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1. 发明申请

US20130338467A1 Electrode catheter device with indifferent electrode for direct current tissue therapies 有权
标题翻译：用于直流组织治疗的具有无关电极的电极导管装置
公开(公告)号：US20130338467A1
公开(公告)日：2013-12-19
申请号：US13885776
申请日：2011-11-18
申请人： Martin M. Grasse , Richard E. Stehr , Israel A. Byrd , Lynn E. Clark , D. Curtis Deno , Troy T. Tegg , James V. Kauphusman , Saurav Paul , Jeffrey A. Schweitzer
发明人： Martin M. Grasse , Richard E. Stehr , Israel A. Byrd , Lynn E. Clark , D. Curtis Deno , Troy T. Tegg , James V. Kauphusman , Saurav Paul , Jeffrey A. Schweitzer
IPC分类号： A61B18/16
CPC分类号： A61B18/16 , A61B5/042 , A61B18/1492 , A61B2018/00357 , A61B2018/00613 , A61B2018/00791 , A61B2018/1435 , A61B2018/162 , A61M25/0147 , A61M2025/0681
摘要： An electrode catheter device with indifferent electrode for direct current tissue therapies is disclosed. An example of the catheter device has a flexible tubing with at least one ablation electrode. The catheter device also may also be used with a sheath for introducing the flexible tubing inside a patient's body. An indifferent electrode on the sheath can provide a ground for a direct current (DC) pulse to deliver electrical energy and create an electrical field adjacent a tissue. Various other embodiments are also disclosed.
摘要翻译：公开了一种具有用于直流组织治疗的无电极的电极导管装置。导管装置的示例具有带有至少一个消融电极的柔性管。导管装置还可以与护套一起使用以将柔性管引入患者体内。护套上的无电极可以为直流（DC）脉冲提供接地，以传递电能并在组织附近产生电场。还公开了各种其它实施例。

2. 发明授权

US09877781B2 Electrode catheter device with indifferent electrode for direct current tissue therapies 有权
公开(公告)号：US09877781B2
公开(公告)日：2018-01-30
申请号：US13885776
申请日：2011-11-18
申请人： Martin M. Grasse , Richard E. Stehr , Israel A. Byrd , Lynn E. Gilmour , D. Curtis Deno , Troy T. Tegg , James V. Kauphusman , Saurav Paul , Jeffrey A. Schweitzer
发明人： Martin M. Grasse , Richard E. Stehr , Israel A. Byrd , Lynn E. Gilmour , D. Curtis Deno , Troy T. Tegg , James V. Kauphusman , Saurav Paul , Jeffrey A. Schweitzer
IPC分类号： A61N1/00 , A61B5/04 , A61B18/16 , A61B5/042 , A61B18/14 , A61B18/00 , A61M25/01 , A61M25/06
CPC分类号： A61B18/16 , A61B5/042 , A61B18/1492 , A61B2018/00357 , A61B2018/00613 , A61B2018/00791 , A61B2018/1435 , A61B2018/162 , A61M25/0147 , A61M2025/0681
摘要： An electrode catheter device with indifferent electrode for direct current tissue therapies is disclosed. An example of the catheter device has a flexible tubing with at least one ablation electrode. The catheter device also may also be used with a sheath for introducing the flexible tubing inside a patient's body. An indifferent electrode on the sheath can provide a ground for a direct current (DC) pulse to deliver electrical energy and create an electrical field adjacent a tissue. Various other embodiments are also disclosed.

3. 发明申请

US20120035460A1 MOVABLE MAGNET FOR MAGNETICALLY GUIDED CATHETER 有权
标题翻译：用于磁导管的可变磁铁
公开(公告)号：US20120035460A1
公开(公告)日：2012-02-09
申请号：US12851407
申请日：2010-08-05
申请人： Todd R. Stangenes , Saurav Paul , James V. Kauphusman , Troy T. Tegg , Jeffrey A. Schweitzer
发明人： Todd R. Stangenes , Saurav Paul , James V. Kauphusman , Troy T. Tegg , Jeffrey A. Schweitzer
IPC分类号： A61M25/092 , A61B5/055 , A61B6/12
CPC分类号： A61M25/0127 , A61B5/0422 , A61B5/055 , A61B5/062 , A61B5/6857 , A61B6/12 , A61B6/487 , A61B18/1492 , A61B34/32 , A61B34/73 , A61B2018/00375 , A61B2018/00577 , A61B2018/00791 , A61B2034/301 , A61B2034/303 , A61B2034/731 , A61B2034/732 , A61B2562/0271 , A61M25/0158
摘要： A catheter is disclosed having a flexible tubing with a proximal end and a distal end. The catheter comprising at least one movable magnet provided within the distal end of the flexible tubing. A control mechanism is operable to selectively activate the at least one movable magnet from the proximal end of the flexible tubing. The at least one movable magnet is responsive to an external magnetic field to position and guide the distal end of the flexible tubing within a body of a patient.
摘要翻译：公开了一种具有近端和远端的柔性管的导管。导管包括设置在柔性管的远端内的至少一个可动磁体。控制机构可操作以从柔性管的近端选择性地启动至少一个可动磁体。所述至少一个可移动磁体响应外部磁场来定位和引导患者体内的柔性管的远端。

4. 发明授权

US08532743B2 Movable magnet for magnetically guided catheter 有权
标题翻译：磁导管用可动磁铁
公开(公告)号：US08532743B2
公开(公告)日：2013-09-10
申请号：US12851407
申请日：2010-08-05
申请人： Todd R. Stangenes , Saurav Paul , James V. Kauphusman , Troy T. Tegg , Jeffrey A. Schweitzer
发明人： Todd R. Stangenes , Saurav Paul , James V. Kauphusman , Troy T. Tegg , Jeffrey A. Schweitzer
IPC分类号： A61B5/05 , A61M25/00 , A61M31/00
CPC分类号： A61M25/0127 , A61B5/0422 , A61B5/055 , A61B5/062 , A61B5/6857 , A61B6/12 , A61B6/487 , A61B18/1492 , A61B34/32 , A61B34/73 , A61B2018/00375 , A61B2018/00577 , A61B2018/00791 , A61B2034/301 , A61B2034/303 , A61B2034/731 , A61B2034/732 , A61B2562/0271 , A61M25/0158
摘要： A catheter is disclosed having a flexible tubing with a proximal end and a distal end. The catheter comprising at least one movable magnet provided within the distal end of the flexible tubing. A control mechanism is operable to selectively activate the at least one movable magnet from the proximal end of the flexible tubing. The at least one movable magnet is responsive to an external magnetic field to position and guide the distal end of the flexible tubing within a body of a patient.
摘要翻译：公开了一种具有近端和远端的柔性管的导管。导管包括设置在柔性管的远端内的至少一个可动磁体。控制机构可操作以从柔性管的近端选择性地启动至少一个可动磁体。所述至少一个可移动磁体响应外部磁场来定位和引导患者体内的柔性管的远端。

5. 发明授权

US09289606B2 System for electroporation therapy 有权
标题翻译：电穿孔治疗系统
公开(公告)号：US09289606B2
公开(公告)日：2016-03-22
申请号：US12874788
申请日：2010-09-02
申请人： Saurav Paul , Troy T. Tegg , Israel A. Byrd , Riki Thao , Harry A. Puryear , Linda Nemec , John M. Berns
发明人： Saurav Paul , Troy T. Tegg , Israel A. Byrd , Riki Thao , Harry A. Puryear , Linda Nemec , John M. Berns
IPC分类号： A61B18/18 , A61N1/32 , A61B18/14 , A61B18/00
CPC分类号： A61N1/327 , A61B18/14 , A61B2018/0016
摘要： Catheter systems include direction-sensitive, multi-polar tip electrode assemblies for electroporation-mediated therapy, electroporation-induced primary necrosis therapy and electric field-induced apoptosis therapy, including configurations for producing narrow, linear lesions as well as distributed, wide area lesions. A monitoring system for electroporation therapy includes a mechanism for delivering electrochromic dyes to a tissue site as well as a fiber optic arrangement to optically monitor the progress of the therapy as well as to confirm success post-therapy. A fiber optic temperature sensing electrode catheter includes a tip electrode having a cavity whose inner surface is impregnated or coated with thermochromic/thermotropic material that changes color with changes in temperature. An optic fiber/detector arrangement monitors the thermochromic or thermotropic materials, acquiring a light signal and generating an output signal indicative of the spectrum of the light signal. An analyzer determines an electrode temperature based on the detector output and predetermined spectrum versus temperature calibration data.
摘要翻译：导管系统包括用于电穿孔介导治疗的方向敏感的多极尖端电极组件，电穿孔诱导的原发性坏死治疗和电场诱导的凋亡治疗，包括用于产生狭窄的线性损伤以及分布的广泛区域损伤的构造。用于电穿孔治疗的监测系统包括将电致变色染料递送到组织部位的机制以及光学配置以光学监测治疗进展以及确认疗法后的成功。光纤温度感测电极导管包括具有腔体的尖端电极，其内表面被浸渍或涂覆有随着温度变化而改变颜色的热变色/热致变色材料。光纤/检测器装置监测热致变色或热致变色材料，获取光信号并产生指示光信号光谱的输出信号。分析仪基于检测器输出和预定的频谱对温度校准数据来确定电极温度。

6. 发明申请

US20120059255A1 CATHETER SYSTEMS 有权
标题翻译：导管系统
公开(公告)号：US20120059255A1
公开(公告)日：2012-03-08
申请号：US12874788
申请日：2010-09-02
申请人： Saurav Paul , Troy T. Tegg , Israel A. Byrd , Riki Thao , Harry A. Puryear , Linda Nemec , John M. Berns
发明人： Saurav Paul , Troy T. Tegg , Israel A. Byrd , Riki Thao , Harry A. Puryear , Linda Nemec , John M. Berns
IPC分类号： A61N1/30 , A61B18/14 , A61B6/00
CPC分类号： A61N1/327 , A61B18/14 , A61B2018/0016
摘要： Catheter systems include direction-sensitive, multi-polar tip electrode assemblies for electroporation-mediated therapy, electroporation-induced primary necrosis therapy and electric field-induced apoptosis therapy, including configurations for producing narrow, linear lesions as well as distributed, wide area lesions. A monitoring system for electroporation therapy includes a mechanism for delivering electrochromic dyes to a tissue site as well as a fiber optic arrangement to optically monitor the progress of the therapy as well as to confirm success post-therapy. A fiber optic temperature sensing electrode catheter includes a tip electrode having a cavity whose inner surface is impregnated or coated with thermochromic/thermotropic material that changes color with changes in temperature. An optic fiber/detector arrangement monitors the thermochromic or thermotropic materials, acquiring a light signal and generating an output signal indicative of the spectrum of the light signal. An analyzer determines an electrode temperature based on the detector output and predetermined spectrum versus temperature calibration data.
摘要翻译：导管系统包括用于电穿孔介导治疗的方向敏感的多极尖端电极组件，电穿孔诱导的原发性坏死治疗和电场诱导的凋亡治疗，包括用于产生狭窄的线性损伤以及分布的广泛区域损伤的构造。用于电穿孔治疗的监测系统包括将电致变色染料递送到组织部位的机制以及光学配置以光学监测治疗进展以及确认疗法后的成功。光纤温度感测电极导管包括具有腔体的尖端电极，其内表面被浸渍或涂覆有随着温度变化而改变颜色的热变色/热致变色材料。光纤/检测器装置监测热致变色或热致变色材料，获取光信号并产生指示光信号光谱的输出信号。分析仪基于检测器输出和预定的频谱对温度校准数据来确定电极温度。

7. 发明授权

US08577447B2 Optic-based contact sensing assembly and system 有权
标题翻译：基于光学的接触感测组件和系统
公开(公告)号：US08577447B2
公开(公告)日：2013-11-05
申请号：US11941073
申请日：2007-11-15
申请人： Troy T. Tegg , Saurav Paul , Richard E. Stehr , Reed R. Heimbecher
发明人： Troy T. Tegg , Saurav Paul , Richard E. Stehr , Reed R. Heimbecher
IPC分类号： A61B18/14
CPC分类号： A61B5/6885 , A61B5/0084 , A61B5/6852 , A61B5/6886 , A61B18/1492 , A61B18/24 , A61B2017/00057 , A61B2017/00084 , A61B2090/065 , A61M25/0069 , A61M25/007 , A61M25/0071 , A61M2025/0002
摘要： The invention relates to an optic-based sensing assembly and a system incorporating the assembly and related use of the assembly. In particular, the invention relates to an optic-based catheter assembly and related system used to determine contact between a catheter and surrounding proximate environment, such as tissue. An embodiment of such a system may, for example, be used for visualization, mapping, ablation, or other methods of diagnosis and treatment of tissue and/or surrounding areas.
摘要翻译：本发明涉及一种基于光学的感测组件以及结合该组件的组件和该组件的相关使用的系统。特别地，本发明涉及一种基于光学的导管组件和相关系统，其用于确定导管和周围的近处环境（例如组织）之间的接触。这种系统的实施例可以例如用于组织和/或周围区域的可视化，映射，消融或其它诊断和治疗方法。

8. 发明申请

US20110270046A1 Optic-based contact sensing assembly and system 有权
标题翻译：基于光学的接触感测组件和系统
公开(公告)号：US20110270046A1
公开(公告)日：2011-11-03
申请号：US13143001
申请日：2009-12-30
申请人： Saurav Paul , Troy T. Tegg , Reed R. Heimbecher , Richard E. Stehr , Riki Chou Thao
发明人： Saurav Paul , Troy T. Tegg , Reed R. Heimbecher , Richard E. Stehr , Riki Chou Thao
IPC分类号： A61B5/00 , A61M39/10
CPC分类号： A61M39/10 , A61B5/0084 , A61B5/042 , A61B5/061 , A61B5/065 , A61B5/1076 , A61B5/6852 , A61B5/6885 , A61B18/1492 , A61B18/24 , A61B2017/00057 , A61B2017/00084 , A61B2090/065 , A61M25/0043 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M25/0071 , A61M25/0074 , A61M25/01 , A61M25/0138 , A61M25/0141 , A61M2025/0002
摘要： A contact sensing assembly including a catheter and an electrode including a tip portion and a base portion, and a generally central axis, with the electrode being connected to a distal end of the catheter. Optical sensor(s) may be provided for emitting and/or receiving an optical signal, with a part of the optical signal being transverse to the central axis. Optical interference member(s) may be provided for interfering with the optical signal. A method for sensing contact force exerted by an electrode on a tissue includes directing an optical signal along a portion of a catheter, emitting and/or receiving an optical signal, with a part of the optical signal being at a predetermined angle relative to the central axis, and sensing changes in intensity of the optical signal based on displacement associated with the electrode tip portion based on the contact force exerted by the electrode on the tissue.
摘要翻译：一种接触检测组件，包括导管和包括尖端部分和基部部分的电极以及大致中心的轴线，电极连接到导管的远端。可以提供光学传感器用于发射和/或接收光学信号，其中一部分光学信号横向于中心轴线。可以提供光干涉构件以干涉光信号。用于感测由电极施加在组织上的接触力的方法包括沿着导管的一部分引导光学信号，发射和/或接收光信号，其中光信号的一部分相对于中心处于预定角度并且基于由电极施加在组织上的接触力，基于与电极末端部分相关联的位移来感测光信号的强度变化。

9. 发明申请

US20080275428A1 OPTIC-BASED CONTACT SENSING ASSEMBLY AND SYSTEM 有权
标题翻译：基于光学的接触感应组件和系统
公开(公告)号：US20080275428A1
公开(公告)日：2008-11-06
申请号：US11941073
申请日：2007-11-15
申请人： Troy T. Tegg , Saurav Paul , Richard E. Stehr , Reed R. Heimbecher
发明人： Troy T. Tegg , Saurav Paul , Richard E. Stehr , Reed R. Heimbecher
IPC分类号： A61M25/18
CPC分类号： A61B5/6885 , A61B5/0084 , A61B5/6852 , A61B5/6886 , A61B18/1492 , A61B18/24 , A61B2017/00057 , A61B2017/00084 , A61B2090/065 , A61M25/0069 , A61M25/007 , A61M25/0071 , A61M2025/0002
摘要： The invention relates to an optic-based sensing assembly and a system incorporating the assembly and related use of the assembly. In particular, the invention relates to an optic-based catheter assembly and related system used to determine contact between a catheter and surrounding proximate environment, such as tissue. An embodiment of such a system may, for example, be used for visualization, mapping, ablation, or other methods of diagnosis and treatment of tissue and/or surrounding areas.
摘要翻译：本发明涉及一种基于光学的感测组件以及结合该组件的组件和该组件的相关使用的系统。特别地，本发明涉及一种基于光学的导管组件和相关系统，其用于确定导管和周围的近处环境（例如组织）之间的接触。这种系统的实施例可以例如用于组织和/或周围区域的可视化，映射，消融或其它诊断和治疗方法。

10. 发明授权

US09855410B2 Optic-based contact sensing assembly and system 有权
公开(公告)号：US09855410B2
公开(公告)日：2018-01-02
申请号：US13143001
申请日：2009-12-30
申请人： Saurav Paul , Troy T. Tegg , Reed R. Heimbecher , Richard E. Stehr , Riki Chou Thao
发明人： Saurav Paul , Troy T. Tegg , Reed R. Heimbecher , Richard E. Stehr , Riki Chou Thao
IPC分类号： A61B6/00 , A61M39/10 , A61B5/00 , A61B18/14 , A61M25/00 , A61M25/01 , A61B5/06 , A61B5/107 , A61B18/24 , A61B17/00 , A61B90/00
CPC分类号： A61M39/10 , A61B5/0084 , A61B5/042 , A61B5/061 , A61B5/065 , A61B5/1076 , A61B5/6852 , A61B5/6885 , A61B18/1492 , A61B18/24 , A61B2017/00057 , A61B2017/00084 , A61B2090/065 , A61M25/0043 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M25/0071 , A61M25/0074 , A61M25/01 , A61M25/0138 , A61M25/0141 , A61M2025/0002
摘要： A contact sensing assembly including a catheter and an electrode including a tip portion and a base portion, and a generally central axis, with the electrode being connected to a distal end of the catheter. Optical sensor(s) may be provided for emitting and/or receiving an optical signal, with a part of the optical signal being transverse to the central axis. Optical interference member(s) may be provided for interfering with the optical signal. A method for sensing contact force exerted by an electrode on a tissue includes directing an optical signal along a portion of a catheter, emitting and/or receiving an optical signal, with a part of the optical signal being at a predetermined angle relative to the central axis, and sensing changes in intensity of the optical signal based on displacement associated with the electrode tip portion based on the contact force exerted by the electrode on the tissue.

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