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1. 发明授权

US4582719A Process for producing a slow release composite 失效
标题翻译：缓释复合材料的制备方法
公开(公告)号：US4582719A
公开(公告)日：1986-04-15
申请号：US514026
申请日：1983-07-15
申请人： Isao Kaetsu , Masaharu Asano , Minoru Kumakura , Masaru Yoshida
发明人： Isao Kaetsu , Masaharu Asano , Minoru Kumakura , Masaru Yoshida
IPC分类号： A01N25/10 , A61K9/20 , A61K9/22 , A61K9/52 , B01J19/12 , B05D3/06
CPC分类号： A01N25/10 , A61K9/2063
摘要： A process is, herein disclosed, for producing a slow release composite having a physiologically active substance encapsulated therein, which comprises preparing a system wherein one or more physiologically active substances are in contact with protein from one or more protein sources, and bringing said system into direct contact with steam at temperatures between 50.degree. C. and 100.degree. C. to denature the protein and make the same hydrophobic, to thereby make a slow release composite having the physiologically active substance dispersed, fixed and encapsulated therein. And a process is also disclosed for producing a slow release composite which comprises preparing a mixture of one or more hydrophilic polymerizable monomers containing the body fluid and/or isotonic solution, protein from one or more protein sources, and one or more physiologically active substances, subjecting the mixture to direct contact with steam and irradiation with light or ionizing radiation, said treatment with steam being performed either before or simultaneously with irradiation with light or ionizing radiation.
摘要翻译：本文公开了一种用于生产包含其中的生理活性物质的缓释复合物的方法，其包括制备其中一种或多种生理活性物质与来自一种或多种蛋白质来源的蛋白质接触的系统，并将所述系统引入在50℃至100℃的温度下直接与蒸汽接触以使蛋白质变性并制成相同的疏水性，从而制备其生理活性物质分散，固定和包封的缓释复合物。还公开了用于生产缓释复合物的方法，其包括制备含有体液和/或等渗溶液的一种或多种亲水性可聚合单体，来自一种或多种蛋白质来源的蛋白质和一种或多种生理活性物质的混合物，使混合物与蒸汽直接接触并用光或电离辐射照射，所述用蒸汽进行的处理在用光或电离辐射照射之前或同时进行。

2. 发明授权

US4311732A Primer composition and a process for producing a coated product using the same 失效
标题翻译：底漆组合物和使用其的涂布产品的制备方法
公开(公告)号：US4311732A
公开(公告)日：1982-01-19
申请号：US45854
申请日：1979-06-05
申请人： Isao Kaetsu , Minoru Kumakura , Masaru Yoshida , Goro Shimaoka , Masanobu Urabe
发明人： Isao Kaetsu , Minoru Kumakura , Masaru Yoshida , Goro Shimaoka , Masanobu Urabe
IPC分类号： B05D7/02 , B32B27/00 , C08G59/00 , C08J7/04 , C08L63/00 , C09D163/00 , D21H13/26
CPC分类号： C08J7/042 , C08J2369/00 , C08J2433/06 , C08J2483/04 , Y10T428/31507
摘要： In accordance with this invention, there is provided a primer composition prepared by dissolving in an organic solvent at least one diepoxy compound selected from the group consisting of:(1) polyalkylene glycol diglycidyl ether of the formula; ##STR1## (2) poly(alkylene glycol) diglycidyl ether of the formula; ##STR2## and (3) diepoxide derived from a bisphenol of the formula; (wherein R.sub.1 is a linear or branched alkylene group having less than 8 carbon atoms; R.sub.2 is a linear or branched alkyl group having less than 4 carbon atoms, R.sub.3 is a linear or branched alkylene group having less than 8 carbon atoms, or a binding group selected from the class consisting of ##STR3## l, m and n are each an integer of from 0 to less than 10, the sum of l and m being more than 1).Also in accordance with the invention, there is provided a process for producing a coated product using such primer composition.
摘要翻译：根据本发明，提供了一种底漆组合物，其通过将有机溶剂中至少一种选自以下的二环氧化合物溶解于（1）下式的聚亚烷基二醇二缩水甘油醚：（2）下式的聚（亚烷基二醇）二缩水甘油醚; ＆lt; IMAGE＆gt; + TR＆lt; IMAGE＆gt;和（3）衍生自下式双酚的二环氧化物; （其中R 1为碳原子数少于8个的直链或支链亚烷基; R 2为碳原子数小于4的直链或支链烷基，R3为具有少于4个碳原子的直链或支链亚烷基或者选自由以下组成的组的结合基团，其中，所述结构基团是由0和小于10的整数，1和m的和大于1）。还根据本发明，提供了使用这种底漆组合物生产涂布产品的方法。

3. 发明授权

US4411754A Process for preparing a polymer composition 失效
标题翻译：制备聚合物组合物的方法
公开(公告)号：US4411754A
公开(公告)日：1983-10-25
申请号：US234839
申请日：1981-02-13
申请人： Isao Kaetsu , Masaru Yoshida , Minoru Kumakura
发明人： Isao Kaetsu , Masaru Yoshida , Minoru Kumakura
IPC分类号： A61K9/16 , A61K9/20 , A61K9/22 , A61K9/70 , C08F2/44
CPC分类号： C08F2/44 , A61K9/1635 , A61K9/2027 , A61K9/7007
摘要： A polymer composition containing a physiologically active substance which can be released at a controlled rate is prepared by contacting one or more polymerizable monomers with the physiologically active substance, making the monomers into a specific shape and then irradiating the shaped article with light or an ionizing radiation at a low temperature below room temperature to polymerize the polymerizable monomers.
摘要翻译：通过使一种或多种可聚合单体与生理活性物质接触来制备含有可以以受控速率释放的生理活性物质的聚合物组合物，使单体成为特定形状，然后用光或电离辐射照射成形制品在低于室温的低温下聚合可聚合单体。

4. 发明授权

US4272617A Immobilization of enzymes or bacteria cells 失效
标题翻译：固定酶或细菌细胞
公开(公告)号：US4272617A
公开(公告)日：1981-06-09
申请号：US060867
申请日：1979-07-26
申请人： Isao Kaetsu , Minoru Kumakura , Masaru Yoshida
发明人： Isao Kaetsu , Minoru Kumakura , Masaru Yoshida
IPC分类号： C08F220/00 , C08F220/26 , C12N11/04 , C12N11/08
CPC分类号： C12N11/04
摘要： Enzymes and/or bacteria cells are immobilized by forming an aqueous mixture of enzymes and/or bacteria cells and a hydrophobic, vitrifiable monomer in an amount of at least 76% by weight of all monomers present, and irradiating the mixture by means of ionizing radiation at a temperature less than -10.degree. C. to polymerize the monomer.
摘要翻译：酶和/或细菌细胞通过形成酶和/或细菌细胞的水性混合物和疏水的可玻璃化单体来固定，其量为所存在的所有单体的至少76重量％，并通过电离辐射照射混合物在低于-10℃的温度下聚合单体。

5. 发明授权

US4226938A Method for immobilizing enzymes 失效
标题翻译：固定酶的方法
公开(公告)号：US4226938A
公开(公告)日：1980-10-07
申请号：US944444
申请日：1978-09-21
申请人： Masaru Yoshida , Minoru Kumakura , Isao Kaetsu
发明人： Masaru Yoshida , Minoru Kumakura , Isao Kaetsu
IPC分类号： C12N11/04 , C12N11/14
CPC分类号： C12N11/04
摘要： Enzymes are adsorbed on an adsorbent powder in an aqueous medium and a water-miscible monomer is added thereto, and said monomer is polymerized to form a porous gel lump through which a substrate solution can freely pass. The thus formed enzyme composition has long-lasting activity and thus the enzymes can be easily separated from the reaction system and can be used repeatedly.
摘要翻译：将酶吸附在水性介质中的吸附剂粉末上，向其中加入水混溶性单体，并使所述单体聚合形成多孔凝胶块，通过该多孔凝胶块可以自由通过底物溶液。由此形成的酶组合物具有持久的活性，因此酶可以容易地从反应体系中分离出来并可以重复使用。

6. 发明授权

US4177107A Process for producing composition containing insolubilized enzyme and/or insolubilized bacterial cells 失效
标题翻译：用于生产含有不溶性酶和/或不溶菌体的组合物的方法
公开(公告)号：US4177107A
公开(公告)日：1979-12-04
申请号：US763601
申请日：1977-01-28
申请人： Minoru Kumakura , Masaru Yoshida , Isao Kaetsu
发明人： Minoru Kumakura , Masaru Yoshida , Isao Kaetsu
IPC分类号： C12N11/08 , C12N11/04 , C12N11/14 , C07G7/02
CPC分类号： C12N11/04
摘要： A process for producing a composition containing insolubilized enzyme and/or insolubilized bacterial cells which comprises (i) the step of mixing (a) an aqueous solution of enzyme and/or an aqueous dispersion of bacterial cells, (b) at least one porous adsorbent and (c) at least one vitrifiable monomer.
摘要翻译：一种制备含有不溶性酶和/或不溶菌体细胞的组合物的方法，其包括（i）混合（a）酶水溶液和/或细菌细胞的水分散体的步骤，（b）至少一种多孔吸附剂和（c）至少一种可玻璃化的单体。

7. 发明授权

US4321117A Process for preparing a polymer composition 失效
标题翻译：制备聚合物组合物的方法
公开(公告)号：US4321117A
公开(公告)日：1982-03-23
申请号：US18617
申请日：1979-03-08
申请人： Isao Kaetsu , Masaru Yoshida , Minoru Kumakura
发明人： Isao Kaetsu , Masaru Yoshida , Minoru Kumakura
IPC分类号： A61K9/16 , A61K9/20 , A61K9/22 , A61K9/70 , C08F2/44
CPC分类号： C08F2/44 , A61K9/1635 , A61K9/2027 , A61K9/7007
摘要： A polymer composition containing a physiologically active substance which can be released at a controlled rate is prepared by contacting one or more polymerizable monomers with the physiologically active substance, mking the monomers into a specific shape and then irradiating the shaped article with light or an ionizing radiation at a low temperature below room temperature to polymerize the polymerizable monomers.
摘要翻译：通过使一种或多种可聚合单体与生理活性物质接触，将单体混合成特定形状，然后用光或电离辐射照射成形制品，制备含有可以以受控速率释放的生理活性物质的聚合物组合物在低于室温的低温下聚合可聚合单体。

8. 发明授权

US4912000A Electrophotographic photoreceptor 失效
标题翻译：电子照相感光体
公开(公告)号：US4912000A
公开(公告)日：1990-03-27
申请号：US302931
申请日：1989-01-30
申请人： Minoru Kumakura , Isao Kaetsu , Masahiro Horigome , Tsuneo Isomura , Tomio Yoneyama , Tadaichi Murata
发明人： Minoru Kumakura , Isao Kaetsu , Masahiro Horigome , Tsuneo Isomura , Tomio Yoneyama , Tadaichi Murata
IPC分类号： G03G5/14 , G03G5/147
CPC分类号： G03G5/1476 , G03G5/14773
摘要： An electrophotographic photoreceptor comprises an electrically conductive support, a photoconductive layer provided thereon, and a protective layer coated on the photoconductive layer, wherein the protective layer comprises a product of uncatalized hydrolysis of a composition essentially consisting of at least one specific epoxysilane compound, at least one specific alkylalkoxysilane compound, and at least one specific aminosilane compound. The photoreceptor is very useful in that it is free from wear due to friction with paper and cleaning members, keeps high resolving power, and is sufficiently proof against continuous copying under conditions of high temperature and high humidity.
摘要翻译：电子照相感光体包括导电支撑体，设置在其上的光电导层和涂覆在光电导层上的保护层，其中保护层包含基本由至少一种特定环氧硅烷化合物组成的组合物的非催化水解产物，至少一种特定的烷基烷氧基硅烷化合物和至少一种特定的氨基硅烷化合物。感光体是非常有用的，因为它与纸和清洁部件的摩擦没有磨损，保持高的分辨能力，并且足够证明在高温和高湿度的条件下连续复印。

9. 发明授权

US4839109A Process for producing a contact lens 失效
标题翻译：隐形眼镜的制造方法
公开(公告)号：US4839109A
公开(公告)日：1989-06-13
申请号：US886266
申请日：1986-07-16
申请人： Isao Kaetsu , Minoru Kumakura , Hidenari Suyama , Nobuo Kameda , Hideo Koyama
发明人： Isao Kaetsu , Minoru Kumakura , Hidenari Suyama , Nobuo Kameda , Hideo Koyama
IPC分类号： G02C7/04 , C08F230/08 , G02B1/04
CPC分类号： C08F230/08 , G02B1/043
摘要： A mixture of a specified siloxanylalkyl ester monomer and a specified vinyl monomer is polymerized by exposure to an ionizing radiation at low temperatures and the resulting polymer is worked with a lathe cut to form a contact lens. The contact lens obtained is free from any optical distortion, has good dimensional stability and exhibits high oxygen permeability. In a preferred embodiment, a monomer mixture comprising a siloxanylalkyl ester, a methacrylate or acrylate, N-vinylpyrrolidone, and a small amount of a dimethacrylate or diacrylate is exposed to a total dose of 1.times.10.sup.5 -5.times.10.sup.6 roentgens at a low temperature (-80.degree. C. to -20.degree. C. and at a dose rate of 8.times.10.sup.4 -2.times.10.sup.6 roentgens per hour, and the resulting polymer is worked into a contact lens by a suitable forming process involving cutting, grinding and polishing operations.
摘要翻译：指定的硅氧烷基烷基酯单体和特定乙烯基单体的混合物通过在低温下暴露于电离辐射而聚合，并且所得聚合物用车床切割加工以形成隐形眼镜。获得的隐形眼镜没有任何光学变形，具有良好的尺寸稳定性和显示出高的透氧性。在优选的实施方案中，包含硅氧烷基烷基酯，甲基丙烯酸酯或丙烯酸酯，N-乙烯基吡咯烷酮和少量二甲基丙烯酸酯或二丙烯酸酯的单体混合物在低温（-80℃）下暴露于总量为1×105-5×10 6个以-20℃，剂量率为8×10 4 -2×10 6个/小时，并且通过涉及切割，研磨和抛光操作的合适的成型方法将所得聚合物加工成隐形眼镜。

10. 发明授权

US4552633A Fine particulate for use in clinical testing and a process for producing thereof 失效
标题翻译：用于临床测试的细颗粒及其生产方法
公开(公告)号：US4552633A
公开(公告)日：1985-11-12
申请号：US534661
申请日：1983-09-22
申请人： Minoru Kumakura , Isao Kaetsu , Mieko Suzuki , Masakazu Adachi
发明人： Minoru Kumakura , Isao Kaetsu , Mieko Suzuki , Masakazu Adachi
IPC分类号： C08F2/46 , C08F2/54 , C08F16/34 , G01N33/543 , G01N33/545 , C08F2/48
CPC分类号： G01N33/54313 , C08F16/34 , G01N33/545
摘要： A fine particulate carrier for use in clinical testing which has a size of 0.5 to 20 microns and a process for producing thereof are herein disclosed.
摘要翻译：本文公开了一种用于临床测试的细颗粒载体，其尺寸为0.5至20微米及其生产方法。

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