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1. 发明申请

US20050149129A1 Baropacing and cardiac pacing to control output 审中-公开
标题翻译：支架和心脏起搏来控制输出
公开(公告)号：US20050149129A1
公开(公告)日：2005-07-07
申请号：US10746135
申请日：2003-12-24
申请人： Imad Libbus , Joseph Pastore
发明人： Imad Libbus , Joseph Pastore
IPC分类号： A61N1/36 , A61N1/362
CPC分类号： A61N1/362 , A61N1/36114
摘要： One aspect of the present subject matter relates to an implantable medical system. An embodiment of the system includes a baroreflex stimulator and a cardiac stimulator. The baroreflex stimulator applies a baroreflex stimulation signal through an electrode and provides a signal indicating that the baroreflex signal is being applied. The cardiac stimulator applies a pacing therapy with a pacing rate, receives the signal from the baroreflex stimulator, and increases the pacing rate of the pacing therapy to compensate for cardiac output compromised by applying the baroreflex stimulation signal. Other aspects are provided herein.
摘要翻译：本主题的一个方面涉及可植入医疗系统。系统的一个实施例包括压力反射刺激器和心脏刺激器。压力反射刺激器通过电极施加压力反射刺激信号，并提供指示正在施加压力反射信号的信号。心脏刺激器应用起搏速率的起搏治疗，接收来自压力反射刺激器的信号，并增加起搏治疗的起搏速率，以补偿通过应用压力反射刺激信号而损害的心输出量。本文提供了其他方面。

2. 发明授权

US08805501B2 Baroreflex stimulation to treat acute myocardial infarction 有权
标题翻译： Baroreflex刺激治疗急性心肌梗死
公开(公告)号：US08805501B2
公开(公告)日：2014-08-12
申请号：US13357932
申请日：2012-01-25
申请人： Imad Libbus
发明人： Imad Libbus
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36117 , A61N1/36564
摘要： An aspect of the present subject relates to an implantable medical system. An embodiment of the system includes a baroreflex stimulator, a myocardial infarction detector, and a controller. The baroreflex stimulator applies a baroreflex stimulation signal through an electrode. The myocardial infarction detector detects an event indicative of myocardial infarction, The controller is connected to the baroreflex stimulator and to the myocardial infarction detector, and is adapted to apply a baroreflex therapy in response to a detected event indicative of myocardial infarction. Other aspects are provided herein.
摘要翻译：本发明的一个方面涉及可植入医疗系统。系统的一个实施例包括压力反射刺激器，心肌梗死检测器和控制器。压力反射刺激器通过电极施加压力反射刺激信号。心肌梗死检测器检测到指示心肌梗死的事件。控制器连接到压力反射刺激器和心肌梗塞检测器，并且适于对检测到的指示心肌梗塞的事件应用压力反射治疗。本文提供了其他方面。

3. 发明授权

US08755892B2 Systems for stimulating neural targets 有权
标题翻译：刺激神经靶点的系统
公开(公告)号：US08755892B2
公开(公告)日：2014-06-17
申请号：US11749500
申请日：2007-05-16
申请人： Badri Amurthur , Imad Libbus
发明人： Badri Amurthur , Imad Libbus
IPC分类号： A61N1/04 , A61N1/36
CPC分类号： A61N1/36017 , A61B5/021 , A61B5/02405 , A61B5/02416 , A61B5/026 , A61B5/14532 , A61B5/1455 , A61B5/4041 , A61B5/6815 , A61B5/6826 , A61B5/6838 , A61B8/06 , A61N1/0452 , A61N1/0456 , A61N1/0492 , A61N1/36114 , A61N1/36117
摘要： Disclosed herein, among other things, is a method for stimulating neural targets in the vicinity of a human ear. According to an embodiment, a device is clipped on a patient ear lobe, the device including a neural stimulation electrode. A neural stimulation signal is applied to the electrode to transcutaneously stimulate neural targets in the vicinity of the ear lobe, according to an embodiment. A physiological parameter is sensed using a sensor connected to the device. According to an embodiment, the neural stimulation signal is adjusted in response to the sensed parameter. The method is used is a variety of treatment regimens, including anti-hypertensive and cardiac improvement therapy.
摘要翻译：本文公开了一种用于刺激人耳附近的神经靶的方法。根据实施例，将装置夹在患者耳垂上，该装置包括神经刺激电极。根据实施例，神经刺激信号被施加到电极以经皮刺激耳垂附近的神经靶。使用连接到该装置的传感器感测生理参数。根据实施例，响应于所感测的参数来调整神经刺激信号。使用的方法是多种治疗方案，包括抗高血压和心脏改善治疗。

4. 发明授权

US08571654B2 Vagus nerve neurostimulator with multiple patient-selectable modes for treating chronic cardiac dysfunction 有权
标题翻译：迷走神经神经刺激器具有多种患者可选择的治疗慢性心脏功能障碍的模式
公开(公告)号：US08571654B2
公开(公告)日：2013-10-29
申请号：US13352244
申请日：2012-01-17
申请人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
IPC分类号： A61N1/365
CPC分类号： A61N1/0551 , A61N1/36053 , A61N1/36114 , A61N1/3727
摘要： A vagus nerve neurostimulator system with multiple patient-selectable modes for treating chronic cardiac dysfunction is provided. An implantable neurostimulator includes a pulse generator coupled to a therapy lead terminated by a pair of helical electrodes positioned over a cervical vagus nerve. The pulse generator is configured to deliver through the helical electrodes continuously-cycling, intermittent and periodic electrical stimulation that is parametrically defined to bi-directionally propagate through nerve fibers in the cervical vagus nerve. The implantable neurostimulator includes a magnetic switch configured to switch the pulse generator between a plurality of operating modes that are each separately selectable in response to a unique and remotely-applied magnetic signal. An external controller includes patient-actuatable controls configured to enable selection of one of the operating modes of the pulse generator. The external controller includes an electromagnetic transmitter configured to output the magnetic signal uniquely associated with the operating mode as selected with the controls.
摘要翻译：提供了一种具有多种患者可选择的用于治疗慢性心脏功能障碍的模式的迷走神经神经刺激器系统。可植入的神经刺激器包括一个脉冲发生器，该脉冲发生器耦合到由位于颈部迷走神经上的一对螺旋电极终止的治疗引线。脉冲发生器被配置为通过螺旋电极连续循环，间歇和周期性电刺激传递，其被参数限定以通过颈部迷走神经中的神经纤维双向传播。可植入神经刺激器包括磁开关，其被配置为在多个操作模式之间切换脉冲发生器，所述多个操作模式可以响应于独特的和远程施加的磁信号而分别可选择。外部控制器包括被配置为能够选择脉冲发生器的一个操作模式的患者致动控制。外部控制器包括电磁发射机，其被配置为输出与通过控制选择的操作模式唯一相关联的磁信号。

5. 发明授权

US08447397B2 Systems, devices and methods used in verifying neural stimulation capture 有权
标题翻译：用于验证神经刺激捕获的系统，设备和方法
公开(公告)号：US08447397B2
公开(公告)日：2013-05-21
申请号：US13460949
申请日：2012-05-01
申请人： Imad Libbus , Andrew P. Kramer
发明人： Imad Libbus , Andrew P. Kramer
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/36117
摘要： Various system embodiments comprise a neural stimulator, a premature ventricular contraction (PVC) event detector, a heart rate detector, an analyzer, and a controller. The neural stimulator is adapted to generate a stimulation signal adapted to stimulate an autonomic neural target. The analyzer is adapted to, in response to a PVC event signal from the PVC event detector, generate an autonomic balance indicator (ABI) as a function of pre-PVC heart rate data and post-PVC heart rate data. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施例包括神经刺激器，早产性心室收缩（PVC）事件检测器，心率检测器，分析器和控制器。神经刺激器适于产生适于刺激自主神经靶标的刺激信号。分析器适于响应来自PVC事件检测器的PVC事件信号，产生作为PVC前心率数据和PVC后心率数据的函数的自主平衡指示器（ABI）。本文提供了其它方面和实施例。

6. 发明授权

US08447394B2 Physical conditioning system, device and method 有权
标题翻译：物理调理系统，装置及方法
公开(公告)号：US08447394B2
公开(公告)日：2013-05-21
申请号：US12620132
申请日：2009-11-17
申请人： Imad Libbus , Julio C. Spinelli , Joseph M. Pastore , Andrew P. Kramer
发明人： Imad Libbus , Julio C. Spinelli , Joseph M. Pastore , Andrew P. Kramer
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/36014 , A61N1/37282 , A61N1/37288 , A61N2001/0585
摘要： Various system embodiments comprise a neural stimulator and a controller. The neural stimulator is adapted to generate a stimulation signal adapted to elicit sympathetic activity at a neural target. The controller is adapted to control the neural stimulator to provide a physical conditioning therapy. The controller is adapted to control the neural stimulator to intermittently elicit sympathetic activity at the neural target. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施例包括神经刺激器和控制器。神经刺激器适于产生适于在神经靶标处引起交感神经活动的刺激信号。控制器适于控制神经刺激器以提供物理调理疗法。该控制器适于控制神经刺激器间歇地在神经靶标上引起交感神经活动。本文提供了其它方面和实施例。

7. 发明授权

US08391972B2 Safety control system for implantable neural stimulator 有权
公开(公告)号：US08391972B2
公开(公告)日：2013-03-05
申请号：US13282325
申请日：2011-10-26
申请人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
发明人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
IPC分类号： A61N1/00
CPC分类号： A61N1/36142 , A61N1/36114 , A61N1/36139 , A61N1/37
摘要： A neural stimulation system includes a safety control system that prevents delivery of neural stimulation pulses from causing potentially harmful effects. The neural stimulation pulses are delivered to one or more nerves to control the physiological functions regulated by the one or more nerves. Examples of such harmful effects include unintended effects in physiological functions associated with autonomic neural stimulation and nerve injuries caused by excessive delivery of the neural stimulation pulses.

8. 发明授权

US08374688B2 System and methods for wireless body fluid monitoring 有权
标题翻译：无线体液监测系统及方法
公开(公告)号：US08374688B2
公开(公告)日：2013-02-12
申请号：US12210078
申请日：2008-09-12
申请人： Imad Libbus , Mark Bly
发明人： Imad Libbus , Mark Bly
IPC分类号： A61B5/05
CPC分类号： A61B5/02028 , A61B5/0002 , A61B5/0004 , A61B5/0006 , A61B5/0008 , A61B5/01 , A61B5/02055 , A61B5/02405 , A61B5/0245 , A61B5/04012 , A61B5/04085 , A61B5/04087 , A61B5/044 , A61B5/0452 , A61B5/0531 , A61B5/0535 , A61B5/0537 , A61B5/08 , A61B5/0816 , A61B5/1114 , A61B5/1116 , A61B5/1118 , A61B5/443 , A61B5/4875 , A61B5/6833 , A61B5/6843 , A61B5/6885 , A61B5/7264 , A61B5/7275 , A61B5/7282 , A61B5/746 , A61B2560/0412 , A61B2560/0468 , A61B2562/0209 , A61B2562/0214 , A61B2562/043 , A61B2562/164 , G06F19/00 , G06F19/3418 , G16H50/30
摘要： An adherent device to monitor a tissue hydration of a patient comprises an adhesive patch to adhere to a skin of the patient. At least four electrodes are connected to the patch and capable of electrically coupling to the patient. Impedance circuitry is coupled to the at least four electrodes to measure a tissue resistance of the patient, where the circuitry is configured to determine the tissue hydration in response to tissue resistance. The circuitry may comprise a processor system and the tissue resistance may correspond to a change in patient body fluid. The impedance circuitry is configured to measure the hydration signal using at least one low measurement frequency, which may be in the range of 0 to 10 kHz. Multiple measurement frequencies may be used and the hydration signal may include a tissue reactance measurement.
摘要翻译：用于监测患者的组织水合的粘附装置包括粘附到患者皮肤上的粘合贴片。至少四个电极连接到贴片并且能够电耦合到患者。阻抗电路耦合到至少四个电极以测量患者的组织电阻，其中电路被配置为响应于组织电阻确定组织水合。电路可以包括处理器系统，并且组织电阻可以对应于患者体液的变化。阻抗电路被配置为使用至少一个低测量频率来测量水合信号，该低测量频率可以在0至10kHz的范围内。可以使用多个测量频率，并且水合信号可以包括组织电抗测量。

9. 发明授权

US08332047B2 System and method for closed-loop neural stimulation 有权
标题翻译：闭环神经刺激的系统和方法
公开(公告)号：US08332047B2
公开(公告)日：2012-12-11
申请号：US11280940
申请日：2005-11-16
申请人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
发明人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/36053 , A61N1/36117
摘要： Various device embodiments comprise a pulse generator, a signal processing module and a controller. The pulse generator is adapted to provide a neural stimulation signal to be applied at a neural simulation site within an autonomic nervous system (ANS). The signal processing module is adapted to receive and process sensed neural traffic at a neural sensing site within the ANS. The controller is connected to the pulse generator and adapted to provide a neural stimulation control signal to the pulse generator to generate the neural stimulation signal, and to the signal processing module to receive a feedback control signal indicative of the sensed neural traffic. The controller is adapted to adjust the neural stimulation control signal to adjust at least one parameter of the neural stimulation signal to converge on desired sensed neural traffic at the neural sensing site. Other aspects and embodiments are provided herein.
摘要翻译：各种装置实施例包括脉冲发生器，信号处理模块和控制器。脉冲发生器适于提供在自主神经系统（ANS）内的神经模拟部位应用的神经刺激信号。信号处理模块适于在ANS内的神经感测部位接收和处理感测到的神经流量。控制器连接到脉冲发生器并且适于向脉冲发生器提供神经刺激控制信号以产生神经刺激信号，并且向信号处理模块接收指示所感测的神经流量的反馈控制信号。控制器适于调整神经刺激控制信号以调整神经刺激信号的至少一个参数以收敛于神经感测位置处的期望感测的神经交通。本文提供了其它方面和实施例。

10. 发明授权

US08321023B2 Baroreflex modulation to gradually decrease blood pressure 有权
标题翻译： Baroreflex调制逐渐降低血压
公开(公告)号：US08321023B2
公开(公告)日：2012-11-27
申请号：US12321949
申请日：2009-01-27
申请人： Imad Libbus , Julio C. Spinelli
发明人： Imad Libbus , Julio C. Spinelli
IPC分类号： A61N1/36
CPC分类号： A61N1/36053 , A61N1/3611 , A61N1/36114 , A61N1/36117 , A61N1/36146 , A61N1/36564
摘要： An aspect of the present subject matter relates to a baroreflex stimulator. An embodiment of the stimulator includes a pulse generator to provide a baroreflex stimulation signal through an electrode, and a modulator. The modulator modulates the baroreflex stimulation signal to increase the baroreflex stimulation therapy by a predetermined rate of change to lower systemic blood pressure to a target pressure. Other aspects are provided herein.
摘要翻译：本主题的一个方面涉及一种压力反射刺激器。刺激器的实施例包括脉冲发生器，以通过电极提供压力反射刺激信号和调制器。该调节剂调节压力反射刺激信号以增加压力反射刺激疗法预定的变化率，从而将全身血压降低到目标压力。本文提供了其他方面。

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