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1. 发明授权

US09820672B2 Colon screening by using magnetic particle imaging 有权
公开(公告)号：US09820672B2
公开(公告)日：2017-11-21
申请号：US13883603
申请日：2011-11-07
申请人： Jörn Borgert , Ingo Schmale , Jürgen Erwin Rahmer , Bernhard Gleich , Michael Harald Kuhn
发明人： Jörn Borgert , Ingo Schmale , Jürgen Erwin Rahmer , Bernhard Gleich , Michael Harald Kuhn
IPC分类号： A61B5/05 , A61K49/18
CPC分类号： A61B5/0515 , A61B5/05 , A61K49/1818
摘要： A method for colon screening and collecting data by using Magnetic Particle Imaging wherein an imaging magnetic field is generated with a spatial distribution of the magnetic field strength such that the area of examination in the colon consists of a first sub-area with lower magnetic field strength, where the magnetization of a magnetic particle which was pre-delivered to the colon is not saturated, and a second sub-area with a higher magnetic field strength, where the magnetization of said magnetic particle is saturated. The spatial location of both sub-areas in the area of examination is modified so that the magnetization of said particles changes locally. Signals are acquired and are evaluated to obtain information about the spatial distribution of the signals in the area of examination. The method may be carried out during an entire peristaltic cycle in a colon portion or segment.

2. 发明申请

US20130225979A1 COLON SCREENING BY USING MAGNETIC PARTICLE IMAGING 有权
标题翻译：使用磁性粒子成像进行彩色扫描
公开(公告)号：US20130225979A1
公开(公告)日：2013-08-29
申请号：US13883603
申请日：2011-11-07
申请人： Jörn Borgert , Ingo Schmale , Jürgen Erwin Rahmer , Bernhard Gleich , Michael Harald Kuhn
发明人： Jörn Borgert , Ingo Schmale , Jürgen Erwin Rahmer , Bernhard Gleich , Michael Harald Kuhn
IPC分类号： A61B5/05
CPC分类号： A61B5/0515 , A61B5/05 , A61K49/1818
摘要： The present invention relates to a method for colon screening by using Magnetic Particle Imaging comprising the steps of: (a) generating an imaging magnetic field with a spatial distribution of the magnetic field strength such that the area of examination in the colon consists of a first sub-area of the colon with lower magnetic field strength, where the magnetization of a magnetic particle which was pre-delivered to the colon is not saturated, and a second sub-area of the colon with a higher magnetic field strength, where the magnetization of said magnetic particle is saturated; (b) changing the spatial location of both sub-areas in the area of examination so that the magnetization of said particles changes locally; (c) acquiring signals that depend on the magnetization in the area of examination influenced by this change; and (d) evaluating said signals to obtain information about the spatial distribution of the signals in the area of examination. The area of examination in the colon preferably comprises a portion or segment of the colon and steps (a) to (c) may be carried out during an entire peristaltic cycle in said colon portion or segment. The present invention further relates to a corresponding method for collecting data, the use of a magnetic particle for colon screening via Magnetic Particle Imaging, a food stuff or liquid for in vivo diagnostic use comprising a magnetic particle, and a method for preparing a patient for colon screening by using Magnetic Particle Imaging.
摘要翻译：本发明涉及一种通过使用磁性粒子成像进行结肠筛查的方法，包括以下步骤：（a）产生具有磁场强度的空间分布的成像磁场，使得冒号中的检查区域由第一具有较低磁场强度的结肠的子区域，其中预先输送到结肠的磁性颗粒的磁化不饱和，以及具有较高磁场强度的结肠的第二子区域，其中磁化强度的所述磁性颗粒是饱和的; （b）改变检查区域中两个子区域的空间位置，使得所述颗粒的磁化在局部变化; （c）获取取决于受该变化影响的检查区域的磁化强度的信号; 和（d）评估所述信号以获得关于检查区域中的信号的空间分布的信息。结肠检查的区域优选包含结肠的一部分或部分，并且步骤（a）至（c）可以在结肠部分或段中的整个蠕动循环期间进行。本发明还涉及用于收集数据的相应方法，通过磁性粒子成像进行结肠筛选的磁性颗粒的使用，用于包括磁性颗粒的体内诊断用途的食物或液体，以及用于制备患者的方法使用磁粉成像进行结肠筛查。

3. 发明授权

US09999789B2 Temperature distribution determining apparatus 有权
公开(公告)号：US09999789B2
公开(公告)日：2018-06-19
申请号：US13697823
申请日：2011-05-09
申请人： Michael Harald Kuhn
发明人： Michael Harald Kuhn
IPC分类号： A61B18/00 , A61B8/08 , A61N7/00 , A61B18/12 , A61B5/01 , G01K11/24 , G01K13/00 , A61B8/00 , A61B17/00 , A61B8/06
CPC分类号： A61N7/00 , A61B5/015 , A61B8/06 , A61B8/085 , A61B8/463 , A61B8/469 , A61B8/48 , A61B8/483 , A61B8/485 , A61B8/488 , A61B8/5261 , A61B8/58 , A61B18/00 , A61B18/1206 , A61B2017/00084 , A61B2018/00803 , A61B2562/0204 , G01K11/24 , G01K13/002 , G01K2213/00
摘要： The invention relates to a temperature distribution determining apparatus for determining a temperature distribution within an object caused by applying energy to the object. A temperature distribution measuring unit (6, 7) measures a spatially and temporally dependent first temperature distribution in the object (3), while the energy is applied to the object (3) such that the object (3) is heated to a temperature within a first temperature range, and a temperature distribution estimating unit (5) estimates a spatially and temporally dependent second temperature distribution in the object (3) within a second temperature range, which is different to the first temperature range, based on the spatial and temporal dependence of the measured first temperature distribution. Since temperature distributions can be obtained not only in the first temperature range, but also in the second temperature range, the overall temperature range, in which the temperature distribution can be determined, can be increased.

4. 发明申请

US20110306870A1 THERAPEUTIC APPARATUS FOR TREATING A SUBJECT USING MAGNETIC NANOPARTICLES 有权
标题翻译：用于使用磁性纳米粒子处理主体的治疗设备
公开(公告)号：US20110306870A1
公开(公告)日：2011-12-15
申请号：US13202435
申请日：2010-02-22
申请人： Michael Harald Kuhn
发明人： Michael Harald Kuhn
IPC分类号： A61N2/10 , A61B5/055
CPC分类号： G01R33/4804 , A61B5/01 , A61B5/0515 , A61B5/055 , A61B5/7207 , A61B5/7267 , A61B17/2251 , A61B18/18 , A61B18/1815 , A61B2017/00084 , A61B2018/00666 , A61B2018/00678 , A61B2018/00791 , A61B2090/374 , A61N1/406 , A61N2/02 , A61N5/02 , A61N7/02 , G01R33/4808 , G01R33/4814
摘要： A therapeutic apparatus for treating a subject comprising: a first heating means adapted for heating a first region of the subject, a first control means for controlling the power directed into the first region by the first heating means such that the power stays below a threshold value, a particle heating means adapted for heating magnetic nanoparticles within a second region of the subject using a time varying magnetic field, wherein the first region comprises the second region.
摘要翻译：一种用于治疗受试者的治疗装置，包括：第一加热装置，适于加热受试者的第一区域;第一控制装置，用于通过第一加热装置控制引导到第一区域的功率，使得功率保持在阈值以下，适于使用时变磁场加热所述受试者的第二区域内的磁性纳米颗粒的颗粒加热装置，其中所述第一区域包括所述第二区域。

5. 发明申请

US20100179414A1 IMAGE GUIDED THERAPY 有权
标题翻译：图像指导治疗
公开(公告)号：US20100179414A1
公开(公告)日：2010-07-15
申请号：US12602795
申请日：2008-06-04
申请人： Michael Harald Kuhn , Julius Cohen
发明人： Michael Harald Kuhn , Julius Cohen
IPC分类号： A61B5/055 , G06K9/00
CPC分类号： A61N7/02 , A61B5/015 , A61B5/055 , A61B18/14 , A61B18/20 , A61B34/20 , A61B2017/00084 , A61B2090/376 , A61B2090/3904 , A61B2090/3954
摘要： A therapeutic system comprises a therapy module to direct a therapeutic action, e.g. focused ultrasound or RF energy to a target. An imaging module such as an magnetic resonance examination system generates image information of a therapy region that includes the target. By way of a motion analysis module a motion vector field is derived from the image information of the therapy region. A control module controls the therapy module on the basis of the motion vector field. Notably, on the basis of the motion vector field an accurate temperature distribution is derived from magnetic resonance signals and the motion vector field. Also magnetic resonance elastography data may be employed to improve the accuracy of the temperature distribution.
摘要翻译：一种治疗系统包括用于引导治疗作用的治疗模块，例如，聚焦超声或射频能量到目标。诸如磁共振检查系统的成像模块生成包括目标的治疗区域的图像信息。通过运动分析模块，从治疗区域的图像信息导出运动矢量场。控制模块基于运动矢量场控制治疗模块。值得注意的是，基于运动矢量场，从磁共振信号和运动矢量场导出准确的温度分布。也可以使用磁共振弹性成像数据来提高温度分布的精度。

6. 发明申请

US20090232379A1 RECONSTRUCTION OF AN IMAGE OF A MOVING OBJECT FROM VOLUMETRIC DATA 有权
标题翻译：从体积数据重建运动对象的图像
公开(公告)号：US20090232379A1
公开(公告)日：2009-09-17
申请号：US12471511
申请日：2009-05-26
申请人： Thomas Kohler , Michael Grass , Michael Harald Kuhn , Roland Proksa
发明人： Thomas Kohler , Michael Grass , Michael Harald Kuhn , Roland Proksa
IPC分类号： G06K9/00
CPC分类号： G06T7/20 , G06T11/005 , G06T2207/10081 , G06T2207/30048 , G06T2211/404 , G06T2211/412
摘要： In the CT imaging of non-homogeneously moving objects such as the heart or the coronary vessel tree, there is a problem that different parts of the objects are at rest at different points in time. Thus, a gated reconstruction with a globally selected time point does not yield a sharp image of such objects. According to the present invention, a motion of the object is estimated, describing the motion of selected regions of these objects. Then, on the basis of the estimated motion, time points are determined, where these areas have minimal motion. Then, an image is reconstructed, wherein the data from which the respective regions are reconstructed, correspond to the respective time points, where the regions have minimal motion. Due to this, an improved image quality may be provided.
摘要翻译：在诸如心脏或冠状血管树之类的非均匀运动物体的CT成像中，存在不同部分的物体在不同时间点处于静止状态的问题。因此，具有全局选择的时间点的门控重构不会产生这样的对象的清晰图像。根据本发明，估计对象的运动，描述这些对象的选定区域的运动。然后，在估计运动的基础上，确定这些区域具有最小运动的时间点。然后，重建图像，其中各个区域被重构的数据对应于各个时间点，其中区域具有最小的运动。由此，可以提供改善的图像质量。

7. 发明授权

US06505063B2 Diagnostic imaging system with ultrasound probe 有权
标题翻译：超声探头诊断成像系统
公开(公告)号：US06505063B2
公开(公告)日：2003-01-07
申请号：US09736014
申请日：2000-12-13
申请人： Johan Samuel Van Den Brink , Frederik Visser , Michael Harald Kuhn
发明人： Johan Samuel Van Den Brink , Frederik Visser , Michael Harald Kuhn
IPC分类号： A61B500
CPC分类号： G01R33/4814 , A61B8/00 , A61B8/5238 , Y10S128/922
摘要： A diagnostic imaging system, notably a magnetic resonance imaging system comprises a receiver antenna for picking-up magnetic resonance signals and an ultrasound probe for receiving ultrasound echoes. A reconstruction unit is arranged to reconstruct a diagnostic image from the magnetic resonance signals and the ultrasound echoes in particular, the magnetic resonance image and ultrasound images are registered in a common reference frame and geometric distortions in the ultrasound image are corrected on the basis of the magnetic resonance image. Different tissues types are distinguished in the magnetic resonance image and corrections are made for differences between ultrasound sound velocities in these tissue types. Further, information contained in the magnetic resonance signals can be displayed in combination in the ultrasound echoes.
摘要翻译：诊断成像系统，特别是磁共振成像系统包括用于拾取磁共振信号的接收器天线和用于接收超声回波的超声波探头。重建单元被布置成特别地从磁共振信号和超声回波重构诊断图像，磁共振图像和超声图像被登记在公共参考帧中，并且基于超声波图像校正超声图像中的几何失真磁共振图像。在磁共振图像中区分不同的组织类型，并且对这些组织类型中的超声声速之间的差异进行校正。此外，包含在磁共振信号中的信息可以组合显示在超声回波中。

8. 发明授权

US5755666A Method and device for imaging a curved region by means of magnetic resonance 失效
标题翻译：用于通过磁共振成像弯曲区域的方法和装置
公开(公告)号：US5755666A
公开(公告)日：1998-05-26
申请号：US683992
申请日：1996-07-19
申请人： Peter Bornert , Tobias Schaffter , Michael Harald Kuhn
发明人： Peter Bornert , Tobias Schaffter , Michael Harald Kuhn
IPC分类号： G01R33/48 , A61B5/055 , G01R33/483 , G01R33/54
CPC分类号： G01R33/4833
摘要： A magnetic resonance method for imaging a curved portion of a body in which only MR signals in the curved portion of the body are generated by pulse sequences which include RF pulses and temporary magnetic fields. From the received MR signals an image of the curved portion can be reconstructed by use of linear transformations.
摘要翻译：一种用于对身体的弯曲部分的弯曲部分进行成像的磁共振方法，其中仅通过包括RF脉冲和临时磁场的脉冲序列来生成身体的弯曲部分中的仅MR信号。从接收的MR信号中，可以通过使用线性变换来重建弯曲部分的图像。

9. 发明申请

US20100014736A1 REDUCTION OF HEART MOTION ARTIFACTS IN THORACIC CT IMAGING 有权
标题翻译：减少心脏CT成像中心脏运动的影响
公开(公告)号：US20100014736A1
公开(公告)日：2010-01-21
申请号：US12438952
申请日：2007-08-27
申请人： Hans Barschdorf , Jens Von Berg , Michael Harald Kuhn , Cristian Lorenz , Thomas Blaffert
发明人： Hans Barschdorf , Jens Von Berg , Michael Harald Kuhn , Cristian Lorenz , Thomas Blaffert
IPC分类号： G06K9/32 , G06K9/00
CPC分类号： G06T7/251 , G06T7/149 , G06T7/33 , G06T2200/04 , G06T2207/10081 , G06T2207/30048 , G06T2207/30061 , G06T2211/412
摘要： The invention relates to a system (100) for adapting a plurality of model meshes to a plurality of image data, the system comprising a registration unit (110) for registering the plurality of model meshes with the plurality of image data on the basis of a computation of a registration transformation for transforming the plurality of model meshes, and an adaptation unit (120) for adapting the plurality of registered model meshes to the plurality of image data on the basis of a computation of locations of mesh vertices of the plurality of model meshes. The system (100) may further comprise a computing unit (130) for computing sparse vector fields comprising vectors of displacements of vertices of the adapted model meshes, an approximation unit (140) for computing dense vector fields on the basis of the sparse vector fields, a merge unit (150) for merging image data sets by means of the computed dense vector fields, and a reconstruction unit (155) for reconstructing a motion-compensated image data from the computed dense vector fields. The described system (100) is capable of reducing motion artifacts in tomographic images computed from data acquired at a plurality of different cardiac cycle phases.
摘要翻译：本发明涉及一种用于将多个模型网格适配到多个图像数据的系统（100），该系统包括：注册单元（110），用于基于多个图像数据登记多个模型网格与多个图像数据用于变换多个模型网格的注册变换的计算;以及适应单元，用于根据多个模型的网格顶点的位置的计算来将多个注册模型网格适配到多个图像数据网格系统（100）还可以包括计算单元（130），用于计算包括适应模型网格的顶点位移矢量的稀疏矢量场，用于基于稀疏矢量场计算密集矢量场的近似单元（140），用于通过所计算的密集矢量场合并图像数据组的合并单元（150），以及用于从所计算的密集矢量场重构运动补偿图像数据的重建单元（155）。所描述的系统（100）能够减少从在多个不同的心动周期阶段获取的数据计算的断层图像中的运动伪影。

10. 发明授权

US07545903B2 Reconstruction of an image of a moving object from volumetric data 有权
标题翻译：从体积数据重建移动物体的图像
公开(公告)号：US07545903B2
公开(公告)日：2009-06-09
申请号：US10564572
申请日：2004-07-07
申请人： Thomas Köhler , Michael Grass , Michael Harald Kuhn , Roland Proksa
发明人： Thomas Köhler , Michael Grass , Michael Harald Kuhn , Roland Proksa
IPC分类号： A61B6/03
CPC分类号： G06T7/20 , G06T11/005 , G06T2207/10081 , G06T2207/30048 , G06T2211/404 , G06T2211/412
摘要： In the CT imaging of non-homogeneously moving objects such as the heart or the coronary vessel tree, there is a problem that different parts of the objects are at rest at different points in time. Thus, a gated reconstruction with a globally selected time point does not yield a sharp image of such objects. According to the present invention, a motion of the objects is estimated, describing the motion of selected regions of these objects. Then, on the basis of the estimated motion, time points are determined, where these areas have minimal motion. Then, an image is reconstructed, wherein the data from which the respective regions are reconstructed, correspond to the respective time points, where the regions have minimal motion. Due to this, an improved image qualify maybe provided.
摘要翻译：在诸如心脏或冠状血管树之类的非均匀运动物体的CT成像中，存在不同部分的物体在不同时间点处于静止状态的问题。因此，具有全局选择的时间点的门控重构不会产生这样的对象的清晰图像。根据本发明，估计对象的运动，描述这些对象的选定区域的运动。然后，在估计运动的基础上，确定这些区域具有最小运动的时间点。然后，重建图像，其中各个区域被重构的数据对应于各个时间点，其中区域具有最小的运动。因此，可以提供改进的图像资格。

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