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1. 发明授权

US08519051B2 Block copolymer for drug conjugates and pharmaceutical composition 有权
标题翻译：用于药物偶联物和药物组合物的嵌段共聚物
公开(公告)号：US08519051B2
公开(公告)日：2013-08-27
申请号：US12445710
申请日：2007-10-19
申请人： IuIian Bobe , Naoya Shibata , Hiroyuki Saito , Mitsunori Harada
发明人： IuIian Bobe , Naoya Shibata , Hiroyuki Saito , Mitsunori Harada
IPC分类号： C08L89/00
CPC分类号： C08G65/3326 , A61K31/706 , A61K47/60 , A61K47/645 , C08G65/33306 , C08G2650/50 , C08L71/02 , C08L77/00 , C08L2203/02 , C08L2205/05 , C08L2666/20
摘要： The present invention provides a block copolymer for a drug conjugate which comprises a water-soluble polymer region consisting of polyethylene glycol and a polyamino acid region having a hydrazide group and a hydrophobic group in the side chain.
摘要翻译：本发明提供一种药物偶联物的嵌段共聚物，其包含由聚乙二醇和在侧链具有酰肼基和疏水基团的聚氨基酸区域组成的水溶性聚合物区域。

2. 发明申请

US20100298495A1 BLOCK COPOLYMER FOR DRUG CONJUGATES AND PHARMACEUTICAL COMPOSITION 有权
标题翻译：用于药物结合和药物组合物的嵌段共聚物
公开(公告)号：US20100298495A1
公开(公告)日：2010-11-25
申请号：US12445710
申请日：2007-10-19
申请人： Iulian Bobe , Naoya Shibata , Hiroyuki Saito , Mitsunori Harada
发明人： Iulian Bobe , Naoya Shibata , Hiroyuki Saito , Mitsunori Harada
IPC分类号： C08L89/00
CPC分类号： C08G65/3326 , A61K31/706 , A61K47/60 , A61K47/645 , C08G65/33306 , C08G2650/50 , C08L71/02 , C08L77/00 , C08L2203/02 , C08L2205/05 , C08L2666/20
摘要： The present invention provides a block copolymer for a drug conjugate which comprises a water-soluble polymer region consisting of polyethylene glycol and a polyamino acid region having a hydrazide group and a hydrophobic group in the side chain.
摘要翻译：本发明提供一种药物偶联物的嵌段共聚物，其包含由聚乙二醇和在侧链具有酰肼基和疏水基团的聚氨基酸区域组成的水溶性聚合物区域。

3. 发明申请

US20090074874A1 Process for Producing Polymer Micelles Encapsulating Low Molecular Weight Drugs 审中-公开
标题翻译：生产低分子量药物的聚合物胶束的方法
公开(公告)号：US20090074874A1
公开(公告)日：2009-03-19
申请号：US12226693
申请日：2007-04-24
申请人： Yuko Amano , Yasuki Kato , Mitsunori Harada , Naoya Shibata , Hiroyuki Saito
发明人： Yuko Amano , Yasuki Kato , Mitsunori Harada , Naoya Shibata , Hiroyuki Saito
IPC分类号： A61K9/10
CPC分类号： A61K31/4745 , A61K9/1075 , A61K31/704 , A61K47/6907
摘要： The present invention provides a method of encapsulating a low molecular weight drug in a polymer micelle, the method comprising the steps of: (a) dissolving or dispersing the drug having an electric charge in an aqueous medium; (b) preparing an aqueous medium containing a polymer micelle comprising a block copolymer having an overall hydrophobic region and a hydrophilic region, the overall hydrophobic region containing hydrophobic side chains and side chains having an electric charge opposite to that of the low molecular weight drug in random order; (c) mixing the aqueous medium having the low molecular weight drug dissolved or dispersed therein and the aqueous medium containing the polymer micelle; and (d) adjusting the pH of the mixed aqueous medium to a pH at which the encapsulation of the low molecular weight drug is stabilized.
摘要翻译：本发明提供一种将低分子量药物包封在聚合物胶束中的方法，该方法包括以下步骤：（a）将具有电荷的药物溶解或分散在水性介质中; （b）制备含有聚合物胶束的水性介质，所述聚合物胶束包含具有总疏水区域和亲水区域的嵌段共聚物，所述整个疏水区域含有疏水侧链和具有与低分子量药物相反的电荷的侧链随机顺序; （c）将溶解或分散在其中的低分子量药物的水性介质和含有聚合物胶束的水性介质混合; 和（d）将混合水性介质的pH调节至低分子量药物的包封稳定的pH。

4. 发明申请

US20090179176A1 Fluorescent substance- or contrast medium-containing latex polymer particles, and a process to produce the same 审中-公开
标题翻译：含有荧光物质或造影剂的胶乳聚合物颗粒及其制备方法
公开(公告)号：US20090179176A1
公开(公告)日：2009-07-16
申请号：US12292808
申请日：2008-11-26
申请人： Naoya Shibata , Yukio Nagasaki , Kazunori Kataoka
发明人： Naoya Shibata , Yukio Nagasaki , Kazunori Kataoka
IPC分类号： C09K11/08 , C09K11/02
CPC分类号： C08F290/06 , A61K49/0414 , C08F2/44 , C08F290/00 , C08F290/02 , C08F290/062
摘要： This invention provides a method to effectively incorporate inorganic fluorescent substance or inorganic contrast medium into latex polymer particles which are used for diagnostic test or the like, and also provides thus produced fluorescent substance-containing latex polymer particles which show decreased non-specific adsorption of protein or the like. Said latex polymer particles are produced by making latex-forming monomer, macromer which has at least a hydrophilic polymer segment and an inorganic fluorescent substance or an inorganic contrast medium co-existent simultaneously in an aqueous medium, and subjecting them to a polymerization reaction.
摘要翻译：本发明提供了一种将无机荧光物质或无机造影剂有效地并入用于诊断试验等的胶乳聚合物颗粒中的方法，并且还提供了由此产生的荧光物质的胶乳聚合物颗粒，其表现出降低的非特异性吸附蛋白质或类似物。所述胶乳聚合物颗粒通过制备胶乳形成单体，至少具有亲水性聚合物链段的大分子单体和无机荧光物质或无机造影剂同时存在于水性介质中并使其进行聚合反应而制备。

5. 发明申请

US20060115775A1 METHOD FOR FORMING IMAGES AND SILVER HALIDE COLOR PHOTOGRAPHIC PHOTOSENSITIVE MATERIAL 失效
标题翻译：形成图像和银色彩色摄影感光材料的方法
公开(公告)号：US20060115775A1
公开(公告)日：2006-06-01
申请号：US11333453
申请日：2006-01-18
申请人： Naoto Ohshima , Akito Yokozawa , Naoya Shibata
发明人： Naoto Ohshima , Akito Yokozawa , Naoya Shibata
IPC分类号： G03C7/00
CPC分类号： G03C1/09 , G03C1/16 , G03C1/18 , G03C1/30 , G03C5/04 , G03C7/3022 , G03C7/3046 , G03C7/39216 , G03C7/39232 , G03C7/39236 , G03C7/39248 , G03C7/39252 , G03C7/3926 , G03C7/39268 , G03C7/39272 , G03C7/39296 , G03C7/407 , G03C7/44 , G03C2001/0158 , G03C2001/03517 , G03C2001/03594 , G03C2001/0818 , G03C2001/093 , G03C2200/39 , G03C2200/40 , G03C2200/43 , G03C2200/52
摘要： A method for forming images on a silver halide color photographic photosensitive material having a substrate and photographic structural layers thereon, including at least three silver halide color photosensitive layers having different photosensitive regions, respectively, and at least one non-photosensitive hydrophilic colloid layer, is disclosed. At least one of the photosensitive layers contains 90 mol % or more of silver chloride. Shortly after the silver halide color photographic photosensitive material has been scan-exposed with laser beams, the material is rapid-processed with a low replenishing amount.
摘要翻译：一种在其上具有基底和其上的照相结构层的卤化银彩色照相感光材料上形成图像的方法，包括分别具有不同感光区域的至少三个卤化银彩色光敏层和至少一个非感光亲水胶体层，披露感光层中的至少一层含有90mol％以上的氯化银。在卤化银彩色照相感光材料用激光束扫描曝光之后不久，材料以低补充量快速处理。

6. 发明授权

US07470763B2 Latex polymer particles containing fluorescent substance or contrast medium and process for producing the same 失效
标题翻译：含有荧光物质或造影剂的胶乳聚合物颗粒及其制备方法
公开(公告)号：US07470763B2
公开(公告)日：2008-12-30
申请号：US10539746
申请日：2003-12-19
申请人： Naoya Shibata , Yukio Nagasaki , Kazunori Kataoka
发明人： Naoya Shibata , Yukio Nagasaki , Kazunori Kataoka
IPC分类号： C08F12/04
CPC分类号： C08F290/06 , A61K49/0414 , C08F2/44 , C08F290/00 , C08F290/02 , C08F290/062
摘要： This invention provides a method to effectively incorporate inorganic fluorescent substance or inorganic contrast medium into latex polymer particles which are used for diagnostic test or the like, and also provides thus produced fluorescent substance-containing latex polymer particles which show decreased non-specific adsorption of protein or the like. Said latex polymer particles are produced by making latex-forming monomer, macromer which has at least a hydrophilic polymer segment and an inorganic fluorescent substance or an inorganic contrast medium co-existent simultaneously in an aqueous medium, and subjecting them to a polymerization reaction.
摘要翻译：本发明提供了一种将无机荧光物质或无机造影剂有效地并入用于诊断试验等的胶乳聚合物颗粒中的方法，并且还提供了由此产生的荧光物质的胶乳聚合物颗粒，其表现出降低的非特异性吸附蛋白质或类似物。所述胶乳聚合物颗粒通过制备胶乳形成单体，至少具有亲水性聚合物链段的大分子单体和无机荧光物质或无机造影剂同时存在于水性介质中并使其进行聚合反应而制备。

7. 发明申请

US20060138381A1 Latex polymer particles containing fluorescent substance or contrast medium and process for producing the same 失效
标题翻译：含有荧光物质或造影剂的胶乳聚合物颗粒及其制备方法
公开(公告)号：US20060138381A1
公开(公告)日：2006-06-29
申请号：US10539746
申请日：2003-12-19
申请人： Naoya Shibata , Yukio Nagasaki , Kazunori Kataoka
发明人： Naoya Shibata , Yukio Nagasaki , Kazunori Kataoka
IPC分类号： H01F1/26
CPC分类号： C08F290/06 , A61K49/0414 , C08F2/44 , C08F290/00 , C08F290/02 , C08F290/062
摘要： This invention provides a method to effectively incorporate inorganic fluorescent substance or inorganic contrast medium into latex polymer particles which are used for diagnostic test or the like, and also provides thus produced fluorescent substance-containing latex polymer particles which show decreased non-specific adsorption of protein or the like. Said latex polymer particles are produced by making latex-forming monomer, macromer which has at least a hydrophilic polymer segment and an inorganic fluorescent substance or an inorganic contrast medium co-existent simultaneously in an aqueous medium, and subjecting them to a polymerization reaction.
摘要翻译：本发明提供了一种将无机荧光物质或无机造影剂有效地并入用于诊断试验等的胶乳聚合物颗粒中的方法，并且还提供了由此产生的荧光物质的胶乳聚合物颗粒，其表现出降低的非特异性吸附蛋白质或类似物。所述胶乳聚合物颗粒通过制备胶乳形成单体，至少具有亲水性聚合物链段的大分子单体和无机荧光物质或无机造影剂同时存在于水性介质中并使其进行聚合反应而制备。

8. 发明授权

US06949334B2 Method for forming images and silver halide color photographic photosensitive material 失效
标题翻译：形成图像和卤化银彩色感光材料的方法
公开(公告)号：US06949334B2
公开(公告)日：2005-09-27
申请号：US10412418
申请日：2003-04-14
申请人： Naoto Ohshima , Akito Yokozawa , Naoya Shibata
发明人： Naoto Ohshima , Akito Yokozawa , Naoya Shibata
IPC分类号： G03C1/09 , G03C1/16 , G03C1/18 , G03C1/30 , G03C7/30 , G03C7/392 , G03C7/407 , G03C7/44 , G03C1/34
CPC分类号： G03C1/09 , G03C1/16 , G03C1/18 , G03C1/30 , G03C5/04 , G03C7/3022 , G03C7/3046 , G03C7/39216 , G03C7/39232 , G03C7/39236 , G03C7/39248 , G03C7/39252 , G03C7/3926 , G03C7/39268 , G03C7/39272 , G03C7/39296 , G03C7/407 , G03C7/44 , G03C2001/0158 , G03C2001/03517 , G03C2001/03594 , G03C2001/0818 , G03C2001/093 , G03C2200/39 , G03C2200/40 , G03C2200/43 , G03C2200/52
摘要： A method for forming images on a silver halide color photographic photosensitive material having a substrate and photographic structural layers thereon, including, at least three silver halide color photosensitive layers having different photosensitive regions, respectively, and at least one non-photosensitive hydrophilic colloid layer is disclosed. At least one of the photosensitive layers contains 90 mol % or more of silver chloride. Shortly after the silver halide color photographic photosensitive material has been scan-exposed with laser beams, the material is rapid-processed with a low replenishing amount.
摘要翻译：一种在具有基底和其上的照相结构层的卤化银彩色照相感光材料上形成图像的方法，包括分别具有不同光敏区域的至少三个卤化银彩色光敏层和至少一个非感光亲水胶体层，披露感光层中的至少一层含有90mol％以上的氯化银。在卤化银彩色照相感光材料用激光束扫描曝光之后不久，材料以低补充量快速处理。

9. 发明授权

US08586648B2 Aqueous colorant dispersion, production method of aqueous colorant dispersion, and aqueous ink for inkjet recording 有权
标题翻译：水性着色剂分散体，水性着色剂分散液的制造方法和喷墨记录用水性油墨
公开(公告)号：US08586648B2
公开(公告)日：2013-11-19
申请号：US12391894
申请日：2009-02-24
申请人： Takafumi Hosokawa , Misato Sasada , Naoya Shibata
发明人： Takafumi Hosokawa , Misato Sasada , Naoya Shibata
IPC分类号： C08L31/02
CPC分类号： C09D133/10 , C09D11/326
摘要： An aqueous colorant dispersion including a colorant (A), a polymer (B), and an aqueous liquid medium (I), wherein the polymer (B) is a copolymer including a hydrophilic structural unit and a hydrophobic structural unit, the content of the hydrophobic structural unit in the polymer (B) being more than 80% by mass but less than 100% by mass, the hydrophobic structural unit includes a hydrophobic structural unit (a) having an aromatic ring linked via a linking group to an atom included in the main chain of the polymer (B), the content of aromatic rings in the polymer (B) is 10% by mass or more but less than 20% by mass with respect to the mass of the polymer (B), the hydrophilic structural unit includes a hydrophilic structural unit (b) including an ionic group, and the polymer (B) includes a structural unit (c) different from the hydrophobic structural unit (a) and from the hydrophilic structural unit (b), the content of the structural unit (c) in the polymer (B) being more than 15% by mass but less than 90% by mass.
摘要翻译：包含着色剂（A），聚合物（B）和水性液体介质（I）的水性着色剂分散体，其中聚合物（B）是包含亲水结构单元和疏水结构单元的共聚物，其含量聚合物（B）中的疏水性结构单元大于80质量％但小于100质量％，疏水性结构单元包括疏水结构单元（a），其具有通过连接基团与包含在聚合物（B）的主链，聚合物（B）中的芳环的含量相对于聚合物（B）的质量为10质量％以上且小于20质量％，亲水结构单元包括包含离子基团的亲水性结构单元（b），聚合物（B）包括与疏水性结构单元（a）不同的结构单元（c）和亲水性结构单元（b）的含量聚合物（B）中的结构单元（c）大于15％屁股，但小于90质量％。

10. 发明申请

US20120149649A1 SHORT-CHAIN CATIONIC POLYAMINO ACID AND USE THEREOF 有权
标题翻译：短链阳离子聚氨酯酸及其用途
公开(公告)号：US20120149649A1
公开(公告)日：2012-06-14
申请号：US13258663
申请日：2011-02-23
申请人： Yasuki Kato , Atsushi Ishii , Naoya Shibata , Tatsuyuki Hayashi , Kazunori Kataoka , Kanjiro Miyata , Nobuhiro Nishiyama
发明人： Yasuki Kato , Atsushi Ishii , Naoya Shibata , Tatsuyuki Hayashi , Kazunori Kataoka , Kanjiro Miyata , Nobuhiro Nishiyama
IPC分类号： A61K38/16 , C07K7/08 , A61P43/00 , A61K38/08 , A61K38/10 , C07K7/06 , C07K14/00
CPC分类号： C08G69/10 , A61K47/60 , A61K47/6455 , C12N15/111 , C12N2310/14 , C12N2320/32
摘要： The present invention provides a cationic polyamino acid suitable for a carrier that can form a stable complex with a nucleic acid under a physiological condition and release the nucleic acid in cells suitably. The cationic polyamino acid can associate with a nucleic acid and includes a cationic amino acid residue having a cationic group in a side chain and a hydrophobic amino acid residue having a hydrophobic group in a side chain. The cationic polyamino acid includes 1 to 20 units of the cationic amino acid residue and is represented by the following formula (1). The meaning of each symbol in the formula is as shown in the description.
摘要翻译：本发明提供一种适用于可在生理条件下与核酸形成稳定复合物的载体的阳离子聚氨基酸，并适当地释放细胞中的核酸。阳离子聚氨基酸可以与核酸结合，并且包括在侧链中具有阳离子基团的阳离子氨基酸残基和在侧链中具有疏水基团的疏水性氨基酸残基。阳离子聚氨基酸包含1〜20个单元的阳离子氨基酸残基，由下式（1）表示。公式中每个符号的含义如说明书所示。

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