申请人：株式会社日立製作所 , Hitachi Ltd
发明人： NANBA MASARU , HAGA RYOICHI , MURAKAMI SEI , SUZUKI HARUO
IPC分类号： C12M1/00
CPC分类号： C12M41/30 , C12M23/14 , C12M23/22 , C12M23/26 , C12M37/00 , C12M41/36
摘要：【課題】外部から無菌バッグ内に濁度センサを挿入することなしに細胞培養液の濁度を連続的且つ正確に測定し、細胞を培養することのできる細胞培養装置を提供する。【解決手段】細胞培養装置1は、装置内の所定の位置にセットされ、光透過性と可撓性を有し、内部で細胞培養液4を培養する無菌バッグ2と、前記無菌バッグ2の一部2aを介して前記無菌バッグ2内の細胞培養液4に光を照射する光照射部31、及び、前記無菌バッグ2の他の一部2bを介して前記無菌バッグ2内の細胞培養液4を透過した光を受光する光受光部32を有し、前記光照射部31、前記無菌バッグ2の一部2a、前記無菌バッグ2の他の一部2b及び前記光受光部32を光学的に一直線に配置した濁度センサ部3と、を備えることを特徴とする。【選択図】図1
摘要翻译：要解决的问题：提供一种连续精确地测量细胞培养液浊度的细胞培养装置，而不将浊度传感器从外部插入无菌袋中，并可培养细胞。解决方案：细胞培养装置1包括：设置在设备中规定位置的无菌袋2具有透光性和柔韧性，并在其中培养细胞培养液4; 以及具有通过无菌袋2的部分2a将无菌袋2中的细胞培养液4照射到无菌袋2中的光照射部31的浊度传感器部分3和接收通过细胞培养液的光的受光部32 4的无菌袋2通过无菌袋2的另一部分2b，并将光照射部31，无菌袋2的部分2a，无菌袋2的另一部分2b和光接收部32配置在光学直线。

10. 发明专利

JPH08299923A WASHING METHOD AND WASHER 失效
公开(公告)号：JPH08299923A
公开(公告)日：1996-11-19
申请号：JP11282395
申请日：1995-05-11
申请人： HITACHI LTD
发明人： HAGA RYOICHI , NITSUTA MICHIYO , MURAKAMI SEI
IPC分类号： B08B3/10
摘要： PURPOSE: To prevent defective washing when the composition, the temperature, the flow rate and the washing time of a washing liquid is set in advance to wash a material to be washed by preparing change pattern with time in which various conditions in a case when washing had suitably been performed in advance are fetched and performing washing while comparing the actually measured value with the change pattern. CONSTITUTION: Washing work of a pipe line 53 partitioned by valves 42, 45, 46, 47, 48 is carried out in compliance with work procedures prepared based on the results of a washing test made in advance. That is, first, a washing liquid is prepared in a washing liquid preparing tank 1 based on the work procedures and is heated to a prescribed temp. Next, the washing liquid is forcibly fed by a pump 5 with the opening degree of a valve 19 being controlled so that the flow rate in the pipe line 53 becomes a prescribed value. During washing,by a flow meter 9, a temperature gage 10, a pH meter 11, conductometric devices 12, 13, flow meters 21, 22 and temperature gages 24, 26, information on washing is collected with time to monitor the washing conditions. From a point of time when all the monitors satisfy the prescribed washing conditions, washing is continued for a set time.

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