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1. 发明授权

US08318491B2 Method of differentiating hematopoietic stem cells into natural killer cells using YC-1 or IL-21 有权
标题翻译：使用YC-1或IL-21将造血干细胞分化成自然杀伤细胞的方法
公开(公告)号：US08318491B2
公开(公告)日：2012-11-27
申请号：US12671814
申请日：2007-10-02
申请人： Inpyo Choi , SukRan Yoon , Sohyun Yun , Jin Woong Chung
发明人： Inpyo Choi , SukRan Yoon , Sohyun Yun , Jin Woong Chung
IPC分类号： C07K5/02 , C12N5/02 , C07D209/04
CPC分类号： A61K31/416
摘要： The present invention relates to an agent for differentiating hematopoietic stem cells into natural killer cells and a method for the differentiation, more precisely an agent for differentiating hematopoietic stem cells into natural killer cells comprising YC-I [3-(5′-hydroxymethyl-2′-furyl)-1-benzylindazole] or IL-21 (Interleukin-21) as an active ingredient and a method for differentiating hematopoietic stem cells into natural killer cells using the same. The YC-I and IL-21 regulate the differentiation of hematopoietic stem cells into natural killer cells and increase the killing activity of NK cells. Therefore, the agent for NK cell differentiation of the present invention can be effectively used for cell therapy for the treatment of cancer by regulating the differentiation of hematopoietic stem cells into natural killer cells having tumor cell killing activity.
摘要翻译：本发明涉及用于将造血干细胞分化为天然杀伤细胞的试剂和分化方法，更准确地说，用于将造血干细胞分化成包含YC-1 [3-（5'-羟甲基-2 糠基）-1-苄基吲唑]或IL-21（白细胞介素-21）作为活性成分，以及使用其将造血干细胞分化为天然杀伤细胞的方法。 YC-1和IL-21调节造血干细胞分化为自然杀伤细胞，增加NK细胞的杀伤活性。因此，通过调节造血干细胞分化为具有肿瘤细胞杀伤活性的天然杀伤细胞，本发明的NK细胞分化剂可以有效地用于治疗癌症的细胞治疗。

2. 发明申请

US20110033415A1 AGENT FOR DIFFERENTIATING HEMATOPOIETIC STEM CELL INTO NATURAL KILLER CELL COMPRISING YC-1 OR IL-2 1 AND A METHOD OF DIFFERENTIATING HEMATOPOIETIC STEM CELL INTO NATURAL KILLER CELL USING THE SAME 有权
标题翻译：将HEMATOPOIETIC干细胞分化成包含YC-1或IL-2的自然杀伤细胞的药剂和将HEMATOPOIETIC干细胞分化为使用其的天然杀伤细胞的方法
公开(公告)号：US20110033415A1
公开(公告)日：2011-02-10
申请号：US12671814
申请日：2007-10-02
申请人： Inpyo Choi , SukRan Yoon , Sohyun Yun , Jin Woong Chung
发明人： Inpyo Choi , SukRan Yoon , Sohyun Yun , Jin Woong Chung
IPC分类号： A61K38/20 , C12N5/0783 , A61K35/12 , A61P35/00
CPC分类号： A61K31/416
摘要： The present invention relates to an agent for differentiating hematopoietic stem cells into natural killer cells and a method for the differentiation, more precisely an agent for differentiating hematopoietic stem cells into natural killer cells comprising YC-I [3-(5′-hydroxymethyl-2′-furyl)-1-benzylindazole] or IL-21 (Interleukin-21) as an active ingredient and a method for differentiating hematopoietic stem cells into natural killer cells using the same. The YC-I and IL-21 regulate the differentiation of hematopoietic stem cells into natural killer cells and increase the killing activity of NK cells. Therefore, the agent for NK cell differentiation of the present invention can be effectively used for cell therapy for the treatment of cancer by regulating the differentiation of hematopoietic stem cells into natural killer cells having tumor cell killing activity.
摘要翻译：本发明涉及用于将造血干细胞分化为天然杀伤细胞的试剂和分化方法，更准确地说，用于将造血干细胞分化成包含YC-1 [3-（5'-羟甲基-2 糠基）-1-苄基吲唑]或IL-21（白细胞介素-21）作为活性成分，以及使用其将造血干细胞分化为天然杀伤细胞的方法。 YC-1和IL-21调节造血干细胞分化为自然杀伤细胞，增加NK细胞的杀伤活性。因此，通过调节造血干细胞分化为具有肿瘤细胞杀伤活性的天然杀伤细胞，本发明的NK细胞分化剂可以有效地用于治疗癌症的细胞治疗。

3. 发明申请

US20110305680A1 Composition Containing Osteopontin for Differentiating Natural Killer Cell as an Active Ingredient and a Method of Differentiation Using Thereof 审中-公开
标题翻译：含有骨桥蛋白的组合物，用于将天然杀伤细胞分化为活性成分和使用它们的分化方法
公开(公告)号：US20110305680A1
公开(公告)日：2011-12-15
申请号：US12995020
申请日：2008-11-10
申请人： Inpyo Choi , Jin Woong Chung , Misun Kim , Suk Ran Yoon
发明人： Inpyo Choi , Jin Woong Chung , Misun Kim , Suk Ran Yoon
IPC分类号： A61K35/12 , A61P35/00 , C12N5/0783
CPC分类号： A61K38/19 , A61K35/17 , C12N5/0646 , C12N2501/998
摘要： The present invention relates to a composition for differentiating natural killer cells comprising osteopontin (OPN) as an active ingredient and a method for differentiation using the same. More precisely, osteopontin of the present invention accelerates differentiation of natural killer cells from hematopoietic stem cells and increases cytotoxic activity of natural killer cells, so that it can be effectively used as a composition for differentiating natural killer cells. OPN of the present invention regulates differentiation of natural killer cells capable of killing cancer cells, so that it can be effectively used for the treatment of cancer.
摘要翻译：本发明涉及用于分化包含骨桥蛋白（OPN）作为活性成分的天然杀伤细胞的组合物和使用其的分化方法。更准确地说，本发明的骨桥蛋白加速了造血干细胞中天然杀伤细胞的分化，并增加了天然杀伤细胞的细胞毒活性，因此可有效地用作分化天然杀伤细胞的组合物。本发明的OPN调节能够杀死癌细胞的天然杀伤细胞的分化，从而可以有效地用于治疗癌症。

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