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1. 发明申请

WO2012035480A2 PHARMACEUTICAL COMPOSITIONS OF CURCUMIN 审中-公开
标题翻译： CURCUMIN的药物组合物
公开(公告)号：WO2012035480A2
公开(公告)日：2012-03-22
申请号：PCT/IB2011/053974
申请日：2011-09-12
申请人： CADILA PHARMACEUTICALS LIMITED , KHAMAR, Bakulesh Mafatlal , GOGIA, Ashish Premkumar , GODA, Chirag Chandrakant , SHENOY, Dinesh Balkunje , SHRIVASTAVA, Rajneesh Ramesh , PATRAVALE, Vandana Bharat , MODI, Indravadan Ambalal , LADDHA, Ritu Nitin , KHAN, Imran Ahmad
发明人： KHAMAR, Bakulesh Mafatlal , GOGIA, Ashish Premkumar , GODA, Chirag Chandrakant , SHENOY, Dinesh Balkunje , SHRIVASTAVA, Rajneesh Ramesh , PATRAVALE, Vandana Bharat , MODI, Indravadan Ambalal , LADDHA, Ritu Nitin , KHAN, Imran Ahmad
IPC分类号： A61K31/12 , A61K47/14
CPC分类号： A61K31/12 , A61K9/1075 , A61K31/121 , A61K47/14 , A61K47/44
摘要： The present invention relates to stable liquid pharmaceutical compositions of curcumin or its pharmaceutically acceptable salts or its derivatives with higher curcumin concentration and improved bioavailability without the use of buffer and/or molecular aggregation inhibitor(s). In accordance with present invention the curcumin is in the solubilized form to make a stable liquid pharmaceutical composition.
摘要翻译：本发明涉及姜黄素或其药学上可接受的盐或其衍生物的稳定液体药物组合物，其在不使用缓冲剂和/或分子聚集抑制剂的情况下具有较高的姜黄素浓度和改善的生物利用度。根据本发明，姜黄素处于增溶形式以制备稳定的液体药物组合物。

2. 发明申请

WO2012035480A3 PHARMACEUTICAL COMPOSITIONS OF CURCUMIN 审中-公开
标题翻译：曲霉素的药物组合物
公开(公告)号：WO2012035480A3
公开(公告)日：2012-07-05
申请号：PCT/IB2011053974
申请日：2011-09-12
申请人： CADILA PHARMACEUTICALS LTD , KHAMAR BAKULESH MAFATLAL , GOGIA ASHISH PREMKUMAR , GODA CHIRAG CHANDRAKANT , SHENOY DINESH BALKUNJE , SHRIVASTAVA RAJNEESH RAMESH , PATRAVALE VANDANA BHARAT , MODI INDRAVADAN AMBALAL , LADDHA RITU NITIN , KHAN IMRAN AHMAD
发明人： KHAMAR BAKULESH MAFATLAL , GOGIA ASHISH PREMKUMAR , GODA CHIRAG CHANDRAKANT , SHENOY DINESH BALKUNJE , SHRIVASTAVA RAJNEESH RAMESH , PATRAVALE VANDANA BHARAT , MODI INDRAVADAN AMBALAL , LADDHA RITU NITIN , KHAN IMRAN AHMAD
IPC分类号： A61K31/05 , A61K31/121
CPC分类号： A61K31/12 , A61K9/1075 , A61K31/121 , A61K47/14 , A61K47/44
摘要： The present invention relates to stable liquid pharmaceutical compositions of curcumin or its pharmaceutically acceptable salts or its derivatives with higher curcumin concentration and improved bioavailability without the use of buffer and/or molecular aggregation inhibitor(s). In accordance with present invention the curcumin is in the solubilized form to make a stable liquid pharmaceutical composition.
摘要翻译：本发明涉及姜黄素或其药学上可接受的盐或其衍生物的稳定液体药物组合物，其具有较高的姜黄素浓度和改进的生物利用度，而不使用缓冲剂和/或分子聚集抑制剂。根据本发明，姜黄素是溶解形式，以制备稳定的液体药物组合物。

3. 发明授权

US09750812B2 Lipid based pharmaceutical preparations for oral and topical application; their compositions, methods, and uses thereof 有权
公开(公告)号：US09750812B2
公开(公告)日：2017-09-05
申请号：US13120127
申请日：2009-09-25
申请人： Shoukath M. Ali , Ateeq Ahmad , Moghis U. Ahmad , Saifuddin Sheikh , Imran Ahmad
发明人： Shoukath M. Ali , Ateeq Ahmad , Moghis U. Ahmad , Saifuddin Sheikh , Imran Ahmad
IPC分类号： A61K47/24 , A61K9/127 , A61K8/04 , A61K9/00 , A61K9/08 , A61K9/10 , A61K31/506 , A61K31/58 , A61K45/06 , A61K47/44
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/08 , A61K9/10 , A61K31/506 , A61K31/58 , A61K45/06 , A61K47/44 , Y02A50/409 , A61K2300/00
摘要： The present invention relates to the topical and oral delivery of a composition comprising one or more active agents for treating a disease or symptoms in a subject. In some embodiments, the present invention comprises a composition comprising at least one active compound, e.g., finasteride or minoxidil, and one or more lipids. In some embodiments, the present invention relates to composition and method of preparation for treating androgenic alopecia (AGA), prevention of hair loss and female hirsutism. In some embodiment, the present invention comprises finasteride and at least one lipid component for the treatment of benign prostatic hyperplasia. In some embodiment, the present invention comprises tacrolimus or amphotericin B and at least one lipid component for the treatment of skin or eye related diseases. The present invention provides a method of preparation of a composition comprising at least one active compound and at least one lipid and administering the composition to a subject by oral or topical delivery. In certain embodiments the subject is a mammal. In certain preferred embodiment, the subject is human.

4. 发明授权

US08298573B2 Stable sterile filterable liposomal encapsulated taxane and other antineoplastic drugs 有权
标题翻译：稳定无菌可过滤脂质体包封的紫杉烷等抗肿瘤药物
公开(公告)号：US08298573B2
公开(公告)日：2012-10-30
申请号：US11196123
申请日：2005-08-03
申请人： Jia-Ai Zhang , Sydney Ugwu , Lan Ma , Gopal Anyarambhatla , Imran Ahmad
发明人： Jia-Ai Zhang , Sydney Ugwu , Lan Ma , Gopal Anyarambhatla , Imran Ahmad
IPC分类号： A61K9/127 , A61K31/335
CPC分类号： A61K9/127 , A61K9/1272 , A61K9/19 , A61K31/337
摘要： The invention provides a formulation of one or more antineoplastic drugs encapsulated in liposomes including at least a lipid fraction in addition to the antineoplastic drug, wherein the composition is stable in an aqueous solution at room temperature.
摘要翻译：本发明提供了包封在脂质体中的一种或多种抗肿瘤药物的制剂，其包括至少除了抗肿瘤药物之外的脂质部分，其中该组合物在室温下在水溶液中是稳定的。

5. 发明申请

US20110104252A1 ANTI-APOPTOTIC GENE SCC-S2 AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF 审中-公开
标题翻译：抗APT基因SCC-S2及其诊断和治疗方法
公开(公告)号：US20110104252A1
公开(公告)日：2011-05-05
申请号：US12858360
申请日：2010-08-17
申请人： USHA KASID , Deepak Kumar , Prafulla Gokhale , Imran Ahmad
发明人： USHA KASID , Deepak Kumar , Prafulla Gokhale , Imran Ahmad
IPC分类号： A61K9/127 , A61K31/7088 , A61K39/395 , C12Q1/68 , G01N33/53 , G01N33/566 , A61P35/00 , A61P35/02
CPC分类号： C07K14/4747 , A61K38/1709 , A61K2039/505
摘要： A gene that is a positive mediator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of SCC-S2 such as renal, ovarian, head and neck, breast, prostate, brain, chronic myelogenous leukemia, lung, lymphoblastic leukemia, and colorectal adenocarcinoma cells.
摘要翻译：提供了一种在某些癌症类型中是肿瘤生长和转移的阳性介质的基因。该基因和相应的多肽具有检测和治疗涉及SCC-S2表达的癌症的诊断和治疗应用，例如肾，卵巢，头颈部，乳腺，前列腺，脑，慢性骨髓性白血病，肺，淋巴细胞白血病和结肠直肠腺癌细胞。

6. 发明申请

US20100323000A1 METHOD AND PROCESS FOR PREPARING CARDIOLIPIN 审中-公开
标题翻译：制备心脏纤维蛋白酶的方法和方法
公开(公告)号：US20100323000A1
公开(公告)日：2010-12-23
申请号：US12280102
申请日：2007-02-22
申请人： Shoukath M. Ali , Moghis U. Ahmad , Imran Ahmad
发明人： Shoukath M. Ali , Moghis U. Ahmad , Imran Ahmad
IPC分类号： A61K9/127 , C07F9/10 , A61P43/00 , C12N5/071 , A61K31/6615
CPC分类号： C07F9/106
摘要： The invention provides novel methods for preparing cardiolipin and cardiolipin analogs having varying fatty acid chain lengths, particularly 1,1′,2,2′-tetramyristoyl cardiolipin. The methods comprise reacting a starting compound, such as a 1,2-O-sn-diacylglycerol and a 2-protected glycerol, with a phosphoramidite reagent to produce a protected cardiolipin, which is deprotected to prepare cardiolipin. The cardiolipin and cardiolipin analogs may be prepared in the presence of an activator, such as pyridinium trifluororacetate. The methods of the present invention are used to prepare cardiolipin and cardiolipin analogs in large quantities. The cardiolipin prepared by the present methods can be incorporated into liposomes which can also include active agents such as hydrophobic or hydrophilic drugs. Such liposomes can be used to treat diseases or in diagnostic and/or analytical assays.
摘要翻译：本发明提供了制备具有不同脂肪酸链长度的心磷脂和心磷脂类似物的新方法，特别是1,1'，2,2'-四磺酰基心磷脂。所述方法包括将起始化合物，例如1,2-O-sn-二酰基甘油和2-保护的甘油与亚磷酰胺试剂反应，以产生受保护的心磷脂，将其去保护以制备心磷脂。心磷脂和心磷脂类似物可以在活化剂如三氟乙酸吡啶鎓存在下制备。本发明的方法用于大量制备心磷脂和心磷脂类似物。通过本发明方法制备的心磷脂可以并入脂质体中，脂质体还可以包括活性剂如疏水或亲水药物。这样的脂质体可用于治疗疾病或在诊断和/或分析测定中。

7. 发明申请

US20100151002A1 Guggulphospholipid Methods and Compositions 有权
标题翻译： Guculphospholipid方法和组成
公开(公告)号：US20100151002A1
公开(公告)日：2010-06-17
申请号：US12513654
申请日：2007-11-06
申请人： Moghis U. Ahmad , Shoukath M. Ali , Ateeq Ahmad , Saifuddin Sheikh , Imran Ahmad
发明人： Moghis U. Ahmad , Shoukath M. Ali , Ateeq Ahmad , Saifuddin Sheikh , Imran Ahmad
IPC分类号： A61K9/127 , C07J13/00 , C07J31/00 , A61K31/56 , A61K31/66 , C12N15/00 , C12N5/00 , A61P3/10 , A61P9/00
CPC分类号： C07J13/007 , A61K31/337 , A61K47/554 , A61K47/6907 , A61K47/6911 , C07J7/0005 , C07J31/006 , C07J41/0005 , C07J41/0088 , C07J51/00 , C12N15/85
摘要： The present invention relates to the methods for preparing synthetic guggulphospholipids, their fatty acid analogues and other bioactive molecules. The present invention relates to E-guggulsterone and Z-guggulsterone or mixture of E- and Z-guggulsterones. The present invention also provides a novel method for the preparation of E-guggulsterol and Z-guggulsterol or mixture of E- and Z-guggulsterols from a mixture of E- and Z-guggulsterones. The present invention further relates to guggulphospholipids and other bioactive molecules incorporated into complexes such as liposomes, complexes, emulsions, vesicles, micelles, and mixed micelles, which can include other active agents, such as hydrophobic or hydrophilic drugs for use, e.g., in treatment of human and animal diseases.
摘要翻译：本发明涉及制备合成瓜瓜磷脂，其脂肪酸类似物和其它生物活性分子的方法。本发明涉及戊二酮和Z-鬼臼酮或E-和Z-格鲁酮的混合物。本发明还提供了一种从E-和Z-庚烷酮的混合物制备E-guggulsterol和Z-guggulsterol或E-和Z-瓜焦糖醇的混合物的新方法。本发明还涉及结合到诸如脂质体，复合物，乳液，囊泡，胶束和混合胶束的复合物中的瓜瓜磷脂和其它生物活性分子，其可以包括其它活性剂，例如用于治疗的疏水或亲水药物的人类和动物疾病。

8. 发明申请

US20090011001A1 Manufacturing process for liposomal preparations 审中-公开
标题翻译：脂质体制备的制备过程
公开(公告)号：US20090011001A1
公开(公告)日：2009-01-08
申请号：US11666644
申请日：2005-10-28
申请人： Zafeer Ahmad , Gopal Anyarambhatla , Sushil Prem , Imran Ahmad
发明人： Zafeer Ahmad , Gopal Anyarambhatla , Sushil Prem , Imran Ahmad
IPC分类号： A61K9/127 , A61K31/337
CPC分类号： A61K9/1277 , A61K9/19
摘要： The present invention provides a manufacturing process for liposomal preparations comprising water-insoluble or hydrophobic active principals. In accordance with one aspect of the inventive method, at least one active principal and lipid fraction are dissolved in an organic solvent. This solution is then subjected to reduced pressure (vacuum) in a container with or with out inert packing to remove the organic solvent, thereby forming a puffy cake comprising the active principal or principals and lipid fraction. This puffy cake is then mixed with an aqueous solution, under controlled conditions suitable to form a bulk liposomal preparation. Because the active principal is imbedded in the lipid bilayer, removal of the aqueous solution is optional.
摘要翻译：本发明提供了包含水不溶性或疏水性活性成分的脂质体制剂的制备方法。根据本发明方法的一个方面，将至少一种活性主要和脂质部分溶解在有机溶剂中。然后将该溶液在具有或不具有惰性填料的容器中进行减压（真空）以除去有机溶剂，从而形成包含活性主体或原料和脂质部分的膨化饼。然后在适于形成体积脂质体制剂的受控条件下，将该松软饼与水溶液混合。因为活性物质嵌入在脂质双层中，所以去除水溶液是任选的。

9. 发明授权

US07244565B2 Gene shinc-3 and diagnostic and therapeutic uses thereof 失效
标题翻译：基因shine-3及其诊断和治疗用途
公开(公告)号：US07244565B2
公开(公告)日：2007-07-17
申请号：US10411930
申请日：2003-04-10
申请人： Usha Kasid , Isamu Sakabe , Imran Ahmad
发明人： Usha Kasid , Isamu Sakabe , Imran Ahmad
IPC分类号： C07H21/02
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/505 , C07H21/04
摘要： The invention provides a SHINC-3 polynucleotide, which can be a nucleic acid encoding all or a portion of a SHINC-3 protein, or a complementary polynucleotide or antisense polynucleotide. In another aspect, the invention provides a SHINC-3 polypeptide, which can be a full-length SHINC-3 protein or a fragment thereof or an analog or homolog thereof. Desirably, the SHINC-3 polypeptide modulates apoptosis. In another aspect, the invention provides an antibody that specifically binds a SHINC-3 polypeptide.In another aspect, the invention provides diagnostic methods. For example, the method affords a method for identifying compounds that modulate apoptosis. In another aspect, the invention provides a method for detecting or evaluating the prognosis of a cancer. In another aspect, the invention provides diagnostic compositions for detection of cancer.In another aspect, the invention provides a method of modulating apoptosis or invention or preventing a cancer, tumor growth and/or metastasis by administration of an agent that modulates the expression and/or activity of SHINC-3.In another aspect, the invention provides formulations of SHINC-3 polynucleotides or proteins. Preferably, such compositions will comprise liposomal formulations.
摘要翻译：本发明提供了SHINC-3多核苷酸，其可以是编码SHINC-3蛋白的全部或部分的核酸或互补多核苷酸或反义多核苷酸。另一方面，本发明提供了SHINC-3多肽，其可以是全长SHINC-3蛋白或其片段或其类似物或同系物。理想地，SHINC-3多肽调节凋亡。另一方面，本发明提供了特异性结合SHINC-3多肽的抗体。另一方面，本发明提供诊断方法。例如，该方法提供了鉴定调节凋亡的化合物的方法。另一方面，本发明提供了用于检测或评价癌症预后的方法。另一方面，本发明提供了用于检测癌症的诊断组合物。另一方面，本发明提供调节凋亡或发明的方法或通过施用调节SHINC-3的表达和/或活性的试剂来预防癌症，肿瘤生长和/或转移。另一方面，本发明提供SHINC-3多核苷酸或蛋白质的制剂。优选地，这样的组合物将包含脂质体制剂。

10. 发明申请

US20060165744A1 Combination liposomal formulations 审中-公开
标题翻译：组合脂质体制剂
公开(公告)号：US20060165744A1
公开(公告)日：2006-07-27
申请号：US10558159
申请日：2004-05-22
申请人： Haris Jamil , Imran Ahmad , Zafeer Ahmad , Gopal Anyarambhatla
发明人： Haris Jamil , Imran Ahmad , Zafeer Ahmad , Gopal Anyarambhatla
IPC分类号： A01N25/00 , A61K9/127 , C12N15/88
CPC分类号： C12N15/88 , A61K9/127 , A61K48/00 , Y02A50/463
摘要： The present invention provides a composition comprising a physiologically acceptable carrier and two or more agents encapsulated in a liposome, wherein the combination of the two or more agents possess the following properties: (1) cytotoxicity to tumor cells, (2) nutritional properties, (3) use in application to nails, hair, skin or lips or (4) activity against parasites and insects. The invention also provides a method of making such a composition. The invention further provides a method of treating cancer when the combination of the two or more agents is cytotoxic to tumor cells.
摘要翻译：本发明提供包含生理学上可接受的载体和包封在脂质体中的两种或更多种试剂的组合物，其中两种或更多种试剂的组合具有以下性质：（1）对肿瘤细胞的细胞毒性，（2）营养特性， 3）用于指甲，头发，皮肤或嘴唇或（4）抵抗寄生虫和昆虫的活动。本发明还提供了制备这种组合物的方法。本发明还提供了当两种或更多种药剂的组合对肿瘤细胞具有细胞毒性时治疗癌症的方法。

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