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1. 发明授权

US07993650B2 Polypeptides having binding affinity for HER2 有权
标题翻译：对HER2具有结合亲和力的多肽
公开(公告)号：US07993650B2
公开(公告)日：2011-08-09
申请号：US10563310
申请日：2004-06-30
申请人： Jörgen Carlsson , Stefan Ståhl , Tove Eriksson , Elin Gunneriusson , Fredrik Nilsson
发明人： Jörgen Carlsson , Stefan Ståhl , Tove Eriksson , Elin Gunneriusson , Fredrik Nilsson
IPC分类号： A61K39/00 , A61K39/38 , G01N33/53
CPC分类号： C07K14/31 , A61K38/00 , C07K2319/20 , C07K2319/21 , C07K2319/22
摘要： A polypeptide is provided, which has a binding affinity for HER2 and which is related to a domain of staphylococcal protein A (SPA) in that the sequence of the polypeptide corresponds to the sequence of the SPA domain having from 1 to about 20 substitution mutations. Nucleic acid encoding the polypeptide, as well as expression vector and host cell for expressing the nucleic acid, are also provided. Also provided is the use of such a polypeptide as a medicament, and as a targeting agent for directing substances conjugated thereto to cells overexpressing HER2. Methods, and kits for performing the methods, are also provided, which methods and kits rely on the binding of the polypeptide to HER2.
摘要翻译：提供了多肽，其具有对HER2的结合亲和力，并且其与葡萄球菌蛋白A（SPA）的结构域相关，因为多肽的序列对应于具有1至约20个取代突变的SPA结构域的序列。还提供了编码多肽的核酸，以及用于表达核酸的表达载体和宿主细胞。还提供了作为药物的这种多肽的用途，以及用于将与其缀合的物质引导至过表达HER2的细胞的靶向剂。还提供了用于进行方法的方法和试剂盒，哪些方法和试剂盒依赖于多肽与HER2的结合。

2. 发明申请

US20100048868A1 Polypeptides Having Binding Affinity for Her2 有权
标题翻译：具有Her2结合亲和力的多肽
公开(公告)号：US20100048868A1
公开(公告)日：2010-02-25
申请号：US10563310
申请日：2004-06-30
申请人： Jorgen Carlsson , Stefan Stahl , Tove Eriksson , Elin Gunneriusson , Fredrik Nilsson
发明人： Jorgen Carlsson , Stefan Stahl , Tove Eriksson , Elin Gunneriusson , Fredrik Nilsson
IPC分类号： C07K14/705 , C07K14/31 , C12N1/21 , A61K38/16 , C07H21/04 , C12P21/06
CPC分类号： C07K14/31 , A61K38/00 , C07K2319/20 , C07K2319/21 , C07K2319/22
摘要： A polypeptide is provided, which has a binding affinity for HER2 and which is related to a domain of staphylococcal protein A (SPA) in that the sequence of the polypeptide corresponds to the sequence of the SPA domain having from 1 to about 20 substitution mutations. Nucleic acid encoding the polypeptide, as well as expression vector and host cell for expressing the nucleic acid, are also provided. Also provided is the use of such a polypeptide as a medicament, and as a targeting agent for directing substances conjugated thereto to cells overexpressing HER2. Methods, and kits for performing the methods, are also provided, which methods and kits rely on the binding of the polypeptide to HER2.
摘要翻译：提供了多肽，其具有对HER2的结合亲和力，并且其与葡萄球菌蛋白A（SPA）的结构域相关，因为多肽的序列对应于具有1至约20个取代突变的SPA结构域的序列。还提供了编码多肽的核酸，以及用于表达核酸的表达载体和宿主细胞。还提供了作为药物的这种多肽的用途，以及用于将与其缀合的物质引导至过表达HER2的细胞的靶向剂。还提供了用于进行方法的方法和试剂盒，哪些方法和试剂盒依赖于多肽与HER2的结合。

3. 发明授权

US08247375B2 Polypeptides 有权
标题翻译：多肽
公开(公告)号：US08247375B2
公开(公告)日：2012-08-21
申请号：US12085576
申请日：2006-12-05
申请人： Fredrik Nilsson , Tove Eriksson , Andreas Jonsson , Stefan Ståhl , Mikaela Friedman
发明人： Fredrik Nilsson , Tove Eriksson , Andreas Jonsson , Stefan Ståhl , Mikaela Friedman
IPC分类号： C07K14/00 , C07K14/485
CPC分类号： A61K51/088 , A61K38/1808 , A61K49/14 , C07K14/31 , C07K14/485 , C07K2319/20 , C07K2319/21 , C07K2319/22
摘要： This invention relates to polypeptides which bind to EGFR family receptors and to applications of those polypeptides in medicine, veterinary medicine, diagnosis diagnostics and imaging.
摘要翻译：本发明涉及结合EGFR家族受体的多肽以及这些多肽在医学，兽医学，诊断诊断和成像中的应用。

4. 发明申请

US20140178301A1 POLYPEPTIDES 审中-公开
公开(公告)号：US20140178301A1
公开(公告)日：2014-06-26
申请号：US14055443
申请日：2013-10-16
申请人： Fredrik Nilsson , Tove Eriksson , Andreas Jonsson , Stefan Stahl , Mikaela Friedman
发明人： Fredrik Nilsson , Tove Eriksson , Andreas Jonsson , Stefan Stahl , Mikaela Friedman
IPC分类号： A61K51/08 , A61K49/14
CPC分类号： A61K51/088 , A61K38/1808 , A61K49/14 , C07K14/31 , C07K14/485 , C07K2319/20 , C07K2319/21 , C07K2319/22
摘要： This invention relates to polypeptides which bind to EGFR family receptors and to applications of those polypeptides in medicine, veterinary medicine, diagnosis, diagnostics, and imaging.
摘要翻译：本发明涉及结合EGFR家族受体的多肽以及这些多肽在医药，兽医学，诊断，诊断和成像中的应用。

5. 发明授权

US08598113B2 Polypeptides 有权
公开(公告)号：US08598113B2
公开(公告)日：2013-12-03
申请号：US13549588
申请日：2012-07-16
申请人： Fredrik Nilsson , Tove Eriksson , Andreas Jonsson , Stefan Stahl , Mikaela Friedman
发明人： Fredrik Nilsson , Tove Eriksson , Andreas Jonsson , Stefan Stahl , Mikaela Friedman
IPC分类号： A61K38/22 , C07K14/485
CPC分类号： A61K51/088 , A61K38/1808 , A61K49/14 , C07K14/31 , C07K14/485 , C07K2319/20 , C07K2319/21 , C07K2319/22
摘要： This invention relates to polypeptides which bind to EGFR family receptors and to applications of those polypeptides in medicine, veterinary medicine, diagnosis diagnostics and imaging.

6. 发明申请

US20090016957A1 Polypeptides 有权
标题翻译：多肽
公开(公告)号：US20090016957A1
公开(公告)日：2009-01-15
申请号：US12085576
申请日：2006-12-05
申请人： Fredrik Nilsson , Tove Eriksson , Andreas Jonsson , Stefan Stahl , Mikaela Friedman
发明人： Fredrik Nilsson , Tove Eriksson , Andreas Jonsson , Stefan Stahl , Mikaela Friedman
IPC分类号： A61K51/00 , C07K14/00 , C12N15/11 , C07K1/00 , A61K38/00 , A61P31/00 , A61K49/00 , G01N33/53 , C12P21/04
CPC分类号： A61K51/088 , A61K38/1808 , A61K49/14 , C07K14/31 , C07K14/485 , C07K2319/20 , C07K2319/21 , C07K2319/22
摘要： This invention relates to polypeptides which bind to EGFR family receptors and to applications of those polypeptides in medicine, veterinary medicine, diagnosis diagnostics and imaging.
摘要翻译：本发明涉及结合EGFR家族受体的多肽以及这些多肽在医学，兽医学，诊断诊断和成像中的应用。

7. 发明申请

US20110014203A1 FORMULATION 审中-公开
标题翻译：公式
公开(公告)号：US20110014203A1
公开(公告)日：2011-01-20
申请号：US12810906
申请日：2008-12-22
申请人： Fredrik Nilsson , Karl Johan Brink
发明人： Fredrik Nilsson , Karl Johan Brink
IPC分类号： A61K39/395 , A61P9/10 , A61M5/178
CPC分类号： C07K16/00 , A61K9/0019 , A61K47/02 , A61K47/183 , A61K47/26
摘要： A stable, aqueous pharmaceutical composition comprising an antibody having a heavy chain amino acid sequence of SEQ ID No: 3 and a light chain amino acid sequence of SEQ ID No: 4 and a pharmaceutically-acceptable adjuvant, diluent, carrier or excipient, wherein said composition has a pH of 4 to 6.
摘要翻译：一种稳定的水性药物组合物，其包含具有SEQ ID No：3的重链氨基酸序列和SEQ ID No：4的轻链氨基酸序列的抗体和药学上可接受的佐剂，稀释剂，载体或赋形剂，其中所述组合物的pH为4〜6。

8. 发明授权

US08623373B2 Compositions and methods for treatment of angiogenesis in pathological lesions 有权
标题翻译：用于治疗病理损伤中血管生成的组合物和方法
公开(公告)号：US08623373B2
公开(公告)日：2014-01-07
申请号：US10204581
申请日：2001-02-22
申请人： Luciano Zardi , Dario Neri , Barbara Carnemolla , Fredrik Nilsson , Lorenzo Tarli , Laura Borsi , Cornelia Halin
发明人： Luciano Zardi , Dario Neri , Barbara Carnemolla , Fredrik Nilsson , Lorenzo Tarli , Laura Borsi , Cornelia Halin
IPC分类号： A61K39/44 , C07K16/00
CPC分类号： A61K47/48423 , A61K31/704 , A61K38/1709 , A61K38/191 , A61K38/2013 , A61K38/208 , A61K38/217 , A61K47/62 , A61K47/6803 , A61K47/6813 , A61K47/6851 , A61K2039/505 , C07K14/475 , C07K14/525 , C07K14/5434 , C07K14/55 , C07K14/57 , C07K14/70596 , C07K16/18 , C07K2317/622 , C07K2319/00
摘要： Treatment of lesions of pathological angiogenesis, especially tumors, rheumatoid arthritis, diabetic retinopathy, age-related muscular degeneration. and angiomas. A conjugate is used comprising a molecule that exerts a biocidal or cytotoxic effect on target cells in the lesions and an antibody directed against an extracellular matrix component which is present in such lesions. The antibody may be directed against fibronectin-2 (IL-2), doxorubicin, interleukin-12(IL-12), Interferon-γ (IFN-γ), Tumor Necrosis Factor α(TNFα) or Tissue Factor protein (which may be truncated).
摘要翻译：治疗病理性血管生成病变，特别是肿瘤，类风湿关节炎，糖尿病性视网膜病变，年龄相关性肌肉退变。和血管瘤。使用包含对损伤中的靶细胞具有杀生物或细胞毒性作用的分子的缀合物和针对存在于这种损伤中的细胞外基质成分的抗体。抗体可以针对纤连蛋白-2（IL-2），多柔比星，白细胞介素-12（IL-12），干扰素-γ（IFN-γ），肿瘤坏死因子α（TNFalpha）或组织因子蛋白（可能是截断）。

9. 发明授权

US07084989B2 Measuring apparatus and method in a distribution system 有权
标题翻译：配电系统中的测量装置和方法
公开(公告)号：US07084989B2
公开(公告)日：2006-08-01
申请号：US10827896
申请日：2004-04-19
申请人： Mattias Johannesson , Fredrik Nilsson , Karl-Gunnar Gunnarsson
发明人： Mattias Johannesson , Fredrik Nilsson , Karl-Gunnar Gunnarsson
IPC分类号： G01B11/24 , G01B11/14
CPC分类号： G01B11/046
摘要： The present invention relates to the field of measuring apparatuses in distribution systems allowing for measuring presence, position and/or shape of an object placed on a carrier and a method for such measuring. The measuring apparatus comprises at least one light source arranged to illuminate said object and said carrier with incident light; at least one sensor placed on a predetermined distance from said at least one light source and arranged to repeatedly measure said object and said carrier by detecting reflected light from said object and said carrier when said carrier is moved in said direction of movement and to convert the detected light into electrical signals; an image-processing unit arranged to use the electrical signals and obtain a three-dimensional sub-image of each of the measurements of said object and said carrier and to obtain a three-dimensional image of said object and said carrier from one or more of said obtained sub-images; and, a calculating unit arranged to determine the presence, position and/or shape of said object on said carrier from said three-dimensional image.
摘要翻译：本发明涉及允许测量放置在载体上的物体的存在，位置和/或形状的分配系统中的测量装置领域和用于这种测量的方法。测量装置包括至少一个光源，其布置成用入射光照射所述物体和所述载体; 至少一个传感器与所述至少一个光源放置在预定距离上，并被布置成当所述载体在所述移动方向上移动时，通过检测来自所述物体和所述载体的反射光来反复测量所述物体和所述载体，将光检测为电信号; 图像处理单元，被配置为使用所述电信号并获得所述对象和所述载体的每个测量值的三维子图像，并从所述对象和所述载体的一个或多个获得所述对象和所述载体的三维图像表示获得的子图像; 以及计算单元，被布置成从所述三维图像确定所述载体上的所述物体的存在，位置和/或形状。

10. 发明授权

US06778501B1 Selective repeat ARQ with efficient utilization of bitmaps 有权
标题翻译：选择性重复ARQ，有效利用位图
公开(公告)号：US06778501B1
公开(公告)日：2004-08-17
申请号：US09543156
申请日：2000-04-04
申请人： Göran Malmgren , Gunnar Rydnell , Jan Lindskog , György Miklos , Hui Li , Fredrik Nilsson
发明人： Göran Malmgren , Gunnar Rydnell , Jan Lindskog , György Miklos , Hui Li , Fredrik Nilsson
IPC分类号： H04L1256
CPC分类号： H04L1/1809 , H04L1/1614 , H04L1/187
摘要： In a wireline or wireless telecommunications system or data network, which employs a Selective Repeat Automatic Repeat Request (ARQ) to convey data packet reception status for a sequence of data packets grouped together into a number of blocks of data packets, partial bit mapping is employed to improve efficiency, particularly with respect to bandwidth. This may be accomplished, more specifically, by including in the ARQ message that is sent from the receiver to the sender, a number of partial bitmaps, along with a corresponding number of bitmap block numbers, where a first bitmap block number identifies a particular one of the blocks of data packets and the corresponding bitmap defines the reception status of the data packets in that block. Each of the remaining bitmap block numbers identify an additional block of data packets relative to the first block of data packets. Accordingly, the remaining bitmap block numbers require fewer bits to identify their corresponding data packet blocks.
摘要翻译：在有线或无线电信系统或数据网络中，其使用选择性重复自动重传请求（ARQ）来将分组在一起的数据分组序列的数据分组接收状态传送到多个数据分组块，采用部分比特映射以提高效率，特别是在带宽方面。这可以更具体地通过将从接收器发送到发送器的ARQ消息中包括多个部分位图以及相应数量的位图块号码来实现，其中第一位图块号码标识特定的一个的数据分组块和相应的位图定义了该块中的数据分组的接收状态。剩余的位图块号码中的每一个标识相对于第一数据包块的附加数据包块。因此，剩余的位图块号需要较少的比特来标识它们对应的数据分组块。

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