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1. 发明授权

US6017557A Carriers containing an etherlipid/complementarily shape lipid combination and therapeutic uses thereof 失效
标题翻译：含有脂质/互补形状脂质组合的载体及其治疗用途
公开(公告)号：US6017557A
公开(公告)日：2000-01-25
申请号：US950773
申请日：1997-10-15
申请人： J. Craig Franklin , Eric Mayhew , Walter Perkins , Andrew Janoff
发明人： J. Craig Franklin , Eric Mayhew , Walter Perkins , Andrew Janoff
IPC分类号： A61K9/127 , A61K31/661 , A61K31/685 , A61P35/00
CPC分类号： A61K9/1272 , A61K31/685 , Y10T428/2984
摘要： Lipid-based carriers are provided herein that have a lamellar lipid component composed of an etherlipid and a complementarily shaped lipid. This novel combination of lipids allows for the incorporation of etherlipids in the carriers at higher concentrations than would otherwise be possible. Pharmaceutical compositions containing the carriers can be used therapeutically, for example, in the treatment of cancers.
摘要翻译：本文提供了具有由醚脂和互补形状的脂质组成的层状脂质组分的脂质载体。脂质的这种新型组合允许以比其它方式更高的浓度将乙醚掺入载体中。含有载体的药物组合物可用于治疗，例如治疗癌症。

2. 发明授权

US5932242A Ether lipid-containing pharmaceutical compositions and therapeutic uses thereof 失效
标题翻译：含醚类脂质的药物组合物及其治疗用途
公开(公告)号：US5932242A
公开(公告)日：1999-08-03
申请号：US720997
申请日：1996-10-15
申请人： J. Craig Franklin , Eric Mayhew , Walter Perkins , Andrew Janoff
发明人： J. Craig Franklin , Eric Mayhew , Walter Perkins , Andrew Janoff
IPC分类号： A61K9/127 , A61K31/661 , A61K31/685 , A61P35/00
CPC分类号： A61K9/1272 , A61K31/685 , Y10T428/2984
摘要： Pharmaceutical compositions are provided herein that contain, in addition to a pharmaceutically acceptable carrier, a lamellar lipid. The lipid is composed of an ether lipid and a lipid having a molecular shape that is complementary to the molecular shape of the glycerolipid. These compositions can be used therapeutically, for example, in the treatment of cancers and inflammatory conditions.
摘要翻译：本文提供的药物组合物除了药学上可接受的载体外还含有片状脂质。脂质由醚脂质和具有与甘油脂分子形状互补的分子形状的脂质组成。这些组合物可用于治疗，例如治疗癌症和炎性病症。

3. 发明授权

US06500461B2 Particulate formulations 失效
标题翻译：颗粒配方
公开(公告)号：US06500461B2
公开(公告)日：2002-12-31
申请号：US09314338
申请日：1999-05-19
申请人： Walter Perkins , Xingong Li , Donald Hirsh , Eric Mayhew , Imran Ahmad , Shaukat Ali , Andrew Janoff
发明人： Walter Perkins , Xingong Li , Donald Hirsh , Eric Mayhew , Imran Ahmad , Shaukat Ali , Andrew Janoff
IPC分类号： A61K914
CPC分类号： A61K47/6929 , A61K47/542
摘要： This invention provides vehicles capable of delivering high concentrations of poorly hydrophilic/poorly lipophilic compounds to animals, by combining compounds having biocompatible hydrophobic domains with conjugates having both hydrophobic and hydrophilic regions. Such formulations are suitable for a number of uses in animals, particularly the administration thereto of high concentrations of therapeutically useful compound, without an undue level of side effects.
摘要翻译：本发明提供能够通过将具有生物相容性疏水域的化合物与具有疏水和亲水区两者的缀合物组合的化合物，将能够将高浓度亲水性差/亲脂性差的化合物递送给动物的载体。这样的制剂适用于动物中的许多用途，特别是其给予高浓度的治疗有用的化合物，而没有不适当的副作用水平。

4. 发明申请

US20150020802A1 LOW RESISTANCE AEROSOL EXHALATION FILTER 审中-公开
标题翻译：低电阻气溶胶排气过滤器
公开(公告)号：US20150020802A1
公开(公告)日：2015-01-22
申请号：US14334121
申请日：2014-07-17
申请人： Walter Perkins , Zhili Li
发明人： Walter Perkins , Zhili Li
IPC分类号： A61M16/00 , A61K31/70 , A61M16/14 , A61M16/10 , A61M16/20
CPC分类号： A61M16/1065 , A61K9/007 , A61K9/0073 , A61K9/127 , A61K31/70 , A61K31/7036 , A61K47/24 , A61K47/28 , A61M11/00 , A61M11/005 , A61M11/06 , A61M15/0018 , A61M16/0093
摘要： Low resistance aerosol exhalation filters, and methods of their use are provided. The exhalation filters provided herein are used in conjunction with a nebulizer in the treatment of a pulmonary infection in a patient in need thereof. In one method, an antiinfective formulation is administered to a patient in need of treatment of a pulmonary infection, with a nebulizer comprising a low resistance aerosol exhalation filter of the invention. The pulmonary infection, in one embodiment, is a Pseudomonas or mycobacterial (e.g., NTM) infection.
摘要翻译：提供低阻力气溶胶呼气过滤器及其使用方法。本文提供的呼气过滤器与雾化器联合用于治疗有需要的患者的肺部感染。在一种方法中，使用包含本发明的低阻力气溶胶呼气过滤器的喷雾器将抗感染制剂施用于需要治疗肺部感染的患者。在一个实施方案中，肺部感染是假单胞菌属或分枝杆菌（例如NTM）感染。

5. 发明申请

US20070065522A1 Administration of high potency platinum compound formulations by inhalation 审中-公开
标题翻译：通过吸入给药高效铂化合物制剂
公开(公告)号：US20070065522A1
公开(公告)日：2007-03-22
申请号：US11505236
申请日：2006-08-16
申请人： Frank Pilkiewicz , Walter Perkins , Beth Metzheiser
发明人： Frank Pilkiewicz , Walter Perkins , Beth Metzheiser
IPC分类号： A61K33/24 , A61K31/555 , A61K31/282
CPC分类号： A61K33/24 , A61K9/0078 , A61K9/127
摘要： Provided is a method for treating a patient having cancer. The method includes administering high potency lipid-platinum compound formulations to the patient's respiratory tract. Also provided is a method of reducing treatment times for administering platinum compound formulations to a patient in need thereof by administering high potency lipid-platinum compound formulations to the patient.
摘要翻译：提供一种治疗患有癌症的患者的方法。该方法包括向患者的呼吸道施用高效力的脂质 - 铂化合物制剂。还提供了一种通过向患者施用高效力的脂质 - 铂化合物制剂来减少向有需要的患者施用铂化合物制剂的治疗时间的方法。

6. 发明申请

US20080107723A1 Methods of Treating Pulmonary Distress 审中-公开
标题翻译：治疗肺痛的方法
公开(公告)号：US20080107723A1
公开(公告)日：2008-05-08
申请号：US11864070
申请日：2007-09-28
申请人： Walter Perkins
发明人： Walter Perkins
IPC分类号： A61K31/7036 , A61K9/127 , A61P11/00
CPC分类号： A61K31/7036 , A61K9/0014
摘要： Provided is a method of increasing the forced expiratory volume in one second (FEV1) in a subject comprising administering to the subject in need thereof a therapeutically effective amount of a liposomal formulation. In some embodiments, the liposomal formulation comprises empty liposomes. Also provided is a method of increasing FEV1 in a subject consisting essentially of administering to the subject a therapeutically effective amount of empty liposomes and pharmaceutical carrier. Additionally, provided is a method of treating cystic fibrosis in a subject comprising administering to the subject a therapeutically effective amount of empty liposomes.
摘要翻译：提供了增加受试者中一秒钟（FEV1）中的呼气量的方法，包括向有需要的受试者施用治疗有效量的脂质体制剂。在一些实施方案中，脂质体制剂包含空脂质体。还提供了一种在受试者中增加FEV1的方法，其基本上包括向受试者施用治疗有效量的空脂质体和药物载体。另外，提供了一种治疗受试者的囊性纤维化的方法，包括向受试者施用治疗有效量的空脂质体。

7. 发明申请

US20070190182A1 Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally 审中-公开
标题翻译：用腹膜内给药的高效脂质型铂化合物制剂治疗癌症的方法
公开(公告)号：US20070190182A1
公开(公告)日：2007-08-16
申请号：US11592754
申请日：2006-11-03
申请人： Frank Pilkiewicz , Roman Perez-Soler , Yiyu Zou , Walter Perkins , Jin Lee
发明人： Frank Pilkiewicz , Roman Perez-Soler , Yiyu Zou , Walter Perkins , Jin Lee
IPC分类号： A61K33/24 , A61K31/555 , A61K31/282
CPC分类号： A61K31/555 , A61K9/0019 , A61K9/127 , A61K31/282 , A61K33/24
摘要： One aspect of the invention relates to methods of treating cancer in a patient comprising administering intraperitoneally to a patient in need thereof a cancer treating effective amount of a lipid-based platinum compound formulation wherein the concentration of the platinum compound of the lipid-based platinum compound formulation is greater than about 1.2 mg/ml. Another aspect of the invention relates to lipid-based platinum compound formulations where the concentration of the platinum compound is greater than about 1.2 mg/ml.
摘要翻译：本发明的一个方面涉及在患者中治疗癌症的方法，包括向有需要的患者腹膜内施用治疗有效量的基于脂质的铂化合物制剂的癌症，其中脂质基铂化合物的铂化合物的浓度制剂大于约1.2mg / ml。本发明的另一方面涉及其中铂化合物的浓度大于约1.2mg / ml的基于脂质的铂化合物制剂。

8. 发明申请

US20070122350A1 Safe and effective methods of administering therapeutic agents 审中-公开
标题翻译：安全有效的治疗剂的施用方法
公开(公告)号：US20070122350A1
公开(公告)日：2007-05-31
申请号：US11606392
申请日：2006-11-29
申请人： Frank Pilkiewicz , Walter Perkins
发明人： Frank Pilkiewicz , Walter Perkins
IPC分类号： A61K9/12 , A61K9/127 , A61K33/24 , A61K31/282
CPC分类号： A61K31/282 , A61K9/0078 , A61K9/127 , A61K31/555 , A61K33/24 , A61M11/00 , A61M15/0015 , A61M16/0833 , A61M16/0875 , A61M16/1065 , A61M2209/084
摘要： In one embodiment, the invention relates to a kit for administering a lipid-based platinum compound formulation via inhalation comprising: an inhalation device comprising a lipid-based platinum compound formulation, a demistifier tent of sufficient size to at least cover a patient's head and the inhalation device, and instructions for use thereof. In another embodiment, the invention relates to a methods of administering therapeutics and increasing safety of administering therapeutics thereof. In another embodiment, the invention relates to an inhalation device for administering a therapeutic agent to a patient comprising a mouth piece, a nebulizer, and a holder for preventing the patient's saliva from entering the nebulizer or returning to the patient during administration.
摘要翻译：在一个实施方案中，本发明涉及一种用于通过吸入施用基于脂质的铂化合物制剂的试剂盒，其包括：包含基于脂质的铂化合物制剂的吸入装置，足够尺寸的去雾剂帐篷，以至少覆盖患者的头部，吸入装置及其使用说明书。在另一个实施方案中，本发明涉及给予治疗剂的方法并提高其给予治疗剂的安全性。在另一个实施方案中，本发明涉及一种用于向患者施用治疗剂的吸入装置，包括口部件，喷雾器和保持器，用于防止患者的唾液进入雾化器或在给药期间返回给患者。

9. 发明申请

US20060034906A1 Treatment of lung diseases and pre-lung disease conditions 审中-公开
标题翻译：治疗肺部疾病和肺前病情况
公开(公告)号：US20060034906A1
公开(公告)日：2006-02-16
申请号：US11135625
申请日：2005-05-23
申请人： Lawrence Boni , Walter Perkins , Roman Perez-Soler , Frank Pilkiewicz
发明人： Lawrence Boni , Walter Perkins , Roman Perez-Soler , Frank Pilkiewicz
IPC分类号： A61K33/24 , A61K9/127 , A61K31/56
CPC分类号： A61K9/0078 , A61K9/127 , A61K9/1277 , A61K31/55 , A61K31/56 , A61K31/565 , A61K31/575 , A61K33/24 , A61K2300/00
摘要： In part, the present invention relates to a method of treating lung diseases and pre-lung disease conditions such as precancerous lesions comprising administering to a patient in need a therapeutic agent comprising lipid composition. The present invention also relates to an inhalation device for administering lipid complexes comprising therapeutic agents. The inhalation device may be disposable. In one embodiment, the lung diseases pretreated by the methods of the present invention are those diseases associated with tobacco related products. The present invention also relates to a method of preparing liposomes by an infusion method that yields high entrapment percentages.
摘要翻译：部分地，本发明涉及治疗肺部疾病和肺前病变疾病如癌前病变的方法，其包括向需要的患者施用包含脂质组合物的治疗剂。本发明还涉及用于施用包含治疗剂的脂质复合物的吸入装置。吸入装置可以是一次性的。在一个实施方案中，通过本发明的方法预处理的肺部疾病是与烟草相关产品相关的那些疾病。本发明还涉及一种通过输注方法制备脂质体的方法，该方法产生高的包埋百分比。

10. 发明申请

US20060135765A1 Antineoplastic ether lipid compounds 审中-公开
标题翻译：抗肿瘤醚类脂质化合物
公开(公告)号：US20060135765A1
公开(公告)日：2006-06-22
申请号：US10541863
申请日：2004-01-08
申请人： Walter Perkins
发明人： Walter Perkins
IPC分类号： C07F9/6533 , C07F9/02
CPC分类号： C07F9/6533 , C07F9/10 , C07F9/117
摘要： Ether lipid compounds of formula (1): Formula (I) pharmaceutically-acceptable salts, prodrugs or isomers thereof are provided, where the variables are as defined herein. The compounds of the invention have anti-neoplastic activity, and accordingly have utility in treating cancer and related diseases. Enantiomers of these compounds, pharmaceutical compositions, and methods for treating cancer with the pharmaceutical compositions are also provided.
摘要翻译：提供式（1）的醚类脂质化合物：式（I）其药学上可接受的盐，前药或异构体，其中变量如本文所定义。本发明的化合物具有抗肿瘤活性，因此具有治疗癌症和相关疾病的效用。还提供了这些化合物的对映异构体，药物组合物和用药物组合物治疗癌症的方法。

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