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1. 发明授权

US4418691A Method of promoting the regeneration of tissue at a wound 失效
标题翻译：促进伤口组织再生的方法
公开(公告)号：US4418691A
公开(公告)日：1983-12-06
申请号：US315234
申请日：1981-10-26
申请人： Ioannis V. Yannas , John F. Burke , Dennis P. Orgill , Eugene M. Skrabut
发明人： Ioannis V. Yannas , John F. Burke , Dennis P. Orgill , Eugene M. Skrabut
IPC分类号： A61K35/36 , A61K31/715 , A61K38/00 , A61L15/00 , A61L15/64 , A61L26/00 , A61L27/60 , A61P17/00
CPC分类号： A61L27/60 , Y10S623/915
摘要： This invention comprises the use of centrifugal force to introduce viable cells into a fibrous lattice, as well as fibrous lattices that are seeded with cells by the use of centrifugal force. A variety of fibrous lattices may be seeded by the methods of this invention, such as a highly porous lattice comprising collagen fibers crosslinked with glycosaminoglycan. Before the centrifugation, a piece of intact tissue is harvested from a donor site. It is treated with one or more substances, such as trypsin or collagenase, to dissociate cells from the tissue. The cells are then mixed with an aqueous solution to create an aqueous suspension of cells. A piece of fibrous lattice is placed within a container, referred to herein as a "bucket," that is suitable for rotation by a centrifuge. The aqueous suspension of cells is placed within the bucket, in contact with the lattice. The centrifuge is then rotated. Centrifugal force causes the cells, which are denser than the aqueous solution, to be forced into the lattice in a relatively uniform distribution. By controlling various parameters, cells can be seeded into any desired location within a lattice.
摘要翻译：本发明包括使用离心力将活细胞引入纤维网格，以及通过使用离心力与细胞接种的纤维网格。各种纤维网格可以通过本发明的方法接种，例如包含与糖胺聚糖交联的胶原纤维的高度多孔的网格。在离心之前，从供体部位收获一块完整的组织。用一种或多种物质（例如胰蛋白酶或胶原酶）处理以从组织中分离细胞。然后将细胞与水溶液混合以产生细胞的水悬浮液。将一片纤维格子放置在适合于离心机旋转的容器内，这里称为“桶”。将细胞的水悬浮液置于桶内，与晶格接触。然后旋转离心机。离心力使得比水溶液更致密的细胞以相对均匀的分布被迫进入晶格。通过控制各种参数，可将细胞接种到晶格内的任何所需位置。

2. 发明授权

US5716411A Method of skin regeneration using a collagen-glycosaminoglycan matrix and cultured epithelial autograft 失效
公开(公告)号：US5716411A
公开(公告)日：1998-02-10
申请号：US596060
申请日：1996-02-06
申请人： Dennis P. Orgill , Charles E. Butler , Mark Barlow , Scott Ritterbush , Ioannis V. Yannas , Carolyn C. Compton
发明人： Dennis P. Orgill , Charles E. Butler , Mark Barlow , Scott Ritterbush , Ioannis V. Yannas , Carolyn C. Compton
IPC分类号： A61F2/00 , A61F2/10 , A61L27/24 , A61L27/60
CPC分类号： A61L27/60 , A61L27/24 , A61F2/105 , A61F2310/00365 , Y10S623/915
摘要： The present invention relates to a method of skin regeneration of a wound or burn in an animal or human. This method comprises the steps of initially covering the wound with a collagen glycosaminoglycan matrix, allowing infiltration of the grafted GC matrix by mesenchymal cells and blood vessels from healthy underlying tissue and applying a cultured epithelial autograft sheet grown from epidermal cells taken from the animal or human at a wound free site on the animal's or human's body surface. The resulting graft has excellent take rates and has the appearance, growth, maturation and differentiation of normal skin.

3. 发明授权

US5489304A Method of skin regeneration using a collagen-glycosaminoglycan matrix and cultured epithelial autograft 失效
标题翻译：使用胶原 - 糖胺聚糖基质和培养的上皮自体移植的皮肤再生方法
公开(公告)号：US5489304A
公开(公告)日：1996-02-06
申请号：US229732
申请日：1994-04-19
申请人： Dennis P. Orgill , Charles E. Butler , Mark Barlow , Scott Ritterbush , Ioannis V. Yannas , Carolyn C. Compton
发明人： Dennis P. Orgill , Charles E. Butler , Mark Barlow , Scott Ritterbush , Ioannis V. Yannas , Carolyn C. Compton
IPC分类号： A61F2/00 , A61F2/10 , A61L27/24 , A61L27/60
CPC分类号： A61L27/60 , A61L27/24 , A61F2/105 , A61F2310/00365 , Y10S623/915
摘要： The present invention relates to a method of skin regeneration of a wound or burn in an animal or human. This method comprises the steps of initially covering the wound with a collagen glycosaminoglycan matrix, allowing infiltration of the grafted GC matrix by mesenchymal cells and blood vessels from healthy underlying tissue and applying a cultured epithelial autograft sheet grown from epidermal cells taken from the animal or human at a wound free site on the animal's or human's body surface. The resulting graft has excellent take rates and has the appearance, growth, maturation and differentiation of normal skin.
摘要翻译：本发明涉及动物或人类的伤口或烧伤皮肤再生方法。该方法包括以下步骤：首先用胶原糖胺聚糖基质覆盖伤口，允许移植的GC基质通过来自健康的下面的组织的间充质细胞和血管渗透，并应用从动物或人的表皮细胞生长的培养的上皮自体移植片在动物或人体表面的伤口自由场所。所得移植物具有优良的摄取率，具有正常皮肤的外观，生长，成熟和分化。

4. 发明授权

US4955893A Prosthesis for promotion of nerve regeneration 失效
标题翻译：假体促进神经再生
公开(公告)号：US4955893A
公开(公告)日：1990-09-11
申请号：US327530
申请日：1989-03-23
申请人： Ioannis V. Yannas , Dennis P. Orgill , Howard M. Loree, II , James F. Kirk , Albert S. P. Chang , Borivoje B. Mikic , Christian Krarup , Thorkild V. Norregaard
发明人： Ioannis V. Yannas , Dennis P. Orgill , Howard M. Loree, II , James F. Kirk , Albert S. P. Chang , Borivoje B. Mikic , Christian Krarup , Thorkild V. Norregaard
IPC分类号： A61B17/00 , A61B17/11 , A61F2/00 , A61L27/24
CPC分类号： A61L27/24 , A61B17/1128 , A61B2017/00004 , A61F2310/00365 , A61L2430/32 , Y10S128/08 , Y10S623/92
摘要： A method for producing a biodegradable polymer having a preferentially oriented pore structure and a method for using the polymer to regenerate damaged nerve tissue is disclosed. The preferentially oriented pores are produced by an axial freezing process and serve to promote proper vascularation and regeneration of the damaged nerve. Preferably, the biodegradable polymer comprises uncrosslinked collagen-glycosaminoglycan.
摘要翻译：公开了一种制备具有优先取向的孔结构的可生物降解聚合物的方法和使用该聚合物来再生损伤的神经组织的方法。优先取向的孔通过轴向冷冻过程产生，并用于促进受损神经的适当的血管形成和再生。优选地，可生物降解的聚合物包括未交联的胶原 - 糖胺聚糖。

5. 发明授权

US4522753A Method for preserving porosity in porous materials 失效
标题翻译：保存多孔材料孔隙率的方法
公开(公告)号：US4522753A
公开(公告)日：1985-06-11
申请号：US287930
申请日：1981-07-29
申请人： Ioannis V. Yannas , John F. Burke , Peter J. Stasikelis
发明人： Ioannis V. Yannas , John F. Burke , Peter J. Stasikelis
IPC分类号： A61F2/00 , A61F13/00 , A61L15/42 , A61L17/08 , A61L27/24 , B01J20/28 , C08J9/28 , B29D27/00
CPC分类号： C08J9/28 , A61F13/00008 , A61L15/425 , A61L17/08 , A61L27/24 , A61F2013/00255 , A61F2013/0074 , A61F2013/00863 , A61F2310/00365 , C08J2201/048 , C08J2389/00 , Y10S602/90
摘要： A method for preserving the porosity of porous materials is disclosed. In this method, the porous material is subjected to elevated temperature and vacuum conditions to thereby produce a dimensionally-stable, non-collapsible porous material.
摘要翻译：公开了一种保存多孔材料孔隙率的方法。在该方法中，多孔材料经历升高的温度和真空条件，从而产生尺寸稳定的，不可折叠的多孔材料。

6. 发明授权

US4458678A Cell-seeding procedures involving fibrous lattices 失效
标题翻译：涉及纤维网格的细胞播种程序
公开(公告)号：US4458678A
公开(公告)日：1984-07-10
申请号：US315233
申请日：1981-10-26
申请人： Ioannis V. Yannas , John F. Burke
发明人： Ioannis V. Yannas , John F. Burke
IPC分类号： A61K35/36 , A61F2/00 , A61K31/715 , A61K38/00 , A61L15/00 , A61L15/64 , A61L27/24 , A61L27/60 , A61P17/00 , A61F13/00
CPC分类号： A61L27/60 , A61L27/24 , A61F2310/00365
摘要： This invention relates to the introduction of viable cells into a fibrous lattice by surgical, force-utilizing, or other manipulative techniques, all of which are referred to herein as "seeding." One embodiment comprises an autografting technique which involves intact tissue. Other embodiments which involve the distribution of an aqueous suspension of cells comprise centrifugal, spraying, pipetting and syringe emplacement. Each cell that survives the seeding process may reproduce into a colony of cells which grow until they reach confluence, thereby creating a uniform layer or volume of tissue. By proper placement of cells capable of generating such colonies, the period of recovery of a wound may be drastically reduced. In addition, research by the Applicants indicates that tissue that is regenerated using the methods of this invention to seed a lattice comprising collagen and glycosaminoglycan tends to be smoother, more uniform, less fibrotic, less scarred and more flexible than tissue that is regenerated by wound contraction or conventional autografting.
摘要翻译：本发明涉及通过手术，强力利用或其他操作技术将活细胞引入纤维网格，所有这些在本文中称为“播种”。一个实施例包括涉及完整组织的自动移植技术。涉及细胞水性悬浮液分布的其它实施方案包括离心，喷雾，移液和注射器放置。在接种过程中存活的每个细胞可以再生成细胞的集落，其生长直到它们达到汇合，从而产生均匀的组织或体积的组织。通过适当放置能够产生这种菌落的细胞，伤口的恢复时间可以大大降低。此外，申请人的研究表明，使用本发明的方法再生的组织使含有胶原蛋白和糖胺聚糖的晶格种子的组织趋于比由伤口再生的组织更平滑，更均匀，更少的纤维化，更少的伤痕和更灵活收缩或常规自动移植。

7. 发明授权

US4280954A Crosslinked collagen-mucopolysaccharide composite materials 失效
标题翻译：交联胶原 - 粘多糖复合材料
公开(公告)号：US4280954A
公开(公告)日：1981-07-28
申请号：US30183
申请日：1979-04-16
申请人： Ioannis V. Yannas , Philip L. Gordon , Chor Huang , Frederick H. Silver , John F. Burke
发明人： Ioannis V. Yannas , Philip L. Gordon , Chor Huang , Frederick H. Silver , John F. Burke
IPC分类号： A23J1/10 , A61F2/00 , A61L17/10 , A61L27/24 , A61L27/26 , C08B37/00 , C08H1/00
CPC分类号： C08H1/00 , A23J1/10 , A61L17/10 , A61L27/24 , A61L27/26 , C08B37/0063 , A61F2310/00365
摘要： Composite materials are disclosed which are formed by contacting collagen with a mucopolysaccharide and subsequently covalently crosslinking the resultant polymer. These composite materials have a balance of mechanical, chemical and physiological properties which make them useful in surgical sutures and prostheses of controlled biodegradability (resorption) and controlled ability to prevent development of a foreign body reaction, and many are also useful in applications in which blood compatibility is required.
摘要翻译：公开了通过使胶原与粘多糖接触并随后共价交联所得聚合物而形成的复合材料。这些复合材料具有机械，化学和生理特性的平衡，使得它们可用于可控生物降解性（吸收）的手术缝线和假体以及防止异物反应发展的受控能力，并且许多也可用于血液需要兼容性。

8. 发明授权

US4505266A Method of using a fibrous lattice 失效
标题翻译：使用纤维网格的方法
公开(公告)号：US4505266A
公开(公告)日：1985-03-19
申请号：US601233
申请日：1984-04-17
申请人： Ioannis V. Yannas , John F. Burke
发明人： Ioannis V. Yannas , John F. Burke
IPC分类号： A61F2/00 , A61L27/24 , A61L27/60 , A61B19/00
CPC分类号： A61L27/24 , A61L27/60 , A61F2310/00365 , Y10S623/915
摘要： This invention relates to the introduction of viable cells into a fibrous lattice by surgical, force-utilizing, or other manipulative techniques, all of which are referred to herein as "seeding." One embodiment comprises an autografting technique which involves intact tissue. Other embodiments which involve the distribution of an aqueous suspension of cells comprise centrifugal, spraying, pipetting and syringe emplacement. Each cell that survives the seeding process may reproduce into a colony of cells which grow until they reach confluence, thereby creating a uniform layer or volume of tissue. By proper placement of cells capable of generating such colonies, the period of recovery of a wound may be drastically reduced. In addition, research by the Applicants indicates that tissue that is regenerated using the methods of this invention to seed a lattice comprising collagen and glycosaminoglycan tends to be smoother, more uniform, less fibrotic, less scarred and more flexible than tissue that is regenerated by wound contraction or conventional autografting.
摘要翻译：本发明涉及通过手术，强力利用或其他操作技术将活细胞引入纤维网格，所有这些在本文中称为“播种”。一个实施例包括涉及完整组织的自动移植技术。涉及细胞水性悬浮液分布的其它实施方案包括离心，喷雾，移液和注射器放置。在接种过程中存活的每个细胞可以再生成细胞的集落，其生长直到它们达到汇合，从而产生均匀的组织或体积的组织。通过适当放置能够产生这种菌落的细胞，伤口的恢复时间可以大大降低。此外，申请人的研究表明，使用本发明的方法再生的组织使含有胶原蛋白和糖胺聚糖的晶格种子的组织趋于比由伤口再生的组织更平滑，更均匀，更少的纤维化，更少的伤痕和更灵活收缩或常规自动移植。

9. 发明授权

US4060081A Multilayer membrane useful as synthetic skin 失效
标题翻译：多层膜可用作合成皮肤
公开(公告)号：US4060081A
公开(公告)日：1977-11-29
申请号：US596112
申请日：1975-07-15
申请人： Ioannis V. Yannas , John F. Burke , Philip L. Gordon , Chor Huang
发明人： Ioannis V. Yannas , John F. Burke , Philip L. Gordon , Chor Huang
IPC分类号： B32B9/00 , A61F2/00 , A61F2/02 , A61F2/10 , A61L15/22 , A61L27/00 , A61L27/24 , A61L33/10 , B01D61/00 , B01D71/08 , A61L15/00
CPC分类号： A61L27/24 , A61F2/105 , A61L15/225 , A61L27/60 , A61F2310/00365 , Y10S128/08
摘要： A multilayer membrane, which is useful as synthetic skin, is disclosed herein. A first layer is formed from a material which does not provoke an immune response and which is also insoluble and nondegradable in the presence of body fluids and/or body enzymes. Preferred materials for the first layer are crosslinked composites of collagen and a mucopolysaccharide. A second layer is formed from a nontoxic material which controls the moisture flux of the overall membrane to about 0.1 to 1 mg./cm.sup.2 /hr. Suitable materials for the second layer include synthetic polymers such as silicone resins, polyacrylate or polymethacrylate esters or their copolymers, and polyurethanes.
摘要翻译：本文公开了可用作合成皮肤的多层膜。第一层由不引起免疫应答的材料形成，并且在体液和/或体内酶的存在下也是不溶的和不可降解的。用于第一层的优选材料是胶原和粘多糖的交联复合物。第二层由无毒材料形成，其将整个膜的水分通量控制在约0.1至1mg./cm 2 / hr。用于第二层的合适的材料包括合成聚合物，例如硅树脂，聚丙烯酸酯或聚甲基丙烯酸酯或它们的共聚物，以及聚氨酯。

10. 发明授权

US08318902B2 Biomaterial 有权
标题翻译：生物材料
公开(公告)号：US08318902B2
公开(公告)日：2012-11-27
申请号：US12377221
申请日：2007-08-10
申请人： Andrew Lynn , William Bonfield , Zachary D. Wissner-Gross , Brendan A. Harley , Ioannis V. Yannas , Lorna J. Gibson
发明人： Andrew Lynn , William Bonfield , Zachary D. Wissner-Gross , Brendan A. Harley , Ioannis V. Yannas , Lorna J. Gibson
IPC分类号： A61K38/17
CPC分类号： A61L27/46 , A61L27/48 , A61L27/56 , C08L89/06
摘要： A process for the preparation of a composite biomaterial comprising: providing a first substantially solid component comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and optionally an inorganic material, said component having at least a surface portion that is porous; providing a fluid composition comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and a liquid carrier, and optionally an inorganic material; contacting said fluid composition with said porous surface portion of said first component; cooling said fluid composition to a temperature at which the liquid carrier transforms into a plurality of solid crystals or particles; removing at least some of the plurality of solid crystals or particles by sublimation and/or evaporation.
摘要翻译：一种制备复合生物材料的方法，包括：提供包含胶原，糖胺聚糖，白蛋白，透明质酸，壳聚糖和包含胶原多肽序列的一部分的合成多肽中的一种或多种的第一基本上固体的组分，以及任选的无机所述组分至少具有多孔的表面部分; 提供包含胶原，糖胺聚糖，白蛋白，透明质酸，壳聚糖和包含胶原多肽序列的一部分的合成多肽，液体载体和任选的无机材料中的一种或多种的流体组合物; 使所述流体组合物与所述第一组分的所述多孔表面部分接触; 将所述流体组合物冷却至液体载体转变成多个固体晶体或颗粒的温度; 通过升华和/或蒸发去除多个固体晶体或颗粒中的至少一些。

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