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1. 发明授权

US07258987B2 Methods of cytodiagnostic staging of neoplasia and squamous cell carcinoma 失效
标题翻译：肿瘤和鳞状细胞癌的细胞诊断分期方法
公开(公告)号：US07258987B2
公开(公告)日：2007-08-21
申请号：US10251887
申请日：2002-09-23
申请人： Vickie J. LaMorte , Melinda Szendefi , Heinrich Walt
发明人： Vickie J. LaMorte , Melinda Szendefi , Heinrich Walt
IPC分类号： G01N33/53
CPC分类号： G01N33/574 , G01N33/57411 , G01N33/6875
摘要： Methods of diagnosing whether an epithelial tissue is an abnormal tissue by determining an expression pattern for PML in the epithelial tissue; determining an expression pattern for nuclear bodies in the epithelial tissue; determining SUMO-1 colocalization and comparing the expression pattern for PML and the expression pattern for nuclear bodies with a control are disclosed. Also disclosed are methods for diagnosing whether a subject has mild dysplasia, moderate dysplasia, Type A severe dysplasia, Type B severe dysplasia, cervical squamous cell carcinoma, or poorly-differentiated cervical squamous cell carcinoma, by determining an expression pattern for PML, an expression pattern for nuclear bodies, and SUMO-1 colocalization and determining whether the sample is consistent with expression patterns expected for mild dysplasia, moderate dysplasia, Type A severe dysplasia, Type B severe dysplasia, cervical squamous cell carcinoma, or poorly-differentiated cervical squamous cell carcinoma.
摘要翻译：通过确定上皮组织中PML的表达模式来诊断上皮组织是否是异常组织的方法; 确定上皮组织中核体的表达模式; 公开了确定SUMO-1共定位和比较PML的表达模式和具有对照的核体的表达模式。还公开了通过确定PML的表达模式来诊断受试者是否具有轻度发育不良，中度发育不良，A型严重发育不良，B型严重发育不良，宫颈鳞状细胞癌或分化不全的子宫颈鳞状细胞癌的方法， SUMO-1共定位和确定样本是否符合预期的轻度发育不良，中度发育不良，A型严重发育不良，B型严重发育不良，宫颈鳞状细胞癌或分化不良的宫颈鳞状细胞的表达模式癌。

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