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1. 发明授权

US07840266B2 Integrated lead for applying cardiac resynchronization therapy and neural stimulation therapy 有权
标题翻译：应用心脏再同步治疗和神经刺激治疗的综合导联
公开(公告)号：US07840266B2
公开(公告)日：2010-11-23
申请号：US11077970
申请日：2005-03-11
申请人： Imad Libbus , Julio C. Spinelli , Randy Westlund , Julia Moffitt , Sophia H. Wang
发明人： Imad Libbus , Julio C. Spinelli , Randy Westlund , Julia Moffitt , Sophia H. Wang
IPC分类号： A61N1/08
CPC分类号： A61N1/3627 , A61N1/0551 , A61N1/0556 , A61N1/0558 , A61N1/056 , A61N1/057 , A61N1/0587 , A61N1/36114 , A61N2001/0585
摘要： An embodiment includes a main lead assembly having a proximal portion adapted for connection to a device and a distal portion adapted for placement in a coronary sinus, the distal portion terminating in a distal end for placement proximal a left ventricle. Additionally, the main lead assembly includes a left ventricular electrode located at its distal end which is adapted to deliver cardiac resynchronization therapy to reduce ventricular wall stress. The main lead assembly also includes a fat pad electrode disposed along the main lead assembly a distance from the distal end to position the fat pad electrode proximal to at least one parasympathetic ganglia located in a fat pad bounded by an inferior vena cava and a left atrium. The fat pad electrode is adapted to stimulate the parasympathetic ganglia to reduce ventricular wall stress.
摘要翻译：一个实施例包括具有适于连接到装置的近端部分和适于放置在冠状窦中的远端部分的主引导组件，该远端部分终止于用于放置在左心室附近的远端。另外，主引线组件包括位于其远端处的左心室电极，其适于递送心脏再同步治疗以减少心室壁应力。主引线组件还包括脂肪垫电极，沿着主引线组件设置距离远端的距离，以将脂肪垫电极定位在靠近由下腔静脉和左心房限定的脂肪垫中的至少一个副交感神经节。脂肪垫电极适于刺激副交感神经节以减少心室壁应力。

2. 发明授权

US08483823B2 Integrated lead for applying cardiac resynchronization therapy and neural stimulation therapy 有权
标题翻译：应用心脏再同步治疗和神经刺激治疗的综合导联
公开(公告)号：US08483823B2
公开(公告)日：2013-07-09
申请号：US12902844
申请日：2010-10-12
申请人： Imad Libbus , Julio C. Spinelli , Randy Westlund , Julia Moffitt , Sophia H. Wang
发明人： Imad Libbus , Julio C. Spinelli , Randy Westlund , Julia Moffitt , Sophia H. Wang
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/0551 , A61N1/0556 , A61N1/0558 , A61N1/056 , A61N1/057 , A61N1/0587 , A61N1/36114 , A61N2001/0585
摘要： An embodiment includes a main lead assembly having a proximal portion adapted for connection to a device and a distal portion adapted for placement in a coronary sinus, the distal portion terminating in a distal end for placement proximal a left ventricle. Additionally, the main lead assembly includes a left ventricular electrode located at its distal end which is adapted to deliver cardiac resynchronization therapy to reduce ventricular wall stress. The main lead assembly also includes a fat pad electrode disposed along the main lead assembly a distance from the distal end to position the fat pad electrode proximal to at least one parasympathetic ganglia located in a fat pad bounded by an inferior vena cava and a left atrium. The fat pad electrode is adapted to stimulate the parasympathetic ganglia to reduce ventricular wall stress.
摘要翻译：一个实施例包括具有适于连接到装置的近端部分和适于放置在冠状窦中的远端部分的主引导组件，该远端部分终止于用于放置在左心室附近的远端。另外，主引线组件包括位于其远端处的左心室电极，其适于递送心脏再同步治疗以减少心室壁应力。主引线组件还包括脂肪垫电极，沿着主引线组件设置距离远端的距离，以将脂肪垫电极定位在靠近由下腔静脉和左心房限定的脂肪垫中的至少一个副交感神经节。脂肪垫电极适于刺激副交感神经节以减少心室壁应力。

3. 发明申请

US20110040347A1 INTEGRATED LEAD FOR APPLYING CARDIAC RESYNCHRONIZATION THERAPY AND NEURAL STIMULATION THERAPY 有权
标题翻译：综合治疗心脏康复治疗与神经刺激治疗
公开(公告)号：US20110040347A1
公开(公告)日：2011-02-17
申请号：US12902844
申请日：2010-10-12
申请人： Imad Libbus , Julio C. Spinelli , Randy Westlund , Julia Moffitt , Tong Wang
发明人： Imad Libbus , Julio C. Spinelli , Randy Westlund , Julia Moffitt , Tong Wang
IPC分类号： A61N1/362 , A61N1/08
CPC分类号： A61N1/3627 , A61N1/0551 , A61N1/0556 , A61N1/0558 , A61N1/056 , A61N1/057 , A61N1/0587 , A61N1/36114 , A61N2001/0585
摘要： An embodiment includes a main lead assembly having a proximal portion adapted for connection to a device and a distal portion adapted for placement in a coronary sinus, the distal portion terminating in a distal end for placement proximal a left ventricle. Additionally, the main lead assembly includes a left ventricular electrode located at its distal end which is adapted to deliver cardiac resynchronization therapy to reduce ventricular wall stress. The main lead assembly also includes a fat pad electrode disposed along the main lead assembly a distance from the distal end to position the fat pad electrode proximal to at least one parasympathetic ganglia located in a fat pad bounded by an inferior vena cava and a left atrium. The fat pad electrode is adapted to stimulate the parasympathetic ganglia to reduce ventricular wall stress.
摘要翻译：一个实施例包括具有适于连接到装置的近端部分和适于放置在冠状窦中的远端部分的主引导组件，该远端部分终止于用于放置在左心室附近的远端。另外，主引线组件包括位于其远端处的左心室电极，其适于递送心脏再同步治疗以减少心室壁应力。主引线组件还包括脂肪垫电极，沿着主引线组件设置距离远端的距离，以将脂肪垫电极定位在靠近由下腔静脉和左心房限定的脂肪垫中的至少一个副交感神经节。脂肪垫电极适于刺激副交感神经节以减少心室壁应力。

4. 发明申请

US20060206153A1 Integrated lead for applying cardiac resynchronization therapy and neural stimulation therapy 有权
公开(公告)号：US20060206153A1
公开(公告)日：2006-09-14
申请号：US11077970
申请日：2005-03-11
申请人： Imad Libbus , Julio Spinelli , Randy Westlund , Julia Moffitt , Sophia Wang
发明人： Imad Libbus , Julio Spinelli , Randy Westlund , Julia Moffitt , Sophia Wang
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/0551 , A61N1/0556 , A61N1/0558 , A61N1/056 , A61N1/057 , A61N1/0587 , A61N1/36114 , A61N2001/0585
摘要： An embodiment includes a main lead assembly having a proximal portion adapted for connection to a device and a distal portion adapted for placement in a coronary sinus, the distal portion terminating in a distal end for placement proximal a left ventricle. Additionally, the main lead assembly includes a left ventricular electrode located at its distal end which is adapted to deliver cardiac resynchronization therapy to reduce ventricular wall stress. The main lead assembly also includes a fat pad electrode disposed along the main lead assembly a distance from the distal end to position the fat pad electrode proximal to at least one parasympathetic ganglia located in a fat pad bounded by an inferior vena cava and a left atrium. The fat pad electrode is adapted to stimulate the parasympathetic ganglia to reduce ventricular wall stress.

5. 发明授权

US08929990B2 Transvascular neural stimulation device and method for treating hypertension 有权
标题翻译：血管神经刺激装置及治疗高血压的方法
公开(公告)号：US08929990B2
公开(公告)日：2015-01-06
申请号：US12968831
申请日：2010-12-15
申请人： Julia Moffitt , Imad Libbus
发明人： Julia Moffitt , Imad Libbus
IPC分类号： A61N1/36 , A61N1/05 , A61N1/362
CPC分类号： A61N1/37288 , A61M31/00 , A61N1/0558 , A61N1/056 , A61N1/36053 , A61N1/3611 , A61N1/36114 , A61N1/36117 , A61N1/362 , A61N1/3627 , A61N1/37217
摘要： This document discusses, among other things, apparatus, systems, and methods for transvascularly stimulation of a nerve or nerve trunk. In an example, an apparatus is configured to transvascularly stimulate a nerve trunk through a blood vessel. The apparatus includes an expandable electrode that is chronically implantable in a blood vessel proximate a nerve trunk. The expandable electrode is configured to abut a predetermined surface area of the vessel wall along a predetermined length of the vessel. An electrical lead is coupled to the expandable electrode. An implantable pulse generator is coupled to the lead and configured to deliver an electrical stimulation signal to the electrode through the lead. In an example method, an electrical signal is delivered from an implanted medical device to an electrode chronically implanted in a blood vessel proximate a nerve trunk to transvascularly deliver neural stimulation from the electrode to the nerve trunk.
摘要翻译：本文件还讨论了用于神经或神经干的经血管刺激的装置，系统和方法。在一个实例中，一种装置构造成通过血管经血管刺激神经干。该装置包括可长期植入在靠近神经干的血管中的可扩张电极。可膨胀电极构造成沿容器的预定长度邻接容器壁的预定表面积。电引线耦合到可扩张电极。可植入脉冲发生器耦合到引线并且被配置为通过引线将电刺激信号传递到电极。在一个示例性方法中，将电信号从植入的医疗装置输送到长期植入在靠近神经干的血管中的电极，从而将神经刺激从电极转移到神经干。

6. 发明申请

US20130190837A1 SYSTEM AND METHOD FOR CLOSED-LOOP NEURAL STIMULATION 审中-公开
标题翻译：闭环神经刺激的系统和方法
公开(公告)号：US20130190837A1
公开(公告)日：2013-07-25
申请号：US13792805
申请日：2013-03-11
申请人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
发明人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
IPC分类号： A61N1/36
CPC分类号： A61N1/36117 , A61N1/08 , A61N1/36171
摘要： Various aspects of the present subject matter provide a device. In various embodiments, the device comprises a port adapted to connect a lead, a pulse generator connected to the port and adapted to provide a neural stimulation signal to the lead, and a signal processing module connected to the port and adapted to receive and process a nerve traffic signal from the lead into a signal indicative of the nerve traffic. The device includes a controller connected to the pulse generator and the signal processing module. The controller is adapted to implement a stimulation protocol to provide the neural stimulation signal with desired neural stimulation parameters based on the signal indicative of the nerve traffic. Other aspects are provided herein.
摘要翻译：本主题的各个方面提供了一种装置。在各种实施例中，该装置包括适于连接引线的端口，连接到端口的脉冲发生器，并适于向引线提供神经刺激信号，以及信号处理模块，连接到端口并适于接收和处理神经交通信号从引导到指示神经交通的信号。该装置包括连接到脉冲发生器和信号处理模块的控制器。控制器适于实现刺激方案，以基于指示神经交通的信号向神经刺激信号提供期望的神经刺激参数。本文提供了其他方面。

7. 发明申请

US20120232604A1 SYSTEM TO TREAT AV-CONDUCTED VENTRICULAR TACHYARRHYTHMIA 有权
标题翻译：系统治疗AV导致的心室TachyarRHYTHMIA
公开(公告)号：US20120232604A1
公开(公告)日：2012-09-13
申请号：US13473774
申请日：2012-05-17
申请人： Julia Moffitt , Andrew P. Kramer , Imad Libbus
发明人： Julia Moffitt , Andrew P. Kramer , Imad Libbus
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61N1/36114 , A61B5/0464 , A61N1/0587 , A61N1/3622 , A61N1/3627 , A61N1/368 , A61N1/3684 , A61N1/3962 , A61N2001/0585
摘要： Various aspects of the present subject matter provide devices and methods to treat AV-conducted ventricular tachyarrhythmia (AVCVT). According to various embodiments of the method, an AVCVT is sensed, an IVC-LA fat pad is stimulated when the AVCVT is sensed to block AV conduction, and bradycardia support pacing is provided while the IVC-LA fat pad is stimulated. Other aspects and embodiments are provided herein.
摘要翻译：本主题的各个方面提供了治疗AV进行性室性快速性心律失常（AVCVT）的装置和方法。根据该方法的各种实施例，感测到AVCVT，当检测到AVCVT以阻止AV传导时刺激IVC-LA脂肪垫，并且在IVC-LA脂肪垫被刺激的同时提供心动过缓支持起搏。本文提供了其它方面和实施例。

8. 发明申请

US20110082537A1 TRANSVASCULAR NEURAL STIMULATION DEVICE 审中-公开
标题翻译：超声神经刺激装置
公开(公告)号：US20110082537A1
公开(公告)日：2011-04-07
申请号：US12968831
申请日：2010-12-15
申请人： Julia Moffitt , Imad Libbus
发明人： Julia Moffitt , Imad Libbus
IPC分类号： A61N1/36 , A61M37/00 , A61F2/82
CPC分类号： A61N1/37288 , A61M31/00 , A61N1/0558 , A61N1/056 , A61N1/36053 , A61N1/3611 , A61N1/36114 , A61N1/36117 , A61N1/362 , A61N1/3627 , A61N1/37217
摘要： This document discusses, among other things, apparatus, systems, and methods for transvascularly stimulation of a nerve or nerve trunk. In an example, an apparatus is configured to transvascularly stimulate a nerve trunk through a blood vessel. The apparatus includes an expandable electrode that is chronically implantable in a blood vessel proximate a nerve trunk. The expandable electrode is configured to abut a predetermined surface area of the vessel wall along a predetermined length of the vessel. An electrical lead is coupled to the expandable electrode. An implantable pulse generator is coupled to the lead and configured to deliver an electrical stimulation signal to the electrode through the lead. In an example method, an electrical signal is delivered from an implanted medical device to an electrode chronically implanted in a blood vessel proximate a nerve trunk to transvascularly deliver neural stimulation from the electrode to the nerve trunk.
摘要翻译：本文件还讨论了用于神经或神经干的经血管刺激的装置，系统和方法。在一个实例中，一种装置构造成通过血管经血管刺激神经干。该装置包括可长期植入在靠近神经干的血管中的可扩张电极。可膨胀电极构造成沿容器的预定长度邻接容器壁的预定表面积。电引线耦合到可扩张电极。可植入脉冲发生器耦合到引线并且被配置为通过引线将电刺激信号传递到电极。在一个示例性方法中，将电信号从植入的医疗装置输送到长期植入在靠近神经干的血管中的电极，从而将神经刺激从电极转移到神经干。

9. 发明授权

US07805193B2 Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device 有权
标题翻译：通过可植入心脏装置的联合重塑控制治疗和抗重塑治疗
公开(公告)号：US07805193B2
公开(公告)日：2010-09-28
申请号：US11777394
申请日：2007-07-13
申请人： Imad Libbus , Bruce H. KenKnight , Julia Moffitt , Yatheendhar D. Manicka
发明人： Imad Libbus , Bruce H. KenKnight , Julia Moffitt , Yatheendhar D. Manicka
IPC分类号： A61N1/368
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： A method and device for delivering ventricular resynchronization pacing therapy in conjunction with electrical stimulation of nerves which alter the activity of the autonomic nervous system is disclosed. Such therapies may be delivered by an implantable device and are useful in preventing the deleterious ventricular remodeling which occurs as a result of a heart attack or heart failure. The device may perform an assessment of cardiac function in order to individually modulate the delivery of the two types of therapy.
摘要翻译：公开了一种用于将脑室再同步起搏治疗与神经改变自主神经系统的活动的电刺激结合的方法和装置。这样的治疗可以由可植入装置递送，并且可用于防止由于心脏病发作或心力衰竭而发生的有害心室重构。该装置可以执行心脏功能的评估，以便单独地调节两种类型的治疗的递送。

10. 发明授权

US07769446B2 Neural stimulation system for cardiac fat pads 有权
标题翻译：心脏脂肪垫的神经刺激系统
公开(公告)号：US07769446B2
公开(公告)日：2010-08-03
申请号：US11077583
申请日：2005-03-11
申请人： Julia Moffitt , Imad Libbus
发明人： Julia Moffitt , Imad Libbus
IPC分类号： A61N1/08
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/056 , A61N1/0587 , A61N1/36135 , A61N1/36514 , A61N1/3962 , A61N1/3987
摘要： Various aspects relate to a device which, in various embodiments, comprises a header, a neural stimulator, a detector and a controller. The header includes at least one port to connect to at least one lead, and includes first and second channels for use to provide neural stimulation to first and second neural stimulation sites for a heart. The controller is connected to the detector and the neural stimulator to selectively deliver a therapy based on the feedback signal. A first therapy signal is delivered to the first neural stimulation site to selectively control contractility and a second therapy signal is delivered to the second neural stimulation site to selectively control one of a sinus rate and an AV conduction. Other aspects and embodiments are provided herein.
摘要翻译：各种方面涉及在各种实施例中包括头部，神经刺激器，检测器和控制器的装置。头部包括至少一个连接至少一个引线的端口，并且包括用于向心脏的第一和第二神经刺激部位提供神经刺激的第一和第二通道。控制器连接到检测器和神经刺激器，以基于反馈信号选择性地递送治疗。第一治疗信号被递送到第一神经刺激部位以选择性地控制收缩性，并且第二治疗信号被递送到第二神经刺激部位以选择性地控制窦速率和AV传导之一。本文提供了其它方面和实施例。

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