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1. 发明申请

US20090171349A1 ADJUSTABLE LENGTH FLEXIBLE POLYMER ELECTRODE CATHETER AND METHOD FOR ABLATION 有权
标题翻译：可调节长度柔性聚合物电极导体和方法
公开(公告)号：US20090171349A1
公开(公告)日：2009-07-02
申请号：US12347097
申请日：2008-12-31
申请人： Israel A. Byrd , Saurav Paul , Claire T. Edlebeck , Riki C. Thao
发明人： Israel A. Byrd , Saurav Paul , Claire T. Edlebeck , Riki C. Thao
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B18/1815
摘要： An ablation catheter includes a flexible elongated shaft having a flexible electrode at its distal end. The flexible electrode includes an inner, flexible, electrically-conductive element and an outer, flexible, electrically-conductive polymer layer in electrical contact with the inner, flexible, electrically-conductive element. The catheter further includes an electrically insulative sheath surrounding at least a portion of the flexible electrode and a linear displacement mechanism capable of adjusting at least one of the electrically insulative sheath and the flexible electrode to vary a length of the flexible electrode exposed at the distal end of the shaft. Also disclosed is an adjustable length ablation electrode and methods of ablating tissue.
摘要翻译：消融导管包括在其远端具有柔性电极的柔性细长轴。柔性电极包括内部柔性导电元件和与内部柔性导电元件电接触的外部柔性导电聚合物层。所述导管还包括围绕所述柔性电极的至少一部分的电绝缘护套和能够调节所述电绝缘护套和所述柔性电极中的至少一个的线性位移机构，以改变在所述远端暴露的所述柔性电极的长度的轴。还公开了可调节长度的消融电极和消融组织的方法。

2. 发明授权

US08500731B2 Adjustable length flexible polymer electrode catheter and method for ablation 有权
标题翻译：可调长度柔性聚合物电极导管和消融方法
公开(公告)号：US08500731B2
公开(公告)日：2013-08-06
申请号：US12347097
申请日：2008-12-31
申请人： Israel A. Byrd , Saurav Paul , Claire T. Edlebeck , Riki C. Thao
发明人： Israel A. Byrd , Saurav Paul , Claire T. Edlebeck , Riki C. Thao
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/1815
摘要： An ablation catheter includes a flexible elongated shaft having a flexible electrode at its distal end. The flexible electrode includes an inner, flexible, electrically-conductive element and an outer, flexible, electrically-conductive polymer layer in electrical contact with the inner, flexible, electrically-conductive element. The catheter further includes an electrically insulative sheath surrounding at least a portion of the flexible electrode and a linear displacement mechanism capable of adjusting at least one of the electrically insulative sheath and the flexible electrode to vary a length of the flexible electrode exposed at the distal end of the shaft. Also disclosed is an adjustable length ablation electrode and methods of ablating tissue.
摘要翻译：消融导管包括在其远端具有柔性电极的柔性细长轴。柔性电极包括内部柔性导电元件和与内部柔性导电元件电接触的外部柔性导电聚合物层。所述导管还包括围绕所述柔性电极的至少一部分的电绝缘护套和能够调节所述电绝缘护套和所述柔性电极中的至少一个的线性位移机构，以改变在所述远端暴露的所述柔性电极的长度的轴。还公开了可调节长度的消融电极和消融组织的方法。

3. 发明授权

US09198726B2 Photodynamic-based cardiac ablation device and method via the esophagus 有权
标题翻译：基于光动力学的心脏消融装置和通过食道的方法
公开(公告)号：US09198726B2
公开(公告)日：2015-12-01
申请号：US11967350
申请日：2007-12-31
申请人： Saurav Paul , Israel A. Byrd
发明人： Saurav Paul , Israel A. Byrd
IPC分类号： A61B18/18 , A61B18/24 , A61N5/06 , A61B18/22
CPC分类号： A61B18/24 , A61B2018/2272 , A61N5/0601 , A61N5/062
摘要： A method and system for ablation of cardiac tissue in a living being via the esophagus is provided. The method includes the step of introducing a photodynamic substance to the cardiac tissue. A deformable, elongated body defining a proximal end and a distal end is inserted into an esophagus of the living being. The distal end of the elongated body is located proximate the cardiac tissue. A first set of electromagnetic radiation is then directed from the distal end of the elongated body towards the cardiac tissue. Reflective and opaque surfaces at the distal end of the elongated body may be used to direct the electromagnetic radiation and an expandable membrane at the distal end may be used to urge the distal end of the elongated body to a predetermined position within the esophagus.
摘要翻译：提供了一种通过食道消融心脏组织的方法和系统。该方法包括将光动力学物质引入心脏组织的步骤。限定近端和远端的可变形的细长主体被插入到生命的食道中。细长体的远端位于心脏组织附近。然后将第一组电磁辐射从细长体的远端引向心脏组织。在细长体的远端处的反射和不透明表面可以用于引导电磁辐射，并且在远端处的可扩张膜可以用于将细长体的远端推动到食道内的预定位置。

4. 发明授权

US09877781B2 Electrode catheter device with indifferent electrode for direct current tissue therapies 有权
公开(公告)号：US09877781B2
公开(公告)日：2018-01-30
申请号：US13885776
申请日：2011-11-18
申请人： Martin M. Grasse , Richard E. Stehr , Israel A. Byrd , Lynn E. Gilmour , D. Curtis Deno , Troy T. Tegg , James V. Kauphusman , Saurav Paul , Jeffrey A. Schweitzer
发明人： Martin M. Grasse , Richard E. Stehr , Israel A. Byrd , Lynn E. Gilmour , D. Curtis Deno , Troy T. Tegg , James V. Kauphusman , Saurav Paul , Jeffrey A. Schweitzer
IPC分类号： A61N1/00 , A61B5/04 , A61B18/16 , A61B5/042 , A61B18/14 , A61B18/00 , A61M25/01 , A61M25/06
CPC分类号： A61B18/16 , A61B5/042 , A61B18/1492 , A61B2018/00357 , A61B2018/00613 , A61B2018/00791 , A61B2018/1435 , A61B2018/162 , A61M25/0147 , A61M2025/0681
摘要： An electrode catheter device with indifferent electrode for direct current tissue therapies is disclosed. An example of the catheter device has a flexible tubing with at least one ablation electrode. The catheter device also may also be used with a sheath for introducing the flexible tubing inside a patient's body. An indifferent electrode on the sheath can provide a ground for a direct current (DC) pulse to deliver electrical energy and create an electrical field adjacent a tissue. Various other embodiments are also disclosed.

5. 发明授权

US07824377B2 Tissue anchoring catheter systems and methods 有权
标题翻译：组织锚固导管系统及方法
公开(公告)号：US07824377B2
公开(公告)日：2010-11-02
申请号：US11962512
申请日：2007-12-21
申请人： James V. Kauphusman , Israel A. Byrd , Saurav Paul
发明人： James V. Kauphusman , Israel A. Byrd , Saurav Paul
IPC分类号： A61M5/178
CPC分类号： A61M25/04 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2090/065 , A61M25/0084 , A61M2025/0089 , A61M2025/0095
摘要： Catheter systems and methods are disclosed for anchoring the catheter system to tissue, e.g., for delivery of biologic or chemical agents, or other therapeutic fluid during various procedures. An exemplary tissue anchoring catheter comprises an outer catheter shaft connected to a catheter handle. A delivery sheath is provided within the outer catheter shaft, the delivery sheath housing a needle. At least one anchor is operatively associated with the delivery sheath, the at least one anchor operable at the catheter handle to secure the delivery sheath to tissue for conveying biologic or chemical agents, or other therapeutic fluid from the needle to the tissue. The tissue anchoring catheter may further comprise sensing means such as piezoelectric, pressure, thermistor, thermocouple, or ultrasound sensors.
摘要翻译：公开了用于将导管系统锚定到组织的导管系统和方法，例如用于在各种程序期间递送生物或化学试剂或其它治疗性流体。示例性组织锚定导管包括连接到导管手柄的外导管轴。输送护套设置在外导管轴内，输送护套容纳针。至少一个锚定件与输送护套可操作地相关联，所述至少一个锚固件可在导管手柄处操作以将输送护套固定到组织，用于将生物或化学试剂或其它治疗流体从针输送到组织。组织锚定导管还可以包括诸如压电，压力，热敏电阻，热电偶或超声波传感器的感测装置。

6. 发明申请

US20090171337A1 Photodynamic-Based Cardiac Ablation Device and Method Via the Esophagus 有权
标题翻译：基于光动力学的心脏消融装置和方法通过食管
公开(公告)号：US20090171337A1
公开(公告)日：2009-07-02
申请号：US11967350
申请日：2007-12-31
申请人： Saurav Paul , Israel A. Byrd
发明人： Saurav Paul , Israel A. Byrd
IPC分类号： A61B18/18
CPC分类号： A61B18/24 , A61B2018/2272 , A61N5/0601 , A61N5/062
摘要： A method and system for ablation of cardiac tissue in a living being via the esophagus is provided. The method includes the step of introducing a photodynamic substance to the cardiac tissue. A deformable, elongated body defining a proximal end and a distal end is inserted into an esophagus of the living being. The distal end of the elongated body is located proximate the cardiac tissue. A first set of electromagnetic radiation is then directed from the distal end of the elongated body towards the cardiac tissue. Reflective and opaque surfaces at the distal end of the elongated body may be used to direct the electromagnetic radiation and an expandable membrane at the distal end may be used to urge the distal end of the elongated body to a predetermined position within the esophagus.
摘要翻译：提供了一种通过食道消融心脏组织的方法和系统。该方法包括将光动力学物质引入心脏组织的步骤。限定近端和远端的可变形的细长主体被插入到生命的食道中。细长体的远端位于心脏组织附近。然后将第一组电磁辐射从细长体的远端引向心脏组织。在细长体的远端处的反射和不透明表面可以用于引导电磁辐射，并且在远端处的可扩张膜可以用于将细长体的远端推动到食道内的预定位置。

7. 发明申请

US20130338467A1 Electrode catheter device with indifferent electrode for direct current tissue therapies 有权
标题翻译：用于直流组织治疗的具有无关电极的电极导管装置
公开(公告)号：US20130338467A1
公开(公告)日：2013-12-19
申请号：US13885776
申请日：2011-11-18
申请人： Martin M. Grasse , Richard E. Stehr , Israel A. Byrd , Lynn E. Clark , D. Curtis Deno , Troy T. Tegg , James V. Kauphusman , Saurav Paul , Jeffrey A. Schweitzer
发明人： Martin M. Grasse , Richard E. Stehr , Israel A. Byrd , Lynn E. Clark , D. Curtis Deno , Troy T. Tegg , James V. Kauphusman , Saurav Paul , Jeffrey A. Schweitzer
IPC分类号： A61B18/16
CPC分类号： A61B18/16 , A61B5/042 , A61B18/1492 , A61B2018/00357 , A61B2018/00613 , A61B2018/00791 , A61B2018/1435 , A61B2018/162 , A61M25/0147 , A61M2025/0681
摘要： An electrode catheter device with indifferent electrode for direct current tissue therapies is disclosed. An example of the catheter device has a flexible tubing with at least one ablation electrode. The catheter device also may also be used with a sheath for introducing the flexible tubing inside a patient's body. An indifferent electrode on the sheath can provide a ground for a direct current (DC) pulse to deliver electrical energy and create an electrical field adjacent a tissue. Various other embodiments are also disclosed.
摘要翻译：公开了一种具有用于直流组织治疗的无电极的电极导管装置。导管装置的示例具有带有至少一个消融电极的柔性管。导管装置还可以与护套一起使用以将柔性管引入患者体内。护套上的无电极可以为直流（DC）脉冲提供接地，以传递电能并在组织附近产生电场。还公开了各种其它实施例。

8. 发明申请

US20120059255A1 CATHETER SYSTEMS 有权
标题翻译：导管系统
公开(公告)号：US20120059255A1
公开(公告)日：2012-03-08
申请号：US12874788
申请日：2010-09-02
申请人： Saurav Paul , Troy T. Tegg , Israel A. Byrd , Riki Thao , Harry A. Puryear , Linda Nemec , John M. Berns
发明人： Saurav Paul , Troy T. Tegg , Israel A. Byrd , Riki Thao , Harry A. Puryear , Linda Nemec , John M. Berns
IPC分类号： A61N1/30 , A61B18/14 , A61B6/00
CPC分类号： A61N1/327 , A61B18/14 , A61B2018/0016
摘要： Catheter systems include direction-sensitive, multi-polar tip electrode assemblies for electroporation-mediated therapy, electroporation-induced primary necrosis therapy and electric field-induced apoptosis therapy, including configurations for producing narrow, linear lesions as well as distributed, wide area lesions. A monitoring system for electroporation therapy includes a mechanism for delivering electrochromic dyes to a tissue site as well as a fiber optic arrangement to optically monitor the progress of the therapy as well as to confirm success post-therapy. A fiber optic temperature sensing electrode catheter includes a tip electrode having a cavity whose inner surface is impregnated or coated with thermochromic/thermotropic material that changes color with changes in temperature. An optic fiber/detector arrangement monitors the thermochromic or thermotropic materials, acquiring a light signal and generating an output signal indicative of the spectrum of the light signal. An analyzer determines an electrode temperature based on the detector output and predetermined spectrum versus temperature calibration data.
摘要翻译：导管系统包括用于电穿孔介导治疗的方向敏感的多极尖端电极组件，电穿孔诱导的原发性坏死治疗和电场诱导的凋亡治疗，包括用于产生狭窄的线性损伤以及分布的广泛区域损伤的构造。用于电穿孔治疗的监测系统包括将电致变色染料递送到组织部位的机制以及光学配置以光学监测治疗进展以及确认疗法后的成功。光纤温度感测电极导管包括具有腔体的尖端电极，其内表面被浸渍或涂覆有随着温度变化而改变颜色的热变色/热致变色材料。光纤/检测器装置监测热致变色或热致变色材料，获取光信号并产生指示光信号光谱的输出信号。分析仪基于检测器输出和预定的频谱对温度校准数据来确定电极温度。

9. 发明申请

US20110144657A1 SYSTEMS AND METHODS FOR DETERMINING THE LIKELIHOOD OF ENDOCARDIAL BAROTRAUMA IN TISSUE DURING ABLATION 有权
标题翻译：系统和方法，用于确定髋关节置换术中组织内BAROTRAUMA
公开(公告)号：US20110144657A1
公开(公告)日：2011-06-16
申请号：US12964956
申请日：2010-12-10
申请人： Jeffrey M. Fish , Israel A. Byrd , Lynn E. Clark , Jeremy D. Dando , Christopher J. Geurkink , Rohan Lathia , Harry A. Puryear , Valtino X. Afonso , Saurav Paul
发明人： Jeffrey M. Fish , Israel A. Byrd , Lynn E. Clark , Jeremy D. Dando , Christopher J. Geurkink , Rohan Lathia , Harry A. Puryear , Valtino X. Afonso , Saurav Paul
IPC分类号： A61B19/00 , A61B5/053
CPC分类号： A61B18/1492 , A61B5/036 , A61B5/0538 , A61B2017/00026 , A61B2017/00119 , A61B2018/00351 , A61B2018/00702 , A61B2018/00875 , A61B2034/105 , A61B2034/2051 , A61B2034/2053 , A61B2034/301 , A61B2090/372
摘要： A method and system for determining a likelihood of barotrauma occurring in tissue during the formation of a lesion therein is provided. The system includes an electronic control unit (ECU). The ECU is configured to acquire at least one value of at least one component of a complex impedance between an electrode and the tissue. The ECU is further configured to calculate an index responsive to the at least one value of the at least one complex impedance component. The index is indicative of a likelihood of barotrauma occurring in the tissue. The method comprises acquiring at least one value of at least one component of a complex impedance between an electrode and the tissue. The method further comprises calculating an index responsive to the at least one value of the at least one complex impedance component. The calculating index is indicative of a likelihood of barotrauma occurring in the tissue.
摘要翻译：提供了一种用于确定在其中形成病变期间在组织中发生的气压伤的可能性的方法和系统。该系统包括电子控制单元（ECU）。 ECU被配置为获取电极和组织之间的复阻抗的至少一个分量的至少一个值。 ECU还被配置为响应于至少一个复阻抗分量的至少一个值来计算索引。该指数表示在组织中发生气压伤的可能性。该方法包括获取电极和组织之间的复阻抗的至少一个分量的至少一个值。该方法还包括响应于至少一个复阻抗分量的至少一个值来计算索引。计算指标表示在组织中发生气压伤的可能性。

10. 发明申请

US20110028837A1 Photodynamic-based myocardial mapping device and method 审中-公开
标题翻译：基于光动力学的心肌贴壁装置及方法
公开(公告)号：US20110028837A1
公开(公告)日：2011-02-03
申请号：US12934601
申请日：2009-04-02
申请人： Israel A. Byrd , Saurav Paul , Dale E. Just , Jamie Skoglund , Paul McDowall
发明人： Israel A. Byrd , Saurav Paul , Dale E. Just , Jamie Skoglund , Paul McDowall
IPC分类号： A61B6/00 , A61B1/07 , A61B1/04
CPC分类号： A61B5/6859 , A61B1/07 , A61B5/0044 , A61B5/0071 , A61B5/0084 , A61B5/4839 , A61B5/6858 , A61B5/7278 , A61B2562/0233 , A61B2562/046 , A61B2576/023 , A61M5/007 , A61M25/007 , A61M25/0147
摘要： A photodynamic mapping device includes a shaft with a proximal end and a distal end, at least one optical electrode at the distal end of the shaft, and at least one optical fiber positioned inside the shaft. In embodiments, the at least one optical fiber extends from the distal end of the shaft and is coupled to the at least one optical electrode provided at or about an outer surface of the device. In an embodiment, at least one optical fiber is coupled, at or about the proximal end of the shaft, to a light source coupled and an optical sensor. An analyzer can be coupled to the optical sensor. Embodiments of such devices can be configured to deliver substances, such as photodynamic therapeutic substances.
摘要翻译：光动力测绘装置包括具有近端和远端的轴，在轴的远端处的至少一个光电极和位于轴内部的至少一个光纤。在实施例中，至少一个光纤从轴的远端延伸并且耦合到设置在设备的外表面处或周围的至少一个光电极。在一个实施例中，至少一个光纤在轴的近端处或周围耦合到耦合的光源和光学传感器。分析仪可以耦合到光学传感器。这种装置的实施例可以被配置为递送物质，例如光动力学治疗物质。

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