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1. 发明授权

US08447394B2 Physical conditioning system, device and method 有权
标题翻译：物理调理系统，装置及方法
公开(公告)号：US08447394B2
公开(公告)日：2013-05-21
申请号：US12620132
申请日：2009-11-17
申请人： Imad Libbus , Julio C. Spinelli , Joseph M. Pastore , Andrew P. Kramer
发明人： Imad Libbus , Julio C. Spinelli , Joseph M. Pastore , Andrew P. Kramer
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/36014 , A61N1/37282 , A61N1/37288 , A61N2001/0585
摘要： Various system embodiments comprise a neural stimulator and a controller. The neural stimulator is adapted to generate a stimulation signal adapted to elicit sympathetic activity at a neural target. The controller is adapted to control the neural stimulator to provide a physical conditioning therapy. The controller is adapted to control the neural stimulator to intermittently elicit sympathetic activity at the neural target. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施例包括神经刺激器和控制器。神经刺激器适于产生适于在神经靶标处引起交感神经活动的刺激信号。控制器适于控制神经刺激器以提供物理调理疗法。该控制器适于控制神经刺激器间歇地在神经靶标上引起交感神经活动。本文提供了其它方面和实施例。

2. 发明授权

US08321023B2 Baroreflex modulation to gradually decrease blood pressure 有权
标题翻译： Baroreflex调制逐渐降低血压
公开(公告)号：US08321023B2
公开(公告)日：2012-11-27
申请号：US12321949
申请日：2009-01-27
申请人： Imad Libbus , Julio C. Spinelli
发明人： Imad Libbus , Julio C. Spinelli
IPC分类号： A61N1/36
CPC分类号： A61N1/36053 , A61N1/3611 , A61N1/36114 , A61N1/36117 , A61N1/36146 , A61N1/36564
摘要： An aspect of the present subject matter relates to a baroreflex stimulator. An embodiment of the stimulator includes a pulse generator to provide a baroreflex stimulation signal through an electrode, and a modulator. The modulator modulates the baroreflex stimulation signal to increase the baroreflex stimulation therapy by a predetermined rate of change to lower systemic blood pressure to a target pressure. Other aspects are provided herein.
摘要翻译：本主题的一个方面涉及一种压力反射刺激器。刺激器的实施例包括脉冲发生器，以通过电极提供压力反射刺激信号和调制器。该调节剂调节压力反射刺激信号以增加压力反射刺激疗法预定的变化率，从而将全身血压降低到目标压力。本文提供了其他方面。

3. 发明授权

US08032215B2 Method and apparatus for controlling autonomic balance using neural stimulation 有权
标题翻译：使用神经刺激来控制自主神经平衡的方法和装置
公开(公告)号：US08032215B2
公开(公告)日：2011-10-04
申请号：US12483031
申请日：2009-06-11
申请人： Imad Libbus , Andrew P. Kramer , Julio C. Spinelli
发明人： Imad Libbus , Andrew P. Kramer , Julio C. Spinelli
IPC分类号： A61N1/362
CPC分类号： A61N1/36057 , A61N1/36114 , A61N1/36139 , A61N1/3621 , A61N1/3627 , A61N1/36585
摘要： A neural stimulation system senses autonomic activities and applies neural stimulation to sympathetic and parasympathetic nerves to control autonomic balance. The neural stimulation system is capable of delivering neural stimulation pulses for sympathetic excitation, sympathetic inhibition, parasympathetic excitation, and parasympathetic inhibition.
摘要翻译：神经刺激系统感知自主活动，并将神经刺激应用于交感神经和副交感神经以控制自主神经平衡。神经刺激系统能够传递交感神经激励，交感神经抑制，副交感神经激动和副交感神经抑制的神经刺激脉冲。

4. 发明授权

US07761151B2 Intermittent high-energy cardiac stimulation for therapeutic effect 有权
标题翻译：间歇性高能心脏刺激治疗效果
公开(公告)号：US07761151B2
公开(公告)日：2010-07-20
申请号：US11466679
申请日：2006-08-23
申请人： Joseph M. Pastore , Imad Libbus , Andrew P. Kramer , Julio C. Spinelli
发明人： Joseph M. Pastore , Imad Libbus , Andrew P. Kramer , Julio C. Spinelli
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/3622
摘要： A device and method for delivering high-energy electrical stimulation to the heart in order to improve cardiac function in heart failure patients. The high-energy stimulation mimics the effects of exercise and improves symptoms even in patients who are exercise intolerant. The high-energy stimulation may be delivered on an intermittent basis either as pacing pulses in accordance with a programmed pacing mode and with a higher pacing pulse energy than used for conventional pacing or as low energy shock pulses.
摘要翻译：用于向心脏递送高能电刺激以改善心力衰竭患者的心脏功能的装置和方法。高能量刺激模拟运动的影响，即使在运动不耐受的患者中也能改善症状。高能量刺激可以间歇地作为起搏脉冲递送，或者作为起搏脉冲根据编程的起搏模式和较高的起搏脉冲能量而不是用于常规起搏或低能量冲击脉冲。

5. 发明授权

US07630760B2 Neural stimulation therapy system for atherosclerotic plaques 失效
标题翻译：动脉粥样硬化斑块神经刺激治疗系统
公开(公告)号：US07630760B2
公开(公告)日：2009-12-08
申请号：US11284370
申请日：2005-11-21
申请人： Imad Libbus , Julio C. Spinelli , Tamara Colette Baynham
发明人： Imad Libbus , Julio C. Spinelli , Tamara Colette Baynham
IPC分类号： A61N1/32
CPC分类号： A61N1/056 , A61N1/0556 , A61N1/36014 , A61N1/36114 , A61N1/36135 , A61N1/362
摘要： A neural stimulation therapy system for atherosclerotic plaques is provided. One aspect of this disclosure relates to a medical device for applying neural stimulation therapy for atherosclerotic plaques. The device includes a neural stimulator adapted to deliver an electrical signal through at least one electrode to an autonomic neural target. The device also includes a controller to control the neural stimulator to provide a therapy for atherosclerotic plaques. The device is external to a human body in an embodiment, and includes an implantable medical device (IMD) in various embodiments. According to an embodiment, the device includes a neural stimulation lead connected to the neural stimulator. The neural stimulator delivers electrical signals with waveform parameters based on sensed arterial blockage levels, according to various embodiments. Other aspects and embodiments are provided herein.
摘要翻译：提供了一种用于动脉粥样硬化斑块的神经刺激治疗系统。本公开的一个方面涉及用于对动脉粥样硬化斑块施加神经刺激疗法的医疗装置。该装置包括适于将电信号通过至少一个电极输送到自主神经靶的神经刺激器。该装置还包括控制器以控制神经刺激器以提供动脉粥样硬化斑块的治疗。在一个实施例中，该装置在人体外部，并且在各种实施例中包括可植入医疗装置（IMD）。根据实施例，该装置包括连接到神经刺激器的神经刺激引线。根据各种实施例，神经刺激器基于感测的动脉阻塞水平递送具有波形参数的电信号。本文提供了其它方面和实施例。

6. 发明授权

US09037233B2 Intermittent high-energy cardiac stimulation for therapeutic effect 有权
标题翻译：间歇性高能心脏刺激治疗效果
公开(公告)号：US09037233B2
公开(公告)日：2015-05-19
申请号：US12838792
申请日：2010-07-19
申请人： Joseph M. Pastore , Imad Libbus , Andrew P. Kramer , Julio C. Spinelli
发明人： Joseph M. Pastore , Imad Libbus , Andrew P. Kramer , Julio C. Spinelli
IPC分类号： A61N1/00 , A61N1/362
CPC分类号： A61N1/3627 , A61N1/3622
摘要： A device and method for delivering high-energy electrical stimulation to the heart in order to improve cardiac function in heart failure patients. The high-energy stimulation mimics the effects of exercise and improves symptoms even in patients who are exercise intolerant. The high-energy stimulation may be delivered on an intermittent basis either as pacing pulses in accordance with a programmed pacing mode and with a higher pacing pulse energy than used for conventional pacing or as low energy shock pulses.
摘要翻译：用于向心脏递送高能电刺激以改善心力衰竭患者的心脏功能的装置和方法。高能量刺激模拟运动的影响，即使在运动不耐受的患者中也能改善症状。高能量刺激可以间歇地作为起搏脉冲递送，或者作为起搏脉冲根据编程的起搏模式和较高的起搏脉冲能量而不是用于常规起搏或低能量冲击脉冲。

7. 发明授权

US08401672B2 Method and apparatus for controlling autonomic balance using neural stimulation 有权
公开(公告)号：US08401672B2
公开(公告)日：2013-03-19
申请号：US13248161
申请日：2011-09-29
申请人： Imad Libbus , Andrew P. Kramer , Julio C. Spinelli
发明人： Imad Libbus , Andrew P. Kramer , Julio C. Spinelli
IPC分类号： A61N1/05 , A61N1/18
CPC分类号： A61N1/36057 , A61N1/36114 , A61N1/36139 , A61N1/3621 , A61N1/3627 , A61N1/36585
摘要： A neural stimulation system senses autonomic activities and applies neural stimulation to sympathetic and parasympathetic nerves to control autonomic balance. The neural stimulation system is capable of delivering neural stimulation pulses for sympathetic excitation, sympathetic inhibition, parasympathetic excitation, and parasympathetic inhibition.

8. 发明申请

US20120022608A1 METHOD AND APPARATUS FOR CONTROLLING AUTONOMIC BALANCE USING NEURAL STIMULATION 有权
标题翻译：使用神经刺激来控制自动平衡的方法和装置
公开(公告)号：US20120022608A1
公开(公告)日：2012-01-26
申请号：US13248161
申请日：2011-09-29
申请人： Imad Libbus , Andrew P. Kramer , Julio C. Spinelli
发明人： Imad Libbus , Andrew P. Kramer , Julio C. Spinelli
IPC分类号： A61N1/365 , A61N1/372
CPC分类号： A61N1/36057 , A61N1/36114 , A61N1/36139 , A61N1/3621 , A61N1/3627 , A61N1/36585
摘要： A neural stimulation system senses autonomic activities and applies neural stimulation to sympathetic and parasympathetic nerves to control autonomic balance. The neural stimulation system is capable of delivering neural stimulation pulses for sympathetic excitation, sympathetic inhibition, parasympathetic excitation, and parasympathetic inhibition.
摘要翻译：神经刺激系统感知自主活动，并将神经刺激应用于交感神经和副交感神经以控制自主神经平衡。神经刺激系统能够传递交感神经激励，交感神经抑制，副交感神经激动和副交感神经抑制的神经刺激脉冲。

9. 发明申请

US20110040347A1 INTEGRATED LEAD FOR APPLYING CARDIAC RESYNCHRONIZATION THERAPY AND NEURAL STIMULATION THERAPY 有权
标题翻译：综合治疗心脏康复治疗与神经刺激治疗
公开(公告)号：US20110040347A1
公开(公告)日：2011-02-17
申请号：US12902844
申请日：2010-10-12
申请人： Imad Libbus , Julio C. Spinelli , Randy Westlund , Julia Moffitt , Tong Wang
发明人： Imad Libbus , Julio C. Spinelli , Randy Westlund , Julia Moffitt , Tong Wang
IPC分类号： A61N1/362 , A61N1/08
CPC分类号： A61N1/3627 , A61N1/0551 , A61N1/0556 , A61N1/0558 , A61N1/056 , A61N1/057 , A61N1/0587 , A61N1/36114 , A61N2001/0585
摘要： An embodiment includes a main lead assembly having a proximal portion adapted for connection to a device and a distal portion adapted for placement in a coronary sinus, the distal portion terminating in a distal end for placement proximal a left ventricle. Additionally, the main lead assembly includes a left ventricular electrode located at its distal end which is adapted to deliver cardiac resynchronization therapy to reduce ventricular wall stress. The main lead assembly also includes a fat pad electrode disposed along the main lead assembly a distance from the distal end to position the fat pad electrode proximal to at least one parasympathetic ganglia located in a fat pad bounded by an inferior vena cava and a left atrium. The fat pad electrode is adapted to stimulate the parasympathetic ganglia to reduce ventricular wall stress.
摘要翻译：一个实施例包括具有适于连接到装置的近端部分和适于放置在冠状窦中的远端部分的主引导组件，该远端部分终止于用于放置在左心室附近的远端。另外，主引线组件包括位于其远端处的左心室电极，其适于递送心脏再同步治疗以减少心室壁应力。主引线组件还包括脂肪垫电极，沿着主引线组件设置距离远端的距离，以将脂肪垫电极定位在靠近由下腔静脉和左心房限定的脂肪垫中的至少一个副交感神经节。脂肪垫电极适于刺激副交感神经节以减少心室壁应力。

10. 发明授权

US07840266B2 Integrated lead for applying cardiac resynchronization therapy and neural stimulation therapy 有权
标题翻译：应用心脏再同步治疗和神经刺激治疗的综合导联
公开(公告)号：US07840266B2
公开(公告)日：2010-11-23
申请号：US11077970
申请日：2005-03-11
申请人： Imad Libbus , Julio C. Spinelli , Randy Westlund , Julia Moffitt , Sophia H. Wang
发明人： Imad Libbus , Julio C. Spinelli , Randy Westlund , Julia Moffitt , Sophia H. Wang
IPC分类号： A61N1/08
CPC分类号： A61N1/3627 , A61N1/0551 , A61N1/0556 , A61N1/0558 , A61N1/056 , A61N1/057 , A61N1/0587 , A61N1/36114 , A61N2001/0585
摘要： An embodiment includes a main lead assembly having a proximal portion adapted for connection to a device and a distal portion adapted for placement in a coronary sinus, the distal portion terminating in a distal end for placement proximal a left ventricle. Additionally, the main lead assembly includes a left ventricular electrode located at its distal end which is adapted to deliver cardiac resynchronization therapy to reduce ventricular wall stress. The main lead assembly also includes a fat pad electrode disposed along the main lead assembly a distance from the distal end to position the fat pad electrode proximal to at least one parasympathetic ganglia located in a fat pad bounded by an inferior vena cava and a left atrium. The fat pad electrode is adapted to stimulate the parasympathetic ganglia to reduce ventricular wall stress.
摘要翻译：一个实施例包括具有适于连接到装置的近端部分和适于放置在冠状窦中的远端部分的主引导组件，该远端部分终止于用于放置在左心室附近的远端。另外，主引线组件包括位于其远端处的左心室电极，其适于递送心脏再同步治疗以减少心室壁应力。主引线组件还包括脂肪垫电极，沿着主引线组件设置距离远端的距离，以将脂肪垫电极定位在靠近由下腔静脉和左心房限定的脂肪垫中的至少一个副交感神经节。脂肪垫电极适于刺激副交感神经节以减少心室壁应力。

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