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1. 发明申请

US20080234780A1 SELECTIVE NERVE STIMULATION WITH OPTIONALLY CLOSED-LOOP CAPABILITIES 有权
标题翻译：选择性神经刺激具有可选的闭环能力
公开(公告)号：US20080234780A1
公开(公告)日：2008-09-25
申请号：US11687809
申请日：2007-03-19
申请人： David J. Smith , Randy Westlund , Imad Libbus
发明人： David J. Smith , Randy Westlund , Imad Libbus
IPC分类号： A61N1/05
CPC分类号： A61N1/36139 , A61N1/36071 , A61N1/36114 , A61N1/36185
摘要： Systems and methods for steering one or more stimulation fields to a selected nerve target, thereby optimizing one or a combination of low stimulation thresholds, desired therapy outcomes, or a minimization of adverse stimulation side-effects. An array of electrodes disposed, at least in part, on two or more neural stimulation leads are used for steering the stimulation fields to the selected nerve target and are positioned adjacent the selected target. The stimulation may be titrated based on, among other things, a detected physiologic response to the applied stimulation.
摘要翻译：用于将一个或多个刺激场转向所选择的神经靶的系统和方法，从而优化低刺激阈值，期望的治疗结果或不利刺激副作用的最小化中的一个或组合。使用至少部分地设置在两个或更多个神经刺激引线上的电极阵列，用于将刺激场转向所选择的神经靶，并且定位成与所选择的靶相邻。基于对所施加的刺激的检测到的生理反应，刺激可以被滴定。

2. 发明授权

US08406877B2 Selective nerve stimulation with optionally closed-loop capabilities 有权
标题翻译：选择性神经刺激具有可选闭环功能
公开(公告)号：US08406877B2
公开(公告)日：2013-03-26
申请号：US11687809
申请日：2007-03-19
申请人： David J. Smith , Randy Westlund , Imad Libbus
发明人： David J. Smith , Randy Westlund , Imad Libbus
IPC分类号： A61N1/00
CPC分类号： A61N1/36139 , A61N1/36071 , A61N1/36114 , A61N1/36185
摘要： Systems and methods for steering one or more stimulation fields to a selected nerve target, thereby optimizing one or a combination of low stimulation thresholds, desired therapy outcomes, or a minimization of adverse stimulation side-effects. An array of electrodes disposed, at least in part, on two or more neural stimulation leads are used for steering the stimulation fields to the selected nerve target and are positioned adjacent the selected target. The stimulation may be titrated based on, among other things, a detected physiologic response to the applied stimulation.
摘要翻译：用于将一个或多个刺激场转向所选择的神经靶的系统和方法，从而优化低刺激阈值，期望的治疗结果或不利刺激副作用的最小化中的一个或组合。使用至少部分地设置在两个或更多个神经刺激引线上的电极阵列，用于将刺激场转向所选择的神经靶，并且定位成与所选择的靶相邻。基于对所施加的刺激的检测到的生理反应，刺激可以被滴定。

3. 发明申请

US20110040347A1 INTEGRATED LEAD FOR APPLYING CARDIAC RESYNCHRONIZATION THERAPY AND NEURAL STIMULATION THERAPY 有权
标题翻译：综合治疗心脏康复治疗与神经刺激治疗
公开(公告)号：US20110040347A1
公开(公告)日：2011-02-17
申请号：US12902844
申请日：2010-10-12
申请人： Imad Libbus , Julio C. Spinelli , Randy Westlund , Julia Moffitt , Tong Wang
发明人： Imad Libbus , Julio C. Spinelli , Randy Westlund , Julia Moffitt , Tong Wang
IPC分类号： A61N1/362 , A61N1/08
CPC分类号： A61N1/3627 , A61N1/0551 , A61N1/0556 , A61N1/0558 , A61N1/056 , A61N1/057 , A61N1/0587 , A61N1/36114 , A61N2001/0585
摘要： An embodiment includes a main lead assembly having a proximal portion adapted for connection to a device and a distal portion adapted for placement in a coronary sinus, the distal portion terminating in a distal end for placement proximal a left ventricle. Additionally, the main lead assembly includes a left ventricular electrode located at its distal end which is adapted to deliver cardiac resynchronization therapy to reduce ventricular wall stress. The main lead assembly also includes a fat pad electrode disposed along the main lead assembly a distance from the distal end to position the fat pad electrode proximal to at least one parasympathetic ganglia located in a fat pad bounded by an inferior vena cava and a left atrium. The fat pad electrode is adapted to stimulate the parasympathetic ganglia to reduce ventricular wall stress.
摘要翻译：一个实施例包括具有适于连接到装置的近端部分和适于放置在冠状窦中的远端部分的主引导组件，该远端部分终止于用于放置在左心室附近的远端。另外，主引线组件包括位于其远端处的左心室电极，其适于递送心脏再同步治疗以减少心室壁应力。主引线组件还包括脂肪垫电极，沿着主引线组件设置距离远端的距离，以将脂肪垫电极定位在靠近由下腔静脉和左心房限定的脂肪垫中的至少一个副交感神经节。脂肪垫电极适于刺激副交感神经节以减少心室壁应力。

4. 发明授权

US07840266B2 Integrated lead for applying cardiac resynchronization therapy and neural stimulation therapy 有权
标题翻译：应用心脏再同步治疗和神经刺激治疗的综合导联
公开(公告)号：US07840266B2
公开(公告)日：2010-11-23
申请号：US11077970
申请日：2005-03-11
申请人： Imad Libbus , Julio C. Spinelli , Randy Westlund , Julia Moffitt , Sophia H. Wang
发明人： Imad Libbus , Julio C. Spinelli , Randy Westlund , Julia Moffitt , Sophia H. Wang
IPC分类号： A61N1/08
CPC分类号： A61N1/3627 , A61N1/0551 , A61N1/0556 , A61N1/0558 , A61N1/056 , A61N1/057 , A61N1/0587 , A61N1/36114 , A61N2001/0585
摘要： An embodiment includes a main lead assembly having a proximal portion adapted for connection to a device and a distal portion adapted for placement in a coronary sinus, the distal portion terminating in a distal end for placement proximal a left ventricle. Additionally, the main lead assembly includes a left ventricular electrode located at its distal end which is adapted to deliver cardiac resynchronization therapy to reduce ventricular wall stress. The main lead assembly also includes a fat pad electrode disposed along the main lead assembly a distance from the distal end to position the fat pad electrode proximal to at least one parasympathetic ganglia located in a fat pad bounded by an inferior vena cava and a left atrium. The fat pad electrode is adapted to stimulate the parasympathetic ganglia to reduce ventricular wall stress.
摘要翻译：一个实施例包括具有适于连接到装置的近端部分和适于放置在冠状窦中的远端部分的主引导组件，该远端部分终止于用于放置在左心室附近的远端。另外，主引线组件包括位于其远端处的左心室电极，其适于递送心脏再同步治疗以减少心室壁应力。主引线组件还包括脂肪垫电极，沿着主引线组件设置距离远端的距离，以将脂肪垫电极定位在靠近由下腔静脉和左心房限定的脂肪垫中的至少一个副交感神经节。脂肪垫电极适于刺激副交感神经节以减少心室壁应力。

5. 发明授权

US08483823B2 Integrated lead for applying cardiac resynchronization therapy and neural stimulation therapy 有权
标题翻译：应用心脏再同步治疗和神经刺激治疗的综合导联
公开(公告)号：US08483823B2
公开(公告)日：2013-07-09
申请号：US12902844
申请日：2010-10-12
申请人： Imad Libbus , Julio C. Spinelli , Randy Westlund , Julia Moffitt , Sophia H. Wang
发明人： Imad Libbus , Julio C. Spinelli , Randy Westlund , Julia Moffitt , Sophia H. Wang
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/0551 , A61N1/0556 , A61N1/0558 , A61N1/056 , A61N1/057 , A61N1/0587 , A61N1/36114 , A61N2001/0585
摘要： An embodiment includes a main lead assembly having a proximal portion adapted for connection to a device and a distal portion adapted for placement in a coronary sinus, the distal portion terminating in a distal end for placement proximal a left ventricle. Additionally, the main lead assembly includes a left ventricular electrode located at its distal end which is adapted to deliver cardiac resynchronization therapy to reduce ventricular wall stress. The main lead assembly also includes a fat pad electrode disposed along the main lead assembly a distance from the distal end to position the fat pad electrode proximal to at least one parasympathetic ganglia located in a fat pad bounded by an inferior vena cava and a left atrium. The fat pad electrode is adapted to stimulate the parasympathetic ganglia to reduce ventricular wall stress.
摘要翻译：一个实施例包括具有适于连接到装置的近端部分和适于放置在冠状窦中的远端部分的主引导组件，该远端部分终止于用于放置在左心室附近的远端。另外，主引线组件包括位于其远端处的左心室电极，其适于递送心脏再同步治疗以减少心室壁应力。主引线组件还包括脂肪垫电极，沿着主引线组件设置距离远端的距离，以将脂肪垫电极定位在靠近由下腔静脉和左心房限定的脂肪垫中的至少一个副交感神经节。脂肪垫电极适于刺激副交感神经节以减少心室壁应力。

6. 发明申请

US20060206153A1 Integrated lead for applying cardiac resynchronization therapy and neural stimulation therapy 有权
公开(公告)号：US20060206153A1
公开(公告)日：2006-09-14
申请号：US11077970
申请日：2005-03-11
申请人： Imad Libbus , Julio Spinelli , Randy Westlund , Julia Moffitt , Sophia Wang
发明人： Imad Libbus , Julio Spinelli , Randy Westlund , Julia Moffitt , Sophia Wang
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/0551 , A61N1/0556 , A61N1/0558 , A61N1/056 , A61N1/057 , A61N1/0587 , A61N1/36114 , A61N2001/0585
摘要： An embodiment includes a main lead assembly having a proximal portion adapted for connection to a device and a distal portion adapted for placement in a coronary sinus, the distal portion terminating in a distal end for placement proximal a left ventricle. Additionally, the main lead assembly includes a left ventricular electrode located at its distal end which is adapted to deliver cardiac resynchronization therapy to reduce ventricular wall stress. The main lead assembly also includes a fat pad electrode disposed along the main lead assembly a distance from the distal end to position the fat pad electrode proximal to at least one parasympathetic ganglia located in a fat pad bounded by an inferior vena cava and a left atrium. The fat pad electrode is adapted to stimulate the parasympathetic ganglia to reduce ventricular wall stress.

7. 发明申请

US20080195188A1 IMPLANTABLE MEDICAL DEVICE WITH FIXATION MECHANISM 审中-公开
标题翻译：具有固定机构的可植入医疗器械
公开(公告)号：US20080195188A1
公开(公告)日：2008-08-14
申请号：US11673186
申请日：2007-02-09
申请人： Imad Libbus , Randy Westlund
发明人： Imad Libbus , Randy Westlund
IPC分类号： A61N1/05
CPC分类号： A61N1/0558 , A61N1/36114 , A61N1/372 , A61N1/37205 , A61N1/3756
摘要： Miniature implantable medical devices each include a fixation mechanism to prevent the device from migrating in the body of a patient after implantation. The fixation mechanism is activated after the device is positioned in the body. In one embodiment, the miniature implantable medical devices each include a circuit to deliver neurostimulation. In one embodiment, the fixation mechanism includes one or more externally activated anchoring devices each configured to switch from a substantially non-anchoring state to a substantially anchoring state in response to an externally applied energy. In another embodiment, implantable medical devices are magnetically attracted to each other to prevent the devices from migrating in the body after implantation.
摘要翻译：微型可植入医疗装置各自包括固定机构，以防止装置在植入后在患者体内迁移。在装置定位在体内后，固定机构被激活。在一个实施例中，微型可植入医疗装置各自包括用于递送神经刺激的电路。在一个实施例中，固定机构包括一个或多个外部激活的锚固装置，其各自被配置为响应于外部施加的能量而从基本上非锚定状态转换到基本锚定状态。在另一个实施例中，可植入医疗装置彼此磁吸引以防止装置在植入后在体内迁移。

8. 发明授权

US08224462B2 Medical lead system utilizing electromagnetic bandstop filters 有权
公开(公告)号：US08224462B2
公开(公告)日：2012-07-17
申请号：US13312741
申请日：2011-12-06
申请人： Randy Westlund , Robert A. Stevenson , Christine A. Frysz , Warren S. Dabney , Henry R. Halperin
发明人： Randy Westlund , Robert A. Stevenson , Christine A. Frysz , Warren S. Dabney , Henry R. Halperin
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61N1/0534 , A61N1/0539 , A61N1/0556 , A61N1/0587 , A61N1/086 , A61N2001/0585 , H03H1/0007 , H03H2001/0042 , H03H2001/005 , H03H2007/013
摘要： Medical lead systems utilizing electromagnetic bandstop filters are provide which can be utilized in a magnetic resonance imaging (MRI) environment for patients who have implanted medical devices. The medical lead system includes an implanted lead having at least one bandstop filter associated therewith, for attenuating current flow through the lead over a range of frequencies. The bandstop filter has an overall circuit Q wherein the resultant 3 dB bandwidth is at least 10 kHz. The values of capacitance and inductance of the bandstop filter are selected such that the bandstop filter is resonant at a selected center frequency. Preferably, the bandstop filter has an overall circuit Q wherein the resultant 10 dB bandwidth is at least 10 kHz. Such bandstop filters are backwards compatible with known implantable deployment systems and extraction systems.

9. 发明申请

US20120083864A1 MEDICAL LEAD SYSTEM UTILIZING ELECTROMAGNETIC BANDSTOP FILTERS 审中-公开
公开(公告)号：US20120083864A1
公开(公告)日：2012-04-05
申请号：US13299278
申请日：2011-11-17
申请人： Randy Westlund , Robert A. Stevenson , Christine A. Frysz , Warren S. Dabney
发明人： Randy Westlund , Robert A. Stevenson , Christine A. Frysz , Warren S. Dabney
IPC分类号： A61N1/04
CPC分类号： A61N1/05 , A61N1/0534 , A61N1/0539 , A61N1/0556 , A61N1/0587 , A61N1/086 , A61N2001/0585 , H03H1/0007 , H03H7/0115 , H03H7/1766 , H03H2001/0085 , H03H2007/013
摘要： Medical lead systems utilizing electromagnetic bandstop filters are provide which can be utilized in a magnetic resonance imaging (MRI) environment for patients who have implanted medical devices. The medical lead system includes an implanted lead having at least one bandstop filter associated therewith, for attenuating current flow through the lead over a range of frequencies. The bandstop filter has an overall circuit Q wherein the resultant 3 dB bandwidth is at least 10 kHz. The values of capacitance and inductance of the bandstop filter are selected such that the bandstop filter is resonant at a selected center frequency. Preferably, the bandstop filter has an overall circuit Q wherein the resultant 10 dB bandwidth is at least 10 kHz. Such bandstop filters are backwards compatible with known implantable deployment systems and extraction systems.

10. 发明授权

US07875018B2 Method for manipulating an adjustable shape guide catheter 失效
标题翻译：用于操纵可调整导向导管的方法
公开(公告)号：US07875018B2
公开(公告)日：2011-01-25
申请号：US11027114
申请日：2004-12-30
申请人： Bruce Tockman , Randy Westlund
发明人： Bruce Tockman , Randy Westlund
IPC分类号： A61M31/00
CPC分类号： A61M25/0041 , A61M25/0105 , A61M25/0136
摘要： A method of manipulating a catheter assembly involves providing an inner catheter member movably disposed within an outer catheter member. At least a distal end portion of the inner catheter member has a stiffness greater than that of at least a distal end portion of the outer catheter member. The distal end portion of the outer catheter member includes a deflectable distal end. The method further involves advancing the inner catheter member through the outer catheter member toward the deflectable distal end of the outer catheter member, and longitudinally displacing the distal end portion of the inner catheter member relative to the deflectable distal end of the outer catheter member to alter a shape of the deflectable distal end.
摘要翻译：操作导管组件的方法包括提供可移动地设置在外导管构件内的内导管构件。至少内导管部件的远端部分的刚度大于外导管部件的至少远端部分的刚度。外导管构件的远端部分包括可偏转的远端。该方法还包括使内部导管构件通过外部导管构件朝向外部导管构件的可偏转远端推进，并且相对于外部导管构件的可偏转远端纵向移动内部导管构件的远端部分以改变可偏转的远端的形状。

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