专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06617324B1 Substituted pyrazoles as p38 kinase inhibitors 失效
标题翻译：取代的吡唑作为p38激酶抑制剂
公开(公告)号：US06617324B1
公开(公告)日：2003-09-09
申请号：US10114297
申请日：2002-04-02
申请人： Ashok S. Naraian , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xi , Ish K. Khanna , Yi Yu
发明人： Ashok S. Naraian , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xi , Ish K. Khanna , Yi Yu
IPC分类号： A61K31496
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D487/04
摘要： A class of pyrazole derivatives described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA wherein R1, R2, R3 and R4 are as described in the specification.
摘要翻译：一类描述用于治疗p38激酶介导的病症的吡唑衍生物。特别感兴趣的化合物由式IA定义，其中R1，R2，R3和R4如说明书中所述。

2. 发明授权

US06979686B1 Substituted pyrazoles as p38 kinase inhibitors 失效
标题翻译：取代的吡唑作为p38激酶抑制剂
公开(公告)号：US06979686B1
公开(公告)日：2005-12-27
申请号：US10021780
申请日：2001-12-07
申请人： Ashok S. Naraian , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xu , Ish K. Khanna , Yi Yu , Win Naing , John Walker , Syaulan Yang
发明人： Ashok S. Naraian , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xu , Ish K. Khanna , Yi Yu , Win Naing , John Walker , Syaulan Yang
IPC分类号： A61K31/496 , A61K31/501 , A61K31/5355 , C07D211/06 , C07D413/04
CPC分类号： C07D401/14 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D473/00 , C07D487/04 , C07D491/10 , C07D495/04
摘要： A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula (IA), wherein R1, R2, R3 and R4 are as described in the specification.
摘要翻译：描述了一类吡唑衍生物用于治疗p38激酶介导的病症。特别感兴趣的化合物由式（IA）定义，其中R 1，R 2，R 3和R 4， SUP>如说明书中所述。

3. 发明授权

US06525059B1 Substituted pyrazoles as p38 kinase inhibitors 失效
标题翻译：取代的吡唑作为p38激酶抑制剂
公开(公告)号：US06525059B1
公开(公告)日：2003-02-25
申请号：US09513351
申请日：2000-02-24
申请人： Ashok Anantanarayan , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xu , Ish K. Khanna , Yi Yu
发明人： Ashok Anantanarayan , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xu , Ish K. Khanna , Yi Yu
IPC分类号： A61K31506
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D487/04
摘要： A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA wherein R1, R 2, R3 and R4 are as described in the specification.
摘要翻译：描述了一类吡唑衍生物用于治疗p38激酶介导的病症。特别感兴趣的化合物由式IA定义，其中R 1，R 2，R 3和R 4如说明书中所述。

4. 发明授权

US5635514A Heteroaralkyl and heteroarylthioalkyl thiophenolic compounds as 5-lipoxgenase inhibitors 失效
标题翻译：杂芳基烷基和杂芳硫基烷基硫代酚化合物作为5-脂氧合酶抑制剂
公开(公告)号：US5635514A
公开(公告)日：1997-06-03
申请号：US328212
申请日：1994-10-25
申请人： Ish K. Khanna , Michael A. Stealey , Richard M. Weier
发明人： Ish K. Khanna , Michael A. Stealey , Richard M. Weier
IPC分类号： C07D209/08 , C07D215/22 , C07D215/227 , C07D235/06 , C07D263/58 , C07D471/04 , A61K31/44 , A61K31/47
CPC分类号： C07D215/227 , C07D209/08 , C07D235/06 , C07D263/58 , C07D471/04
摘要： Compounds of the formula: ##STR1## and the pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising a therapeutically-effective amount of the compounds or salts in combination with a pharmaceutically-acceptable carrier and methods for treating 5-lipoxygenase mediated conditions, inflammation-associated disorders and allergies.
摘要翻译：式I化合物及其药学上可接受的盐，包含治疗有效量的化合物或盐与药学上可接受的载体组合的药物组合物和用于治疗5-脂氧合酶介导的病症的方法，相关疾病和过敏。

5. 发明授权

US5359073A Substituted-phenyl (N,N'-cycloalkyl/alkyl carboxamide)-1H/3H-imidazo[4,5-b]pyridine compounds as PAF antagonists 失效
标题翻译：取代的苯基（N，N'-环烷基/烷基甲酰胺）-1H / 3H-咪唑并[4,5-b]吡啶化合物作为PAF拮抗剂
公开(公告)号：US5359073A
公开(公告)日：1994-10-25
申请号：US981957
申请日：1992-11-24
申请人： Richard M. Weier , Ish K. Khanna , Michael A. Stealey , Janet A. Julien , Kirk T. Lentz
发明人： Richard M. Weier , Ish K. Khanna , Michael A. Stealey , Janet A. Julien , Kirk T. Lentz
IPC分类号： A61K31/435 , A61P9/14 , A61P11/00 , A61P29/00 , C07D471/04 , C07F7/18 , C07D471/06
CPC分类号： C07F7/1856 , C07D471/04
摘要： A class of N,N'-cycloalkyl/alkyl benzamides of certain 1H-imidazo[4,5-b]pyridine and 3H-imidazo[4,5-b]pyridine compounds is described for treating cardiovascular and immuno-inflammatory related disorders mediated by platelet activating factor (PAF). Compounds of particular interest are those of the formula: ##STR1## wherein each of X.sup.a and X.sup.b is independently selected from nitrogen atom and --CH--, with the proviso that when one of X.sup.a and X.sup.b is selected as nitrogen atom, then the other of X.sup.a and X.sup.b must be --CH--; wherein R.sup.1 is selected from hydrido, alkyl, hydroxyalkyl, alkoxyalkyl, phenyl, halophenyl, alkylsilyloxyalkyl, amino, monoalkylamino, dialkylamino, aminoalkyl, monoalkylaminoalkyl and dialkylaminoalkyl; wherein each of R.sup.5, R.sup.6, R.sup.7 and R.sup.8 is independently selected from hydrido, hydroxy, alkyl, alkoxy, fluoro, chloro, bromo, haloalkyl, alkylthio, alkoxyalkyl, hydroxyalkyl, alkylthioalkyl, cyano, amino, monoalkylamino and dialkylamino; wherein each of R.sup.9 and R.sup.10 is independently selected from hydrido, alkyl, cycloalkyl, bicycloalkyl, heteroaryl, aryl, alkenyl and cycloalkenyl, and wherein any of said R.sup.9 and R.sup.10 substituents may be further substituted or a pharmaceutically-acceptable salt thereof.
摘要翻译：描述了某些1H-咪唑并[4,5-b]吡啶和3H-咪唑并[4,5-b]吡啶化合物的一类N，N'-环烷基/烷基苯甲酰胺，用于治疗心血管和免疫炎性相关病症介导通过血小板激活因子（PAF）。特别感兴趣的化合物是下式的化合物：其中Xa和Xb各自独立地选自氮原子和-CH-，条件是当Xa和Xb中的一个被选为氮原子时，则另一个 Xa和Xb必须是-CH-; 其中R 1选自氢，烷基，羟基烷基，烷氧基烷基，苯基，卤代苯基，烷基甲硅烷氧基烷基，氨基，单烷基氨基，二烷基氨基，氨基烷基，单烷基氨基烷基和二烷基氨基烷基。其中R5，R6，R7和R8各自独立地选自氢，羟基，烷基，烷氧基，氟，氯，溴，卤代烷基，烷硫基，烷氧基烷基，羟基烷基，烷硫基烷基，氰基，氨基，单烷基氨基和二烷基氨基。其中R 9和R 10各自独立地选自氢化，烷基，环烷基，双环烷基，杂芳基，芳基，烯基和环烯基，并且其中所述R9和R10取代基中的任一个可以被进一步取代或其药学上可接受的盐。

6. 发明授权

US07153959B2 Substituted pyrazoles as p38 kinase inhibitors 失效
标题翻译：取代的吡唑作为p38激酶抑制剂
公开(公告)号：US07153959B2
公开(公告)日：2006-12-26
申请号：US10374781
申请日：2003-02-25
申请人： Ashok S. Naraian , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xu , Ish K. Khanna , Yi Yu , Win Naing , Syaulan Yang
发明人： Ashok S. Naraian , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xu , Ish K. Khanna , Yi Yu , Win Naing , Syaulan Yang
IPC分类号： C07D401/04 , C07D401/14 , C07D413/02
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D487/04
摘要： A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA wherein R1, R2, R3 and R4 are as described in the specification.
摘要翻译：描述了一类吡唑衍生物用于治疗p38激酶介导的病症。特别感兴趣的化合物由式IA定义，其中R 1，R 2，R 3和R 4是如说明书中所述。

8. 发明授权

US06423713B1 Substituted pyrazoles as p38 kinase inhibitors 失效
标题翻译：取代的吡唑作为p38激酶抑制剂
公开(公告)号：US06423713B1
公开(公告)日：2002-07-23
申请号：US09918481
申请日：2001-07-31
申请人： Ashok Anantanarayan , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xi , Ish K. Khanna , Yi Yu
发明人： Ashok Anantanarayan , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xi , Ish K. Khanna , Yi Yu
IPC分类号： A61K31496
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D487/04
摘要： A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA wherein R1, R2, R3 and R4 are as described in the specification.
摘要翻译：描述了一类吡唑衍生物用于治疗p38激酶介导的病症。特别感兴趣的化合物由式IA定义，其中R1，R2，R3和R4如说明书中所述。

9. 发明授权

US5270468A 2- and 3- amino azido derivatives of 1,5-iminosugars 失效
标题翻译： 1,5-亚氨基二糖的2-和3-氨基叠氮衍生物
公开(公告)号：US5270468A
公开(公告)日：1993-12-14
申请号：US1953
申请日：1993-01-08
申请人： Ish K. Khanna , Richard A. Mueller , Richard M. Weier , Michael A. Stealey
发明人： Ish K. Khanna , Richard A. Mueller , Richard M. Weier , Michael A. Stealey
IPC分类号： A61K31/435 , A61K31/445 , A61K31/4468 , A61P31/12 , A61P31/14 , C07D211/42 , C07D211/56 , C07D211/58 , C07D491/04 , C07D491/056
CPC分类号： C07D491/04 , C07D211/42 , C07D211/56
摘要： Novel derivatives of 1-deoxynojirimycin are disclosed which have amino or azido substituents at C-2 and/or C-3. These compounds are useful inhibitors of lentiviruses. Methods of chemical synthesis of these derivatives and intermediates therefor are also disclosed.

10. 发明授权

US5262426A N,N'-cycloalkyl/alkyl carboxamide 4H-imidazo-[4,5-b]pyridine compounds as PAF antagonists 失效
标题翻译： N，N'-环烷基/烷基甲酰胺4H-咪唑并[4,5-b]吡啶化合物作为PAF拮抗剂
公开(公告)号：US5262426A
公开(公告)日：1993-11-16
申请号：US7461
申请日：1993-01-22
申请人： Richard M. Weier , Ish K. Khanna , Michael A. Stealey , Janet A. Julien
发明人： Richard M. Weier , Ish K. Khanna , Michael A. Stealey , Janet A. Julien
IPC分类号： A61K31/435 , A61P7/02 , C07D471/04 , C07F7/18
CPC分类号： C07D471/04
摘要： A class of N,N'-cycloalkyl/alkyl benzamides of certain 4H-imidazo[4,5-b]pyridine compounds is described for treating cardiovascular and immuno-inflammatory related disorders mediated by platelet activating factor (PAF). Compounds of particular interest are those of the formula: ##STR1## wherein R.sup.1 is selected from hydrido, alkyl, hydroxyalkyl, alkoxyalkyl, phenyl, halophenyl, pyridinyl, alkylsilyloxyalkyl, amino, monoalkylamino, dialkylamino, aminoalkyl, monoalkylaminoalkyl and dialkylaminoalkyl; wherein each of R.sup.5, R.sup.6, R.sup.7 and R.sup.8 is independently selected from hydrido, hydroxy, alkyl, alkoxy, fluoro, chloro, bromo, haloalkyl, alkylthio, alkoxyalkyl, hydroxyalkyl, alkylthioalkyl, cyano, amino, monoalkylamino and dialkylamino; wherein each of R.sup.9 and R.sup.10 is independently selected from hydrido, alkyl, cycloalkyl, bicycloalkyl, heterocyclic, heterocyclicalkyl, aryl, alkenyl and cycloalkenyl, and wherein any of said R.sup.9 and R.sup.10 substituents may be further substituted with one or more groups selected from linear or branched lower alkyl, lower alkoxy, fluoro, chloro and bromo; or a pharmaceutically-acceptable salt thereof.
摘要翻译：描述了某些4H-咪唑并[4,5-b]吡啶化合物的一类N，N'-环烷基/烷基苯甲酰胺，用于治疗由血小板活化因子（PAF）介导的心血管和免疫炎性相关病症。烷基，羟基烷基，烷氧基烷基，苯基，卤代苯基，吡啶基，烷基甲硅烷氧基烷基，氨基，单烷基氨基，二烷基氨基，氨基烷基，单烷基氨基烷基和二烷基氨基烷基的化合物是下式的化合物：其中R 1选自氢，烷基，其中R5，R6，R7和R8各自独立地选自氢，羟基，烷基，烷氧基，氟，氯，溴，卤代烷基，烷硫基，烷氧基烷基，羟基烷基，烷硫基烷基，氰基，氨基，单烷基氨基和二烷基氨基。其中R 9和R 10各自独立地选自氢，烷基，环烷基，双环烷基，杂环，杂环烷基，芳基，烯基和环烯基，并且其中所述R9和R10取代基中的任何一个可以进一步被一个或多个选自直链或支链低级烷基，低级烷氧基，氟，氯和溴; 或其药学上可接受的盐。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式