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1. 发明授权

US6162437A Method for inhibiting interleukin-6 production by administering extracts from root of Stephania tetrandra 失效
标题翻译：通过施用来自Stephania tetrandra的根的提取物来抑制白细胞介素-6产生的方法
公开(公告)号：US6162437A
公开(公告)日：2000-12-19
申请号：US978321
申请日：1997-11-25
申请人： Kwang-Ho Pyun , Inpyo Choi , Hyung-Sik Kang , Jung-Joon Lee , Young-Ho Kim
发明人： Kwang-Ho Pyun , Inpyo Choi , Hyung-Sik Kang , Jung-Joon Lee , Young-Ho Kim
IPC分类号： A61K36/59 , A61K35/78
CPC分类号： A61K36/59
摘要： Method for inhibiting the production of interleukin-6 (hereinafter, referred to as "IL-6") in human body, which comprises administering extracts from a root of Stephania tetrandra S. Moore; and method for treating a patient of an immune disease caused by an overproduction of interleukin-6 by inhibiting the production of interleukin-6, which comprises administering extracts from a root of Stephania tetrandra S. Moore to the patient.
摘要翻译：抑制人体中白细胞介素-6（以下称为“IL-6”）的产生的方法，其包括施用来自Stephania tetrandra S.Moore的根的提取物; 以及通过抑制白细胞介素-6的产生来治疗由白细胞介素-6过量产生引起的免疫疾病的患者的方法，其包括向患者施用来自Stephania tetrandra S.Moore的根的提取物。

2. 发明申请

US20090042188A1 Agent for Differentiating Hematopoietic Stem Cell Into Natural Killer Cell Comprising Vdup1 Protein or Gene Encoding the Same, and a Method of Differentiating Hematopoietic Stem Cell Into Natural Killer Cell Using Thereof 审中-公开
标题翻译：将造血干细胞分化成包含Vdup1蛋白或编码其的基因的天然杀伤细胞的代理，以及将造血干细胞分化成自然杀伤细胞的方法
公开(公告)号：US20090042188A1
公开(公告)日：2009-02-12
申请号：US11916199
申请日：2005-06-08
申请人： Inpyo Choi , SukRan Yoon , KeeNyung Lee , SunWook Kim , DaeYul Yoo
发明人： Inpyo Choi , SukRan Yoon , KeeNyung Lee , SunWook Kim , DaeYul Yoo
IPC分类号： C12Q1/68 , C07K14/47 , C07H21/04 , C12N15/63 , C12Q1/02 , C12N15/87 , C12N5/06 , A01K67/027
CPC分类号： C12N5/0646 , C07K14/4703 , C12N2501/998
摘要： The present invention is related to an agent for differentiating hematopoietic stem cell into natural killer cell comprising VDUP1 protein or gene encoding the same, and a method of differentiating hematopoietic stem cell into natural killer cell using thereof. The present invention reveals for the first time that the VDUP1 gene is a critical factor for the regulation of differentiation of natural killer cell by generating a mouse deficient in VDUP1 gene, which confirms that VDUP1 gene is required for NK maturation. Thus, through the regulation of VDUP1 gene, the modulation of NK cells that have ability to kill cancer cells is possible and can be utilized for cell therapeutics.
摘要翻译：本发明涉及用于将造血干细胞分化成包含VDUP1蛋白或编码其的基因的天然杀伤细胞的试剂，以及使用其将造血干细胞分化为天然杀伤细胞的方法。本发明首次揭示了VDUP1基因是通过产生VDUP1基因缺陷小鼠来调节天然杀伤细胞分化的关键因素，证实了VDUP1基因是NK成熟所必需的。因此，通过调节VDUP1基因，能够杀死癌细胞的NK细胞的调节是可能的并且可以用于细胞治疗。

3. 发明申请

US20070042344A1 Differentiation regulating agent containing gene which regulating differentiation from stem cells into natural killer cells as effective ingredient 审中-公开
标题翻译：分化调节剂含有调节干细胞分化为天然杀伤细胞作为有效成分的基因
公开(公告)号：US20070042344A1
公开(公告)日：2007-02-22
申请号：US10597305
申请日：2005-01-20
申请人： Inpyo Choi , Hyung-Sik Kang , Suk-Ran Yoon , Eun-Mi Kim
发明人： Inpyo Choi , Hyung-Sik Kang , Suk-Ran Yoon , Eun-Mi Kim
IPC分类号： C12Q1/00 , C12Q1/68 , C12N5/08
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4702 , C12N5/0646 , C12Q1/6886 , C12Q2600/158
摘要： The present invention relates to a cell differentiation regulating agent containing a gene regulating differentiation from stem cells into natural killer cells as an effective ingredient, more precisely, a cell differentiation regulating agent containing a gene regulating differentiation from stem cells into premature natural killer cells as an effective ingredient and a screening method of the gene by taking advantage of SAGE. The gene of the present invention is a novel one that is confirmed not to be like any other known genes regulating differentiation from stem cells into natural killer cells. Though, the gene can be easily screened by SAGE and a natural killer cell differentiation-regulating agent containing the gene as an effective ingredient can be effectively used as an anticancer agent.
摘要翻译：本发明涉及含有调节从干细胞分化为天然杀伤细胞作为有效成分的基因的细胞分化调节剂，更确切地说，涉及含有调节从干细胞分化为过早天然杀伤细胞的基因的细胞分化调节剂有效成分和利用SAGE的基因筛选方法。本发明的基因是一种新的，被证明不像调节从干细胞分化为天然杀伤细胞的任何其它已知的基因。虽然该基因可以容易地被SAGE筛选，并且含有该基因作为有效成分的天然杀伤细胞分化调节剂可以有效地用作抗癌剂。

4. 发明授权

US5900434A Method for inhibiting the production of interleukin-1 or tumor necrosis factor-.alpha. by administering acanthoic acid 失效
标题翻译：通过施用棘皮质酸抑制白细胞介素1或肿瘤坏死因子-α的产生的方法
公开(公告)号：US5900434A
公开(公告)日：1999-05-04
申请号：US750459
申请日：1996-12-06
申请人： Kwang-Ho Pyun , Inpyo Choi , Hyung-Sik Kang , Jung-Joon Lee , Young-Ho Kim
发明人： Kwang-Ho Pyun , Inpyo Choi , Hyung-Sik Kang , Jung-Joon Lee , Young-Ho Kim
IPC分类号： A61K31/19 , A61K36/00 , A61K36/25 , A61P1/16 , A61P11/00 , A61P29/00 , A61P37/00 , A61P43/00 , C07C51/42 , C07C61/35 , C07C63/44 , A61K35/78
CPC分类号： C07C61/35 , A61K31/19 , Y10S514/826 , Y10S514/838 , Y10S514/885
摘要： Process for the preparation of (-)-pimara-9(11),15-diene-19-oic acid(acanthoic acid) and pharmaceutical compositions comprising acanthoic acid useful for the treatment of diseases caused by an excessive production of interleukin-1 or tumor necrosis factor-.alpha..
摘要翻译： PCT No.PCT / KR95 / 00074 Sec。 371日期1996年12月6日第 102（e）日期1996年12月6日PCT归档1995年6月7日PCT公布。 WO95 / 34300 PCT出版物日期1995年12月21日制备（ - ） - 匹马拉-9（11），15-二烯-19-酸（棘桃酸）的方法和包含可用于治疗由过量生产引起的疾病的棘酸的药物组合物的白介素-1或肿瘤坏死因子-α。

5. 发明授权

US08318491B2 Method of differentiating hematopoietic stem cells into natural killer cells using YC-1 or IL-21 有权
标题翻译：使用YC-1或IL-21将造血干细胞分化成自然杀伤细胞的方法
公开(公告)号：US08318491B2
公开(公告)日：2012-11-27
申请号：US12671814
申请日：2007-10-02
申请人： Inpyo Choi , SukRan Yoon , Sohyun Yun , Jin Woong Chung
发明人： Inpyo Choi , SukRan Yoon , Sohyun Yun , Jin Woong Chung
IPC分类号： C07K5/02 , C12N5/02 , C07D209/04
CPC分类号： A61K31/416
摘要： The present invention relates to an agent for differentiating hematopoietic stem cells into natural killer cells and a method for the differentiation, more precisely an agent for differentiating hematopoietic stem cells into natural killer cells comprising YC-I [3-(5′-hydroxymethyl-2′-furyl)-1-benzylindazole] or IL-21 (Interleukin-21) as an active ingredient and a method for differentiating hematopoietic stem cells into natural killer cells using the same. The YC-I and IL-21 regulate the differentiation of hematopoietic stem cells into natural killer cells and increase the killing activity of NK cells. Therefore, the agent for NK cell differentiation of the present invention can be effectively used for cell therapy for the treatment of cancer by regulating the differentiation of hematopoietic stem cells into natural killer cells having tumor cell killing activity.
摘要翻译：本发明涉及用于将造血干细胞分化为天然杀伤细胞的试剂和分化方法，更准确地说，用于将造血干细胞分化成包含YC-1 [3-（5'-羟甲基-2 糠基）-1-苄基吲唑]或IL-21（白细胞介素-21）作为活性成分，以及使用其将造血干细胞分化为天然杀伤细胞的方法。 YC-1和IL-21调节造血干细胞分化为自然杀伤细胞，增加NK细胞的杀伤活性。因此，通过调节造血干细胞分化为具有肿瘤细胞杀伤活性的天然杀伤细胞，本发明的NK细胞分化剂可以有效地用于治疗癌症的细胞治疗。

6. 发明申请

US20120282646A1 METHOD FOR ACTIVATING A NATURAL KILLER CELL BY ADJUSTING THE EXPRESSION OF THE SOCS2 GENE 审中-公开
标题翻译：通过调节SOCS2基因的表达来激活自然杀伤细胞的方法
公开(公告)号：US20120282646A1
公开(公告)日：2012-11-08
申请号：US13504109
申请日：2010-08-30
申请人： Inpyo Choi , Suk Hyung Lee , Suk-Ran Yoon
发明人： Inpyo Choi , Suk Hyung Lee , Suk-Ran Yoon
IPC分类号： C12N5/0783 , C12Q1/02 , C12N15/85
CPC分类号： A61K35/17 , C12N5/0646 , C12N2501/998 , C12N2510/00
摘要： The present invention relates to a method for activating natural killer cells (NK cells), and more particularly, to a method for enhancing the cytotoxicity of natural killer cells by inducing the overexpression of suppressor of cytokine signaling 2 (SOCS2) which is a protein involved in cell-signaling pathways in natural killer cells. The inventors of the present invention observed that when natural killer cells were treated with IL-15, a cytokine involved in natural killer cell differentiation, the expression of SOCS2 increased and the expression of proline-rich tyrosine kinase 2 (Pyk2) was inhibited by the SOCS2, the expression of which increased. In addition, when Pyk2 was overexpressed, the ability to produce IFN-γ and the ability to kill tumor cells of natural killer cells decreased. Therefore, SOCS2 can be used for activating natural killer cells and the natural killer cells activated by the method can be used for the prevention or treatment of cancer.
摘要翻译：本发明涉及一种用于激活天然杀伤细胞（NK细胞）的方法，更具体地说，涉及通过诱导涉及蛋白质的细胞因子信号传导抑制剂（SOCS2）的过表达来提高天然杀伤细胞的细胞毒性的方法在自然杀伤细胞的细胞信号通路中。本发明的发明人观察到，当用IL-15（参与自然杀伤细胞分化的细胞因子）处理天然杀伤细胞时，SOCS2的表达增加，富含脯氨酸的酪氨酸激酶2（Pyk2）的表达受到抑制 SOCS2，其表达增加。此外，当Pyk2过表达时，产生IFN-γ的能力和杀死自然杀伤细胞的肿瘤细胞的能力下降。因此，SOCS2可用于激活自然杀伤细胞，并且通过该方法活化的天然杀伤细胞可用于预防或治疗癌症。

7. 发明申请

US20120121544A1 Method for Efficiently Proliferating and Differentiating Natural Killer Cells from Umbilical Cord Blood 审中-公开
标题翻译：有效增殖和分化天然杀伤细胞与脐带血的方法
公开(公告)号：US20120121544A1
公开(公告)日：2012-05-17
申请号：US13125643
申请日：2009-09-28
申请人： Inpyo Choi , Suk-Ran Yoon , Soo Yun Lee , Joo-Yong Lee , Jaeseung Lim
发明人： Inpyo Choi , Suk-Ran Yoon , Soo Yun Lee , Joo-Yong Lee , Jaeseung Lim
IPC分类号： A61K35/12 , A61P35/00 , C12N5/02
CPC分类号： C12N5/0646 , C12N2501/2302 , C12N2501/2315 , C12N2501/2321
摘要： The present invention relates to a method for efficiently proliferating and differentiating natural killer cells (NK cells) from umbilical cord blood, more precisely a method for efficiently proliferating and differentiating natural killer cells from umbilical cord blood comprising the following steps: 1) preparing CD3 negative cells by eliminating CD3 positive T-cells from umbilical cord blood derived mononuclear cells; and 2) culturing the CD3 negative cells after treating various cytokines thereto. The present invention is advantageous in obtaining high purity NK cells in a short period of time by inducing NK cells from CD3 negative cells, compared with the conventional method inducing NK cells from haematopoietic stem cells, and in promoting NK cell proliferation and differentiation by treating different cytokines together, for example by the co-treatment of IL-15 and IL-21. That is, the method of the present invention can induce NK cells with increased anti-cancer cytotoxicity, so that it can be effectively used for anti-cancer cell therapy.
摘要翻译：本发明涉及一种有效增殖和分化脐带血自然杀伤细胞（NK细胞）的方法，更确切地说，一种有效增殖和分化脐带血自然杀伤细胞的方法，包括以下步骤：1）制备CD3阴性通过从脐带血衍生的单核细胞中消除CD3阳性T细胞的细胞; 和2）在处理各种细胞因子后培养CD3阴性细胞。本发明与从造血干细胞诱导NK细胞的常规方法相比，通过诱导CD3阴性细胞的NK细胞在短时间内获得高纯度NK细胞是有利的，并且通过治疗不同的方法促进NK细胞增殖和分化细胞因子在一起，例如通过共同治疗IL-15和IL-21。也就是说，本发明的方法可以诱导具有增加的抗癌细胞毒性的NK细胞，从而可以有效地用于抗癌细胞治疗。

8. 发明授权

US09375456B2 Antiviral composition containing an Aleurites fordii or Daphne kiusiana extract or a fraction thereof as an active ingredient 有权
$Antiviral composition containing an Aleurites fordii or Daphne kiusiana extract or a fraction thereof as an active ingredient$
标题翻译：含有Aleutites fordii或Daphne kiusiana提取物或其一部分作为活性成分的抗病毒组合物
公开(公告)号：US09375456B2
公开(公告)日：2016-06-28
申请号：US13505727
申请日：2010-11-03
申请人： Sei-Ryang Oh , Jae Wha Kim , Hyeong-Kyu Lee , Kyung Seop Ahn , Doo Young Kim , Jung Hee Kim , Jae Sung Song , Ho-Bum Kang , Inpyo Choi
发明人： Sei-Ryang Oh , Jae Wha Kim , Hyeong-Kyu Lee , Kyung Seop Ahn , Doo Young Kim , Jung Hee Kim , Jae Sung Song , Ho-Bum Kang , Inpyo Choi
IPC分类号： A61K36/47 , A61K36/83
CPC分类号： A61K36/47 , A61K36/83
摘要： The present invention relates to an antiviral composition containing an Aleurites fordii or Daphne kiusiana extract or a fraction thereof as an active ingredient. In detail, extracts of Aleurites fordii or Daphne kiusiana or fractions thereof can induce the secretion of an immune-related cytokine, interferon-γ (IFN-γ) in natural killer (NK) cells, and thus exhibit potent antiviral activity and superior effects for viral diseases, and therefore can be effectively used in an antiviral composition.
摘要翻译：本发明涉及含有Aleutites fordii或Daphne kiusiana提取物或其一部分作为活性成分的抗病毒组合物。详细地说，di of i，，，，，，，can can can can for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for 病毒性疾病，因此可以有效地用于抗病毒组合物。

9. 发明申请

US20120308676A1 ANTIVIRAL COMPOSITION CONTAINING AN ALEURITES FORDII OR DAPHNE KIUSIANA EXTRACT OR A FRACTION THEREOF AS AN ACTIVE INGREDIENT 有权
标题翻译：含有ALEURITES FORDII或DAPHNE KIUSIANA提取物或其作为活性成分的分解物的防腐组合物
公开(公告)号：US20120308676A1
公开(公告)日：2012-12-06
申请号：US13505727
申请日：2010-11-03
申请人： Sei-Ryang Oh , Jae Wha Kim , Hyeong-Kyu Lee , Kyung Seop Ahn , Doo Young Kim , Jung Hee Kim , Jae Sung Song , Ho-Bum Kang , Inpyo Choi
发明人： Sei-Ryang Oh , Jae Wha Kim , Hyeong-Kyu Lee , Kyung Seop Ahn , Doo Young Kim , Jung Hee Kim , Jae Sung Song , Ho-Bum Kang , Inpyo Choi
IPC分类号： A61K36/47 , A61P31/16 , A61K36/83 , A61P31/18 , A61P31/14 , A61P31/20 , A61P31/12 , A61P31/22
CPC分类号： A61K36/47 , A61K36/83
摘要： The present invention relates to an antiviral composition containing an Aleurites fordii or Daphne kiusiana extract or a fraction thereof as an active ingredient. In detail, extracts of Aleurites fordii or Daphne kiusiana or fractions thereof can induce the secretion of an immune-related cytokine, interferon-γ (IFN-γ) in natural killer (NK) cells, and thus exhibit potent antiviral activity and superior effects for viral diseases, and therefore can be effectively used in an antiviral composition.
摘要翻译：本发明涉及含有Aleutites fordii或Daphne kiusiana提取物或其一部分作为活性成分的抗病毒组合物。详细地说，di of i，，，，，，，can can can can for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for 病毒性疾病，因此可以有效地用于抗病毒组合物。

10. 发明申请

US20110305680A1 Composition Containing Osteopontin for Differentiating Natural Killer Cell as an Active Ingredient and a Method of Differentiation Using Thereof 审中-公开
标题翻译：含有骨桥蛋白的组合物，用于将天然杀伤细胞分化为活性成分和使用它们的分化方法
公开(公告)号：US20110305680A1
公开(公告)日：2011-12-15
申请号：US12995020
申请日：2008-11-10
申请人： Inpyo Choi , Jin Woong Chung , Misun Kim , Suk Ran Yoon
发明人： Inpyo Choi , Jin Woong Chung , Misun Kim , Suk Ran Yoon
IPC分类号： A61K35/12 , A61P35/00 , C12N5/0783
CPC分类号： A61K38/19 , A61K35/17 , C12N5/0646 , C12N2501/998
摘要： The present invention relates to a composition for differentiating natural killer cells comprising osteopontin (OPN) as an active ingredient and a method for differentiation using the same. More precisely, osteopontin of the present invention accelerates differentiation of natural killer cells from hematopoietic stem cells and increases cytotoxic activity of natural killer cells, so that it can be effectively used as a composition for differentiating natural killer cells. OPN of the present invention regulates differentiation of natural killer cells capable of killing cancer cells, so that it can be effectively used for the treatment of cancer.
摘要翻译：本发明涉及用于分化包含骨桥蛋白（OPN）作为活性成分的天然杀伤细胞的组合物和使用其的分化方法。更准确地说，本发明的骨桥蛋白加速了造血干细胞中天然杀伤细胞的分化，并增加了天然杀伤细胞的细胞毒活性，因此可有效地用作分化天然杀伤细胞的组合物。本发明的OPN调节能够杀死癌细胞的天然杀伤细胞的分化，从而可以有效地用于治疗癌症。

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