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1. 发明申请

US20090022771A1 BIOMATERIAL 审中-公开
标题翻译：生物材料
公开(公告)号：US20090022771A1
公开(公告)日：2009-01-22
申请号：US11908045
申请日：2006-03-06
申请人： Andrew K. Lynn , William Bonfield , Lorna J. Gibson , Ioannis Yannas , Brendan A. Harley
发明人： Andrew K. Lynn , William Bonfield , Lorna J. Gibson , Ioannis Yannas , Brendan A. Harley
IPC分类号： A61F2/28 , A61K31/726 , A61P19/00 , B29C67/20
CPC分类号： A61L27/46 , A61L27/56 , A61L2430/02
摘要： A process for the preparation of a composite biomaterial comprising an inorganic material and an organic material, the process comprising: (a) providing a first slurry composition comprising a liquid carrier, an inorganic material and an organic material; (b) providing a mould for the slurry; (c) depositing the slurry in the mould; (d) cooling the slurry deposited in the mould to a temperature at which the liquid carrier transforms into a plurality of solid crystals or particles; (e) removing at least some of the plurality of solid crystals or particles by sublimation and/or evaporation to leave a porous composite material comprising an inorganic material and an organic material; and (f) removing the material from the mould.
摘要翻译：一种制备包含无机材料和有机材料的复合生物材料的方法，所述方法包括：（a）提供包含液体载体，无机材料和有机材料的第一浆料组合物; （b）为浆料提供模具; （c）将浆料沉积在模具中; （d）将沉积在模具中的浆料冷却至液体载体转变成多个固体晶体或颗粒的温度; （e）通过升华和/或蒸发除去多个固体晶体或颗粒中的至少一些，以留下包含无机材料和有机材料的多孔复合材料; 和（f）从模具中取出材料。

2. 发明申请

US20120294925A1 BIOMATERIAL 审中-公开
标题翻译：生物材料
公开(公告)号：US20120294925A1
公开(公告)日：2012-11-22
申请号：US13482640
申请日：2012-05-29
申请人： Andrew K. Lynn , William Bonfield , Lorna J. Gibson , Ioannis Yannas , Brendan A. Harley
发明人： Andrew K. Lynn , William Bonfield , Lorna J. Gibson , Ioannis Yannas , Brendan A. Harley
IPC分类号： A61F2/28 , A61P19/00 , C08J9/26 , A61K38/39
CPC分类号： A61L27/46 , A61L27/56 , A61L2430/02
摘要： A process for the preparation of a composite biomaterial comprising an inorganic material and an organic material, the process comprising: (a) providing a first slurry composition comprising a liquid carrier, an inorganic material and an organic material; (b) providing a mould for the slurry; (c) depositing the slurry in the mould; (d) cooling the slurry deposited in the mould to a temperature at which the liquid carrier transforms into a plurality of solid crystals or particles; (e) removing at least some of the plurality of solid crystals or particles by sublimation and/or evaporation to leave a porous composite material comprising an inorganic material and an organic material; and (f) removing the material from the mould.
摘要翻译：一种制备包含无机材料和有机材料的复合生物材料的方法，所述方法包括：（a）提供包含液体载体，无机材料和有机材料的第一浆料组合物; （b）为浆料提供模具; （c）将浆料沉积在模具中; （d）将沉积在模具中的浆料冷却至液体载体转变成多个固体晶体或颗粒的温度; （e）通过升华和/或蒸发除去多个固体晶体或颗粒中的至少一些，以留下包含无机材料和有机材料的多孔复合材料; 和（f）从模具中取出材料。

3. 发明授权

US10736992B2 Biomolecular patterning of three dimensional tissue scaffolds 有权
公开(公告)号：US10736992B2
公开(公告)日：2020-08-11
申请号：US14001327
申请日：2012-02-27
申请人： Ryan C. Bailey , Brendan A. Harley , Teresa A. Martin , Steven R. Caliari
发明人： Ryan C. Bailey , Brendan A. Harley , Teresa A. Martin , Steven R. Caliari
IPC分类号： A61L27/38 , A61K35/12 , A61L27/50 , A61L27/56 , A61K35/32 , A61L27/54 , A61L27/26 , A61L27/48 , C08B37/00 , C12N5/00 , C12N5/077 , A61K38/18 , A61K38/30
摘要： The invention provides methods and compositions for making and using collagen-glycosaminoglycan three-dimensional scaffolds immobilized with biomolecules that are spatially and temporally patterned. The method comprises adding benzophenone to a collagen-glycosaminoglycan three dimensional scaffold in the dark; adding one or more biomolecules to one or more areas of the collagen-glycosaminoglycan three-dimensional scaffold (which can be done optionally in the dark or in the light); and exposing the collagen-2glycosaminoglycan three-dimensional scaffold to light at a wavelength of about 350 to about 365 nm.

4. 发明申请

US20190192735A1 Biomolecular Patterning of Three Dimensional Tissue Scaffolds 审中-公开
公开(公告)号：US20190192735A1
公开(公告)日：2019-06-27
申请号：US14001327
申请日：2012-02-27
申请人： Ryan C. Bailey , Brendan A. Harley , Teresa A. Martin , Steven R. Caliari
发明人： Ryan C. Bailey , Brendan A. Harley , Teresa A. Martin , Steven R. Caliari
IPC分类号： A61L27/38 , C12N5/00 , C08B37/00 , C12N5/077
CPC分类号： A61L27/38 , A61K35/12 , A61K35/32 , A61K38/1858 , A61K38/30 , A61L27/26 , A61L27/48 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2430/02 , A61L2430/06 , A61L2430/20 , A61L2430/28 , A61L2430/30 , A61L2430/32 , A61L2430/40 , C08B37/0063 , C12N5/0062 , C12N5/0654 , C12N5/0655 , C12N5/0657 , C12N5/0658 , C12N2533/54 , C08L89/06
摘要： The invention provides methods and compositions for making and using collagen-glycosaminoglycan three-dimensional scaffolds immobilized with biomolecules that are spatially and temporally patterned. The method comprises adding benzophenone to a collagen-glycosaminoglycan three dimensional scaffold in the dark; adding one or more biomolecules to one or more areas of the collagen-glycosaminoglycan three-dimensional scaffold (which can be done optionally in the dark or in the light); and exposing the collagen-2glycosaminoglycan three-dimensional scaffold to light at a wavelength of about 350 to about 365 nm.

5. 发明申请

US20100248368A1 BIOMATERIAL 有权
标题翻译：生物材料
公开(公告)号：US20100248368A1
公开(公告)日：2010-09-30
申请号：US12377221
申请日：2007-08-10
申请人： Andrew Lynn , William Bonfield , Zachary D. Wissner-Gross , Brendan A. Harley , Ioannis V. Yannas , Lorna J. Gibson
发明人： Andrew Lynn , William Bonfield , Zachary D. Wissner-Gross , Brendan A. Harley , Ioannis V. Yannas , Lorna J. Gibson
IPC分类号： C12N5/071
CPC分类号： A61L27/46 , A61L27/48 , A61L27/56 , C08L89/06
摘要： A process for the preparation of a composite biomaterial comprising: providing a first substantially solid component comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and optionally an inorganic material, said component having at least a surface portion that is porous; providing a fluid composition comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and a liquid carrier, and optionally an inorganic material; contacting said fluid composition with said porous surface portion of said first component; cooling said fluid composition to a temperature at which the liquid carrier transforms into a plurality of solid crystals or particles; removing at least some of the plurality of solid crystals or particles by sublimation and/or evaporation.
摘要翻译：一种制备复合生物材料的方法，包括：提供包含胶原，糖胺聚糖，白蛋白，透明质酸，壳聚糖和包含胶原多肽序列的一部分的合成多肽中的一种或多种的第一基本上固体的组分，以及任选的无机所述组分至少具有多孔的表面部分; 提供包含胶原，糖胺聚糖，白蛋白，透明质酸，壳聚糖和包含胶原多肽序列的一部分的合成多肽，液体载体和任选的无机材料中的一种或多种的流体组合物; 使所述流体组合物与所述第一组分的所述多孔表面部分接触; 将所述流体组合物冷却至液体载体转变成多个固体晶体或颗粒的温度; 通过升华和/或蒸发去除多个固体晶体或颗粒中的至少一些。

6. 发明申请

US20100166830A1 Bioactive Scaffold for Therapeutic and Adhesion Prevention Applications 有权
标题翻译：生物活性支架用于治疗和粘附防止应用
公开(公告)号：US20100166830A1
公开(公告)日：2010-07-01
申请号：US12725656
申请日：2010-03-17
申请人： Brendan A. Harley , Eric C. Soller , Eric Aiazian
发明人： Brendan A. Harley , Eric C. Soller , Eric Aiazian
IPC分类号： A61F2/00
CPC分类号： A61K9/0024 , A61L31/129 , A61L31/146 , C08L89/06
摘要： A device for inhibiting adhesion of apposing human body tissue layers includes a scaffold having a designated mean pore size, relative density, and degradation half-life. The scaffold may be operably positioned between apposing tissue layers, such as proximate adhesiogenic layers at a wound site, so as to permit remesothelialization of the tissue without formation of fibrous adhesions. The scaffold device of the invention inhibits adhesion formation by promoting contractile cell migration away from the wound site for a predetermined period of time. The invention further relates to device and methods for promoting internal tissue regeneration, and for provision and/or dispensation of therapeutic and/or diagnostic agents in vivo.
摘要翻译：用于抑制人体组织层粘附的装置包括具有指定平均孔径，相对密度和降解半衰期的支架。支架可以可操作地定位在装配组织层之间，例如在伤口部位处的邻近的粘附生成层，以便允许组织的再附着，而不形成纤维粘连。本发明的支架装置通过促进收缩细胞迁移远离伤口部位预定的时间来抑制粘附形成。本发明还涉及用于促进内部组织再生以及用于在体内提供和/或分配治疗和/或诊断剂的装置和方法。

7. 发明申请

US20210052771A1 NANOPARTICULATE MINERALIZED COLLAGEN GLYCOSAMINOGLYCAN SCAFFOLD WITH AN ANTI-RESORPTION FACTOR 有权
公开(公告)号：US20210052771A1
公开(公告)日：2021-02-25
申请号：US17045470
申请日：2019-02-05
申请人： Brendan A. Harley , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Brendan A. Harley , Justine C. Lee , Timothy A. Miller , Xiaoyan Ren
IPC分类号： A61L27/24 , A61K35/28 , A61K35/32 , A61K35/761 , A61L27/38 , A61L27/54 , C12N5/00
摘要： Compositions including a collagen glycosaminoglycan scaffold and osteoprotegerin are described. The compositions are useful in methods for promoting osteogenesis and attenuating bone resorption.

8. 发明授权

US08431146B2 Scaffold comprising co-precipitated Collgen and glycosaminoglycan for inhibiting adhesion of body tissue layers 有权
标题翻译：支架包括共沉淀的Collgen和糖胺聚糖，用于抑制身体组织层的粘附
公开(公告)号：US08431146B2
公开(公告)日：2013-04-30
申请号：US12725656
申请日：2010-03-17
申请人： Brendan A. Harley , Eric C. Soller , Eric Aiazian
发明人： Brendan A. Harley , Eric C. Soller , Eric Aiazian
IPC分类号： A61F2/00 , A61K38/43 , C12N11/02
CPC分类号： A61K9/0024 , A61L31/129 , A61L31/146 , C08L89/06
摘要： A device for inhibiting adhesion of apposing human body tissue layers includes a scaffold having a designated mean pore size, relative density, and degradation half-life. The scaffold may be operably positioned between apposing tissue layers, such as proximate adhesiogenic layers at a wound site, so as to permit remesothelialization of the tissue without formation of fibrous adhesions. The scaffold device of the invention inhibits adhesion formation by promoting contractile cell migration away from the wound site for a predetermined period of time. The invention further relates to device and methods for promoting internal tissue regeneration, and for provision and/or dispensation of therapeutic and/or diagnostic agents in vivo.
摘要翻译：用于抑制人体组织层粘附的装置包括具有指定平均孔径，相对密度和降解半衰期的支架。支架可以可操作地定位在装配组织层之间，例如在伤口部位处的邻近的粘附生成层，以便允许组织的再附着，而不形成纤维粘连。本发明的支架装置通过促进收缩细胞迁移远离伤口部位预定的时间来抑制粘附形成。本发明还涉及用于促进内部组织再生以及用于在体内提供和/或分配治疗和/或诊断剂的装置和方法。

9. 发明授权

US08318902B2 Biomaterial 有权
标题翻译：生物材料
公开(公告)号：US08318902B2
公开(公告)日：2012-11-27
申请号：US12377221
申请日：2007-08-10
申请人： Andrew Lynn , William Bonfield , Zachary D. Wissner-Gross , Brendan A. Harley , Ioannis V. Yannas , Lorna J. Gibson
发明人： Andrew Lynn , William Bonfield , Zachary D. Wissner-Gross , Brendan A. Harley , Ioannis V. Yannas , Lorna J. Gibson
IPC分类号： A61K38/17
CPC分类号： A61L27/46 , A61L27/48 , A61L27/56 , C08L89/06
摘要： A process for the preparation of a composite biomaterial comprising: providing a first substantially solid component comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and optionally an inorganic material, said component having at least a surface portion that is porous; providing a fluid composition comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and a liquid carrier, and optionally an inorganic material; contacting said fluid composition with said porous surface portion of said first component; cooling said fluid composition to a temperature at which the liquid carrier transforms into a plurality of solid crystals or particles; removing at least some of the plurality of solid crystals or particles by sublimation and/or evaporation.
摘要翻译：一种制备复合生物材料的方法，包括：提供包含胶原，糖胺聚糖，白蛋白，透明质酸，壳聚糖和包含胶原多肽序列的一部分的合成多肽中的一种或多种的第一基本上固体的组分，以及任选的无机所述组分至少具有多孔的表面部分; 提供包含胶原，糖胺聚糖，白蛋白，透明质酸，壳聚糖和包含胶原多肽序列的一部分的合成多肽，液体载体和任选的无机材料中的一种或多种的流体组合物; 使所述流体组合物与所述第一组分的所述多孔表面部分接触; 将所述流体组合物冷却至液体载体转变成多个固体晶体或颗粒的温度; 通过升华和/或蒸发去除多个固体晶体或颗粒中的至少一些。

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