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1. 发明授权

US08568395B2 Light diffuser and process for producing the same 有权
标题翻译：光扩散器及其制造方法
公开(公告)号：US08568395B2
公开(公告)日：2013-10-29
申请号：US12487085
申请日：2009-06-18
申请人： Jörg Mayer , Marcel Aeschlimann , Laurent Torriani , Heinrich Walt
发明人： Jörg Mayer , Marcel Aeschlimann , Laurent Torriani , Heinrich Walt
IPC分类号： A61B18/18
CPC分类号： A61B18/20 , A61B2018/2261
摘要： A light diffuser (10), which is particularly suitable for introducing diffuse light into a tissue, is produced by interpenetration of a diffuser material in a liquid state into a boundary layer (4) of a porous shaping material, by which process a diffuser surface is formed having a surface structure which represents essentially a negative of the pore structure of the shaping material and includes undercut structures induced by a surface tension. The light diffuser (10) is e.g. produced by introducing a diffuser blank (1) including material which is liquefiable through mechanical vibration into the shaping material and simultaneously stimulating it with mechanical vibrations, such that the liquefiable material liquefies at least there where it is in contact with the shaping material and is pressed into the shaping material. An in situ production of the diffuser is particularly advantageous for photodynamic therapy in bone tissue (20).
摘要翻译：特别适于将漫射光引入组织中的光扩散器（10）通过将液态的漫射材料相互渗透到多孔成形材料的边界层（4）中来产生，通过该扩散器，扩散器表面形成有表面结构，其表示成形材料的孔结构的基本上为负的，并且包括由表面张力引起的底切结构。光扩散器（10）通过将包括通过机械振动可液化的材料的扩散器坯料（1）引入到成型材料中并同时用机械振动刺激它，使得液化材料至少在其与成型材料接触的地方液化并被压制成型材料。扩散器的原位生产对于骨组织中的光动力学治疗特别有利（20）。

2. 发明申请

US20090318912A1 LIGHT DIFFUSER AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：光扩散器及其制造方法
公开(公告)号：US20090318912A1
公开(公告)日：2009-12-24
申请号：US12487085
申请日：2009-06-18
申请人： Jörg Mayer , Marcel Aeschlimann , Laurent Torriani , Heinrich Walt
发明人： Jörg Mayer , Marcel Aeschlimann , Laurent Torriani , Heinrich Walt
IPC分类号： A61B18/18
CPC分类号： A61B18/20 , A61B2018/2261
摘要： A light diffuser (10), which is particularly suitable for introducing diffuse light into a tissue, is produced by interpenetration of a diffuser material in a liquid state into a boundary layer (4) of a porous shaping material, by which process a diffuser surface is formed having a surface structure which represents essentially a negative of the pore structure of the shaping material and includes undercut structures induced by a surface tension. The light diffuser (10) is e.g. produced by introducing a diffuser blank (1) including material which is liquefiable through mechanical vibration into the shaping material and simultaneously stimulating it with mechanical vibrations, such that the liquefiable material liquefies at least there where it is in contact with the shaping material and is pressed into the shaping material. An in situ production of the diffuser is particularly advantageous for photodynamic therapy in bone tissue (20).
摘要翻译：特别适于将漫射光引入组织中的光扩散器（10）通过将液态的漫射材料相互渗透到多孔成形材料的边界层（4）中来产生，通过该扩散器，扩散器表面形成有表面结构，其表示成形材料的孔结构的基本上为负的，并且包括由表面张力引起的底切结构。光扩散器（10）通过将包括通过机械振动可液化的材料的扩散器坯料（1）引入到成型材料中并同时用机械振动刺激它，使得液化材料至少在其与成型材料接触的地方液化并被压制成型材料。扩散器的原位生产对于骨组织中的光动力学治疗特别有利（20）。

3. 发明授权

US07274844B2 Light-emitting textile structure, in particular for medical purposes, and use thereof 有权
标题翻译：特别是用于医疗目的的发光织物结构及其用途
公开(公告)号：US07274844B2
公开(公告)日：2007-09-25
申请号：US11126843
申请日：2005-05-11
申请人： Heinrich Walt , Bärbel Selm , Thomas Wessel
发明人： Heinrich Walt , Bärbel Selm , Thomas Wessel
IPC分类号： G02B6/26 , F21V21/08
CPC分类号： G02B6/001 , A61B5/0059 , A61B5/6804 , A61N5/0616 , A61N5/062 , A61N5/0621 , A61N5/0624 , A61N2005/063 , A61N2005/0645
摘要： A light-emitting textile structure, which in particular is useful for medical purposes, comprises a flat support (2) and a plurality of light-emitting elements (4) fixed thereto. Each light-emitting element comprises a light-supplying optical fiber (6), to each optical fiber (6) there being associated exactly one light-emitting element (4), which comprises at least one output zone formed by a local curvature of the optical fiber. The local curvature is selected in such a way that a lateral exit of light from the optical fiber occurs due to the absence of total reflection.
摘要翻译：特别是用于医疗目的的发光纺织品结构包括平坦支撑件（2）和固定到其上的多个发光元件（4）。每个发光元件包括供给光纤（6），其中每个光纤（6）与正好相关联的一个发光元件（4）相关联，该发光元件包括至少一个输出区域，该输出区域由光纤。选择局部曲率，使得由于不存在全反射而发生来自光纤的光的侧向出射。

4. 发明申请

US20060257095A1 Light-emitting textile structure, in particular for medical purposes, and use thereof 有权
标题翻译：特别是用于医疗目的的发光织物结构及其用途
公开(公告)号：US20060257095A1
公开(公告)日：2006-11-16
申请号：US11126843
申请日：2005-05-11
申请人： Heinrich Walt , Barbel Selm , Thomas Wessel
发明人： Heinrich Walt , Barbel Selm , Thomas Wessel
IPC分类号： G02B6/00
CPC分类号： G02B6/001 , A61B5/0059 , A61B5/6804 , A61N5/0616 , A61N5/062 , A61N5/0621 , A61N5/0624 , A61N2005/063 , A61N2005/0645
摘要： A light-emitting textile structure, which in particular is useful for medical purposes, comprises a flat support (2) and a plurality of light-emitting elements (4) fixed thereto. Each light-emitting element comprises a light-supplying optical fiber (6), to each optical fiber (6) there being associated exactly one light-emitting element (4), which comprises at least one output zone formed by a local curvature of the optical fiber. The local curvature is selected in such a way that a lateral exit of light from the optical fiber occurs due to the absence of total reflection.
摘要翻译：特别是用于医疗目的的发光纺织品结构包括平坦支撑件（2）和固定到其上的多个发光元件（4）。每个发光元件包括供给光纤（6），其中每个光纤（6）与正好相关联的一个发光元件（4）相关联，该发光元件包括至少一个输出区域，该输出区域由光纤。选择局部曲率，使得由于不存在全反射而发生来自光纤的光的侧向出射。

5. 发明授权

US07258987B2 Methods of cytodiagnostic staging of neoplasia and squamous cell carcinoma 失效
标题翻译：肿瘤和鳞状细胞癌的细胞诊断分期方法
公开(公告)号：US07258987B2
公开(公告)日：2007-08-21
申请号：US10251887
申请日：2002-09-23
申请人： Vickie J. LaMorte , Melinda Szendefi , Heinrich Walt
发明人： Vickie J. LaMorte , Melinda Szendefi , Heinrich Walt
IPC分类号： G01N33/53
CPC分类号： G01N33/574 , G01N33/57411 , G01N33/6875
摘要： Methods of diagnosing whether an epithelial tissue is an abnormal tissue by determining an expression pattern for PML in the epithelial tissue; determining an expression pattern for nuclear bodies in the epithelial tissue; determining SUMO-1 colocalization and comparing the expression pattern for PML and the expression pattern for nuclear bodies with a control are disclosed. Also disclosed are methods for diagnosing whether a subject has mild dysplasia, moderate dysplasia, Type A severe dysplasia, Type B severe dysplasia, cervical squamous cell carcinoma, or poorly-differentiated cervical squamous cell carcinoma, by determining an expression pattern for PML, an expression pattern for nuclear bodies, and SUMO-1 colocalization and determining whether the sample is consistent with expression patterns expected for mild dysplasia, moderate dysplasia, Type A severe dysplasia, Type B severe dysplasia, cervical squamous cell carcinoma, or poorly-differentiated cervical squamous cell carcinoma.
摘要翻译：通过确定上皮组织中PML的表达模式来诊断上皮组织是否是异常组织的方法; 确定上皮组织中核体的表达模式; 公开了确定SUMO-1共定位和比较PML的表达模式和具有对照的核体的表达模式。还公开了通过确定PML的表达模式来诊断受试者是否具有轻度发育不良，中度发育不良，A型严重发育不良，B型严重发育不良，宫颈鳞状细胞癌或分化不全的子宫颈鳞状细胞癌的方法， SUMO-1共定位和确定样本是否符合预期的轻度发育不良，中度发育不良，A型严重发育不良，B型严重发育不良，宫颈鳞状细胞癌或分化不良的宫颈鳞状细胞的表达模式癌。

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